Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

각종 소화성질환에서의 Campylobacter Pylori의 검출에 관하여

허정욱,강영우,박준호,박승국,하경임,김재룡,안성훈,박선우 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

Peptic disorders are among the most common maladies in korea as the world. In most cases their etiologies not be established and their pathophysioolgy remain obscure. Although the persence of fastric bacteria has been logn established, recently campylobacter pylori seems to be etiologic agent of peptic disorders. Campylobacter pylori is visualized in most cases of peptic disorders and not visualized after treatment of bctericidal agents, bismuth compound or metronidazole. We had a following results for identification of campylocacter pylori in stomach and duodenal mcuosa via endoscipc biopsy. 1. We studied 54 patients who had dyspeptic symptoms, 29 males. 2. Most patients are in 5th decades, next in 3rd and 6th in order. 3. Ptients were composed of 27 peptic ulcer, 22 gastitis and 5 gastric carcinoma. 4. Campylobacter pylori was identified in 69% of total patients, peptic ulcer 63%, gastritis 77%, stomach carcinoma leastly.

혈우병 환자의 임상 양상에 관한 단일기관 연구

허지혜,김형욱,김영대,이영호,김남수,설인준,김상우 인제대학교 2006 仁濟醫學 Vol.27 No.-

Objective : We analyzed and investigated clinical manifestations, laboratory tests, and inhibitor development of hemophilia that had not been thoroughly studied. Methods : We retrospectively reviewed 96 patients with hemophilia who were registered in the Hanyang University hospital from Jan, 1984 to Dec, 2003, Results : The total patients, whose median age at onset was 46.0 months, in clude 84 cases of type A (87.5%) and 12 cases of type B (12.5%). The most common chief complaint was a traumatic hemorrhage. The family histories of hemophilia were revealed in 41 cases (42.7%). The median activated partial thromboplastin time (aPTT) was 66.7 seconds. The number of severe cases was 39 (40.6%). Inhibitors were present in 13 cases (13.5%) and seven cases (53.8%) were high responders. aPTT and factor levels showed reverse correlation (r=-0.467). aPTT is more prolonged in group without family history than the group with family history (P=0.037). Conclusion : In this study, the diagnosis of hemophilia are made at the lower age and the serological positivity of the HCV is decreased. Activated partial thromboplastin time and factor levels shows reverse correlation. Activated partial thromboplastin time is more prolonged in group without family history compared with group with family history. The frequencies of family history are lower than those of other developed countries, because of concealing the family history of hemophilia. The prevalence of the development of inhibitors increased compared with those of previous studies in Korea, but was lower than those of other countries. Further studies would be necessary to decrease the inhibitor development.

CDM과 ICD에 의한 루퍼시스템의 제어기 설계

김영철,허명준,정동근 순천향대학교 부설 산업기술연구소 1999 순천향 산업기술연구소논문집 Vol.5 No.1

채널분해법(ICD)의 개념과 계수도법(CDM)을 이용하여 2 입력 2 출력 다변수 제어시스템을 설계하였다. 시스템을 2 개의 채널로 분해한 후, 우선 각 개별 채널에 대해서 계수도법(CDM)을 이용하여 분산제어기를 설계하고, 그 분산제어기가 포함된 각 채널에 대해서는 새로운 비간섭화 제어기를 제안하고 설계하였다. 제철공정중 열간압연공정의 루퍼시스템 모델에 대한 모의실험을 통하여, 계수도법과 새로운 비간섭화 제어기의 유용성을 입증하였다.

무전해도금에 의한 다공성 니켈의 제조에 관한 연구

신준호,김기원,허보영 국립경상대학교 공과대학 부설 첨단소재연구소 1993 尖端素材 Vol.3 No.-

A new process on the preparation of porous nickel by electroless plating was developed using fine graphite powders of 1㎛-2㎛ particle diameter and polyurethane foam. In this process, graphite powders were introduced into the pores(foams) existing within polyurethane foam in order to supply electric conducting seeds for nickel deposition by electroless plating reaction. After the electroless plating, remaining polyurethane was removed chemically using organic solvent and most of graphite powder seeds also removed by ultrasonic cleaning. Porous nickel plates with 250㎛-300㎛ thickness and porosity comparable to commercial sintered nickel plate were obtained and found out that the platesare of mono-layer structure composed of spherical nickel particles connected each other in two-dimensional scale.

물류시스템 최적화를 위한 설비배치에 관한 연구

박세준,이영해,허선,이문환,유지용 한국경영과학회 1998 한국경영과학회 학술대회논문집 Vol.- No.2

We consider a facility layout problem for optimized material flow system design in the automated production system design. Existing facility layout algorithm have a weak point that arranged facilities have irregular shape or don't preserve their own shape and size. The proposed algorithm give a layout which is minimize total material handling cost and maximize space utility under preserving each facilities own shape and size.

방사선조사된 가토에서 어비윰야그 레이저를 이용한 조사시 수분유무가 골에 미치는 효과

최영옥 ( Young Ok Choi ) , 허영철 ( Young Cheol Hur ) , 정태영 ( Tae Young Chung ) , 이준길 ( Joon Gil Lee ) , 조경안 ( Kyung Ahn Cho ) , 이철우 ( Cheol Woo Lee ) , 김수흥 ( Soo Heung Kim ) , 안영재 ( Young Jae Ahn ) , 오선영 ( 조선대학교 구강생물학연구소 2003 Oral Biology Research (Oral Biol Res) Vol.27 No.2

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Outcomes of bortezomib combination chemotherapies in autologous stem cell transplantation-ineligible patients with AL amyloidosis

Joon Young Hur,Sang Eun Yoon,Darae Kim,Jin-Oh Choi,민주홍,김병준,Jung Sun Kim,Jung Eun Lee,최준영,Eun-Seok Jeon,Seok Jin Kim,Kihyun Kim 대한혈액학회 2021 Blood Research Vol.56 No.4

Background Treatment protocols for light chain (AL) amyloidosis have been derived from myeloma treatment. Bortezomib is a key drug used for the treatment of myeloma and AL amyloidosis. We retrospectively investigated the efficacy and toxicity of bortezomib- based chemotherapy in patients with newly diagnosed AL amyloidosis. Methods We reviewed the outcomes of newly diagnosed autologous stem cell transplantation (auto-SCT)-ineligible AL amyloidosis patients who received bortezomib-based chemotherapy at a referral center between 2011 and 2017. Results Of 63 patients who received bortezomib-based chemotherapy, 32 were male, and the median age was 66 years (range, 42‒82 yr). The hematologic overall response rate (ORR) was 65.1%, and the chemotherapy regimen with the best hematologic response was VMP (75.7%, 28/37). Sixty patients had significant organ (heart or kidney) involvement; 28.3% of patients (N=17) had major organ responses after chemotherapy. With a median follow- up of 34 months, there was no significant difference in progression-free survival (P=0.49) or overall survival (P =0.67) according to regimen. Most hematologic and non-hematologic problems were manageable. Conclusion Various chemotherapy combinations based on bortezomib are currently employed in the clinical setting, but no difference was found in terms of efficacy or toxicity.

The Effect of Public Officers’ Work-Life Balance on Job Satisfaction Differences between Men and Women

( Joon-young Hur ),( Duk-yun Hwang ) 서울대학교 한국행정연구소 2019 Journal of Policy Studies Vol.34 No.2

We performed an empirical analysis based on data from a questionnaire survey that Korean government officers participated in about the effects of worklife balance (WLB) on job satisfaction in order to whether unpaid labor such as housework had a moderating effect on job satisfaction. The subjective balance of an individual’s time input in work and life was used to measure WLB. We find that WLB has a positive and significant effect on job satisfaction and that there is no statistically significant gender difference. However, the WLB effect on married female officers is smaller than that on single female officers, while it is not significant for male public officers. Child-rearing has a negative moderating effect on women’s job satisfaction, although this was not statistically significant. This result suggests that the effect of the household work burden that marriage as well as child care brings is a variable that policy makers should be keep in mind in developing WLB policies.

'Path-Dependency' des Verhältnisses zwischen Staat und Zivilgesellschaft? - Die Rolle der westdeutschen Zivilgesellschaft bei der Integration ostdeutscher Flüchtlinge

Joon-Young Hur 한독사회과학회 2011 한독사회과학논총 Vol.21 No.3

본 연구의 목적은 독일 분단기인 제 2차 세계대전 후부터 통독 시기까지 동독 이탈주민의 서독사회 통합을 위한 서독 시민사회의 역할을 살펴보고 한국에 주는 시사점을 도출하는데 있다. 총 5백만이 넘는 동독 이탈주민의 서독사회로의 통합은 서독의 전 사회적인 노력에 의해 가능했던바 선행연구에서 주로 다루어온 정부영역 뿐만 아니라 비정부영역 특히 시민사회의 다양한 행위자의 참여와 그들의 역할을 감안할 필요성이 제기된다. 이러한 문제의식을 가지고 본 연구는 시민사회의 다양한 참여형태에 대한 논의뿐만 아니라 정부와의 역할분담에 대한 논의와 이러한 체계가 가능하였던 원인을 사회정책의 원리로서 보충성과 서독 사회복지단의 전통에서 찾아보고, 이와 관련하여 한국적인 시사점과 적용가능성을 살펴본다. Thema dieses Aufsatzes ist die Rolle der westdeutschen Zivilgesellschaft bei der Integration ostdeutscher Flühtlinge zwischen dem Ende des zweiten Weltkriegs und der deutschen Wiedervereinigung. Die Integration der gut 5 Millionen ostdeutschen Flühtlinge in die westdeutsche Gesellschaft wurde durch die Anteilnahme der ganzen Gesellschaft mölich. Daher soll hier die Teilnahme und Mitwirkung aus der nicht-öfentlichen Sphäe, u.a. der Zivilgesellschaft berüksichtigt werden, weil sie anders als die öfentliche Sphäe in bisheriger Forschung kaum ausreichend beachtet wird. Vor diesem Hintergrund verfolgt die vorliegende Untersuchung zwei Ziele: Zum einen sollen diese Themen, die vielfätigen Teilnahmeformen der Zivilgesellschaft, die Rollenverteilung zwischen Staat und Zivilgesellschaft, die den Ursprung dieses Verhätnises umfasst, aufgefasst werden. Dabei werden die Subsidiaritä als wichtiges Prinzip der Sozialpolitik und die Tradition der Spitzenverbäde der Wohlfahrtspflege mit bedacht. Zum anderen werden der Standpunkt der vorliegenden Arbeit und die daraus gewonnenen Untersuchungsergebnisse auf die Frage hin geprüt, inwieweit die deutschen Erfahrungen auf die Integrationspolitik Sükoreas fü nordkoreanische Flühtlinge üertragen werden könten.