枸杞 Lycium chinense Miller의 果實이 實驗的 糖尿에 미치는 影響

李珩九,姜孝信,鄭址昌 中央醫學社 1975 中央醫學 Vol.28 No.6

The influence of fruit of Lycium chinense Miller on the blood sugar levels and serum transaminase (SGP-T, SGO-T) activities from alloxan-diabetic rabbits were observed. The Lycii Fructus were extracted with methanol, and the extracted sample was orally administrated to normal and alloxan diabetic rabbits. As for the blood sugar levels and serum transaminase activities of normal rabbits no significant variation were detected by administration of the extracted sample. The blood sugar levels and serum transaminase activity of normal rabbits were significantly increased by administration of the alloxan. The increased blood sugar levels of 'the alloxan-diabetic rabbits were gradually decreased by administration of the extracted samples, and were returned to the control levels after 12 day. The increased transaminase activities in serum of the alloxan-diabetic rabbits were significantly decreased after 96 hours. According to the above results, it would be concluded that the extract of Lycii Fructus influences for the recovery of the increased amount of blood sugar levels and serum transaminase activities by alloxan.

개에서 직장탈의 수술적 치료 1례

박정희,김영실,신영지,박창식,전무형,김명철,정성목 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-

A 3-year old, male Jindo dog was referred with history of tenesmus, dyschezia and recurrent rectal prolapse. On the physical examination, the rectum was prolapsed about 10 cm, congested and necrotized. Fecal incontinence and pain were observed. Complete blood count revealed a mild leukocytosis and there were no remarkable abnormalities in serum biochemistry profiles. It was diagnosed as a rectal prolapse. Rectal resection and anastomosis was performed for necrotic tissue removal. On postoperative fecal smear, protothecosis was observed. Amphotericin B was administered. There has been no evidence of recurrence of rectal prolapse for ten months.

음낭외상시 초음파 촬영술의 유용성

김형지,진정환,이해원,이길호 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: Testicular rupture is a surgical emergency which command immediate repair. If surgery is delayd, a hematoma causes severe pain and loss of spermatogenesis as well as hormonal functions. Scrotal ultrasonography has been helpful in early diagnosis of testicular rupture. But disadvantage of ultrasonography include a relatively low signal-to-noise level, tissue nonspecificity, lack of contrast media, a small field of view, and dependence on the operators skill and the patients physique. Also the diagnostic accuracy, sensitivity or specificity of scrotal ultrasonography was variable in regard to authors. And so, a diagnostic accuracy of scrotal ultrasonography was evaluated in scrotal trauma. Methods·. We reviewed 38 patients of scrotal trauma from May, 1994 to March, 1998. 6 patients were treated conservatively fellowing sonography and 10 patients treated only surgical exploration without ultasonography Surgical exploration was performed in 22 case, which were evaluated by ultasound before surgical treatment. In a such 22 cases, diagnostic accuracy of scrotal ultasonography was evaluated. Results: We compared ultrasound before treatment with surgical exploration finding in a such 22 cases. The ultrasonographic features in 7(31.8%) out of 22 cases, which showed testicular ruptured, but surgical exploration revealed testicular rupture in5 and epididymal rupture in 1, simple hematocele in 1. In 15(68.2%) out of 22cases the simple hematocele was diagnosed by ultrasonography, but surgical finding feature in of the 7 cases revealed testicular rupture, epididymal rupture in 1, simple hematocele in 7. The sensitivity and specificity for the ultrasonography are 42.9% and 87.5%, and the positive and negative predictive values are 86.5%and 46.7%, respectively. Ultrasonography is low sensitive in identifying testicular rupture. Conclusion: 7trasonography include a relatively low signal-to-noise level, tissue nonspecificity, lack of contrast media, a small field of view, and dependence on the operators skill and the patients physique. Therefore, early surgical exploration for saving the testis should be performed that sonographically by seeing hypoehoic peripheral lesions and disappearance of normal ovoid form of testis, hematocele in scrotal sac.

개에서 직장탈의 수술적 치료 1례

박정희,김영실,신영지,박창식,전무형,김명철,정성목 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

A 3-year old, male Jindo dog was referred with history of tenesmus, dyschezia and recurrent rectal prolapse. On the physical examination, the rectum was prolapsed about 10 em, congested and necrotized. Fecal incontinence and pain were observed. Complete blood count revealed a mild leukocytosis and there were no remarkable abnormalities in serum biochemistry profiles. It was diagnosed as a rectal prolapse. Rectal resection and anastomosis was performed for necrotic tissue removal. On postoperative fecal smear, protothecosis was observed. Amphotericin B was administered. There has been no evidence of recurrence of rectal prolapse for ten months.

결절성 및 괴상성 간세포암에서 역동적 전산화단층촬영 소견에 따른 경동맥화학색전술결과의 예측

이성문,김홍,지성우,우성구,이정형,서수지,손철호 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.2

Purpose: To evaluate retrospectively whether it is possible to predict the transarterial chemoembolization(TACE) result with the pre-TACE dynamic CT findings. Materials and Methods: The dynamic CT findings of 33 patients with 35 nodular and 8 massive hepatocellular carcinoma(HCCs) who was taken follow up CT after TACE, were reviewed retrospectively. After excluding the diffuse or infiltrative HCCs, the mass was classified into two groups of nodular and massive types. The size, location, degree of enhancement, pseudocapsule, portal vein(PV) thrombosis and arterioportal(AP) shunt were evaluated on the dynamic CT scans. The vascularity, multiple or parasitic blood supply, AP shunt and the possibility of superselection were considered on the angiography. After TACE, the pattern of lipiodol uptake and residual enhancing nodules were evaluated on the follow-up CT scans. Results: The good TACE results could be obtained in 18 of 35 nodular HCCs with dynamic CT findings of small size(mean=2.94cm), peripheral location, hyper-or iso-enhancement, and absence fo PV thrombosis, with angiographic finding of possible superselection, but the pseudocapsule did not give important effect on the result. Most of the massive HCCs had poor TACE results. Conclusion: The prediction of the TACE results of nodular and massive HCCs was possible with dynamic CT findings. If the good prognostic factors were not observed on the pre-TACE dynamic CT, the multiple TACE and/or combination therapy with percutaneous ethanol injection(PEI), surgical resection or others should be considered for the effective control of the HCCs.

골수 유래 기질 줄기세포의 탐식작용 매개성 케모카인 수용체 발현 연구

정영신,변향민,신지영,김정목,정형민,오유경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4

To design gene delivery systems which can deliver higher amounts of genes into stem cells, we studied the expression of receptors involved in the receptor-mediated endocytosis of bone marrow stromal stem cells. Bone marrow was isolated from ICR mice, and bone marrow stromal stem cells were isolated based on their plastic adherence property. Several cultrure conditions were screened for effective and continuous culture of marrow stromal stem cells. MesenCult medium was finally used to cultivate marrow stromal stem cells in vitro. As candidate receptors, various chemokine receptors were studied. Both bone marrow cells and marrow-derived stromal stem cells showed expression of CC chemokine receptors (CCR) and CXC chemokine receptors (CXCR). Marrow stromal stem cells showed higher expression of CCR5 and CXCR4 chemokine receptors as compared to other types of chemokine receptors. Moreover, though the expression chemokine receptors generally decreased in most chemokine receptors with the cultivation of marrow stromal stem cells, CCR5 and CXCR4 chemokine receptors retained the higher lever of receptor expressions over prolonged periods. These results suggest that the ligands exhibiting specific binding to CCR5 or CXCR4 might be used to modify gene delivery systems for increased level of receptor-mediated gene delivery into stromal stem cells.

관동맥 우회로술 중 경식도 심초음파도로 관찰한 도부타민 투여후와 우회로술후의 좌심실 국소벽운동

김희열,김종진,윤호중,유기동,박지원,이길환,노태호,채장성,김재형,홍순조,최규보 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8

Cytotoxic Terpenoids from the Sponge Sarcotragus Species

Jung Jee Hyung,Choi Jae Sue,Kim Nam Deuk,Im Kwang Sik,Lee Chong-0,Hong Jongki,Liu Yonghong 大韓藥學會 2002 大韓藥學會 總會 및 學術大會 Vol.2002 No.1

Cytotoxic Constituents of Saussurea lappa

Jung, Jee-Hyung,Kim, Young-Soo,Lee, Chong-Ock,Kang, Sam-Sik,Park, Jong-Hee,Im, Kwang-Sik The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.2

The crude extract of Saussurea lappa displayed significant lethality to brine shrimp larvae. Investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of three $C_17$-polyene alcohols. Based on various nmr spectral data, these compounds were identified as shikokiols which had been previously isolated from Cirsium nipponicum and/or Centaurea aegyptica. These $C_17$-polyene alcohols exhibited moderate cytotoxicities against the human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15.

Bioactive Compounds from Tropical Plant and Blue- Green Algae(Cyanobacteria)

Jee Hyung Jung 한국생약학회 1992 생약학회지 Vol.23 No.1