鉛暴露 作業者의 鉛中毒 早期發見을 위한 集團檢診法 改善方案에 관한 硏究

홍대용,김장락,정주화,최현림,윤형렬 慶尙大學校 1995 論文集 Vol.34 No.1

This study was carried out to evaluate the feasibility of current lead indicators used in screening lead who were sspeted to have been exposed to lead were selected as 'case'and 207 female workers from non-lead industry were selected for 'control'. The results obtained were as follows: 1. The mean values of blood lead for case and control were 31.4㎍/dl, 22.2㎍/dl,respectively. The difference observed in the mean concentration between case and control was statistically signifi-ant(P<0.01) 2. The mean values for blood ZPP by hematofluorometer for case and control were 31.3㎍/dl, 25.4㎍/dl,respectiely. And difference between two groups was statistically significant(P<0.01). 3. No statistically significant correlation was found between working duation and blood lead, blood ZPPlovel. 4. According to the simple correlation analysis,ZPPand urine lead were found to be statistically correlated with blood lead(P<0.01) 5. According to the discriminant analysis using blood lead as a dependent variable, it showed 89.1% predictability when using 40㎍/dl as a cutting value which is used as a screenig cutting value for industry workers health examination, while 81.8% for 30㎍/dl,77.54% for 20㎍/dl, respectively. 6. Lead related simptons which is used for screening the lead ntoxicated patients were used as a dependent variables in multiple regression analysis to find useful lead indicator. And significant independent variables were found to be ZPP, Age, and Hct. 7. Above results suggest that objective evalution of feasibbility of several lead indicators should be developed to correct the disutility of current lead screeng system in Korea.

일부 크롬 폭로 근로자들에 있어서 변이원성 지표로서의 소핵검사

윤형렬,김장락,홍대용 大韓産業醫學會 1993 대한직업환경의학회지 Vol.5 No.1

This study was conducted to investigate the possibility of utilizing micronucleus test for buccal mucosa and blood lymphocyte as an indicator for the evaluation of chromium mutagenicity in workers(n=40) exposed to chromium trioxide(CrO₃) and controls(n=40) in Pusan and Changwon cities form April 1 to August 30, 1992. Urine chromium concentration was measured by atomic absorption spectrophotometer. Self-recorded questionnaire were used to collect information on the relevant characteristics of the study subjects. The results were as follows. 1. The mean frequencies of micronucleus in buccal mucosa, blood lymphocytes and average urine chromium concentration of chromium platers were significantly higher than those for controls(p<0.01). 2. The mean frequencies of micronucleus in buccal mucosa and blood lymphocyte of chromium platers by smoking habit were significantly higher than those of controls(p<0.01). However, the difference of mean frequencies of micronucleus between smokers and non-smokers were not statistically significant(p>0.05). 3. The frequencies of micronucleus in buccal mucosa and blood lymphocyte were highly correlated(r=0.7706). Some of the other variables were also correlated, for example, urine Cr concentrations and frequencies of micronucleus in blood lymphocyte(r=0.7259), urine Cr concentrations and frequencies of micronucleus in buccal mucosa(r=0.6247), age and work duration(r=0.4032), work duration and frequencies of micronucleus in buccal mucosa(r=0.3603), age and frequencies of micronucleus in blood lymphocyte(r=0.3260), work duration and frequencies of micronucleus in blood lymphocyte(r=0.3231), age and frequencies of micronucleus in buccal mucosa(r=0.2760). 4. According to the results of multiple classification analysis, frequencies of micronucleus in buccal mucosa were statistically associated with occupation and work duration, frequencies of micronucleus in blood lymphocyte associated with occupation and work duration, and urine Cr concentrations associated with occupation. The results suggested that micronucleus test in buccal mucosa and blood lymphocyte could be used as a biological indicator for evaluating toxic effects of chromium.

아동기 가정 내 스트레스가 공동의존성에 미치는 영향 및 공동의존성과 정신병리와의 관련성

곽운환,손지욱,한규희,박철수,김장락,김붕년,김봉조,강여화,하형래 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.1

연구목적: 본 연구는 공동의존성에 영향을 미치는 아동기 가정내 스트레스 요인과 공동의존성과 다른 병리와의 연관성을 규명하고자 하였다. 더불어 특정한 질환에서의 공동의존성의 평가가 가지는 의의를 탐색해 보고자 하였다. 방 법: 연구 대상은 정상 일반인 남성집단 88명과 알코올리즘 남성 집단 76명으로 구성되어 있다. 평가도구는 본 저자가 직접 작성한 '아동기 가정내 스트레스 요인 측정용 설문'과 공동의존 척도(RPS), 간이증상 진단검사(SCL-90-R)를 사용하였다. 통계적 분석은 Mann-Whitmey test, Kruskall- Wallis test, Multiple linear regression analysis, Spearman correlation analysis를 이용하였다. 결 과: 1) 정상 일반인 군과 알코올리즘 군의 공동의존성 평균값은 각각 49.12점(표준편차=15.41)과 88.31점(표준편차=17.48)이었다. 2) 정상 일반인 군에서는 '아동기 부모 사별'(p<0.01) '부모의 알코올리즘'(p<0.01) '부모의 상습적 구타'(p<0.01)의 3가지 요인에서, 알코올리즘 군에서는 '어린시절 부모 사별'(p<0.01) '부모의 알코올리즘'(p<0.01) '부모의 상습적 구타'(p<0.01) '부도의 도박'(p<0.01) '사회 병질자 부모의 존재'(p<0.05)의 5가지 요인에서 스트레스 유무에 따라 공동의존성에 유의한 차이를 보였다. 3) 두 집단 동시에 SCR-90-R의 8개 소척도 중 '대인관계 예민성'이 공동의존성과 가장 높은 연관성(rs>0.06, p<0.01)을 보였다. 이외에도 '우울증' '불안증'등이 두 집단 모두에서 통계적으로 유의한 연관성을 보였다. 결 론: 본 연구는 부모의 알코올리즘뿐만 아니라 여러 가정 내 스트레스 요인이 공동의존성의 발생에 영향을 미칠 수 있음과 공동의존성이 높은 집단이 다른 정신과 질환을 동반할 가능성이 높음을 증명한다고 할 수 있다. Objectives : The aim of this study was to examine the relationships of codependency with family stressors in childhood and psychopathology. Methods : Subjects were a group of 88 normal adult males and a group of 76 alcoholic males. The degree of codependency was assessed with the Korean version of Recovery Potential Survey(RPS). All subjects filled out questionnaires regarding demographic information and family stressors. The psychopathology was measured by self-administred questionnaires using Symptom Check List-90-Revision(SCL-90-R). Results : 1) There were no significant differences in codependency levels by sociodemographic characteristics in two groups, but obvious difference in mean of codependency scores(normal group : 49.12±15.41, alcoholism group : 88.31±17.48). 2) There were significant differences in codependency levels between the presence and absence of parental physical abuse, parental death, and parental alcoholism(p<0.01) in both groups. 3) Among family stressors, parental physical abuse had the largest contribution to codependency level in multiple linear regression. 4) There were significant correlations between the codependency levels and the scores of SCL-90-R's subscales of interpersonal sensitivity, depression, and anxiety in both groups. Conclusion : The codependency levels were related to some family stressors such as parental physical abuse, parental death, and parental alcoholism and the high-level codependency was correlated with higher level of psychopathology in both normal and alcoholism group. These results suggested that various family stressors, as well as parental alcoholism may be predictors of codependency, and codependency also may be a predictor of other psychiatric disorders.

50세 이상 고관절 주위골절 환자에서의 골다공증 치료

김태영 ( Tae Young Kim ),하용찬 ( Yong Chan Ha ),김연호 ( Yeun Ho Kim ),이성락 ( Sung Rak Lee ),김상림 ( Sang Rim Kim ),김장락 ( Jang Rak Kim ),김신윤 ( Shin Yoon Kim ),구경회 ( Kyung Hoi Koo ) 대한고관절학회 2007 Hip and Pelvis Vol.19 No.4

Simulation study of the thermal and the thermoelastic effects induced by pulsed laser absorption in human skin

Kim, Jae-Young,Jang, Kyungmin,Yang, Seung-Jin,Baek, Jun-Hyeok,Park, Jong-Rak,Yeom, Dong-Il,Kim, Ji-Sun,Kim, Hyung-Sik,Jun, Jae-Hoon,Chung, Soon-Cheol 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.

<P>We studied the thermal and the mechanical effects induced by pulsed laser absorption in human skin by numerically solving the heat-transfer and the thermoelastic wave equations. The simulation of the heat-transfer equation yielded the spatiotemporal distribution of the temperature increase in the skin, which was then used in the driving term of the thermoelastic wave equation. We compared our simulation results for the temperature increase and the skin displacements with the measured and numerical results, respectively. For the comparison, we used a recent report by Jun et al. [Sci. Rep. 5, 11016 (2015)], who measured in vivo skin temperature and performed numerical simulation of the thermoelastic wave equation using a simple assumption about the temporal evolution of the temperature distribution, and found their results to be in good agreement with our results. In addition, we obtained solutions for the stresses in the human skin and analyzed their dynamic behaviors in detail.</P>

The Association of Perceived Neighborhood Walkability and Environmental Pollution With Frailty Among Community-dwelling Older Adults in Korean Rural Areas: A Cross-sectional Study

Kim, Mi-Ji,Seo, Sung-Hyo,Seo, Ae-Rim,Kim, Bo-Kyoung,Lee, Gyeong-Ye,Choi, Yeun-Soon,Kim, Jin-Hwan,Kim, Jang-Rak,Kang, Yune-Sik,Jeong, Baek-Geun,Park, Ki-Soo The Korean Society for Preventive Medicine 2019 예방의학회지 Vol.52 No.6

Objectives: The aim of this study was to evaluate the associations of frailty with perceived neighborhood walkability and environmental pollution among community-dwelling older adults in rural areas. Methods: The participants were 808 community-dwelling men and women aged 65 years and older in 2 rural towns. Comprehensive information, including demographics, socioeconomic status, grip strength, polypharmacy, perceived neighborhood environment (specifically, walkability and environmental pollution), and frailty, was collected from participants using face-to-face interviews conducted between June and August 2018. Perceived neighborhood walkability was measured using 20 items that were selected and revised from the Neighborhood Environment Walkability Scale, the Neighborhood Walkability Checklist from the National Heart Foundation of Australia, and the Physical Activity Neighborhood Environment Survey. The Kaigo-Yobo Checklist was used to assess participants' frailty. Results: The overall prevalence of frailty in this community-dwelling population was 35.5%. Sex, age, cohabitation status, educational attainment, employment status, grip strength, and polypharmacy were significantly associated with frailty. In the logistic regression analysis, frailty was associated with low perceived neighborhood walkability (adjusted odds ratio [aOR], 0.881; 95% confidence interval [CI], 0.833 to 0.932; p<0.001) and severe perceived neighborhood environmental pollution (aOR, 1.052; 95% CI, 1.017 to 1.087; p=0.003) after adjusting for sex, age, cohabitation status, educational attainment, employment status, monthly income, grip strength, and polypharmacy. Conclusions: More studies are warranted to establish causal relationships between walkability and environmental pollution and frailty.

Personality and Learning Behavioral Characteristics as Predictors of Academic Achievement of Medical Students

Jang-Rak Kim,Young-A Ji,Mi-Ji Kim,Jong Ryeal Hahm Yonsei university college of medicine 2024 의학교육논단 Vol.26 No.1

This study investigates whether personality characteristics and learning behaviors can predict medical students' academic achievement in Korea, specifically in terms of successfully completing medical school without delays or achieving a high grade point average (GPA) in their final year. In May 2018, 316 medical students took the Multi-Dimensional Learning Strategy Test, 2nd edition, which provided data on their personality and learning behavioral characteristics. Their final year's GPA and any delays in completing medical school were ascertained by reviewing all electronic academic records of each semester they had been enrolled. The combination of personality and learning behavioral characteristics was significantly associated with completing medical school without delays, even after adjusting for sex and admission path. A multiple logistic regression analysis showed that the adjusted odds ratios and 95% confidence intervals for completing medical school without delays were 1.52 (95% confidence interval [CI], 0.83-2.78) and 3.64 (95% CI, 1.70-7.82) for "others" and "both high" categories, respectively, when compared with the "both low" category. For 235 students who completed medical school without delays, their learning behavioral characteristics (scores) were significantly associated with their final year's GPA even after adjusting for sex, admission path, and personality characteristics (scores) as determined by the multiple linear regression analysis. This study suggests that individual personality and learning behavior characteristics are predictors of medical students' academic achievement. Therefore, interventions such as personalized counseling programs should be provided in consideration of such student characteristics.

인슐린종 1 예

김동수,이용규,김상순,김용기,이민기,이광욱,김상욱,박규현,양웅석,김상호,문한규,허윤,도창호,손덕현,최장락,강필증 대한내과학회 1990 대한내과학회지 Vol.39 No.2

Insulinoma is characterized by fasting hypoglycemia, various neuropsychiatric symptoms, and those caused by secondary to hypoglycemia. A 21-year-old female was admitted due to frequent loss of consciousness and dull mentality for a year and three months. She was diagnosed as insulinoma on the basis of Whipple's triad, celiac, and mesenteric angiography, abdominal C.T, scan, and the inappropriately elevat level of the insulin and C-peptide in the serum. When we transferred her to the Department of General Surgery for the remaval of insulinoma, a large mass was revealed in the pancreatic head portion with the invasion of the adjucent structures. Thus they performed Whipple's operation. Histologic examinations by light and electron microscopy showed islet cell tumor and many secretary granules in the cytoplasm. A brief review of the literature was made.

Purification and Characterization of Substance P-related Peptide from the Body of the African Lungfish, Protopterus dolloi

Kim, Chan-Hee,Kim, Eun-Jung,Go, Hye-Jin,Lee, Hyung-Ho,Hong, Yong-Ki,Kim, Hyung-Rak,Chung, Joon-Ki,Park, Jang-Su,Muneoka, Yojiro,Park, Nam-Gyu Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.7

The peptide with structural similarity to mammalian substance P (M-SP) has been isolated from extract of the body of the African lungfish, Protopterus dolloi, using the rectum of the newt as the bioassay system. The primary structure of the SP-related peptide was identified as Lys-Pro-Arg-Pro-Asp-Gln-Phe-Tyr-Gly-Leu-Met-NH2 (L-SP) and contained four substitutions ($Lys^{1}\rightarrow $ Arg, $Arg^{3}\rightarrow$ Lys, $Asp^{5}\rightarrow$ Gln, and $Tyr^{8}\rightarrow$ Phe) compared with M-SP; this structure is identical to that of the peptide isolated from the gut of the Australian lungfish. Circular dichroism spectra showed that L-SP had an unordered structure in the buffer solution and phospholipid bilayers. This peptide was found to have an excitatory effect on rectal muscle tissues of newt, quail, and fish. L-SP also had a more potent vasodilatory effect on the guinea-pig aorta than that of M-SP. The identification of the peptide provides evidence that SP family, hitherto confined to mammals, have a widespread occurrence in lungfish.

Silibinin inhibits the production of pro-inflammatory cytokines through inhibition of NF-κB signaling pathway in HMC-1 human mast cells

Kim, Beom-Rak,Seo, Hye-Sook,Ku, Jin-Mo,Kim, Gyung-Jun,Jeon, Chan Yong,Park, Jong Hyeong,Jang, Bo-Hyoung,Park, Sun-Ju,Shin, Yong-Cheol,Ko, Seong-Gyu Springer Basel 2013 Inflammation research Vol.62 No.11

<P><B>Background</B></P><P>Silibinin is the major active molecule of silymarin, the mixture of flavonolignans extracted from <I>Cirsium japonicum</I>. It has been used for the treatment of hepatitis and inflammation-related diseases. In the present study, the effects of silibinin on allergic inflammation and its signaling were investigated in the induced human mast cells.</P><P><B>Methods</B></P><P>Cell growth inhibition induced by silibinin was measured by MTS assay. Histamine release was measured by enzyme immunoassay. The tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8) secreted protein levels and mRNA levels were measured by the ELISA assay and RT-PCR, respectively. The NF-κB promoter activity was examined by a luciferase assay.</P><P><B>Results</B></P><P>Silibinin suppressed the growth of HMC-1 cells and also reduced the production and mRNA expression of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-8. Moreover, silibinin inhibited the nuclear translocation of nuclear factor (NF)-κB through inhibition of the phosphorylation of IκBα and suppressed NF-κB transcriptional activity in stimulated HMC-1 cells.</P><P><B>Conclusions</B></P><P>Taken together, these results indicate that silibinin inhibits the production of pro-inflammatory cytokines through inhibition of NF-κB signaling pathway in HMC-1 human mast cells, suggesting that silibinin could be used for the treatment of mast cell-derived allergic inflammatory diseases.</P>