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Primary Aldosteronism and Cerebrovascular Diseases
Zheng-Wei Chen,Chi-Sheng Hung,Vin-Cent Wu,Yen-Hung Lin,TAIPAI study group 대한내분비학회 2018 Endocrinology and metabolism Vol.33 No.4
As diagnostic techniques have advanced, primary aldosteronism (PA) has emerged as the most common cause of secondary hypertension. The excess of aldosterone caused by PA resulted in not only cardiovascular complications, including coronary artery disease,myocardial infarction, arrhythmia, and heart failure, but also cerebrovascular complications, such as stroke and transient ischemicattack. Moreover, PA is associated more closely with these conditions than is essential hypertension. In this review, we present up-todate findings on the association between PA and cerebrovascular diseases.
Swept-sine integration method for complex amplitude extraction of sweptsine signal
Wei Zheng,Xuli Cui,Huaihai Chen,Ronghui Zheng 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.12
Swept-sine vibration test plays a significant role in product validations. As its basic step, the accuracy and efficiency of complex amplitude (which includes the amplitude and phase information of swept-sine signal) extraction have an important impact on the performance of swept-sine vibration test. In order to improve the efficiency while ensuring its accuracy, a swept-sine integration method is proposed. The proposed swept-sine integration method, which is inspired by tracking filter method and tracking integration method, utilizes a weighted integral process to extract the complex amplitude. A numeral example is presented to compare the performance of the proposed method with several other methods for complex amplitude extraction which are also reviewed in this paper. By comparing the results of the numerical example, some light is shed on the strength of the method proposed. Afterwards, the swept-sine integration method is applied in a real test, further validating the appliance value of this method.
Zheng-Wei Chen,Syeda Anam Hashmi,Tanghong Liu,Wenhui Li,Zhuang Sun,Dongrun Liu,Hassan Hemida,Hong-Kang Liu 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.35 No.5
Due to the complex terrain around high-speed railways, the windbreaks were established along different landforms, resulting in irregular windbreak transition regions between different subgrade infrastructures (flat ground, cutting, embankment, etc). In this paper, the effect of a windbreak transition on the wind flow around railways subjected to crosswinds was studied. Wind tunnel testing was conducted to study the wind speed change around a windbreak transition on flat ground with a uniform wind speed inflow, and the collected data were used to validate a numerical simulation based on a detached eddy simulation method. The validated numerical method was then used to investigate the effect of the windbreak transition from the flat ground to cutting (the “cutting” is a railway subgrade type formed by digging down from the original ground) for three different wind incidence angles of 90º, 75º, and 105º. The deterioration mechanism of the flow fields and the reasons behind the occurrence of the peak wind velocities were explained in detail. The results showed that for the windbreak transition on flat ground, the impact was small. For the transition from the flat ground to the cutting, the influence was relatively large. The significant increase in the wind speeds was due to the right-angle structure of the windbreak transition, which resulted in sudden changes of the wind velocity as well as the direction. In addition, the height mismatch in the transition region worsened the protective effect of a typical windbreak.
The Phytotoxic Effects of Selenium–Mercury Interactions on Root Growth in Brassica rapa (LvLing)
Zhi-Wei Bian,Jian Chen,Hui Li,Dan-Dan Liu,Li-Fei Yang,Yue-Lin Zhu,Wen-Li Zhu,Wei Liu,Zheng-Zheng Ying 한국원예학회 2016 Horticulture, Environment, and Biotechnology Vol.57 No.3
Rapid industrial and agricultural development has dramatically increased the emission of selenium (Se) and mercury (Hg) into the environment. Combined soil pollution by Se and Hg poses a potential threat to crop production. However, no toxic effects of Hg–Se interactions on plants have been reported previously. In this study, we investigated the effects of Hg–Se interactions on biochemical and physiological indices in the roots of Brassica rapa (LvLing). Seedlings were treated hydroponically with solutions of mercury chloride (1 μM), sodium selenite (4 μM), or a combination of the two. Combined Hg+Se treatment significantly inhibited root growth, reduced root biomass, and enhanced reactive oxygen species (ROS) and malondialdehyde accumulation and led to a loss of plasma membrane integrity. The combined treatment increased glutathione peroxidase, glutathione S-transferase, and peroxidase activity, reduced superoxide dismutase activity, and had no effect on catalase activity. In addition, we detected increased glutathione concentrations in root tips and reduced ascorbic acid concentrations in the presence of Hg+Se relative to individual treatments with these elements. Thus, Hg–Se interactions enhanced oxidative injury, cell death, and phytotoxicity in B. rapa roots.
Study of the Band-gap Structure of a 1D-photonic Crystal by Using Different Numerical Approaches
Liang-Yao Chen,Jian-Bo Chen,Yue-Rui Chen,Yan Shen,Wei-Xi Zhou,Jiu-Chun Ren,Yu-Xiang Zheng 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.56 No.4
Comparative studies between the transfer matrices method (TMM) and plane wave method (PWM) approaches have been performed on 1D photonics crystal under different conditions to show the differences between these two kinds of calculations. TMM is suitable for the design of 1D photonic crystal device with high precision and is in good agreement with experimental results, but is not suitable for the 2D and 3D photonic structures which are limited by the complicated boundary conditions at micro interfaces. The result based on the PWM approach to deal approximately with the photonic structure in approximation has not yet been strictly verified by experiment, not even for 1D photonic crystal structures. More efforts will be required to explore its validation under all physical conditions to enhance its application.
Zheng Qing-Xiang,Jiang Xiu-Min,Wang Hai-Wei,Ge Li,Lai Yu-Ting,Jiang Xin-Yong,Chen Fan,Huang Ping-Ping 한국미생물학회 2021 The journal of microbiology Vol.59 No.9
Probiotics effectively prevent and improve metabolic diseases such as diabetes by regulating the intestinal microenvironment and gut microbiota. However, the effects of probiotics in gestational diabetes mellitus are not clear. Here, we showed that probiotic supplements significantly improved fasting blood glucose in a gestational diabetes mellitus rat model. To further understand the mechanisms of probiotics in gestational diabetes mellitus, the gut microbiota were analyzed via 16S rRNA sequencing. We found that compared with the normal pregnant group, the gestational diabetes mellitus rats had decreased diversity of gut microbiota. Moreover, probiotic supplementation restored the diversity of the gut microbiota in gestational diabetes mellitus rats, and the gut microbiota structure tended to be similar to that of normal pregnant rats. In particular, compared with gestational diabetes mellitus rats, the abundance of Firmicutes and Actinobacteria was higher after probiotic supplementation. Furthermore, activating carbohydrate metabolism and membrane transport pathways may be involved in the potential mechanisms by which probiotic supplements alleviate gestational diabetes mellitus. Overall, our results suggested that probiotic supplementation might be a novel approach to restore the gut microbiota of gestational diabetes mellitus rats and provided an experimental evidence for the use of probiotic supplements to treat gestational diabetes melitus.
Atomistic Modeling for Interfacial Properties of Ni-Al-V Ternary System
Wei-ping Dong,이병주,Chen Zheng 대한금속·재료학회 2014 METALS AND MATERIALS International Vol.20 No.3
Interatomic potentials for Ni-Al-V ternary systems have been developed based on the second-nearest-neighbormodified embedded-atom method potential formalism. The potentials can describe various fundamentalphysical properties of the relevant materials in good agreement with experimental information. The potentialis utilized for an atomistic computation of interfacial properties of Ni-Al-V alloys. It is found that vanadiumatoms segregate on the γ-fcc/L12 interface and this segregation affects the interfacial properties. The applicabilityof the atomistic approach to an elaborate alloy design of advanced Ni-based superalloys throughthe investigation of the effect of alloying elements on interfacial properties is discussed.
Zheng Chen,Xiang Wu,Li-Hua Hang,Hong Wang,Dong-Hua Shao,Yi-Guo Xu,Wei Cui 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.4
Purpose: Intranasal dexmedetomidine is an effective sedative for premedication and is regularly used to reduce preoperative tension and anxiety in children. This study aimed to assess the effect of intranasally adjunctive dexmedetomidine on perioperativesedative and analgesic requirements in adults. Materials and Methods: Patients were randomly divided into four groups to receive preoperative administration of saline, intranasaldexmedetomidine 1 μg/kg and 2 μg/kg, and intravenous dexmedetomidine 1 μg/kg, respectively. Propofol and remifentanil were target-controlled infused to maintain intraoperative bispectral index at 45–55 and blood pressure at baseline value±20%. Sufentanil was administered to maintain postoperative visual analogue scale ≤3. Perioperative anesthetics requirements were compared using nonparametric tests. Results: Intranasal dexmedetomidine significantly attenuated propofol requirements for anesthesia induction and maintenance in a dose-dependent manner. Patients given intranasal dexmedetomidine 2 μg/kg required less remifentanil for anesthesia maintenance. The first postoperative request for sufentanil analgesia was delayed in patients given intranasal dexmedetomidine 2 μg/kg. The anesthetics-sparing effect of intranasal dexmedetomidine was significantly weaker than intravenous dexmedetomidine at the same dose of 1 μg/kg. The incidences of adverse events, including hemodynamic instability and delayed recovery, were comparablewith and without intranasal dexmedetomidine. Conclusion: Intranasal administration of dexmedetomidine can reduce perioperative anesthetic requirements, and a dose of dexmedetomidine 2 μg/kg produces a better effect in adults. The anesthetics-sparing effect of intranasal dexmedetomidine 1 μg/kg is less than that with the same intravenous dose of dexmedetomidine.
Chen, Mingqing,Wei, Hongbo,Cao, JunWei,Liu, Ruijie,Wang, Youliang,Zheng, Congyi Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.3
Proline accumulation has been shown to correlate with tolerance to drought and salt stresses in plants. We attempt to introduce the wild-type, mutant, and fusion proBA genes derived from Bacillus subtilis into Arabidopsis thaliana under the control of a strong promoter cauliflower mosaic virus 35S (CaMV35S). The transgenic plants produced higher level of free proline than control and the overproduction of proline resulted in the increased tolerance to osmotic stress in transgenic plants. Besides, the mutation in proBA genes, which were proved to lead $\alpha$-glutamyl kinase ($\alpha$-GK) reduces sensitivity to the end-product inhibition and the fusion of proB and proA also result in increasing proline production and confer osmotolerance in transgenic lines.