제2형 당뇨병 환자에서 체내 총항산화능 측정의 의의

윤여일,윤석기,김선규,김용현,남일송,차건영,황의원,김영선 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: The diabetic patients are at significantly increased risk of developing vascular disease. It's etiology may involve oxidative damage by free radiacals and protection againse such damage can be offered by antioxidants. We investigated that oxidative stress as assessed by measurement of total antioxidant status may play a role in development of diabetes mellitus. Method: We measured total antioxiant status using merchandised kit, glycated hemeglobin(HbA1c) in 46 type 2 diabetes mellitus patients and 50 healthy matched control subjects. Result: The total antioxidant status(TAS) was 2.10(±0.04) mmol/L in uncontrolled type 2 DM patients, 2.60(±0.03) in controlled type 2 DM patients and 2.70(±0.16) in healthy control subjects. TAS was significantly lower(P<0.05) in uncontrolled type 2 DM patients, but no significant association between in controlled type 2 DM patients and healthy control subjects. The TAS was 2.00(±0.17) mmol/L in complicated type 2 DM patients and 2.10(±0.29) uncomplicated type 2 DM patients. There was no significant associations between complicated type 2 DM patients and uncomplicated type 2 DM patients. Conclusion: Poor glycemic control is associated with reduced TAS in type 2 DM patients. TAS was thought indirect index that predict glycemic control of type 2 DM patients.

소목(Caesalpinia sappan) 추출물의 Streptococcus mutans에 대한 성장, 산생성, 부착 및 비수용성 글루칸 합성 억제에 미치는 영향

유용욱,유현희,김윤정,유미선,서세정,이황,이흥수 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.2

Streptococcus mutans is known as the causative bacterial playing the most important role in forming plaque and it is being noticed as major causative bacteria of dental caries. Therefore, development of more effective, substantial and safe preventive agent against dental caries and periodontal disease is honestly required. The present study was designed to investigate the effect of chloroform extract(CE), n-butanol extract(BE),methanol extract(ME) and water extract(WE) of Caesalpinia on the growth, acid production, adhesion, and insoluble glucan synthesis of Streptococcus mutans. The CE, BE, ME and WE decreased the growth and acid production of S.mutans than that of control, especially, the ME was more effective than other extracts. The effect of CE, BE, ME and WE on the adherences to saliva-coated hydroxyapatite bead(S-HA) were evaluated. At the concentration of 2,000 ㎍/㎖, the CE showed 32% rate of bacterial adherence to S-HA, whereas, other extracts of the same concentration producedgreater than 50% rate. The CE and BE were significantly decreased the reduction rates of water insoluble glucan formation from sucrose by crude glucosyltransferase of S.mutans. Thus, the application of C. sappan can be considered a useful and a practical method for the prevention of dental caries.

하부 위장관 출혈을 유발한 직장내 Dieulafoy양 병변

김태현,김상욱,최지훈,송우건,윤경호,김진아,최석채,나용호 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Dieulafoy's ulcer is an uncommon lesion that usually presents wih massive bleeding. Although it has been observed, for the most part, in the stomach, it has also been identified in the small bowel and colon A 35-year-old male presented with lower gastrointestinal bleeding, which was found to be caused by a Dieulafoy's ulcer in the rectum. Diagnosis was by colonoscopy. (This lesion was injected initially with endoscopic injection of a solution of hypertonic saline solution with 1/10,000 epinephrine followed by bipolar electrocoagulation.) No further bleeding has occurred with follow-up 6 months. We report one patients with extragastric Dieulafoy's lesion in the rectum.

여성 하부요관석환자에서 무마취하 요관경하 배석술

박영호,송윤섭,임용순,김영호,이남규,구자현,서병욱,김민의,전윤수 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Although ureteroscopy(URS) has been used widely to remove ureteral calculi, there is an argument against the belief that anesthesia or admission is needed for URS. We evaluated the experience of URS without anesthesia in female patients. From September 1997 to July 1998, URS was performed in 31 female patients without anesthesia. EHL(Electrohydraulic Lithotripsy) was used in 21 patients with impacted or large stone over 5mm. All patients were given oral antibiotics for 3 days and follow-up KUB was taken to confirm successful removal of the stone one week after the procedure. Successful treatment was defined as complete removal of the stone or residual fragments less than 2mm. Overall success rate was 96.7%(30 cases among 31 cases). All but one patient tolerated with analgesia through the entire procedures. There were only minimal complications such as mild flank pain and hematuria. So, we recommend that non-anesthetic ureteroscopic removal of stone as the first choice for treatment of lower ureteral stones in female based on the minimal morbidity, high success rate and low cost.

FCL(5-FU, Carboplatin, Leucovorin) 항암 화학요법에서 Gm-CSF의 효과

최지영,김현수,김종숙,박상준,윤환중,조덕연,남상륜,김삼용 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Background: One of the major side effects of cancer chemotherapy is myelosuppression. Neutropenia and/or thrombocytopenia are dose-limiting factors in chemotherapy. Colony-stimulating factor induces proliferation and functional maturation of hematopoietic progenitor cells. GM-CSF is primarily active on progenitor cells of granulocytic and monocytic lineage. Methods: Fifteen patients with histologically proven malignancy diagnosed at Chungnam National University Hospital from January 1993 to August 1995 were included in this study. We could evaluate the clinical efficacy of GM-CSF in 13 patients undergoing FCL(5-FU, Carboplatin and Leucovorin) chemotherapy; the first cycles involved no GM-CSF while the second cycles involved GM-CSF on day 6 through 15 of chemotherapy. Results: 1) The subjects were fifteen patients in all, there were five patients with head and neck cancer, which was the most common types of maligancy. There were four patients with colon cancer, two patients with stomach cancer, and one patient with breast cancer, gallbladder cancer, cervix cancer and cholangiocarcinoma respectively, two patients, who did not complete two cycles of chemotherapy were excluded. 2) Age distribution was from 38 years to 78 years with a median age of 57. 3) In FCL chemotherapy cycles with GM-CSF, the duration of neutropenia(<500/μL) was 0.5±0.3 day, while FCL chemotherapy cycles without GM-CSF, it was 2.9±0.7 day(P=0.008). 3) There was no significant difference in platelet count between the two chemotherapy cycles(P=0.133). 4) Febrile duration without GM-CSF was 4.9±2.1 day, but with GM-CSF the duration was 1.3±0.7 day, which was significantly different(P=0.003). The duration of antibiotics use with GM-CSF was 1.7±1.2 day and without GM-CSF was 6.8±3.2 day, also significantly different(P=0.002). But hospital stay between the two cycles were not significantly different(P=0.064). Conclusion: GM-CSF was effective in preventing or restoring bone marrow depression after FCL chemotherapy.

봉독약침이 류마티스 관절염 환자의 관절 통증, 종창 및 급성 염증 반응에 미치는 영향

이상훈,이현종,백용현,김수영,박재경,홍승재,양형인,김건식,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender Joint counts, swollen joint counts, Visual analog scale(VAS), morning stiffness, ESR. C-reactive protein(CRP) were analyzed before and after BV therapy. Results The results as follows. 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15± 11.4, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy(50±61 vs 15±23, p=0.001). 3. VAS in patients after BV therapy was significantly lower than those before BV therapy(608± 17.6 vs 380± 159, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1± 112.6 min vs 59.0±89.7 min, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed on long-term effect of BV therapy.

Routine chest computed tomography as a preoperative work-up for primary colorectal cancer

Yong Kwon Cho,Woo Yong Lee,Loo Ji Yi,Jun Ho Park,Hae-Ran Yun,Yong Beom Cho,Seong Hyeon Yun,Hee Cheol Kim,Ho-Kyung Chun 대한외과학회 2011 Annals of Surgical Treatment and Research(ASRT) Vol.80 No.5

Purpose: The aim of this study was to assess the role of pre-operative chest computed tomography (CT) compared with abdominopelvic CT (AP-CT) and chest radiography (CXR) for detecting pulmonary metastasis in patients with primary colorectal cancer (CRC). Methods: We retrospectively analyzed the data of 619 patients with primary CRC who simultaneously received a preoperative chest CT (chest CT group), AP-CT with hilar extension, and CXR (CXR group). Results: In the chest CT group, there were 297 (48.0%) normal, 198 (32%) benign, 96 (15.5%) indeterminate, 26 (4.2%) metastasis, and two lung cancers. Eighteen patients (2.9%) in the CXR group who had no pulmonary metastasis were diagnosed with pulmonary metastasis on a chest CT. The sensitivity and accuracy were 83.9% and 99.0% in the chest CT group, respectively, and 29.0% and 91.5% in the CXR group, respectively (P < 0.0001 and P = 0.0003). Conclusion: Chest CT appears to improve the accuracy of pre-operative staging in patients with CRC and is useful for the early detection of pulmonary metastasis as a baseline study for abnormal lung nodules.

Local recurrence after curative resection for rectal carcinoma : The role of surgical resection

Yun, Jung-A,Huh, Jung Wook,Kim, Hee Cheol,Park, Yoon Ah,Cho, Yong Beom,Yun, Seong Hyeon,Lee, Woo Yong,Chun, Ho-Kyung Williams & Wilkins Co 2016 Medicine Vol.95 No.27

<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Local recurrence of rectal cancer is difficult to treat, may cause severe and disabling symptoms, and usually has a fatal outcome. The aim of this study was to document the clinical nature of locally recurrent rectal cancer and to determine the effect of surgical resection on long-term survival.</P><P>A retrospective review was conducted of the prospectively collected medical records of 2485 patients with primary rectal adenocarcinoma who underwent radical resection between September 1994 and December 2008.</P><P>In total, 147 (5.9%) patients exhibited local recurrence. The most common type of local recurrence was lateral recurrence, whereas anastomotic recurrence was the most common type in patients without preoperative concurrent chemoradiotherapy (CCRT). Tumor location with respect to the anal verge significantly affected the local recurrence rate (<I>P</I> < 0.001), whereas preoperative CCRT did not affect the local recurrence rate (<I>P</I> = 0.433). Predictive factors for surgical resection of recurrent rectal cancer included less advanced tumor stage (<I>P</I> = 0.017, RR = 3.840, 95% CI = 1.271–11.597), axial recurrence (<I>P</I> < 0.001, RR = 5.772, 95% CI = 2.281–14.609), and isolated local recurrence (<I>P</I> = 0.006, RR = 8.679, 95% CI = 1.846–40.815). Overall survival after diagnosis of local recurrence was negatively influenced by advanced pathologic tumor stage (<I>P</I> = 0.040, RR = 1.867, 95% CI = 1.028–3.389), positive CRM (<I>P</I> = 0.001, RR = 12.939, 95% CI = 2.906–57.604), combined distant metastases (<I>P</I> = 0.001, RR = 2.086, 95% CI = 1.352–3.218), and nonsurgical resection of recurrent tumor (<I>P</I> < 0.001, RR = 4.865, 95% CI = 2.586–9.153).</P><P>In conclusion, the clinical outcomes of local recurrence after curative resection of rectal cancer are diverse. Surgical resection of locally recurrent rectal cancer should be considered as an initial treatment, especially in patients with less advanced tumors and axial recurrence.</P></▼2>

Testing of a Diagnostic Ultrasonic Array Probe and Estimation of the Acoustic Power Using Radiation Conductance

Yong Hyeon Yun,Moon Jae Jho,Yong Tae Kim,Myoungho Lee IEEE 2012 IEEE SENSORS JOURNAL Vol.12 No.5

<P>In this paper, we describe a test method for an ultrasonic array probe using electroacoustic radiation conductance. The radiation conductance was calculated using the measured acoustic power based on the radiation force balance method and the voltage for the driving element on the probe. To illustrate the usefulness of this method, we conducted the testing with a normal as well as a faulty probe with an open element or a block gain. In the comparison of the test results from each sample, the different values of radiation conductance signified the nonuniform probe gain. Specifically, the value of the radiation conductance of nearly zero revealed a clearly faulty element. To predict the temporal averaged acoustic power from sonography, we calculated the estimated value of the temporal acoustic power of a scan beam and sonography using radiation conductance. The result showed that the uniformity of the radiation conductance of each element is a useful parameter when testing an array probe. It enables an estimation of the acoustic output without additional measurements regardless of whether or not the scanning procedure changes when creating the image.</P>

생리신호를 이용한 연산작업시의 집중도의 평가

윤용현 ( Yong Hyeon Yun ),고한우 ( Han Wo Ko ),김동윤 ( Dong Youn Kim ),양희경 ( Heui Kyung Yang ),김묘향 ( Myo Hyang Kim ) 한국감성과학회 2002 춘계학술대회 Vol.2002 No.-

집중도 변화와 정신피로는 정의 방향의 평가와 부의 방향의 평가가 있으며, 작업 수행시의 집중변화와 정신피로의 평가는 정의 방향보다 부의 방향으로의 평가가 용이하다. 따라서, 저자들은 먼저 피험자에게 부가할 정신작업부하로 난이도 조정이 용이한 연산작업을 사용하여 작업수행시 가장 높은 집중을 요구하는 하나의 난이도를 선정하고 피험자에게 반복 수행시키면서 생리량과 심리량을 동시에 측정하였다. 측정된 생리량은 뇌파, 심전도, 호흡, 맥파, 말초피부온이며 심리량은 저자들이 개발한 정신피로설문지를 사용하였다. 분석결과 작업수행시 심박변화율의 전력스펙트럼 MF/(LF+HF)비가 감소하였으며, 작업이 반복됨에 따라 집중이 저하되고 정신피로가 증가하였다. 특히, 뇌파의 beta파와 호흡간격이 집중도의 변화를 말초피부온이 정신피로를 잘 반영하였다.