위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

65세 이상의 노령층에서 고지혈증의 위험요인

김용배,장원기,황보영,김화성,안규동,이병국,이용진,김세훈,김승수,김승훈,김영록,김웅빈,이성수 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

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표재성 방광암에서 Bacillus Calmette-Guerin 방광 내 주입요법 : 장기적 추적결과 Long-term Follow up Results

김용웅,왕세환,육승모,한동석,노안식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

To evaluated the results of long-term follow up of superficial bladder cancer patients who were treated with transurethral resection and intravesical BCG therapy. Between April 1989 and December 1997, 65 patients with superficial bladder cancer were treated with TUR-B(Transurethral resection of bladder tumor) and intravesical BCG instillation, and follow-up was performed for 5 years longer, and the mean follow-up duration was 82 months. Of 65 patients, pathologic stage were Ta in 17 cases and T1 in 48 cases and grade were G Ⅰ in 22 cases, G Ⅱ in 35 cases and G Ⅲ in 8 cases. The tumor recurred in 22(33.8%) at the median of 21.8 months and the tumor progressed in 9(13.8%) at the median of 20.8 months. Most of the recurrences and progression were within 3 year(838 and 77%). Progression is more likely in higher grade(G Ⅱ, G Ⅲ) and higher stage(T1). The complete response rate after first and second courses of BCG therapy were 53% and 73% and the 5 and 10 year disease specific survival rates were 89.5 and 78% respectively. The complete response rate after first and second courses of BCG therapywere 53% and 73%. Most of recurrences and progressions were within 3 years of the BCG therapy, but some cases occured after 5 years. Therefore, close long-term follow up is needed.

도심지 가로경관의 시지각적 이미지 특성에 관한 연구

김용권,박성진,이청웅 朝鮮大學校 建設技術硏究所 2004 建設技術硏究 Vol.24 No.2

This research is a stage of psychological experiments to analyze the image valuation system with Gwang-Ju Sang-rnu new city development site as the subject, to compare the subject streetscape as in a psychological experiment, to examine what points of view the image users take and select categories for a questionnaire. Therefore, a repertoire grid-development system was used to psychologically experiment and clarify the images of high-rise residential section streetscape, and the result is as following. Group1 is a typical high-rise residential section, which form and color of the buildings appears to have a simple, clean, and natural image. Group2 is consisted of multiple-story commercial buildings with signboards, and had a negative image. In contrast, multiple-story commercial buildings and high-rise residential buildings had a bright, clean, stabile image. Group3 is the most affirmatively preferred tendency which abundant continuative greenery on high-rise residential and business sections is emphasized by the bright, light colored roadside buildings that brought generally increased preference. Group4 is a group which is a business section with connective commercial buildings and construction sites mixed has the lowest preference tendency, and also has a negative tendency of lower than 4.0 of the 14 image categories.

가시오갈피 접합자배로부터 체세포배 발생 과정의 구조적 특성

최용의,소웅영 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.16 No.-

가시오갈피 접합자배를 1.0 mg/L 2,4-D가 첨가된 MS 배지에 배양하였을 때, 배양재료 표면에서 직접 체세포배가 발생되었다. 접합자배를 온전한 상태로 배양하였을 때에 비하여 상처를 주어 배양하였을 때 배발생률이 증가되었으며, 부위별로 절단하여 배양하였을 경우 하배축에서 발생률이 높았다. 체세포배발생에 대한 조직학적 관찰 결과, 유근부위가 잘록한 단일배와 여러개의 배가 서로 융합된 다배가 관찰되었다. 이들 두가지 모양의 체세포배는 접합자배의 부위마다 발생빈도가 달랐는데, 자엽이나 하백축하부에서는 단일배가 주로 관찰되었고, 배형성능이 높은 부위인 자엽절이나 하배축상부에서는 다배의 발생률이 높았다. 단일배는 표피의 단세포 기원되었으나 다배는 모두 표피 및 하표피의 다수세포에서 기원되었음이 조직학적 관찰로 확인되었다. When the zygotic embryos of Acanthopanax senticosus were cultured on MS medium containing 1.0 mg/L 2,4-D, somatic embryos were produced directly from the surface without forming an intervening callus. The frequency of embryo formation was higher in the wounded zygotic embryos than in the intact ones. Hypocotyl explants showed a higher frequency of somatic embryo formation that cotyledon or radicle explants. Two typeds of somatic embryos were observed : one was single embryos with closed radicle which were mainly formed on cotyledon or radicle part; and the other was polyembryos of which hypocotyls were fused one another showing multicotyledons with a single hypocotyl. Histological observation revealed that single embryos originated from the single epidermal cells while polyembryos were derived from massive cells of epidermis of subepidermis.

步速變化에 따른 미끄러짐의 생체역학적 연구

서국웅,윤양진,서국은,이중숙,김용재,이언석,이훈식 釜山大學校 附設 體育科學硏究所 1992 體育科學硏究所 論文集 Vol.8 No.-

The purpose of this study was to analyze walking steps to prevent unnecessary energy consuming and prevention of injury from sliding when someone was walking. The questionnaire, high speed video system, E.M.G. system, and force platform system were used to analyze sliding mechanism in biomechanical perspective. Several results were found as following: 1. According to questionnaire regarding sliding, 93.3% of participants have sliding experiences. People have sliding experiences by greasy floor(48.4%) and obstacle (22.5%). Sliding types were found from different kinds of shoes such as sneakers (48.8%) and boots (34.2%). The results were presented as following 44.6% of participants were fall down front direction and 40.3% of people fell down rear side. 2. According to the high speed video system analyzer, step sliding increased with increasing step speed from distance and acceleration speed experiment with 80 steps/min, 100 steps/min, 120 steps/min. Also, the most sliding were occurred with sneakers, boots, and bare feet as order. 3. According to E.M.G. test results, the vastus lateralis M., the vastus medialis m., and the tibialis anterior m. of electric action potential presented strongly when participants fell front, rear, and right side. The vastus lateralis m. and the tibialis anterior m. of electric action potential presented strongly when someone fell left side, but the vastus medialis m. and the gastrocnemius m. of electirc action potential presented as weaker. 4. According to the force platform test results, the most big change of floor antipower of x-axis presented when someone fell the left side. The most of big change of floor antipower of y-axis presented when someone fell down rear side. The most of big change of floor antipower of z-axis presented similarly when someone fell the front, rear, left, and right side.

복잡한 배경에서 얼굴 영역 추출

박용성,유태웅 群山大學校 1996 論文集 Vol.23 No.-

Finding human faces automatically in a scene is a difficult yet significant problem. This paper proposes a method for detecting face regions from a complex background, and describes the experimental results. We perform face location based on the observation that human faces are characterized by their color information and texture features as follows. Firstly we construct a face chromatic histogram in hue and saturation chromatic space. Secondly we use the chromatic histogram to detect skin pixels from the input image. Thirdly a face texture model is constructed by calculating inertia, inverse difference and correlation of facial images. Finally the locations of the face region are determined by face texture features.

淨水過程에서 生成된 알루미늄 이온 除去 (Ⅰ)

김영웅,노현웅,박승조 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

The objective of this study was to conduct jar-tests to remove residual aluminum ion and turbidity using three coagulants and three alginates as a coaglant aids. The conclusions were obtained from investigation of coagulant demand, zeta potential, residual aluminum ion concentration and turbidity under varying dosage of coagulants are as follows ; The potimum dosages for ALUM, PAC and PASS were 50, 35 and 30 mg/l respectively, at these dosages, residual aluminum ion concentrations were 0.07, 0.10 and 0.13 mg/l. When magnesium alginate(MA) dosage of 1.0 mg/l was applied after addition of optimum dosages of coagulants, ALUM, PAC and PASS removal efficiency of turbidities were 0.10, 0.13 and 0.13 NTU respectively. Adequate zeta-potential range for coagulation was from -20 mV to -10 mV with coagulant only.

급성 단순하부요로감염증 치료에서 노르플록사신과 루플록사신의 임상효과 및 안전성

김세웅,이지열,이승주,조용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 루플록사신은 긴 반감기와 넓은 항균력을 가진 퀴놀론계 항생물질이다. 급성 단순하부요로감염 치료에 있어서의 루플록사신의 효과와 안전성을 평가하기 위하여 기존의 퀴놀론계 항생물질인 노르플록사신과 비교임상시험을 실시하였다. 방법 : 본 임상시험은 전향적, 무작위 방법으로 진행하였으며 1997년 8월부터 1999년 3월까지 가톨릭대학교 의과대학 부속 성모병원 비뇨기과에 내원한 급성 단순하부요로감염 환자 72명을 대상으로 하였다. 연속적 무작위 배정방법을 통하여 루플록사신군 36명과 노르플록사신군 36명이 루플록사신 400㎎을 단회 경구투여 받거나 노르플록사신 400㎎을 12시간 간격으로 3일간 6회 경구투여 받았다. 임상효과, 미생물학적 평가 및 부작용을 비교 관찰하였다. 결과 : 총 64명의 환자가 시험을 완료하여 평가가 가능하였고, 이 중 루플록사신군은 32명이었고, 노르플록사신군은 32명이었다. 증상의 치료 및 개선을 임상적 유효성이 있는 경우로 하였을 때, 루플록사신투여군은 32례중 32예(100%)에서, 노르플록사신투여군은 32례 중 31례(96.9%)에서 만족할 만한 결과를 얻었다. 미생물학적 평가에서 루플록사신투여군은 32례 중 29례(90.6%)에서, 노르플록사신투여군은 32례 중 28례(87.5%)에서 미생물학적 소실을 보였다. 미생물학적 재발은 루플록사신군과 노르플록사신군에서 각각 1례(3.1%)과 2례(6.3%)가 나타났고, 재감염은 각각 2례(6.3%)와 1례(3.1%)가 나타났다. 임상효과와 미생물학적 평가에서는 두 약제간의 통계학적 차이는 없었다. 약물역동학적 검사상 루플록사신은 노르플록사신에 비해 높은 MIC를 갖고 있지만 긴 반감기를 통해 소변내에서 높은 농도와 요 살균력을 유지함을 알 수 있었다. 부작용은 루플록사신투여군 34례 중 5례(14/7%)에서, 노르플록사신투여군 35례 중 1례(2.9%)에서 나타났으며, 대부분의 소화기계통의 이상반응 이었으며, 모두 경증으로 24시간 이내에 소실되었다. 루플록사신투여군 중 2례에서는 경증의 중추신경계의 이상반응이 관찰되었다. 결론 : 결론적으로 루플록사신은 급성 단순하부요로감염에 대하여 1회 투여만으로도 노르플록사신의 3일 투여법과 동등한 효과를 나타내는 유용한 약제라고 생각된다. Background : Rufloxacin is a broad-spectrum quinolone that exhibits a prolonged elimination half-life. The purpose of this study is to evaluate the efficacy and safety of a single dose of rufloxacin, campared with those of a norfloxacin standard treatment. Methods : This was a open. randomized. parallel-group, phase 11 clinical trial. A total of 72 women with acute lower urinary tract infections were included and randomly assigned to one of the treatment regimens: rufloxacin 400㎎ single dose, or norfloxacin 400㎎ b.i.d. for 3 days. Clinical and bacteriological assessments were performed twice at the third day and the seventh or tenth day after inclusion. Results : A total of 64 patients(32 and 32 patients in the rufloxacin and norfloxacin groups, respectively) were considered clinically and bacteriologically evaluable. Overall, a clinical response(recovery and improvement) was observed in 32 (100%) of 32 patients treated with rufloxacin and in 31 (96.95) of 32 patients with norfloxacin. The corresponding eradication rates of the primary pathogens were 90.6%(29/32) and 87.5%(28/32), respectively. The microbiological relapses between the seventh and tenth day were recorded in 1 patient(3.1%) and 2 patients(6.3%) in the rufloxacin and norfloxacin groups, respectively. The superinfections occurred in 2(6.3%) and 1(3.1%) patients, respectively. No statistically significant differences in the clinical or bacteriological outcome were observed between the treatment groups. The pharmacodynamic evaluation showed similar median urine bactericidal titers(UBT) for both treatment groups against initial isolates, despite a higher MIC of rufloxacin than that of norfloxacin. Five patients (14.7%) in the rufloxacin group and 2 patients (5.7%) in the norfloxacin group reported 9 and 4 adverse events, respectively, almost all of them being mild and lasting <24 h. Overall, gastrointestinal reactions were the most frequent adverse events reported. However, 2 patients treated with rufloxacin reported 3 central nervous system adverse events. Conclusion : This study suggests that single dose of rufloxacin treatment is effective and well tolerated as norfloxacin 3-day standard treatment in acute uncomplicated lower urinary tract infections.

간단한 퍼지-신경회로망 동정모델을 이용한 제어기설계

이용구,김주웅,엄기환 동국대학교 산업기술연구원 1996 산업기술논문집 Vol.7 No.-

본 논문에서는 퍼지-신경회로망 동정모델을 이용한 간단한 제어기 설계방식을 제안하였다. 제안된 제어방식은 입력신호와 관련이 없는 시스템함수 f(x)의 동정은 퍼지-신경회로망을 이용하고, 입력신호와 관련된 함수 g(x)는 동정하지 않고 임의의 실수로 놓는 동정모델을 이용하여 제어기를 설계하였다. 제안된 방식의 특징은 기존의 동정을 이용한 제어기 설계방식보다 간단하고 계산량의 감소로 속응성이 개선될 수 있다. 제안된 제어방식의 유용성을 입증하기 위하여 직류 서보전동기를 제어대상으로 위치제어에 대하여 시뮬레이션 하였다. In this paper, we propose a simple controller design method using the fuzzy-neural network identification model. In the proposed control method, the identification for the system function f(x) make use of the fuzzy-nural network, and the system function g(x) replace an arbitrary real number, with no identification, and then designed a controller using the identified information. The characteristics of the proposed method can be improved control performance and can be reduced calculation over a conventional identification method. And then it applies to DC Servo Motor as an controlled process. And then it take a simulation for the position control, so that verify the usefulness of the proposed control method.