CD ROM을 이용한 교육프로그램이 단기입원수술 환자의 수술 전 불안과 수술 후 자가간호 수행을 위한 지식에 미치는 효과

황연자,박연환,박인선,김남이,김정미,김진영 성인간호학회 2004 성인간호학회지 Vol.16 No.1

Purpose: The purpose of this study was to investigate the effect of nursing education using a CD ROM on the anxiety and knowledge of the patients having minor surgery. Method: Forty patients hospitalized in K hospital in Seoul from April to August 2002 participated in this study. In the experimental group, twenty patients received nursing education on the operational procedures and post-operational care. The control group, received conventional nursing care only. Anxiety experienced by patients was measured by Spielberger's State-Trait Anxiety Inventory, and knowledge was measured by an instrument developed by Rahe et al. The data were analyzed by SPSS statistical program. Result: There were no significant differences in anxiety level between two groups. However, subjects in the experimental group were found to have significantly higher postoperative knowledge levels than those in the control group, and were very satisfied with the CD ROM program. Conclusion: The nursing education program using CD ROM before minor surgery proved to be an effective nursing intervention to increase knowledge of patients and contribute to their self care after discharge. To decrease anxiety of the surgery, the nursing education program should be combined with supprortive emotional nursing intervention, such as touch, and massage.

2009년 인플루엔자 대유행 중 인플루엔자 진료소 방문자의 연령 분포 변화

김백남,곽이경,문치숙,김연숙,김의석,배인규,염준섭,이창섭,허지안 대한감염학회 2010 감염과 화학요법 Vol.42 No.2

The pandemic influenza (H1N1 2009) virus, after being introduced in Korea in April, 2009, spread rapidly nationwide in mid-2009. This study was conducted to characterize trend in age distribution of visitors to Flu-clinics during the pandemic. Demographic, clinical and laboratory data of visitors to flu clinic from Week 36 to 52 (August 30 to December 26) of 2009 were retrieved and collected from electronic databases at 9 hospitals. Visitors 0-6, 7-12, 13-18, 19-29, 30-64, and 65 years or more of age were classified into group I to VI, respectively. A total of 107,467 visitors were seen at Flu-clinics for a 17-week study period. Of those, 32,485 were laboratory-confirmed. Antivirals were prescribed for 62,533 visitors. Numbers of visits, prescriptions of antivirals, and laboratory-confirmed cases of the pandemic influenza (H1N1 2009) peaked at Week 44. A large number of visits by group II and III were followed by those of group I and V, especially around the peak. Numbers of visits by group VI were lowest in all hospitals. In some hospitals, higher number of visits lasted longer in children than in adults while vice versa in other hospitals depending on the location. In summary, the pandemic influenza (H1N1 2009) was presumed to peak in late October and involved majorly children and students in Korea. Unique age distribution of visitors to flu clinic was observed in some hospitals.

健脾益氣法의 腫瘍治療活用에 對한 硏究

姜硏伊,金聖勳,金東熙 대전대학교 한의학연구소 2002 한의학연구소 논문집 Vol.10 No.2

In review of "inviorating spleen an supplementing qi" of clinical and experimental studies on malignant tumor, we obtained the conclusions as follows 1. Asthenic splenic qi is an important factor in mutation, occurrence and development of tumor. 2. The anti-tumor mechanism of "invigorating spleen and supplementing qi" is improvement of immune suveillance, cntroling cell proliferating period and enhancing body metabolism. 3. "Invigorating spleen and supplementing qi" is often used with " nourishing kidney" or "expelling pathogen" for treating cnacer. 4. In experimental studies, "invigorating spleen and supplementing qi" has effects on inhibiting occurrence and development of tumor, protecting mutation, inhibiting recurrence and metastasis, immune activity, enhancing metabolism, promoting bone marrow hemopoietic cell proliferation, increasing anti-tumor effect and protecting normal cells. 5. In clinical studies, "invigorating spleen and supplementing qi" has effects on prolonging the survival period of cancer patients, improving clinical symptoms and quality of life of cancer patients, degrading the side effects of western therapie(operation, chemotherapy and radiotherapy). 6. "Invigorating spleen and supplementing qi" is an extensive discipline of syndrome differentiation used to inhibit occurence, development, recurrence and metastasis.

Transforming growth factor-β1 regulates macrophage migration via RhoA

Kim, Jun-Sub,Kim, Jae-Gyu,Moon, Mi-Young,Jeon, Chan-Young,Won, Ha-Young,Kim, Hee-Jun,Jeon, Yee-Jin,Seo, Ji-Yeon,Kim, Jong-Il,Kim, Jaebong,Lee, Jae-Yong,Kim, Pyeung-Hyeun,Park, Jae-Bong American Society of Hematology 2006 Blood Vol.108 No.6

<B>Abstract</B><P>Brief treatment with transforming growth factor (TGF)-β1 stimulated the migration of macrophages, whereas long-term exposure decreased their migration. Cell migration stimulated by TGF-β1 was markedly inhibited by 10 μg/mL Tat-C3 exoenzyme. TGF-β1 increased mRNA and protein levels of macrophage inflammatory protein (MIP)-1α in the initial period, and these effects also were inhibited by 10 μg/mL Tat-C3 and a dominant-negative (DN)-RhoA (N19RhoA). Cycloheximide, actinomycin D, and antibodies against MIP-1α and monocyte chemoattractant protein-1 (MCP-1) abolished the stimulation of cell migration by TGF-β1. These findings suggest that migration of these cells is regulated directly and indirectly via the expression of chemokines such as MIP-1α and MCP-1 mediated by RhoA in response to TGF-β1. TGF-β1 activated RhoA in the initial period, and thereafter inactivated them, suggesting that the inactivation of RhoA may be the cause of the reduced cell migration in response to TGF-β1 at later times. We therefore attempted to elucidate the molecular mechanism of the inactivation of RhoA by TGF-β1. First, TGF-β1 phosphorylated RhoA via protein kinase A, leading to inactivation of RhoA. Second, wild-type p190 Rho GTPase activating protein (p190RhoGAP) reduced and DN-p190RhoGAP reversed the reduction of cell migration induced by TGF-β, suggesting that it inactivated RhoA via p190 Rho GAP.</P>

Phase II, multicentre, randomised trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy in patients with HER2-negative metastatic breast cancer

Park, Yeon Hee,Im, Seock-Ah,Kim, Sung-Bae,Sohn, Joo Hyuk,Lee, Keun Seok,Chae, Yee Soo,Lee, Ki Hyeong,Kim, Jee Hyun,Im, Young-Hyuck,Kim, Ji-Yeon,Kim, Tae-Yong,Lee, Kyung-Hun,Ahn, Jin-Hee,Kim, Gun Min,P Elsevier 2017 European journal of cancer Vol.86 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Paclitaxel plus gemcitabine (PG) combination chemotherapy is a preferred chemotherapeutic regimen for patients with metastatic breast cancer (MBC). Eribulin mesylate is a halichondrin non-taxane inhibitor of microtubule dynamics. A recent pooled analysis with eribulin showed improved overall survival (OS) in various MBC patient subgroups pretreated with anthracycline and taxane. Furthermore, eribulin may have less neurotoxicity than paclitaxel.</P> <P><B>Patients and methods</B></P> <P>This study was a prospective randomised phase II, open-label, two-arm, multicentre study comparing eribulin plus gemcitabine (EG) with PG chemotherapy as a first-line treatment for patients with human epidermal growth factor receptor 2-negative MBC. We hypothesised that EG chemotherapy would not be inferior to PG chemotherapy. The primary end-point was progression-free survival (PFS), which was estimated to be 70% at 6 months for each arm. The secondary end-points were as follows: OS, neuropathic scale, toxicity and clinical benefit rate.</P> <P><B>Results</B></P> <P>A total of 118 patients (median age: 50, 24–66) were enrolled between March 2015 and March 2016 and were randomly assigned to PG (<I>n</I> = <I>59</I>) or EG (<I>n</I> = <I>59</I>) chemotherapy. The mean number of metastatic sites was 3 (range 1–8). The 6-month PFS rates for both arms were 72% for EG and 73% for PG (<I>P</I> = <I>0.457</I>). There was no significant difference in OS between the two groups (not reached versus 21.2 months, <I>P</I> = <I>0.2234</I>). The median number of chemotherapy cycles for both groups was 10 for EG and 8 for PG (range 2–32). Clinical benefit rates were 44% for EG and 49% for PG. Major toxicities were neutropenia and neurotoxicity. Grade II or above neurotoxicity was more common with PG than with EG (13.6% for EG versus 45.8% for PG, <I>P</I> < <I>0.0001</I>).</P> <P><B>Conclusion</B></P> <P>EG chemotherapy had similar clinical benefits to PG chemotherapy in terms of PFS but less neurotoxicity.</P> <P><B>Trial registration</B></P> <P>KCSG BR13-11; ClinicalTrials.gov, NCT02263495.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This study was a prospective randomized phase II, multicentre study comparing EG with PG for MBC patients. </LI> <LI> The 6-month PFS rates for both arms were 72% for EG and 73% for PG (<I>P</I> = 0.457). </LI> <LI> EG chemotherapy had similar clinical benefits to PG chemotherapy in terms of progression-free survival but less neurotoxicity. </LI> </UL> </P>

Subcritical water extraction (SWE) of eugenol and gallic acid from clove (Syzygium aromaticum)

Na-Yeon Kim,So-Yoon Yee,Ju-Yeon Park,Gyu-A Kim,Hye-Won Mok,Yu-Gyeong Kim,Bo-Yeong Seok,Han-Sol Kim,Hye-Young Kwak,Hee-Jeong Hwang,Myong-Soo Chung 한국산업식품공학회 2018 학술대회 및 심포지엄 Vol.2018 No.11

α-Lipoic Acid Prevents Neointimal Hyperplasia Via Induction of p38 Mitogen-Activated Protein Kinase/Nur77-Mediated Apoptosis of Vascular Smooth Muscle Cells and Accelerates Postinjury Reendothelialization

Kim, Han-Jong,Kim, Joon-Young,Lee, Sun Joo,Kim, Hye-Jin,Oh, Chang Joo,Choi, Young-Keun,Lee, Hyo-Jeong,Do, Ji-Yeon,Kim, Sun-Yee,Kwon, Taeg-Kyu,Choi, Hueng-Sik,Lee, Mi-Ock,Park, In-Sun,Park, Keun-Gyu,Le Ovid Technologies Wolters Kluwer -American Heart A 2010 Arteriosclerosis, thrombosis, and vascular biology Vol.30 No.11

Tip60 Histone Acetyltransferase Acts as a Negative Regulator of Notch1 Signaling by Means of Acetylation

Kim, Mi-Yeon,Ann, Eun-Jung,Kim, Jin-Young,Mo, Jung-Soon,Park, Ji-Hye,Kim, Sun-Yee,Seo, Mi-Sun,Park, Hee-Sae American Society for Microbiology 2007 Molecular and cellular biology Vol.27 No.18

<B>ABSTRACT</B><P>The Notch signaling pathway appears to perform an important function in a wide variety of organisms and cell types. In our present study, we provide evidence that UV irradiation-induced Tip60 proteins reduced Notch1 activity to a marked degree. Accumulated UV irradiation-induced Tip60 suppresses Notch1 transcriptional activity via the dissociation of the Notch1-IC-CSL complex. The binding between endogenous Tip60 and Notch1-IC in UV radiation-exposed cells was verified in this study by coimmunoprecipitation. Interestingly, the physical interaction of Tip60 with Notch1-IC occurs to a more profound degree in the presence of CSL but does not exist in a trimeric complex. Using Notch1-IC and Tip60 deletion mutants, we also determined that the N terminus, which harbors the RAM domain and seven ankyrin repeats of Notch1-IC, interacts with the zinc finger and acetyl coenzyme A domains of Tip60. Furthermore, here we report that Notch1-IC is a direct target of the acetyltransferase activity of Tip60. Collectively, our data suggest that Tip60 is an inhibitor of the Notch1 signaling pathway and that Tip60-dependent acetylation of Notch1-IC may be relevant to the mechanism by which Tip60 suppresses Notch1 signaling.</P>

Isolation of Nontuberculous Mycobacteria from a Showerhead in Patient with Nontuberculous Mycobacteria

( Ji Yeon Choi ),( Bo Ra Sim ),( Song Yee Kim ),( Eun Young Kim ),( Sang Hoon Lee ),( Kyung Soo Chung ),( Ji Ye Jung ),( Moo Suk Park ),( Young Sam Kim ),( Young Ae Kang ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0

Background The environments are the source of exposure to most nontuberculous mycobacteria (NTM) involved in human infection, and it is important to reduce the frequency of exposure from environmental sources for preventing NTM infection. The aim of this study was to examine the NTM inside showerheads in patients with NTM pulmonary disease, because household water has been considered as one of the possible sources of NTM. Methods Samples were taken from 32 showerheads in patients with NTM pulmonary disease recruited through the Pulmonary Outpatient Clinic between October 2018 and October 2019. In order to determine the composition of the showerhead, washing fluids were examined using the multiplex PCR assay and cultured by conventional Methods. Subsequently, suspected microbial isolates in washing fluids and culture were identified using sequencing analysis of 16S rRNA gene. Results The patients consisted of 25 females and 7 males, and their ages were 59 years (range 30 to 72 years). The species of NTM that caused the patient’s pulmonary disease infection were Mycobacterium avium (n=17, 57%), M. intracellulare (n=7, 23%), M. abscessus (n=1, 3%), M. massiiliense (n=1, 3%), and M. fortuitum complex (n=1, 3%). In 17 showerhead samples, we identified potentially pathogenic mycobacteria isolated from the showerhead. However, species identified in the showerhead not matched those of the patient’s strain and few NTM causing the human disease were isolated from the showerhead; M. florentinum, M. phocaicum, M. gordonae, M. mucogenicum, M. gilvum, M. llatzerense, M. peregrinum, M. triplex. Despite a predominance of NTM species, we did not demonstrate the main pathogen associated with disease in the patients studied. Conclusion This report provides evidence that the showerhead may present potential exposure to NTM.

Effects of Sangju Honey on Oral Squamous Carcinoma Cells

Nangwon Yee,Hyeonjin Kim,Eungyung Kim,Yong Ho Cha,Lei Ma,Na Eun Cho,Dongwook Kim,Chae Yeon Kim,Sung-Hyun Kim,Zaeyoung Ryoo,이준구,김명옥 대한암예방학회 2022 Journal of cancer prevention Vol.27 No.4

Since ancient times, honey has been used in traditional medicine owing to its pharmacological effects. It possesses anticancer properties. However, the therapeutic implications of Sangju honey in cancer remains unknown. Therefore, we aimed to demonstrate the potential anticancer effects of Sangju honey on human oral squamous cell carcinoma (OSCC), particularly focusing on epithelial–mesenchymal transition (EMT) and apoptotic and mitogen-activated protein kinase (MAPK) signaling pathways. Ca9- 22 and YD-10B human OSCC cells were treated with 0.25% or 0.5% Sangju honey, and the cell viability was examined using the Cell Counting Kit-8 assay. Cell morphology studies were conducted to observe morphological changes, and the wound-healing assay was performed to evaluate the proliferation of honey-treated OSCC cells. Western blot analysis was conducted to investigate protein expression related to EMT and apoptotic and MAPK signaling pathways. Sangju honey reduced cell viability, induced morphological changes, and significantly suppressed the proliferation and migration of Ca9-22 and YD-10B cells. The expression of E-cadherin and N-cadherin was increased and decreased, respectively, in both OSCC cell lines. Moreover, Sangju honey stimulated apoptosis by increasing the expression of p21, p53, cleaved caspase 3, and caspase 9. Furthermore, it downregulated the expression of phospho (p)-extracellular signal-regulated kinases 1 and 2, p-c-Jun amino-terminal kinase, and p-p38 in Ca9-22 and YD-10B cells. Sangju honey inhibits Ca9-22 and YD-10B cell proliferation by regulating EMT, inducing apoptosis, and suppressing the MAPK signaling pathway. Thus, it is a potential anticancer agent for human OSCC.