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        • KCI등재

          성인여성의 인유두종바이러스와 자궁경부암 예방백신에 대한 지식, 암예방 수행 및 자궁경부암 예방백신 수용도 분석

          송갑선,전은미,김주연 대한암예방학회 2013 Journal of cancer prevention Vol.18 No.1

          This study was conducted to identify the knowledge of HPV and HPV vaccines and the acceptance of cancer preventive vaccine targeting adult women. The convenience sampling was conducted on subjects of 271 adult women who have visited Gynecologic Clinics residing in the B-city. For data analysis, it conducted the analysis of mean and standard deviation, t-test, ANOVA, and Pearson's Correlation Coefficient. The research results demonstrate that the knowledge about HPV vaccine was higher in less than 40's in their age, subjects over college-graduates, single status in marriage condition, and subjects who have jobs, but the knowledge appeared to be very low with mean score, 5.34 (range 0∼22). In terms of the performance of cancer prevention, subjects of college graduates, those who have religion and were in higher economic level, those who are married, have no job, have a sex-partner and sexually transmitted diseases experience specially made an effort to prevent cancer. Of the subjects, 66.7% responded that they had a will to receive HPV vaccination and 86% subjects wanted to make their children vaccinate. In addition, there was no correlation found between the knowledge of HPV vaccine and the cancer- preventive performance.

        • KCI등재

          Antioxidation and Cancer Cell (HT-29) Antiproliferation Effects of Rubus coreanus Miquel Bamboo Salt

          Xin Zhao,Jiale Song,Joug-Hynu Lee,So-Young Kim,박건영 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.4

          Bamboo is used by Korean as an important medicinal material. It has many different medicinal efficacy from its stub, roots and leaves. Rubus coreanus Miquel (raspberry) is thought to contain compounds which are important towards having health benefits. Rubus coreanus Miquel bamboo salt sample was prepared and showed in vitro antioxidant, antimutagenic and anticancer effects in this study. The radical scavenging effect of Rubus coreanus Miquel bamboo salt on DPPH radical were tested. The Rubus coreanus Miquel bamboo salt sample revealed better scavenging activities on DPPH radical than the other salt samples at concentrations of 10 and 20%. Antimutagenic effects of Rubus coreanus Miquel Bamboo salt were investigated and compared with other salt samples. Though solar salt exhibited comutagenicty with MNNG, bamboo salt showed antimutagenicity against MNNG. The Rubus coreanus Miquel bamboo salt showed more increased antimutagenicity than the bamboo salt. MTT assay was carried out with the salts treated HT-29 cancer cells. The Rubus coreanus Miquel bamboo salt showed better anticancer activities (69%) than purple bamboo salt (44%) and solar salt (11%) at a concentration of 1%, and Rubus coreanus Miquel bamboo salt also exhibited better anticancer activities than other salt samples at the low concentration of 0.5% (p<0.05). The analysis of apoptosis related genes was carried out using RT-PCR to check the anticancer effect in the colon cancer cells and showed the same anticancer cancer effects as shown in MTT assay. From the experimental results, Rubus coreanus Miquel bamboo salt exhibited better health functional effects than common bamboo salts and solar salt. (Cancer Prev Res 15, 306-312,2010)

        • KCI등재
        • KCI등재

          Tamoxifen Suppresses Inducible Nitric Oxide Synthase Expression in Mouse Macrophages

          Earl Han,하은영,김성훈,정주호,백형환,반주연 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.2

          Excessive nitric oxide (NO) production by inducible NO synthase (iNOS) in stimulated inflammatory cells is thought to be a causative factor of cellular injury. In recent studies, it has been shown that tamoxifen, an anti-breast cancer drug, exhibits anti-inflammatory effects. Thus, we investigated the effects of tamoxifen on the production and expression of iNos in lipopolysaccharide (LPS)-activated RAW264.7macrophages. NO production was assessed by nitrite assay and iNos expression was identified by reverse transcription-polymerase chain reaction (RT-PCR). Activation of nuclear factor-κb (Nfκb) was determined by electrophoretic mobility shift assay (EMSA). The NO production induced by LPS was markedly reduced by tamoxifen. Tamoxifen also suppressed the LPS-activated expression of iNos mRNA and blocked the LPS-induced activation of Nfκb. The phosphorylation level of extracellular signal-regulated kinase 1/2 (Erk) mitogen-activated protein kinase (MAPK) was not affected by tamoxifen,but the phosphorylation level of p38 MAPK was decreased by tamoxifen. Taken together, the results suggest that tamoxifen inhibits LPS-activated NO production via inhibition of p38 MAPK and Nfκb pathways in RAW264.7 macrophage cells. The results of our study provide evidence that tamoxifen possesses an anti-inflammatory effect. (Cancer Prev Res 15, 138-142, 2010)

        • KCI등재

          HT-29 대장암세포에서 Curcumin과 H2O2의 병행처리에 의한 AMP-Activated Protein Kinase 활성과 Apoptosis 유도에 관한 연구

          김윤이,박옥진,김영민,황수경,박송이,이윤경 대한암예방학회 2009 Journal of cancer prevention Vol.14 No.3

          Curcumin, curcuma longa, has been known to exert anti-oxidant effects or anti-inflammatory effects as phytochemical. Also it induces apoptosis in the colon cancer cells and inhibits an angiogenesis of tumor. AMP-activated protein kinase (AMPK) is activated by ATP depletion status such as heat shock, exercise, hypoxia, reactive oxygen species (ROS). Recent studies indicate that AMPK activation strongly suppresses cell proliferation and induces apoptosis in cancer cells. Hence, AMPK plays a critical role as a key signal in prevention of cancer and obesity. In this study, curcumin generated ROS in HT-29 colon cancer cell lines and this ROS seemed to be closely related to an increase in AMPK activation. ROS generated by phytochemical is one of the responsible elements for the activation of AMPK. We hypothesized that combined treatment of H2O2 and curcumin more stronglyactivated AMPK and this effect was abolished by AMPK inhibitor Compound C in HT-29 cells. Our results suggest that combined treatment of H2O2 and curcumin is an effective way in controlling cancer proliferation and apoptosis. Also, the synergistic effect of H2O2 and curcumin were shown to potent a chemotherapy in colon cancer cells. (Cancer Prev Res 14, 225-232, 2009) Curcumin, curcuma longa, has been known to exert anti-oxidant effects or anti-inflammatory effects as phytochemical. Also it induces apoptosis in the colon cancer cells and inhibits an angiogenesis of tumor. AMP-activated protein kinase (AMPK) is activated by ATP depletion status such as heat shock, exercise, hypoxia, reactive oxygen species (ROS). Recent studies indicate that AMPK activation strongly suppresses cell proliferation and induces apoptosis in cancer cells. Hence, AMPK plays a critical role as a key signal in prevention of cancer and obesity. In this study, curcumin generated ROS in HT-29 colon cancer cell lines and this ROS seemed to be closely related to an increase in AMPK activation. ROS generated by phytochemical is one of the responsible elements for the activation of AMPK. We hypothesized that combined treatment of H2O2 and curcumin more stronglyactivated AMPK and this effect was abolished by AMPK inhibitor Compound C in HT-29 cells. Our results suggest that combined treatment of H2O2 and curcumin is an effective way in controlling cancer proliferation and apoptosis. Also, the synergistic effect of H2O2 and curcumin were shown to potent a chemotherapy in colon cancer cells. (Cancer Prev Res 14, 225-232, 2009)

        • KCI등재

          아시아인에서 비만과 식도암 관련 연구의 메타분석

          성낙진,오상우,안홍협,강민수 대한암예방학회 2009 Journal of cancer prevention Vol.14 No.1

          There were several studies on the association between obesity and esophageal cancer in Asian countries which showed variable outcomes. We did a meta-analysis to estimate summary effects on that association. Eight sets of data were extracted from 6 papers which were selected through Pubmed searches during 1985∼2007 and hand searches of bibliographies in these studies. Meta-analysis of 4 data sets on esophageal squamous cell carcinoma incidence showed summary relative risk 0.66 (95% CI: 0.51∼0.86) per 5 kg/m2 higher BMI. Meta-analysis of 3 data sets on histologically unverified esophageal cancer revealed summary relative risk 0.62 (95% CI: 0.54∼0.72) per 5 kg/m2 higher BMI. In conclusion, obesity in Asians was associated with decreased incidence of esophageal squamous cell carcinoma. Obesity was also associated with decreased incidence of all esophageal cancer, which was thought to be mainly due to predominant prevalence of esophageal squamous cell carcinoma over adenocarcinoma in Asian countries. There were several studies on the association between obesity and esophageal cancer in Asian countries which showed variable outcomes. We did a meta-analysis to estimate summary effects on that association. Eight sets of data were extracted from 6 papers which were selected through Pubmed searches during 1985∼2007 and hand searches of bibliographies in these studies. Meta-analysis of 4 data sets on esophageal squamous cell carcinoma incidence showed summary relative risk 0.66 (95% CI: 0.51∼0.86) per 5 kg/m2 higher BMI. Meta-analysis of 3 data sets on histologically unverified esophageal cancer revealed summary relative risk 0.62 (95% CI: 0.54∼0.72) per 5 kg/m2 higher BMI. In conclusion, obesity in Asians was associated with decreased incidence of esophageal squamous cell carcinoma. Obesity was also associated with decreased incidence of all esophageal cancer, which was thought to be mainly due to predominant prevalence of esophageal squamous cell carcinoma over adenocarcinoma in Asian countries.

        • KCI등재후보

          Establishment of a Stable Cell Line Expressing Mouse Leptin Receptor (OB-Rb) in Human Embryonic Kidney 293 Cell and Preadipocyte 3T3L-1 Cell

          Ja Young Seol,Soon Young Choi,Nari Lee 대한암예방학회 2007 Journal of cancer prevention Vol.12 No.4

          Leptin, the product of the obesity (ob) gene, is a multifunctional cytokine and a 16-kDa circulating hormone that primarily acts in the hypothalamus. It plays a key role in the regulation of food intake and energy expenditure. In addition, it has direct effects on many cell types on the periphery. Leptin acts through its transmembrane receptors (OB-Rb), which are the product of the leptin receptor (OB-R) gene. There are several alternative spliced isoforms (a-f). Only one of OB-R, which has the longest cytoplasmic domain, has full signaling capabilities and it is expressed in high levels in the hypothalamus. In the present study, we investigate the obligatory function of normal food intake and body weight regulation. In order to develop a cell model to screen the effects of bio-food materials regulating food intake and to research cancer, the leptin receptor (OB-Rb) gene from mouse brain total RNA was introduced into a retroviral vector (pLNCX2) designed for stably over-expressing OB-Rb. An ecotropic retroviral supernatant (pLNCX2-Ob-Rb) was added to 3T3-L1 (adipocyte cells) and HEK293 (human embryonic kidney cells). G418 was used as selection antibiotic for the establishment of cell lines that constitutively expressed the leptin receptor proteins. We assayed expression of the leptin receptor using western-blot and quantitative RT-PCR. (Cancer Prev Res 12, 240-245, 2007) Key Words: Leptin, Leptin receptor (OB-Rb), Stable cell line, Retroviral vector, Infection Leptin, the product of the obesity (ob) gene, is a multifunctional cytokine and a 16-kDa circulating hormone that primarily acts in the hypothalamus. It plays a key role in the regulation of food intake and energy expenditure. In addition, it has direct effects on many cell types on the periphery. Leptin acts through its transmembrane receptors (OB-Rb), which are the product of the leptin receptor (OB-R) gene. There are several alternative spliced isoforms (a-f). Only one of OB-R, which has the longest cytoplasmic domain, has full signaling capabilities and it is expressed in high levels in the hypothalamus. In the present study, we investigate the obligatory function of normal food intake and body weight regulation. In order to develop a cell model to screen the effects of bio-food materials regulating food intake and to research cancer, the leptin receptor (OB-Rb) gene from mouse brain total RNA was introduced into a retroviral vector (pLNCX2) designed for stably over-expressing OB-Rb. An ecotropic retroviral supernatant (pLNCX2-Ob-Rb) was added to 3T3-L1 (adipocyte cells) and HEK293 (human embryonic kidney cells). G418 was used as selection antibiotic for the establishment of cell lines that constitutively expressed the leptin receptor proteins. We assayed expression of the leptin receptor using western-blot and quantitative RT-PCR. (Cancer Prev Res 12, 240-245, 2007) Key Words: Leptin, Leptin receptor (OB-Rb), Stable cell line, Retroviral vector, Infection

        • KCI등재

          Genomic Profiling of Chronic Myelogenous Leukemia: Basic and Clinical Approach

          Aliasghar Keramatinia,Alireza Ahadi,Mohammad Esmaeil Akbari,Maryam Mohseny,Alireza Mosavi Jarahi,Narjes Mehrvar,Neda Mansouri,S.A. Mortazavi Tabatabaei,Abolfazl Movafagh 대한암예방학회 2017 Journal of cancer prevention Vol.22 No.2

          Chronic myeloid leukemia (CML) is a hematological stem cell cancer driven by BCR-ABL1 fusion protein. We review the previous and recent evidence on the significance of CML in diagnostic and clinic management. The technical monitoring of BCR-ABL1 with quantitative real time-PCR has been used in assessing patient outcome. The cytogenetic mark of CML is Philadelphia chromosome, that is formed by reciprocal chromosomal translocations between human chromosome 9 and 22, t(9:22) (q34:q11). It makes a BCR-ABL1 fusion protein with an anomaly tyrosine kinase activity that promotes the characteristic proliferation of progenitor cells in CML and acute lymphoblastic lymphoma. The targeting of BCR-ABL1 fusion kinase is the first novel paradigm of molecularly targeted curing.

        • KCI등재

          Induction of Apoptosis via Autophagy on SK-Hep1 Human Hepatocellular Carcinoma Cells by Kurarinone Isolated from Sophora flavescens

          김순진,최재수,김군도 대한암예방학회 2012 Journal of cancer prevention Vol.17 No.2

          The dried roots of Sophora flavescens have been used in traditional medicine. Previous studies have shown that the roots of Sophora flvescens have various effects, including anti-oxidation, anti-inflammation and anti-tumor activities. In this study, we targeted the of kurarinone isolated from Sophora flavescens on induction of apoptosis in SK-Hep1 human hepatocarcinoma cells. Kurarinone inhibited the proliferation of SK-Hep1 cells in a dose-dependent manner with IC50 value of 75 μM. Western blot analysis revealed that kurarinone reduced the expression of survival-related proteins but induced apoptosis in dose-dependent manner. Induced apoptosis is reflected by not only increase of caspases, cleaved poly ADP ribose polymerase (PARP) and phosphorylated lamin A/C but also decrease of DNA fragmentation factor (DFF) 45/35. Kurarinone also induced autophagic cell death in the cells through the activation of autophagy-specific gene (Atg), Beclin-1 and microtubule-associated protein 1 light chain 3 (LC3). These results indicate that kurarinone induces cell death by both authophagy and apoptosis through the activation of pro-apoptotic proteins and caspase-dependent pathway in SK-Hep1 cells.

        • KCI등재

          Curcumin Induces Apoptosis by the Regulation of AMPKα1 and HIF-1α Levels

          박송이,김윤이,이윤경,김영민,박옥진 대한암예방학회 2012 Journal of cancer prevention Vol.17 No.2

          Under the hypoxic condition, cancer cells initiate their own adaptive pathways to have a facilitated oxygen and energy supply for survival. In this adaptive response, hypoxia-inducible factor-1α (HIF-1α) is a key regulator to stimulate angiogenesis, glucose transport and metabolism. We applied curcumin to examine the effect on HIF-1α induction and the regulatory effect of AMPKα1 on HIF-1α in HT-29 colon cancer cells. Our results showed that curcumin effectively induced apoptosis, dose dependently and reduced HIF-1α, which was elevated in hypoxic state induced by CoCl2. In addition, curcumin inhibited AMPKα1 activity, a modulator of adaptive pathway in response to hypoxia-induced energy depletion. These observations suggest that AMPKα1 may positively modulate HIF-1α stabilization and therefore, curcumin down-regulates AMPKα1 which seldom occurs in normoxic state. Curcumin induces apoptosis of HT-29 colon cancer cells through regulation of AMPKα1- HIF-1α pathway against hypoxic state.

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