비소세포폐암에서 Microsatellite Instability

전효성,김정란,손지웅,박선하,박태인,김창호,김인산,정태훈,박재용 경북대학교 병원 2001 경북대학교병원의학연구소논문집 Vol.5 No.1

연구베경:MMR 유전자의 불활성화에 의해 야기되는 뮤전적 불안정성은 발암기전의 한 부류로 인정되고 있다.저자들은 비소세포폐암의 발암과정에서의 MSI의 역할을 규명하기 위해 비소세포폐암에서 MSI의 빈도 및 MSI 유무에 따른 임상상의 차이를 조사하였다. 대상 및 방법:근치적 절제술을 받은 비소세포폐암 20예를 대상으로 하였다.동결된 폐암조직과 환자의 림프구에서 DNA를 추출한 후 3P와 9p의 15개의 marker들을 대상으로 PCR을 시행하고 7% polyacrylamide gel에서 전기영동한 후 silver 염색을 시행하였다. 암조직과 림프구 DNA의 PCR product의 band를 비교하여 MSI와 LOH를 판정하였다. 결과:1)대상환자들은 남자 19예,여자 1예였으며 모두 흡연자였고 평균 흠연력은 47 갑년이었다. 폐암의 조직형은 편평상피암 15예, 선암 4예,대세포암 1예였고, 술 후 병리학적 병기는 Ⅰ기 6예,Ⅱ기 5예, ⅢA기 7예,ⅢB기 2예였다. 2)20예 가운데 8예(40%)에서 MSI가 관찰되었으며 3예는 한 개의 marker에서,5예는 2개 이상의 marker에서 MSI가 관찰되었다. 3)LOH는 10예(50%)에서 있었으며,LOH유무에 따른 병가 및 흡연력의 차이가 없었다. 4)분석한 marker의 10% 이상에서 MSI가 관찰된 MSI-L종양은 5예였으며, 대부분의 marker에서 MSI양성인 MSI-H종양은 없었다.MSS종양과 MSI-L종양은 흡연력, 병기, 폐암 조직형 및 LOH 빈도의 유의한 차이가 없었다. 결론:비소세포폐암에서 MSI는 비교적 흔히 관찰되지만 MMR 유전자의 불활성화에 의한 MMP pathway 는 비소세포폐암의 주요 발생기전은 아닐 것으로 생각된다.향 후 비소세포폐암의 발암과정에 있어서 MMP pathway의 역할을 규명하기 위해서는 보다 많은 예를 대상으로 한 연구가 필요할 것으로 생각되며, MSI 발생기전에 관한 추가적인 연구가 필요할 것으로 생각된다. Purpose: Microsatellite instability(MSI) is frequently used as an indicator of microsatellite mutator phenotype (MMP) tumors.MSI has been observed in a percentage of non-small cell lung cancer(NSCLC).However, its role in tumorigenesis of NSCLC remains unknown.The frequency and partten of MSI in NSCLC were evaluted and clinical parameters of MSI-positive tumors with those of MSS(microsatellite stable) tumors were compared. Materials and Methods: Twenty surgically resected NSCLCs were analyzed for 15 microsatellite markers located at chromosomes 3p and 9p.The peripheral blood lymphocytes of patients were used as the source of the normal DNA. Results:1) of 20 cases, 8(40%) demonstrated MSI. 2) Instability was observed more frequently in tri- and tetra-nucleotide repeats that in dinucleotide repeats. In all cases, instability appeared as a shift of individual allelic bands. 3) LOH was observed in 10(50%) of 20 tumors analyzed. 4) Of 20 cases, MSI-H tumor(showing MSI in the majority of markers) was absent. There were 5 MSI-L tumors( showing MSI in a greater than 10% of markers). 5) No significant difference was observed between MSI-L tumors and MSI negative tumors in terms of clinicopathologic features such as pack-year history of smoking, histologic subtype, and (delete) stage of disease.There was also no significant difference in the incidence of LOH in relation to the status of MSI. Conclusion: These data strongly suggest that MSI plays different roles in lung and colon cancer.MMP pathway appears to be far less important in the tumorigenesis of NSCLC, caused mainly by cigarette smoke, with little familial tendency.(tuberculosis and Respiratory Diseases 2000,48:24-32)

보건소를 이용하는 지역주민의 건강 행위와 건강관련 체력간의 관계

전미양,최명애,이인숙,김태수,김의숙,박선홍 대한보건협회 2002 대한보건연구 Vol.28 No.3

The purpose of this study is to identify relationship health behavior and health related physical fitness in order to provide the basic data for health promotion program for community people. The study was conducted 299 people, during the period from June 1, 2000 to October 30, 2000. The result are as follows. 1. Female comprised was 63.2%(189), while male comprised 36.8%(110). The age range of the subject were from 21 to 59 years old. The subject were aged 30s group 52.5%, 40s group 29.1%, 50s group 12.7%, 20s group 5.7%. Twenty subjects (6.7%) had experience smoking and one subject (0.3%) in female and nineteen subjects (6.4%) in male. Seventy-five subjects (25.1%) had experience drinking and twenty-nine subjects (9.7%) in female, and forty-six (15.4%) in male subjects. ninety-nine subjects had exercise and sixty subjects (20.1%) in female subjects and thirty-mine subject (13%) in male. 2. Body fat and flexibility were higher in female than male subjects, but cardioresperatory endurance, muscular strength and muscular endurance were higher in male than female subjects. 3. There were significant differences in body fat and muscular endurance between age group in both gender subjects, and in cardioresperatory endurance and muscular strength between the age group in male subjects. 4. No significant differences health related fitness between non-smoking and smoking group in both gender subjects. 5. No significant differences health related fitness between non-alcohol and alcohol group in both gender subjects. 6. For female subjects, muscular strength, muscular endurance and flexibility of the exercise group were significantly higher than those of the non exercise group. for male subjects, cardiorespiratory endurance of the exercise group were significantly higher than those of the non exercise group.

Investigation on the electronic state of In-doped ZnO nanocrystals by hard X-ray photoemission spectroscopy

Mina Jung,Sunyeo Ha,Seungjun Oh,구지은,Keisuke Kobayashi,Tae-In Jeon,Yoshihiro Murakami,Jiho Chang,Takafumi Yao 한국물리학회 2009 Current Applied Physics Vol.9 No.2

ZnO:In nanocrystals (NCs) with various In contents were synthesized by using a mixed source vapor transportation method. The morphological variation and electronic structure of ZnO:In NCs were studied by bulk sensitive hard X-ray photoemission spectroscopy (HX-PES). ZnO:In NCs are classified into ZnOlike hexagonal and In2O3-like cubic groups, based on the crystal structure, and we have estimated the In content for the phase transformation to be as high as 35 atomic% (atm.%). A filled electronic state in the conduction band was observed from the ZnO-like group, which is regarded as a metallic state, due to an increase of extrinsic carrier density. ZnO:In nanocrystals (NCs) with various In contents were synthesized by using a mixed source vapor transportation method. The morphological variation and electronic structure of ZnO:In NCs were studied by bulk sensitive hard X-ray photoemission spectroscopy (HX-PES). ZnO:In NCs are classified into ZnOlike hexagonal and In2O3-like cubic groups, based on the crystal structure, and we have estimated the In content for the phase transformation to be as high as 35 atomic% (atm.%). A filled electronic state in the conduction band was observed from the ZnO-like group, which is regarded as a metallic state, due to an increase of extrinsic carrier density.

The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE)

( Hae Jun Song ),( Chul Jong Park ),( Tae Yoon Kim ),( Yong Beom Choe ),( Seok-Jong Lee ),( Nack In Kim ),( Jae We Cho ),( Jie Hyun Jeon ),( Min Soo Jang ),( Jai Il Youn ),( Myung Hwa Kim ),( Joonsoo 대한피부과학회 2017 Annals of Dermatology Vol.29 No.4

Background: Psoriasis is an immune-mediated, chronic in-flammatory disease affecting multiple aspects of patients` lives. Its epidemiology varies regionally; however, nation-wide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date. Objective: To understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited uni-versity hospitals in Korea. Methods: This multicenter, non-in-terventional, cross-sectional study recruited 1,278 adult pa-tients with psoriasis across 25 centers in Korea in 2013. Various clinical data including PASI, BSA, DLQI, SF-36 and PASE were collected. Results: A total of 1,260 patients com-pleted the study (male:female=1.47:1). The mean age was 47.0 years with a distribution mostly in the 50s (24.9%). Early onset (<40 years) of psoriasis accounted for 53.9% of patients. The mean disease duration was 109.2 months; mean body mass index was 23.9 kg/m2; and 12.7% of patients had a family history of psoriasis. Plaque and guttate types of psoriasis accounted for 85.8% and 8.4%, respectively. Patients with PASI ≥10 accounted for 24.9%; patients with body surface area ≥10 were 45.9%. Patients with DLQI ≥6 accounted for 78.8%. Between PASI <10 and PASI ≥10 groups, significant difference was noted in age at diagnosis, disease duration, blood pressure, waist cir-cumference of female, and treatment experiences with pho-totherapy, systemic agents, and biologics. Conclusion: This was the first nationwide epidemiologic study of patients with psoriasis in Korea and provides an overview of the epidemio-logic characteristics and clinical profiles of this patient population. (Ann Dermatol 29(4) 462∼470, 2017)

한국인 건선환자에서 발병하는 질환에 대한 연구 - 다기관 연구

김광호(Kwang Ho Kim),전현진(Hyun Jin Jeon),김광중(Kwang Joong Kim),윤재일(Jai Il Youn),김낙인(Nack In Kim),김태윤(Tae Yoon Kim),최지호(Jee Ho Choi),박기범(Ki Beom Park) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.7

N/A Background: The prevalence of other diseases associated with psoriasis has been investigated in recent years. Objective: This study was performed to see diseases associated with psoriasis in Korea. Methods: From September 1999 to May 2000, a total of 293 patients with psoriasis, who visited the department of dermatology in 6 hospitals, were enrolled in a subject group for the study. We surveyed the incidence rates of associated diseases. Results: In our study, diseases more concomitantly present in patients with psoriasis were dermatophyte infection, seborrhea dermatitis and benign tumor & nevus in skin diseases and obesity, diabetes mellitus, hypertension, gastritis and hepatitis in systemic diseases. Less concomitantly present in-patients with psoriasis were erythroderma, acne, contact dermatitis, atomic dermatitis, bacterial infection, tonsillitis, and internal cancer. Conclusion: Our observations show a distinct pattern of diseases associated with psoriasis in Korea. Further investigation will be mandatory to elucidate concomitant diseases in psoriasis. (Korean J Dermatol 2001;39 (7): 743~748)

Trend of Intensive Care Unit Admission in Neurology- Neurosurgery Adult Patients in South Korea : A Nationwide Population-Based Cohort Study

Saeyeon Kim,Tak Kyu Oh,In-Ae Song,Young-Tae Jeon 대한신경외과학회 2024 Journal of Korean neurosurgical society Vol.67 No.1

Objective : We aimed to examine trends in critically ill neurology-neurosurgery (NNS) patients who were admitted to the intensive care unit (ICU) in South Korea and identify risk factors for in-hospital mortality after ICU admission in NNS patients. Methods : This nationwide population-based retrospective cohort study enrolled adult NNS adult patients admitted to the ICU from 2010 to 2019 extracted from the National Health Insurance Service in South Korea. The critically ill NNS patients were defined as those whose main admission departments were neurology or neurosurgery at ICU admission. The number of ICU admission, age, and total cost for hospitalization from 2010 to 2019 in critically ill NNS patients were examined as trend information. Moreover, multivariable logistic regression modeling was used to identify risk factors for in-hospital mortality among critically ill NNS patients. Results : We included 845474 ICU admission cases for 679376 critically ill NNS patients in South Korea between January 1, 2010 to December 31, 2019. The total number of ICU admissions among NNS patients was 79522 in 2010, which increased to 91502 in 2019. The mean age rose from 62.8 years (standard deviation [SD], 15.6) in 2010 to 66.6 years (SD, 15.2) in 2019, and the average total cost for hospitalization per each patient consistently increased from 6206.1 USD (SD, 5218.5) in 2010 to 10745.4 USD (SD, 10917.4) in 2019. In-hospital mortality occurred in 75455 patients (8.9%). Risk factors strongly associated with increased in-hospital mortality were the usage of mechanical ventilator (adjusted odds ratio [aOR], 19.83; 95% confidence interval [CI], 19.42–20.26; p<0.001), extracorporeal membrane oxygenation (aOR, 3.49; 95% CI, 2.42–5.02; p<0.001), and continuous renal replacement therapy (aOR, 6.47; 95% CI, 6.02–6.96; p<0.001). In addition, direct admission to ICU from the emergency room (aOR, 1.38; 95% CI, 1.36–1.41; p<0.001) and brain cancer as the main diagnosis (aOR, 1.30; 95% CI, 1.22–1.39; p<0.001) are also potential risk factors for increased in-hospital mortality. Conclusion : In South Korea, the number of ICU admissions increased among critically ill NNS patients from 2010 to 2019. The average age and total costs for hospitalization also increased. Some potential risk factors are found to increase in-hospital mortality among critically ill NNS patients.

고온 초전도체 Y₁Ba₂Cu₃O_7-δ(CdO)_x의 핵사중극 상호작용 연구

전인,김복수,노태호,김영훈,서용문,송승기,박영민 명지대학교 자연과학연구소 2000 자연과학논문집 Vol.19 No.-

CdO가 첨가된 고온 초전도체 Y1Ba2CU3O7-δ(CdO)x(x=0.00,0.09,0.22,0.34,0.42,0.49)를 고상 반응법으로 제작하여 상온에서 Cu 핵사중극 공명 실험을 하였다. 구리-산소 평면에 있는 63Cu(2)의 핵사중극 공명 진동수는 31.13∼31.39 MHz이고, 65Cu(2)의 공명 진동수는 28.82∼29.06 MHz이었다. 이러한 공명 진동수는 χ가 증가할수록 높은 진동수 방향으로 이동하였다. 63Cu(2)과 65Cu(2)의 NQR 공명 진동수의 비는 모든 시료가 1.08로 63Cu과 65Cu의 핵 사중극 모멘트의 비와 같았다. 구리-산소 사슬에 있는 63Cu(1)의 공명 진동수는 22.15~22.36 MHz에서 관측되었는데, χ에 따른 공명 진동수의 이동 경향은 63Cu(2)과 65Cu(2)의 경우와 비슷하였다. 선폭은 63Cu(2)과 65Cu(2)그리고 63Cu(1)의 경우 모두 약 200∼300 kHz고, 전반적으로 χ가 증가할 수록 감소하였다. 스핀-에코 방법으로 구한 스핀-스핀 이완 시간 T2는 χ가 증가함에 따라 약간씩 증가하였다. We have studied Cu-NQR in CdO-mixed high-Tc superconductor Y1Ba2Cu3O7-δ(CdO)x(x=0.00, 0.09, 0.22, 0.34, 0.42, 0.49) at room temperature prepared by solid state reaction method. In the Cu-O plane, 63Cu(2)-NQR frequencies were measured to be in the range of 31.13-31.39 MHz and those of 65Cu(2) were in the range of 28.82-29.06 MHz. The position of spectrum-peaks shifted to the higher frequency with increasing χ. The ratio of 63Cu(2) and 65Cu(2)-NQR frequencies have the value of 1.08 which is equal to the ratio of 63Cu(2) and 65Cu(2) nuclear quadrupole moment for all samples. The resonance frequencies of 63Cu(1) in the Cu-O chain have been observed in the range of 22.15-22.36 MHz and the tendency of resonance frequency behaviour with χ were nearly the same for both 63Cu(2) and 65Cu(2). The line-widths of 63Cu(2), 65Cu(2) and 63Cu(1) were observed to the value of 200∼300 kHz and they decreased with increasing χ. The spin-spin relaxation time T2 obtained by spin-echo method increased slightly with increasing χ.

TCT-395 Comparison of Clinical Outcomes after Treatment of In-Stent Restenosis Using Drug-Eluting Balloon versus Newer Generation Drug-Eluting Stents: Patient-Level Pooled Analysis of Korean Multicenter In-Stent Restenosis Registry

Rhee, Tae-Min,Lee, Joo Myung,Hahn, Joo-Yong,Hwang, Doyeon,Park, Jonghanne,Woo (KW) Park, Kyung,Kim, Hack-Lyoung,Kim, Sang-Hyun,Chae, In Ho,Doh, Joon-Hyung,JEON, KI-HYUN,Choi, Young Jin,Park, Jin Sik,C Elsevier 2016 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - Vol.68 No.18

남성화를 보이는 여성에서 발견된 난소의 Steroid Cell Tumor 1예

조인호,정대훈,박영미,서영진,손영실,정철회,강영미,정수전,김영남,이경복,성문수,김기태 인제대학교 2006 仁濟醫學 Vol.27 No.-

Steroid cell tumor is a rare ovarian sex cord-stromal tumor which accounts for 0.1% of all ovarian tumors. Until now, only 4 cases have been reported in domestic literatures. Steroid cell tumor often secrets testosterone and presents virilization in adult women or precocious puberty in children. Treatment is often performed by surgical removal, adjuvant chemotherapy and radiation, but completely accepted treatment was not existed. We experienced a case of steroid cell tumor, which was manifested by typical virilization in a 43-year old patient, who was previously performed hysterectomy and unilateral oophorectomy. So, we present with a brief review of the literatures.

V₂O-B₂O₃-PbO 유리의 전자 상자성 공명연구

노태호,전인,박영민,강재필,김성재,박현진,송승기 명지대학교 자연과학연구소 1996 자연과학논문집 Vol.14 No.-

V₂O??-B₂O₃-PbO 유리의 VO??에 관한 전자 상자성 (EPR) 스펙트럼으 연구하였으며, vanadium이온의 스핀해밀토니안 상수들을 구하였다. 유리시료안의 V₂O??양을 증가시킴에 따라 g??과 g??값은 증가하였으나 A??과 A??값은 감소하였다. 이는 V₂O??수가 증가하면 동일 평면상의 vanadium과 oxygen배위간 결합의 공유성이 증가함을 의미한다. 유리내의 vanadium 4가이온은 정방형 일그러진 8면체를 한 vanadyl착물로 존재한다. Electron Paranmagnetic Resonance(EPR) SPECTRA OF (VO)?? in V₂O??-B₂O₃-PbO glasses have been studied and spin hamiltonian paramenters of vanadium ion have been calculated. It is found that the value of g??and g?? increases while the value of A?? and A?? decreases with an increase of V₂O?? content in the glass samples, showing that the covalency in the in-plane vanadium -oxygen ligand bonds increase with increasing the concentration of V₂O??. The tetravalent vanadium ions exist as vanadyl complexes with tetragonally distorted octahedral sites in the glasses.