비대뇌형 모균증 치험 2례

박선홍,김형석,이도용,나한조 조선대학교 1993 The Medical Journal of Chosun University Vol.18 No.2

Mucormycosis is an uncommon opportunisitc fungal infection and seen usually associated with chronic devilitating disease such as ketoacidotic diabetes mellitus, leukemia and immunosuppressive conditions. The most frequent form is rhinocerebral mucormycosis and this form of the disease typically starts in the nose, paransal sinuses, or orbit and extends intracranially either bt direct invasion or through blood vessel. It may result in devasating fatal course rapidly due to cerebral involvement if treatment delayed. Early diagnosis and treatment, including wide surgical debridement and the use of amphotericin B, are needed in order to avoid a rapid fatal course and complications. Recently we experienced two cases of rhinocerebral mucormycosis; one case is rhino-orbito-cerebral type which occured in patient with diabetes and the other is rhinomaxillary type without underlying diseases. We report these cases with the review of literatures..

간섭 신호를 고려한 릴레이 환경에서의 협력 다이버시티

박선홍,이영표,정영민,신형동 경희대학교 경희정보통신 SoC연구소 2009 경희정보통신SOC연구소 논문집 Vol.10 No.-

본 논문에서는 Rayleigh 페이딩 채널에서 간섭 신호가 존재하는 릴레이 환경에서의 협력 다이버시티성능을 확인한다. 1개의 안테나를 갖는 송신단과 고정 이득 증폭 전달 방식으로 작동되는 1개의 릴레이 노드, L개의 안테나를 가진 수신단으로 이루어진 릴레이 시스템에서 가우시안 신호로 모델화된 NI 개의 간섭 신호가 협력 다이버시티에 미치는 영향을 분석한다. 이 경우 수신단에서 Optimum Combining 기법을 적용한 후 얻어지는 다이버시티 차수가 L- NI + min{l ,L- NI } 됨을 시뮬레이션 결과를 통해 확인한다.

Physiological Activity of Polyphenol and Chlorogenic Acid

박선홍,한상배,김영수 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.2

All living organisms through respiration may lead to oxidative stress, a state where increased formation of reactive oxygen species overwhelms host protection and subsequently induces DNA damage, lipid peroxidation, and protein denaturation. Chlorogenic acid, as a phenolic acid, occurs ubiquitously in food. It has been proved to have a number of biological effects in vitro and in vivo, such as antioxidant, anti-inflammatory, and anticarcinogenic properties. Chlorogenic acid can therefore promote human health to some extent, and be hopeful to provide new ways for treatment of chronic diseases. Recent studies are focused on the antioxidant properties of dietary polyphenols. The in vitro data often conflict with results obtained from in vivo studies on the antioxidant capacity of plasma or the resistance of plasma and lipoproteins to oxidation ex vivo after the consumption of polyphenols-rich foods by human subjects. These inconsistencies are likely explained by the limited bioavailability of dietary polyphenols and their extensive metabolism in humans. Polyphenols exert multifacet actions, and any clinical application using these substances should be based on the precise understanding of the physiologically relevant mechanisms.

윤창중 사건에서 나타난 신문편집 행태에 관한 연구: 종합일간지 1면 제목과 사설의 선정성 시비를 중심으로

박선홍 한국정치커뮤니케이션학회 2013 정치커뮤니케이션 연구 Vol. No.

The purpose of this study is to analyze the sensationalism and editing behavior of Korean newspapers. Each headline and editorial of Chosun Ilbo,JoongAng Ilbo, Kyunghyang Shinmun, Hankyoreh on the 'Yunchangjung case'during May 2013 has been compared. As a result, there was a difference between the four newspapers' editing behavior on the front page. During the research period, there was a difference on the number of articles and headline size about the 'Yunchangjung case' between conservative newspapers and progressive newpapers. By comparing the headlines, which are important standards on determinating the sensationalism of the newsfeed, it appeared that Kyunghyang Shinmun and Chosun Ilbo has been more sensational. On the other hand, by comparing the number of editorial during the same survey time,JoongAng Ilbo and Chosun Ilbo has put up 5 articles, while Kyunghyang Shinmun has done 3 and Hankyoreh has done 2. By this, it could be confirmed that conservative newspapers had more of their focus on the incident. However,there wasn't much difference in the details or tone of the press, and most of the editorial titles were emphasizing the downfall of Korea's national status,rather than sensationalism issues. This study has analyzed the editing behavior and the tone of press on the newspapers' first pages, which determinate the valuation of the article. Therefore, it has been meant for fundamental analysis on newspaper editing. 본 연구의 목적은 한국 신문의 편집형태와 선정성 보도를 실증적으로 분석하는데 있다. 본연구는 2013년 5월 조선일보, 중앙일보, 경향신문, 한겨레에 보도된 ‘윤창중 사건’의 1면 제목과각 신문의 사설을 비교했다. 분석결과 첫째, ‘윤창중 사건’ 을 다룬 4개 신문 1면에서 편집의차이가 있었다. 조사기간 동안 1면에 ‘윤창중 사건’관련 기사 게재 건수와 제목의 크기에서 보수신문과 진보신문의 차이가 났고 뉴스가치의 중요한 잣대인 제목을 선정성을 중심으로 척도분석을 한 결과, 경향신문과 조선일보가 상대적으로 선정적인 보도를 한 것으로 나타났다. 반면, 각신문이 ‘윤창중 사건’을 다룬 사설을 보면, 동일한 조사기간 동안 중앙일보와 조선일보가 4건,경향신문이 3건 한겨레가 2건을 게재해 보수신문이 이 사건을 더욱 주목한 것으로 나타났다. 하지만 내용이나 논조의 차이는 없었고 사설 제목이나 기사에서도 선정성보다는 국격을 강조하는 내용이 대부분이었다. 이 연구는 기사의 가치판단 기능을 가진 1면 제목의 크기와 내용 등편집행태와 각 신문 사설의 논조를 선정성이란 척도로 분석했다. 따라서 이 연구는 신문편집에대한 기초적 분석의 사례라는데 의의가 있다.

Clinical Application of Eritoran as Drug Candidate for Sepsis Treatment

박선홍,이기호,임화경,한상배,김영수 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.1

Sepsis is a clinical syndrome defined as a systemic inflammatory response to infection. Eritoran is a synthetic lipid A derivative that competes with lipopolysaccharide in binding to the identical site of myeloid differentiation-2/toll-like receptor 4 complex. Eritoran is effective to decrease the septic mortality of Gram-negative bacteria-infected animals. Eritoran has been highlighted as a drug candidate for treating endotoxemia in the phase I clinical studies with health human volunteers. A phase II trial of eritoran has been conducted in the patients with severe sepsis. Intravenous infusion of eritoran reduces the mortality rate, as compared with placebo group, in sepsis patients who are at a high risk of mortality according to the acute physiology and chronic health evaluation-II scores. A phase III study of eritoran has been completed in 2011. The results seem to be disappointing as there was not a statistically significant difference between the eritoran treatment and the placebo group in the all-cause mortality at day 28 monitored in sepsis patients with a high risk of death. In this review, we focus on the rational for the use of eritoran in sepsis as well as its clinical applications.

우울감을 주호소로 입원한 환자의 자살 시도와 혈청 지질과의 연관성

박선홍,김승준,김지웅,오홍석,이상민,전진용,임우영 한국정신신체의학회 2018 정신신체의학 Vol.26 No.2

연구목적: 우울증은 흔한 정신 질환이며 자살의 주요 원인이다. 혈청 지질이 우울증, 자살과 연관이 있다는 연구가 지속되어 왔으나 아직 논란의 여지가 있다. 본 연구에서는 우울감을 주호소로 입원한 환자를 대상으로 우울과 자살, 혈청 지질과의 연관성을 조사하였다. 방 법: 134명의 연구대상자를 자살 비시도자 86명, 자살 시도자 48명으로 분류하여 혈청 지질 수치, 간이정신상태검사 II (KSCL95) 하위 항목 점수를 비교하였다. 또한 지질과 KSCL95 하위 항목의 상관 관계를 조사하였고, 혈청 지질이 자살 시도의 위험 요인으로 작용하는지 알아보았다. 결 과: 두 집단은 서로 혈청 지질의 차이를 보이지 않았으나, KSCL95 하위 항목 중 강박증(obsession, OBS)이 자살 비시도군에서 더 높게 나타났다. 중성지방은 우울(depression, DEP), 공포 불안(phobic anxiety, PHOB), 광장 공포(agoraphobia, AGO), 정신증(schizophrenia, SCH), 낮은 자기 조절력(self-regulation problem, RGP) 항목과 양의 상관 관계를 보였다. 혈청 지질 중 높은 중성 지방이 자살 시도의 위험 요인으로 확인되었다. 결 론: 중성 지방이 우울, 불안, 자기 조절감과 관련이 있으며, 높은 혈청 중성 지방 농도는 자살 시도의 위험 요인으로 작용하고 있음을 확인하였다. Objectives:Depression is a common mental illness and a major cause of suicide. Although serum lipids have been associated with depression and suicide, there has been much debate. In this study, we investigated the relationship between depression, suicide, and serum lipids in patients admitted with depressed mood. Methods:A total of 134 subjects were divided into 86 non-suicide patients and 48 suicide attempters. The serum lipid levels and sub-scores of the Korean Symptom Checklist-95 (KSCL95) were compared. We also investigated the relationship between serum lipids and sub-scores of KSCL95 and investigated whether serum lipids were risk factors for suicide attempts. Results:There was no difference in serum lipids between the two groups. Among the sub-items of KSCL95, obsession was higher in non-suicide group. Triglyceride showed positive correlations with anxiety, phobic anxiety, agoraphobia, schizophrenia, and self-regulation problem. High triglyceride was a risk factor for suicide attempts. Conclusions:Triglyceride is associated with depression, anxiety, and self - regulation, and high serum triglyceride levels may be a risk factor for suicide attempts.

신문사 편집국 조직변화 현황과 평가 : 국내외 편집부조직 사례 분석

박선홍 연세대학교 언론홍보대학원 1997 연세 커뮤니케이션즈 Vol.1997 No.7

Piperidylmethyloxychalcone improves immunemediated acute liver failure via inhibiting TAK1 activity

박선홍,곽정아,정상헌,안병우,조원제,윤청용,나창선,황방연,홍진태,한상배,김영수 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Mice deficient in the toll-like receptor (TLR) or the myeloid differentiation factor 88 (MyD88) are resistant to acute liver failure (ALF) with sudden death of hepatocytes. Chalcone derivatives from medicinal plants protect from hepatic damages including ALF, but their mechanisms remain to be clarified. Here, we focused on molecular basis of piperidylmethyloxychalcone (PMOC) in the treatment of TLR/MyD88-associated ALF. C57BL/6J mice were sensitized with D-galactosamine (GalN) and challenged with Escherichia coli lipopolysaccharide (LPS, TLR4 agonist) or oligodeoxynucleotide containing unmethylated CpG motif (CpG ODN, TLR9 agonist) for induction of ALF. Post treatment with PMOC sequentially ameliorated hepatic inflammation, apoptosis of hepatocytes, severe liver injury and shock-mediated death in ALF-induced mice. As a mechanism, PMOC inhibited the catalytic activity of TGF-β-activated kinase 1 (TAK1) in a competitive manner with respect to ATP, displaced fluorescent ATP probe from the complex with TAK1, and docked at the ATP-binding active site on the crystal structure of TAK1. Moreover, PMOC inhibited TAK1 auto-phosphorylation, which is an axis in the activating pathways of nuclear factor-κB (NF-κB) or activating protein 1 (AP1), in the liver with ALF in vivo or in primary liver cells stimulated with TLR agonists in vitro. PMOC consequently suppressed TAK1-inducible NF-κB or AP1 activity in the inflammatory injury, an early pathogenesis leading to ALF. The results suggested that PMOC could contribute to the treatment of TLR/MyD88-associated ALF with the ATP-binding site of TAK1 as a potential therapeutic target.

Effect of transportation method on preoperative anxiety in children: a randomized controlled trial

박선홍,박상희,이성헌,최정일,배홍범,유영욱,정성태 대한마취통증의학회 2020 Korean Journal of Anesthesiology Vol.73 No.1

Background: This study was performed to evaluate the effect of a wagon as a transport vehicle instead of the standard stretcher car to reduce children’s anxiety of separation from parents. The secondary goal was to evaluate whether this anxiolytic effect was related to age. Methods: We divided 80 children (age 2–7 years) into two groups. The stretcher group was transferred to the operating room on a conventional stretcher car, whereas the wagon group was transferred using a wagon. The level of anxiety was evaluated three times using the Modified Yale Preoperative Anxiety Scale (mYPAS): in the waiting area (T0), in the hallway to the operating room (T1), and before induction of anesthesia (T2). Results: The mYPAS score was significantly lower in the wagon group (36.7 [31.7, 51.7]) than in the stretcher group (51.7 [36.7, 83.3]) at T1 (P = 0.007). However, there was no difference in the mYPAS score between the two groups at T2 (46.7 [32.5, 54.2] vs. 51.7 [36.7, 75.0], respectively, P = 0.057). The baseline anxiety tended to be lower with increasing age (r = −0.248, P = 0.031). During transportation to the operating room, the increase in the mYPAS score (T1-T0) was greater as the age of children decreased in the stretcher group (r = −0.340, P = 0.034). However, no correlation was observed in the wagon group (r = −0.053, P = 0.756). Conclusions: The wagon method decreased preoperative anxiety, suggesting that it may be a good alternative for reducing preoperative anxiety in children.

스마트 자동차의 개발 동향 및 당면 과제

박선홍 한국통신학회 2011 한국통신학회 학술대회 및 강연회 Vol.2011 No.5