건선의 임상적 연구 - 1 . 침범범위에 따른 경중도의 분류 및 임상적 비교 관찰 -

윤재일(Jai Il Youn),이주홍(Joo Heung Ree),이유신(Yoo Shin Lee) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.6

In study of 360 psoriatic patients between June 1982 and May 1987 in Seoul National University Hospital, psoriasis was classified according to the severity based on the extent of involvement. The guideline of the extent of involvement was as follows, 1) mi1d less than 5% involvement of whole surface area 2) moderate : 5% 30% involvement of whole surface area 3) severe: over 30% involvement of whole surface area This study was done to evaluate the distribution and clinical features of psoriasis according to the extent, of involvement. Among 360 psoriatics, 180(50.0%) patients had mild psoriasis, 140(38.9%) patients had moderate psoriasis and 40(11.1%) patients presented as severe psoriasis. The duration of psoriasis seemed longer in moderate and severe groups than in mild group but the difference was not signifcant. There was also a tendency that patients developing psoriasis before the age of 20 were more prevalent in severe group.

만성지속성 광선과민증

윤재일(Jai Il Youn),정진호(Jin Ho Jung),이유신(Yoo Shin Lee) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.3

Persistent light reaction, actinic reticuloid, photosensitive eczema are three chronic photodermatoses with a feature of clinical, histological, and photobiologieal characteristics in common. These conditions were given the name of chronic persistent photosensitivity. Chronic persistent photosensitivity with the feature of photosensitive eczema developed in a 68-year-old male patient who had experienced persisited dermatitis. On phototesting the patient showed extremely severe photosensitivity to the short wave UVB. A skin biopsy showed microscopic finding of eczematous dermatitis.

한국인의 건선

윤재일 ( Jai Il Youn ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.5

Psoriasis is a chronic cutaneous disease with papules and plaques with white scales on them. Psoriasis is a common skin disease throughout the world. When compared with Caucasian, prevalence rate is lower in Korean, however it has been increasing noticeably. We reported epidemiology, clinical features and HLA typing of psoriasis and psoriatic arthritis from patients who have been enrolled in Seoul National University Hospital psoriasis clinic during 30 years from 1982 to 2012. Peak age of onset in male was in their twenties, while it was in their teens in female patients. Age of onset in 4,526 patients was as follows: 20∼29 (31.3%), 10∼19 (25.9%), 30∼39 (16.6%), 40∼49 (10.6%), 0∼9 (6.3%), 50∼59 (5.7%), 60∼69 (2.8%) and over 70 (0.8%). We confirmed that Korean patients also have a bimodal onset of disease. The early onset type showed more extensive body surface area as well as increased family history as in Caucasians. Most common clinical type was the plaque form (84.6%). Fifty three (10.5%) of the 504 psoriasis patients were demonstrated to have psoriatic arthritis (PA). The mean age of onset of PA was 38.8±14.5. Spondylitis was found in 43.4%. Psoriasis preceded PA in 73.6% of total patients with the mean interval of 12.2 years. HLA-CW*0602 showed the strongest association (76.1%) with psoriasis in Korean patients. (Korean J Dermatol 2012;50(5):387∼402)

전신성 농포성 건선의 임상적 연구

윤재일 ( Jai Il Youn ),오준규 ( Jun Gyu Oh ) 대한피부과학회 1996 大韓皮膚科學會誌 Vol.34 No.2

Background: Generalized pustular psoriasis(GPP) is an uncommon from of psoriasis in which a widespread eruption of sterile oustules occurs. In Korea some cases of generalized pustular psoriasis have been reported, but clinical reviews on generalized pustular psoriasis are not available. Objective : We investegated the clinical and laboratory findings in some patients with generalized pustular psoriasis in Korea. Methods : We studied the clinical and laboratory findings in 27 patients with generalized pustular psoriasis who visited Seoul National University hospital during the past 10 years. All the data were analyzed in total of patients with generalized pustular psoriasis, and analyzed after the patients were separated into 4 clinical types. Results : 1. The male to female ratio was 1:2, and the average age of the first onset of GPP was 27.1 years. 2. The number of patients with previous history of psoriasis vulgaris were 19(70.4%). In these patients, the average age at the onset of psoriasis vulgaris was 23.4 years, and average age at the onset of GPP was 34.3 years. 3. The number of patients with a family history of psoriasis were 2(7.4%) 4. The number of patients with possible provocative factors were 16(59.3%). Systemic corticosteroid therapy was done before the onset of GPP in 7 patients, and was the most common provocative factor. 5. Fever(70.4%), chill(33.3%), and arthralgia(18.5%) were common systemic symptoms associated with GPP. 6. In laboratory tests, leukocytosis(63%), elevated ESR(62.5%), hypoalbuminemia(40.7%), and decreased cortisol(32.5%) were often found. 7. With the clinical types, the acute generalized type was 59.3%, juvenile and infantile type 25. 9%, annular and circinate type 7.4%, and GPP during pregnancy was 7.4%. In juvenile and in fantile type, patients with a previous history of psoriasis vulgaris and possible provocative factors of GPP were much less common than in the other types. Conclusion : In patients with GPP in Korea, a family history of psoriasis is much less frequent than in western countries. In the possible provocative factors of GPP, systemic corticosteroid therapy was the most common, so it is recommended that systemic steroid therapy should be avoided in the treatment of psoriasis vulgaris. In the comparison of the 4 clinical types, juvenile and infantile type showed a marked iifference in that GPP occurred spontaneously without any previous history of psoriasis and with no provocative factors. (Kor J Dermatol 1996;34(2): 233-239)

자외선에 의한 일광화상세포 형성에 미치는 세포분열 변화의 영향

윤재일(Jai Il Youn),김방순(Bang Soon Kim),김태흥(Tae Heung Kim),김정애(Jeong Aee Kim) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.3

The influence of ultraviolet light(UVL) upon sunburn cell(SBC) formation according to the change of mitosis was studied in mouse skin. Decrease of mitosis which suppress cell proliferation was done by methotrexate (MTX) intradermal injection. Increase of mitosis which stimulate cell proliferation was performecl by tape stripping(TS). A total of 75 ICR female albino mice was used in this study. UV light source was UVB using high pressure mercury arc. The arnount exposed was 100m J/cm. 1. The number of SBC in 1cm epidermis after UVI exposure was 42.4+20.9. The number of SBC was decreased by MTX injection(18.4+9.2), and increased by TS(78.5:+ 12.8). 2. Labelling index(LI, %) in normal mouse skin was 8.9+1.8. LI was decreased by MTX injection(4.4+1.7), and markedly increased by TS (24.2 l- 4.7). These results suggest that the change of mitosis which correlated with cell proliferation influence the SBC formation by UV exposure. (Kor J Dermatol 28(3): 269 277, 1990)

Facial Psoriasis as a Marker of Severe Psoriasis

윤재일 ( Jai Il Youn ) 대한피부과학회 2005 초록집 Vol.43 No.10

Anthralin - UVB 광요법에 의한 건선의 치료

윤재일(Jai Il Youn),김규한(Kyu Han Kim),이유신(Yoo Shin Lee) 대한피부과학회 1984 大韓皮膚科學會誌 Vol.22 No.6

Our study was performed to evaluate the efficacy of anthralin-UVB therapy on patients with psoriasis. We studied twenty two patients suffering from plaque-type psoriasis of varying degrees of severity. The results can be summarized as follows. l. 2p patients(90.9%) out of the total 22 patients showed grade 4 improvement. The rernaining 2 patients failed to respond to treatment, 2. Arnong the improved 2Q patients, 2 patients who were treated more than 3p times for grade 4 improvement were excluded, so cleared patients were 18(81.8%). 3. Arnong the 18 cleared patients, the mean nurnber of therapy wasg. 6 for grade 3 and 12. 5 for grade 4 in the cases of trunk lesiona, and 13. 2 for grade 3 and 17. 8 for grade 4 in the cases of extrernities lesions. With above results, anth-ralin-UVB therapy was rnore effective in lesions of the trunk than in those of extremi.ties. 4. Notable side effects were pruritus in 6 patients(27.3pg), staining in 4 patients (18,2%), and 1ITltatioB in 2 patients(9.1%)

한국 청년층의 UVB에 의한 최소홍반량에 따른 광피부형의 분류

윤재일 ( Jai Il Youn ),오준규 ( Jun Gyu Oh ),김병국 ( Byoung Kook Kim ),정진호 ( Jin Ho Chung ),오선진 ( Sun Jin Oh ),김진준 ( Jin Jun Kim ),강세훈 ( Seh Hoon Kang ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.6

Background: We predicted that t.he self reporting questionnaire proposed by Fitzpatrick might not be appropriate for classifyin~v; the skin phoiotype in Korean people. Objective : We classified the skin phototypes in Korean people by measuring the minimal erythema dose (MED) of UVB on t.he basis of MEDs of skin type proposed by Pathak and Fitzpatrick. Methods : Two hundred and eighty-four male Korean rnedical students participated in this study. We irradiated UVB with Waldmann UV 800 and measured MEDs after 24 hours. Results : The mean MED was 70.1+21.3 mJ/cm2. Most of the MEDs were 70, 60, 50 mJ/cm in the order of frequency. On the basis of the skin type proposed by Pathak and Fitzpatrick, the most frequent phototype was the skin type V(56.3%) by MED. 20.8% and 13.8% of the subjects eorresponded to the skin types UV and III, respectively. 9.1% of the subjects fell into the UV sensitive group, skin type l and II. Conclusion : Using these results as groundwork, simple and precisely applicable classification of skin phototype in Korean people needs to be established. (Kor J Dermatol 1996;34(6): 893-897)

한국인에서 8 % Homomenthyl Salicylate 로숀의 광원에 따른 광방어지수의 비교

윤재일 ( Jai Il Youn ),김병국 ( Byoung Kook Kim ),서대헌 ( Dae Hun Suh ),오선진 ( Sun Jin Oh ),김진준 ( Jin Jun Kim ),강세훈 ( Seh Hoon Kang ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1

Background: The need for using sunscreen is increasing today, but we know little about the effect of sunscreens on the skin of Korean people. Objective : We tried to estimate and compare the SPF of 8% homomenthyl salicylate lotion, which was recommended as the control in SPF experiments by the FDA, USA, in Koreans according to different light sources Methods : After application of 8% homomenthyl salicylate lotion to the back, 33 men of the third decade were irradiated by xenon arc solar simulator or by fluorescent sunlamp, We estimated the SPF of them 24 hours later. Results : The SPF of 8% homomenthyl salicylate lotion was 4.8+0.8 with the solar simulator, 2.7+0.6 with the fluorescent sunlamp. Conclusion : We confimed that the SPF of 8% homomenthyl salicylate lotion with xenon arc solar simulator can be used as a control value in Koreans, and found out that the SPF with the fluorescent sunlamp was significantly lower than that with the xenon arc lamp. So it should be taken into consideration that differences of SPF according to light sources exists in studying sunscreens. (Kor J Dermatol 1996;34(1): 46-51)

건선에서의 Anthralin의 치료효과

윤재일(Jai Il Youn),신준우(Jun Woo Shin),이애영(Ai Young Lee),이유신(Yoo Shin Lee) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.1

Our Study was performed to evaluate the effect of anthralin for the treatment of psoriasis. Thirty seven patients with mild form of psoriasis were trested with topical anthralin ointment. 1. Twenty patients(54%) showed clearing of lesion within 8 weeks. 2. Treatment with anthalin was failed in 15 patients(40.5%). 3. Side reaction such as staining, pruritus and erythems was noted in 18 patients (48.6%), among them, 8 patients(21.6%) terminated the therapy with anthralin due to marked side reaction.