레니텍^(�) 정(말레인산 에날라프릴, 10mg)에 대한 에나레이스 정의 생물학적 동등성

조성희,하용화,홍성제,서성훈,류재환,김동현,이경태 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

The purpose of present study was to evaluate the bioequivalence of two enalapril maleate tablets, Renitec^(™) (MSD Korea Ltd.) and Enalace ^(™) (Welfide Korea Ltd.), according to the guidelines of Korea Food Drug Administration (KFDA). Twenty-four normal male volunteers, 22.33±2.55 year in age and 66.54±8.30 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containint 10 ㎎ of enal-april maleate per tablet wre orally administered, blood was taken at predetermined time intervals and concentrations of enalapril in plasma were determined using LC-MS-MS. Pharmacokinetic parameters such as AUC_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t) and C_(max) untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transfored data were acceptance range of log0.8 to log1.25(e.g., log1.02∼log1.14 and log1.03∼log1.19 for AUC_(t) and C_(max), respectively). The major parameters, AUC_(t) and C_(max), met the criteria of KDFA for bioequivalence indicating that Enalace^(™) tablet is bioequivalent to Renitec^(™) tablet.

2.5-헥산디온에 노출된 근로자에게서 발생한 말초 신경병증

조성용,장용석,최은경,김진석,유재영,우극현,최태성 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 영상음향장비 제조업체에서 2,5-헥산디온을 취급한 근로자에게서 발생한 다발성 말초 신경병증 환례를 보고하고, 동일 공정근로자들의 말초 신경기능을 조사하고 자 한다. 방법: 환례에 대해 방사선학적 검사, 소변 및 혈액 검사, 신경전달속도 검사, 작업환경 측정을 하였으며, 2,5-헥산디온의 노출을 중단시킨 후 5개월 후에 다시 신경전달속도 검사를 하였다. 동일공정 근로자들의 영향평가에서는 2,5-헥산디온에 노출된 13명의 남자 근로자를 노출 군으로, 해당 물질에 노출된 적이 없는 5명의 남자 근로자를 비노출군으로 선정하여 검사를 하였다. 결과: 환례의 신경전도 검사결과 양측 척골신경과 정중 신경에 이상소견을 보였으며, 호전여부를 관찰하기 위하여 5개월 후 추적검사를 실시한 결과 증상 및 신경전달속도 검사결과가 호전되었다. 동일공정 근로자들의 영향평가에서 노출군의 정중 신경과 척골신경이 비노출군에 비하여 유의하게 감소되어 있었다. 감각 신경의 진폭의 경우, 노출군의 정중 신경과 비복 신경이 감소되었으며, 운동 신경 전도속도에서는 노출군의 비골신경이 유의하게 감소되어 있었다. 말단 잠복기에서는 노출군의 정중신경, 척골신경, 비골신경, 경골신경이 비노출군에 비해서 유의하게 연장되어 있었다. 결론: 환례의 증상과 신경전달속도 검사의 이상소견은 2,5-헥산디온에 의한 말초신경병증에 부합되었다. 동일공정 근로자 건강영향평가에서 신경전달속도 검사결과 노출 군과 비노출군간의 유의한 차이가 있었는데, 이를 통해 2,5-헥산디온이 근로자들의 신경독성에 영향을 줄 수 있다는 것을 확인할 수가 있었다. Objectives: This study is a case report of 2,5-hexanedione induced occupational peripheral polyneuropathy. We also investigated the peripheral nerve function of all workers who had been exposed to 2,5-hexanedione in the same process. Methods: In June, 2006, a 2,5-hexanedione exposed worker complained of both hand numbness. He received neurologic, radiologic, laboratorial and electrophysiologic evaluation, including measurements of workplace environment. Five months after cessation of exposure to 2,5-hexanedione, a follow-up electrophysiologic examination was done. We evaluated the peripheral nerve function of 2,5-hexanedione exposed workers by comparing 13 male 2,5-hexanedione exposed workers who were in same company with the patient and 5 male workers who had not been exposed to 2,5-hexanedione. Results: Under electrophysiologic examination, there were abnormalities in sensory and motor nerve velocity, terminal latency, and F-latency of both median nerve and ulnar nerve. After 5 months, the patient symptoms and the results of follow-up electrophysiologic examinations were improved. Comparing the 2,5-hexanedione exposed group with the unexposed group, the sensory nerve velocity of the median and ulnar nerves in the exposed group was decreased. The motor nerve velocity of the peroneal nerve, and sensory nerve velocity of the median and sural nerves were decreased. Terminal latency of median, ulnar, peroneal, and tibial nerves in the exposed group were increased compared with the unexposed group(<0.05). Conclusions: 2.5-hexandione can induce peripheral polyneuropathy in male workers.

심실중격결손증-치험 1예-

조광현,우종수,황윤호,이양행,박철호,김종성,김철호,이경순,조영일,박태인 인제대학교 1985 仁濟醫學 Vol.6 No.4

A successful treatment of infants and children with congenital heart defects depends upon several factors: diagnosis must be accurate, the operative technique, including techniques of perfusion and myocardial preservation, must be suited to the needs of patients and intensive cares, including accurate anesthesia, must be applied through all stages of investigation and treatment, i.e. before, during and after the operation. Recently we performed a open heart surgery successfully for a six-years old girl who had suffered from frequent upper respiratory tract infection and mild to moderate exertional dyspnea with congenital heart defects (ventricular septal defect, Kirklin type II, with patent foramen ovale). The operation and postoperative course were very smooth. And now we report this with review of literatures.

정상인에서 전기 및 자기 자극을 이용한 설 근육의 전기생리학적 평가

조은미,류종현,안성환,조경원,임건한,김진호,김후원 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.1

Background: Abnormality of lingual muscles is clinically common. But its exact clinical assessment is quite difficult. Evaluation of motor power of the lingual muscles and their neural pathway is limited because of anatomical inaccessibility and individual variation of subjective symptoms. Transcranial magnetic stimulation (TMS) of the human motor cortex is a non-invasive tool to assess the functional integrity of the fast conducting central motor pathways and electrical stimulation of lingual nerve is a conventional method of peripheral nerve conduction. Therefore both study will be helpful to understanding of pathophysiology of lingual abnormality. Until now there is no such report in Korea. This study was conducted to acquire the easier method and normal control values of Korean subjects. Method: We recorded the motor responses from the lingual muscles of 32 healthy subjects (22 men, 10 women) by focal cortical TMS with a circular coil. Motor potentials were recorded by means of surface electrodes applied on the both side of the tongue, following TMS several centimeters lateral from the vertex and parietooccipital cortex and peripheral electrical stimulation of the 12th cranial nerve at the lateral 1/3 point of the line between the midline and angle of mandible. Results: During moderate motor activation, majority of maximal motor response were obtained 4-6cm lateral to the vertex with similar latencies. And the responses from magnetic stimulation of the intracranial segment of hypoglossal nerve were discarded because of difficulty to obtain and unsatisfactory reproducibility. The latency of motor evoked potentials in right cortical stimulation was 10.08 ± 1.17 msec and in left stimulation 10.04 ± 1.32 msec. The amplitudes in right 2.15 ± 1.02, left 2.09 ± 1.11 mV. The latencies electric hypoglossal nerve stimulation were 2.42 ± 0.34 in right, 2.49 ± 0.35 msec in left side. The amplitudes were 2.90 ± 2.37 in right, 2.43 ± 1.86 mV in left side. Central conduction times as calculated by subtracting the response latencies obtained by magnetic and electric stimulation are right 7.65 ± 1.19, left 7.55 ± 1.35 msec. There was no significant difference between man and woman, Conclusion: The method may be efficient, noninvasive, painless, and easy reproduced. With more extensive application to various neurological disorders, it comes close to being an ideal clinical conduction study technique for this cranial nerve.

첨가성분에 따른 부가중합 실리콘 인상재의 세포독성에 관한 연구

조리라,고성희,정경호,김경남 대한치과기재학회 2001 대한치과재료학회지 Vol.28 No.3

The purpose of this study was to evaluate the biocompatibility of polyvinyl siloxane impression materials and it's components using cell culture techniques. In the cytotoxicity test, using the culture of L929 mouse fibroblast, the degree of gross cytotoxic effects on the cells by changes in the cell morphology was scored for each materials. And the changes in the cell membrane permeability was tested using the agar overlay test. The results were as follows: 1.The effect of Examix impression material had on cell viability by evaluating survival rates was more severe than any other materials and newly added surfactants. 2.NP-4, nonylphenoxy polyethylene ethanol homologs, showed some cytotoxicity than PC-550 and BYK066. 3.In the test of the changes in cell membrane permeability using the agar overlay method, any cytotoxicity was recorded in silicone base groups. 3.In agar overlay test, Examix and NP-4 showed most response index and lysis index. 4.The application of surfactant such as PC-550, NP-4, and BYK066 might be considered relatively biocompatible.

Glucocorticosteroid가 흉선 세포의 아형 및 핵산에 미치는 영향

문성록,이시은,장선일,조성경,정헌택 최신의학사 1991 最新醫學 Vol.34 No.1

Alcaligenes latus의 배양방법에 따른 생분해성 플라스틱의 생산특성

박성연,조강현,최희식,류희욱,조경숙 이화여자대학교 환경문제연구소 1998 이화환경연구 Vol.2 No.-

생장과 동시에 poly(3-hydroxybutyrate, PHB) 를 체내에 축적하고, 값싼 당류인 sucrose를 이용할 수 있는 Alcaligenes latus의 생장과 PHB 생산을 최적화 할 수 있는 배양 조건에 대하여 연구하였다. 균주 생장과 PHB 생산성에 미치는 sucrose의 초기농도의 영향을 5L 발효조를 이용하여 회분식 배양 방법에 의해 조사하였다. PHB생산성은 sucrose농도가 10g/L에서 30g/L로 증가함에 따라 0.11에서 0.36g-PHB/L·h까지 증가하였고, 그 이상의 농도에서는 큰 변화없이 0.36∼0.39g-PHB/L·h에서 일정하게 유지되었다. 균주의 비증식속도는 sucrose 농도 증가함에 따라 증가하여 30g/L에서 최대값 0.44h()을 보였으며, sucrose의 농도가 30g/L을 초과하면 균주의 생장은 기질에 의해 저해 받았다. A. latus를 이용하여 대량으로 PHB를 생산하기 위해 유가식 배양과 반연속 유가식 배양을 수행하였다. 인산염 제한하에서 유가식 배양에 의해 얻은 PHB 생산성은 1.14g-PHB/L·h로, 인산염 제한없는 조건에서 얻은 PHB생산성(2.10g-PHB/L·h)에 비해서 훨씬 작았다. PHB함량은 영양소 제한에 관계없이 55∼60%이었다. 영양소 제한 없이 반연속 유가식 배양법에 의해 PHB생산성을 4.5∼4.8g-PHB/L·h까지 향상시킬 수 있었다. 평균 PHB 함량, 소비된 sucrose당 건조 균체중량 수율 및 PHB 생산 수율은 각각 60%, 0.48 및 0.32이었다. 그러므로, 생장과 동시에 PHB를 축적할 수 있는 A. latus를 이용하여 PHB를 생산할 경우, 반연속 유가식 배양법은 높은 PHB생산성을 얻을 수 있는 유망한 배양법임을 알 수 있다. Optimum conditions for cell growth and poly(3-hydroxybutyrate, PHB) biosynthesis of Alcaligenes latus, which can accumulate PHB simultaneously in associated with cell growth and grows well on a cheap carbon source such as sucrose, were investigated. The effect of initial sucrose concentration, ranged from 10 to 50g/L, on the cell growth and PHB accumulation were studied by a batch culture in a 5L fermentor. PHB productivity was increased from 0.11 to 0.36g-PHB/L·h with increasing sucrose concentration up to 30g/L, and it was fairly constant between concentrations of 30g/L and 50g/L. The maximum specific growth rate, 0.44h(), was obtained at 30g-sucrose/L, and the growth was inhibited at concentrations of sucrose over 30g/L. A. latus was also cultivated to attain high PHB productivity by fed-batch or semicontinuous fed-batch culture techniques. PHB productivity by a fed-batch culture under phosphate limitation(1.14g-PHB/L·h) were smaller than that without nutrient limitation(2.10g-PHB/L·h). but there is no significant difference of PHB content(55∼60%) obtained in both culture. By a semicontinuous fed-batch culture without nutrient limitation, high PHB productivity could be obtained as 4.5∼4.8g-PHB/L·h. The average PHB content, the yield of dry cell weight, and the yield of per consumed sucrose were 60%, 0.48, and 0.32, respectively. These results suggest that the semicontinuous fed-batch culture technique is one of promising methods to achieve high PHB productivity by A. latus.

소아에서 나타난 비구개관낭의 치험례

모정희,정현구,조태식,김효석,박성규,이난영 조선대학교 구강생물학연구소 2002 口腔生物學硏究 Vol.26 No.2

The nasopalatine duct cyst is the most common non-odontogenic cyst in the oral area and is thought to be originated from the epithelial remnants of the nasopalatine duct. The nasopalatine duct cyst have been mentioned to be an overall incidence of 1.7-11.9% of all jaw cyst. More males than females are affected by that. It could occur all around the age, and especially in their 40th and 60th it happens the most and in childhood it is very rare. Proper treatment for nasopalatine duct cyst is enucleation. In the case of very large cysts, it is likely to be a risk of naso-oral or antral-oral fistulas or of devitalization of teeth, marsupialization is indicated. The purpose of case report is that a nasopalatine duct cyst in is very rare in childhood. A 9-year-old boy was referred to the chosun university pedodontics clinic that this child who has anterior palatal swelling is in routine check. The size of the cyst was so big that the marsupialization was committed and obturator was put. This patient is on the continuous observation. we treated the nasopalatine duct cyst with obturator.

peat moss를 이용한 폐수중의 중금속 제거

이경화,김정섭,유현철,최성우,윤철종,우성훈,박승조 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

Adsorption equilibrium of heavy metals ion on the peat moss was confirmed Frundlich isotherm Removal efficiency of heavy metals ion was increased from pH 2 to 10 and heavy metal removal efficiency was increased in the sequence of Cu(Ⅱ) > Pb(Ⅱ) > Cd(Ⅱ) > Mn(Ⅱ) on the PM(Peat Moss). The PM is likely to be more effective adsorption than the PAC to removal of metal ions in the solution, since PM's weakly acidic functional groups which is not founded on the PAC, in addition to its high surface area and porosity. But, the PM is not separated from the solution water by sedimentation process. So, a liquid and solid seperation between the PM and the solution water could be considered for the PM's field application. But peat moss was low cost adsorbent. Thus author propose to adopt PM as a adsorbent for heavy metal removal.

대장-직장암에서 Cyclooxygenase-2의 발현

강원경,천준성,장세진,조현민,천성원,안창혁,오승택 대한대장항문학회 2004 Annals of Coloproctolgy Vol.20 No.2