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      • Quantitative Assay for the Binding of Jun-Fos Dimer and Activator Protein-1 Site

        Lee, Sang-Kyou,Park, Se-Yeon,Jun, Gyo,Hahm, Eun-Ryeong,Lee, Dug-Keun,Yang, Chul-Hak Korean Society for Biochemistry and Molecular Biol 1999 Journal of biochemistry and molecular biology Vol.32 No.6

        The Jun and Fos families of eukaryotic transcription factors form heterodimers capable of binding to their cognate DNA enhancer elements. We are interested in searching for inhibitors or antagonists of the binding of the Jun-Fos heterodimer to the activator protein-1 (AP-1) site. The basic-region leucine zipper (bZIP) domain of c-Fos was expressed as a fusion protein with glutathione S-transferase, and allowed to form a heterodimer with the bZIP domain of c-Jun. The heterodimer was bound to glutathione-agarose, to which were added radiolabeled AP-1 nucleotides. After thorough washing, the gel-bound radioactivity was counted. The assay is faster than the coventional electrophoretic mobility shift assay because the gel electrophoresis step and the autoradiography step are eliminated. Moreover, the assay is very sensitive, allowing the detection of picomolar quantities of nucleotides, and is not affected by up to 50% dimethylsulfoxide, a solvent for hydrophobic inhibitors. Curcumin and dihydroguaiaretic acid, recently known inhibitors of Jun-Fos-DNA complex formation, were applied to this Jun-GST-fused Fos system and revealed to decrease the dimer-DNA binding.

      • SCIESCOPUSKCI등재후보

        Quantitative Assay for the Binding of Jun-Fos Dimer and Activator Protein-1 Site

        Yang, Chul Hak,Jun, Gyo,Lee, Dug Keun,Lee, Sang Kyou,Park, Se Yeon,Hahm, Eun Ryeong 한국생화학회 1998 BMB Reports Vol.31 No.2

        The Jun and Fos families of eukaryotic transcription factors form heterodimers capable of binding to their cognate DNA enhancer elements. We are interested in searching for inhibitors or antagonists of the binding of the Jun-Fos heterodimer to the activator protein-1 (AP-1) site. The basic-region leucine zipper (bZIP) domain of c-Fos was expressed as a fusion protein with glutathione S-transferase, and allowed to form a heterodimer with the bZIP domain of c-Jun. The heterodimer was bound to glutathione-agarose, to which were added radiolabeled AP-1 nucleotides. After thorough washing, the gel-bound radioactivity was counted. The assay is faster than the conventional electrophoretic mobility shift assay because the gel electrophoresis step and the autoradiography step are eliminated. Moreover, the assay is very sensitive, allowing the detection of picomolar quantities of nucleotides, and is not affected by up to 50% dimethylsulfoxide, a solvent for hydrophobic inhibitors. Curcumin and dihydroguaiaretic acid, recently known inhibitors of Jun-Fos-DNA complex formation, were applied to this Jun-GST-fused Fos system and revealed to decrease the dimer-DNA binding.

      • KCI등재

        실용음악 전공 학생들의 발성치료 전후 성대 및 음성 특성 비교

        황연신,심미란,김철준,최용석,김상연,최찬호,선동일,Hwang, Yeon Shin,Shim, Mi Ran,Kim, Chul Jun,Choi, Yong Suk,Kim, Sang Yeon,Choi, Chan Ho,Sun, Dong Il 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2

        Background and Objectives : Many students major in applied music singing have various difficulties in phonation when they sing or perform. But the studies about this cause are lack. The purpose of this study is whether singing voice therapy based on vocal music is effective or not to applied music singing students that have difficulties in phonation. Materials and Methods : Singing voice therapy program had been done to 8 students major in applied music singing during 7 weeks. We did laryngeal stroboscope, perceptual, acoustic and aerodynamic examination before and after singing voice therapy to this students. And we studied post examination results have differences or improvements compared to pre examination results. Results : Four male students don't have effective improvement after singing voice therapy but they shows slight improvement in aerodynamic examination values compared to pre examination values. Four female students shows improvement in aerodynamic examination values and pitch range increasing. Above all, one student's vocal nodules disappeared after singing voice therapy. Conclusion : Singing voice therapy based on music singing is very effective to the students major in applied music singing. Above all, their curriculum in applied music singing should include phonation training based on music singing before training perform and technic practices.

      • 비심분포와 그응용에 관한 연구

        전상표 남서울대학교 2005 남서울대학교 논문집 Vol.11 No.2

        The theories of the central distributions are more popular to all than that of non-central distribution. In this thesis, we discussed the probability density function of non-central distributions and, as an application applied non-central t-distribution to obtain the sampling distribution of correlation coefficient under the Null Hypothesis [H_(0);p≠0]

      • KCI등재

        가시광선과 아르곤 레이저에 의한 복합레진 중합 효과의 비교 연구

        전상언,김용기 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.2

        The purpose of this study was to evaluate the shear bond strengths,microhardness,compressive strength and contraction gap at the resin-tooth interface of two types of composite resins polymerized with visible light and argon laser sourse. The results from the present study can be summarized as follows: 1.Resin sample polymerized either by argon laser or visible light did not show significant difference in their physical properities tested(p>.05). 2.The contraction gap at the resin tooth interface was found to be present in all samples but any significant difference between groups could not be established due to their variability.Although the superiority of argon laser over visible light in enhancing the physical properities of resin could not be elucidated in the present study,continous efforts are deemed to be worthwhile to investigate this using different conditions and materials of experiment.

      • 운동관련 분야 진로상담의 발전 방향

        전선혜,이상연 중앙대학교 스포츠과학연구소 2002 體育硏究 Vol.- No.17

        The career counseling renders a personal assistance in selecting which way of its life, and plays the vital role for the collective goal along with the social goal. As well as the personal level, the career counseling is very much necessary work in that respect to make our society provide with the system to manage and utilize its resources effectively by means of manifesting its best talent and ability of the country's human resources in a right place. In the field related to the exercise, the career counseling has been developed in putting an emphasis on improving some excellent athlete's playing ability, however, it is greatly insufficient to satisfy its scientific background and its application degrees. Moreover the fact is that the research or the application itself of the counseling to the many object in the exercise field has been hardly tried out. To the extent of its good prospect and its vocational diversifying of the related exercise field in the future society, the career counseling is one of the most urgent researching fields for the development of the person and the related exercise field. Referring to the importance and the necessity of the career counseling in the exercise field, also the counseling object and the counseling sphere, this study is to explore the developing way of the career counseling field related to the exercise.

      • Au를 공침한 SnO₂후막센서의 가스 감응 특성

        성정훈,강대원,이윤수,임준우,홍영호,이덕동 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

        High selective and sensitive thick film type methane gas sensors were fabricated and their sensing characteristics for various hydrocarbon gases were investigated. Raw material, SnO_(2)/Au, prepared by coprecipitation was even grain size. SEM, TEM, BET and XRD analyses were carried out for investigation of surface morphology and crystalline structure. The thick film devices using the above materials exhibited high sensitivity to methane gas at the operating temperature of 400°C. The sensitivity of SnO_(2)/Au+Pd thick film devices to methane gas was higher than that to the other hydrocarbon gases such as iso-butane and propane. The optimal adding amounts of Au and Pd were 1wt.% and 3wt.%, respectively. The sensitivity, S, is defined as {(R_(A)-R_(G))/R_(A)}><100, which R_(A) and R_(G) are resistance in air and that in the gas ambient, respectively.

      • KCI등재후보

        기저질환이 없는 사람에서 발생한 Campylobacter fetus에 의한 재발성 심내막염 1예

        전재범,정진원,김성혜,송문희,오형철,안성기,최상호,김남중,김양수,우준희,류지소 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

        C. fetus 심내막염은 드물게 발생하는 질환으로 주로 면역능이 저하된 환자에서 발병하고 대동맥판을 침범하는 경우가 많으며 적절한 치료가 되지 않을 경우 치사율이 높다. 저자들은 기저질환이 없던 69세 남자에서 C. fetus 심내막염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 발열로 내원하여 시행한 혈액배양 검사상 C. fetus가 동정되었고 경식도 초음파 검사상 삼첨판에 증식증이 발견되어 심내막염 진단하에 ceftriaxone에 이어 meropenem으로 총 4주간 항생제를 투여받고 호전되었다가 한달 후 다시 재발하였고 판막부전 소견 진행하여 삼첨판 치환술을 시행받고 전신상태 호전되어 퇴원하였다. Campylobacter fetus is a rare cause of endocarditis. To date, only about 30 cases of C. fetus endocarditis have been reported mainly in the elderly with chronic underlying illnesses. Most cases showed tendency to involve aortic valve. This report describes a case of native tricuspid valve infective endocarditis in a 69-year-old man without any underlying disease. Despite adequate antibiotic therapy for 4-weeks, endocarditis recurred and leading to surgical valve replacement.

      • 공정 조절에서 이상원인의 제거 방법에 대하여

        전상표 남서울대학교 2005 남서울대학교 논문집 Vol.11 No.2

        Assignable causes producing temporary deviation from the underlying system can influence on process adjustment and process monitoring in dynamic feedback control system. In this paper, Chapter Ⅱ will summarize the methods of readjusting unadjusted disturbance when assignable causes occur in dynamic process adjustment, and of removing the causes of assignable causes.

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