백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

Could cluster of risk factors predict clinical outcome in patients with acute myocardial infarction?

( Sang Mi Park ),( Hong Nyun Kim ),( Se Yong Jang ),( Myung Hwan Bae ),( Dong Heon Yang ),( Hun Sik Park ),( Yongkeun Cho ),( Shung Chull Chae ),( Jang Hoon Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Purpose: Conventional risk factors are differently contributed to short-term prognosis of acute myocardial infarction (AMI); hypertension and diabetes increase adverse outcome, whereas hyperlipidemia, smoking, and obesity paradoxically decrease adverse outcome of post-MI patients. The aim of this study is to assess whether cluster of conventional risk factors, PARADOCS (Pressure of ARtery Abnormality, Diabetes, Obesity, Cholesterol, Smoking) score, would improve the ability to predict major adverse cardiac events (MACEs) in patients with AMI. Methods: Between November 2005 and July 2011, 24,020 patients (17,232 men; mean age=63.0±12.8) with AMI were analyzed from Korean AMI registry. PARADOCS score was calculated as follows; [number of non-paradoxical risk factors (NRF) -number of paradoxical risk factors (PRF)]+3 in which non-paradoxical risk factors are hypertension and diabetes, and paradoxical risk factors are the rest. The 1-year MACEs were defined as death and non-fatal MI. Results: NRF including hypertension and diabetes were present in 49.6% and 27.0%, whereas PRF including hyperlipidemia, smoking, and obesity were present in 12.3%, 43.0%, and 34.6%, respectively. During the follow-up, 1,409 (5.9%) MACEs occurred. PARADOCS score was significantly higher in patients with 1-year MACEs (3.38±1.03 versus 2.81±1.08, p<0.001). In Cox proportional hazards model, PARADOCS score was an independent predictor of 1-year MACEs (hazards ratio 1.26, 95% confidence interval 1.18-1.34; p<0.001) after adjusting for confounding variables. Patients were categorized into 3 groups according to the PARADOCS score; PARADOCSLOW (0-1, n=2,446), PARADOCSMID (2-3, n=14,594), and PARADOCSHIGH (4-5, n= 6,980). Kaplan-Meier survival curve showed that there were significant differences in the 1-year MACEs among three groups including 3.5% in PARADOCSLOW, 8.5% in PARADOCSMID, and 16.4% in PARADOCSHIGH, respectively (long-rank p<0.001). Conclusions: In post-MI patients, conventional risk factors are differently associated with short-term prognosis, and score of these risk factors, PARADOCS score, can provide useful prognostic information to clinicians.

마우스에서 조합시험법에 의한 고려홍삼의 생식발생독성 평가

김미라, 박동선, 장자영, 신선희, 이예은, 백인정, 연정민, 이세라 , 남상섭, 황방연, 노재섭, 김순선, 조대현, 남상윤, 이범준, 김윤배, 윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

일부 외래 환자의 병원선택 요인과 간호 서비스 이미지에 관한 연구

성미혜,최수정,강미옥,조승희 인제대학교 2008 仁濟論叢 Vol.23 No.1

Purpose : The purpose of this study was to identify the factor to choice hospital and image of nursing services in outpatients. Method : The subjects were 142 outpatients of the three general hospitals with more than 450 beds. The data was collected using structured questionnaires from May 14, to June 1, 2005. The data was analyzed by the SPSS(ver 1O.0)program, and it included descriptive statistics, and cross tabulation. Result : The rank of construct factors hospital choice which were thought important by subjects was the first 'convenience facilities', the second 'thrust to physician', the third 'kindness of nurse and staff'. The rank of construct factors nursing service image which were thought important by subjects was the first 'kindness', the second 'neat feature', the third 'accuracy', the fourth 'responsibility'. As for the analysis that the nursing service image affected the choice of hospital, 'It affected the choice the hospital' took 87.3%, and it was higher than the 22.7% as 'It did not affected the choice the hospital'. Conclusion : These results suggested that to recognize the merits and demerits of hospitals and to develop their original service area are very important. therefore, these findings give useful information for constructing an effective marketing strategies in hospitals.

Hollow-Fiber LPME를 이용한 잔류농약 검출

조현우,이상섭,신윤지,장미애 경기대학교 기초과학연구소 2008 기초과학논문집 Vol.21 No.-

A method for the determination of trace amount of pesticides in aqueous samples using hollow fiber-liquid phase microextraction(HF-LPME) and capillary gas chromatograph/micro electron capture detector(GC/μ ECD) has been established. HF-LPME method has been optimized with respect to several experimental parameters including the effects of extraction solvent, extraction time and extraction temperature for the determination of pesticides from aqueous samples. The calibration curves for pesticides showed good linearity (above r²=0.98). The established method is feasible for the determination of trace amounts of pesticides in several aqueous sample. The limit of detection(LOD) and the limit of quantitation(LOQ) have been found to be 0.05~1.0 and 0.5~2.5 ng/mL, respectively. The established HF-LPME method for the analysis of pesticides from aqueous sample can be used for the determination of biological, food and environmental samples.

신장의 원시성 신경외배엽 종양

송상용,조은윤,이정원,고재향,김미경,김대식,고영혜 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.3

사업장 소음 폭로에 의한 일과성 역치 상승과 회복

조수헌,하미나,한상환,주영수,성주헌,강종원,윤덕로,송동빈,이명학,김선태 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

To determine the recovery time from noise-induced temporary threshold shift(TTS), a prospective field study was conducted at three worksites where workers are known to be exposed high level of noise. Subjects were selected according to answers on a questionnaire which inquired about otological history and previous noise exposure, including avocational, military and occupational exposures. After excluding employee with past otologic problems, recent exposure to high level noise, and under medications, total 92 employees participated in the study. Among 92 participants, complete consecutive audiometric examinations were carried out at 0∼2 hours, 5∼7 hours, 14∼16 hours after worktime noise exposure on 26 participants wearing hearing protectors and 22 participants wearing no protective devices. The difference between the hearing level 0∼2 hours after noise exposure and 5∼7 hours is statistically significant by paired t-test(p<0.01). The median recovery times calculated from the data of 22 participants wearing no protective hearing devices are 15.6 hours at 4000Hz, and 7.7 hours, 10.3 hours, 8.4 hours at 1000Hz, 2000Hz and 8000Hz respectively. These data suggest that when measuring the pure tone audiometry for noise exposed workers, at least 16 hours noise-free interval is required.

사업장근로자의 구강보건인식 및 실천에 관한 연구

조성숙,최미혜 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study is to investigate the recognition of oral by workers in enterprising place and the degree of their care. The subject of investigation is 198workers at three companies in Kyunggi-Do. The duration to collect the survey takes from September 1 to September 30, 2000. The means for survey is to prove the reliability and property. For the method of analysis, it used frequency, percentage, average, standard deviation, t-test, ANOVA and Duncan's multiple comparison test. The conclusion is as followings. Firstly, regarding the general characteristics, men from all the subject, 198workers for this survey are 73.2%. Regarding ages, 20∼29years or less is 49%. 30∼39years or less is 33.8%. Regarding the school carrier, the graduate from high school is 40.9% and collage is 38.4%. Accordingly, the degree of school carrier was high. People who work for research is 34.8%. Regarding the degree of their economy, middle is 75.3%. Secondly, regarding the recognition of oral health, alveolitis prevention effect was high but decayed tooth effect was low. And the needs of dental surgery were low. Thirdly, reviewing the action of oral health, the recognition of necessity and importance of scaling was low. Most of the workers dont get scaling their teeth regularly. Although they recognized it is necessary to get regular oral examine for oral health, the grade to do actually was low. Fourthly, on the basis of general feature, considering the recognition of oral health, 20∼29years workers were got a high grade. Manufacturing workers was lower than official and technical service workers. In the aspect of the level of economy, middle class is higher than low(p<.05). Reviewing the action, women are higher than men. The more age and the level of economy, the more action become(p<.05).

회전식 제습로터의 성능특성에 관한 실험적 연구

조상준,문인호,정미정 호서대학교 반도체제조장비국산화연구센터 2000 학술대회 자료집 Vol.2000 No.1

본 연구에서는 실제 사용되고 있는 제습로터의 모델(Model Ⅰ, Ⅱ, Ⅲ)을 선정하고 제습성능과 회전수 변화에 따른 성능변화의 특성을 파악하여 최적 사용조건을 확인하고자 하였다. 재생온도와 통과풍속이 일정한 조건에서 회전수 변화 및 처리측 및 재생측의 입출구 온습도 조건을 변화시키면서 성능변화를 측정하였다. 그 결과 재생온도 140℃, 통과풍속 2m/s에서의 재습성능은 Model별로 성능곡선과 대체로 잘 일치하고 있음을 확인하였으며, Model Ⅲ의 경우 상대적으로 처리측 출구온도는 높게 나타나고 있어 공기조화용으로 사용할 경우 장비에서의 열부하로 작용할 수 있는 단점은 있으나, 제습성능은 매우 우수하게 나타나고 있음을 확인하였다. 사용회전수가 Model Ⅰ의 경우 15RPH. Model Ⅱ는 약 18RPH, Model Ⅲ는 약 22.5RPH이나 실험결과 Model Ⅰ과 Ⅱ 모두 약 16RPH에서 최고 성능을 보이고 있으며, Model Ⅲ는 약 20RPH에서 성능의 최고점을 나타내고 있었다.

인조 합성 테니스 바닥재의 지면 반력 분석

조승제,정미라,서국웅,박승범,윤양진,이훈식,강영택 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

Some authors suggest that certain types of surfaces are the origin of such injuries. A few years after the first medical concerns about surfaces were voiced, publications of biomechanical measurements apperared, describing accleration, force, and impact measurement on different types of surfaces. In many sport activities, surfaces can be under very high dynamic load. This was the reason for the development of various methods for impact simulation, like the development of various methods for impact simulation, like the artificial athlete. Furthermore, it is important to collect information about the hardness of new and already existing surfaces in sport arenas. The idea on which this measuring system is based Is as follows: The stiffness of the material can be computed from the kinematics measurd at touch down of a rigid body onto a material sample. The results show the following The result for the artifical surfaces(Synpave ace) is surprising. It is known that these surfaces are much harder than synpave rebound classic, synpave spring. This finding suggests that it may be possible that the subjective impression is used as one criterion in the selection of landing(or style) strategies. The number of subjects in this experiment is too small to make statistically significant conclusions. It is shown analytically that when an object a deformable surface, the acceleration it experiences is inversely propotional to its mass. In future, it need to stress that the interaction between shoe and surface is important, and this aspect has now become well accepted. Considering biomechanical aspect in player's injury, it request Korean Standards for synthetic playing surfaces in sport like ASTM(America Society for Testing & Materials) standards of America, DIN 18035 standards of Germany, BSI standards of U.K.