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PECVD로 제작한 수소화된 비정질 탄소(a-C:H) 박막의 화학결합 구조에 관한 연구
노지연,이석호,오동선,박혁렬,김영산 木浦大學校基礎科學硏究所 1997 基礎科學硏究誌 Vol.15 No.-
Hydrogenated amorphous carbon(a-C:H) films were prepared by PECVD(Plasma enhanced-chemical vapor deposition) method. The films were characterized using various spectroscopic measurements such as Raman scattering, FTIR(Fourier transform infrared) absorption spectroscopy. FRIR absorption reflects only the optically active hydrogen in the a-C:H and, using it together with Raman spectroscopy. The spectral analysis indicated that changes in Raman spectroscopy intensity occurring with increasing substrate temperature 50℃~300℃ were determined to be caused by changes in optically resonant components in the films. Furthermore, a significant correlation was the two crystalline forms of carbon-graphite and -diamond consist of sp² and sp³ bonds, respectively. Significant changes in chemical bonding(sp²/sp³) and micro-structure of hydrogenated amorphous carbon thin films occur as the substrate temperature varies from 50 to 300℃ during.
Spinal anesthesia for single-port-access laparoscopic adnexal surgery: a case series
( Ji Sun Park ),( Kyoung-hee Han ),( Gi Soon Park ),( Ji Young Lee ),( San-hui Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Background: Although laparoscopic surgery has multiple superiority to laparotomy, upper abdominal pain and shoulder pain has newly developed after performing laparoscopy. To control the respiratory variance occurred by pneumoperitoneum effectively during laparoscopy, traditionally general anesthesia was performed. However, general anesthesia has several disadvantages; damage on airway due to intubation, postoperative nausea/vomiting (PONV), slow recovery compared to spinal anesthesia. Several previous studies proved the safety and usefulness of spinal anesthesia in laparoscopic cholecystectomy. As previous studies are limited to the general surgery field and research on the gynecological field is lacking. Methods: This study was conducted at Wonju Severance Christian Hospital from September 2018 to May 2019. Total 11 patients were enrolled prospectively and underwent SPA laparoscopic adnexal surgery under spinal anesthesia. The intensity of postoperative pain by visual analogue scale score (VAS) and the intensity of PONV by emesis score (0-3) at 0, 2, 6, 12, 24, 48 hours after surgery was checked. Results: No case was converted to general anesthesia. The median long axis of ovarian cyst was 5cm (range, 3-7cm), and median total operation time was 38 minutes (range, 22-54min). 4 patients showed hypotension during operation, but all patients were well controlled with ephedrine 40mg intravenous injection. No patients complained pain nor nausea during operation. Postoperative pain checked 0, 2, 6, 12, 24, 48 hours after operation was 0(0), 3(2.5), 4.2(3.0), 3.1(2.9), 2.5(1.9), 1.7(2.2), and emesis score checked 0, 2, 6, 12, 24, 48 hours after operation was 0.1(0.3), 0(0), 0.2(0.6), 0(0), 0(0), 0.3(0.9). No postoperative complication was noted. Conclusions: Performing SPA laparoscopic adnexal surgery under spinal anesthesia is feasible. We are performing prospective study comparing spinal anesthesia and general anesthesia for SPA laparoscopic adnexal surgery.
Apoptotic Activity of Curcumin and EF-24 in HTB-41 Human Salivary Gland Epidermoid Carcinoma Cells
Ji-Won Kim,Seul Ah Lee,Dae-San Go,Byung-Sun Park,Su-Gwan Kim,Sun-Kyoung Yu,Ji-Su Oh,Chun Sung Kim,Jeongsun Kim,Jong-Tae Park,Do Kyung Kim 대한구강생물학회 2015 International Journal of Oral Biology Vol.40 No.2
Curcumin (diferuloylmethane), a constituent of turmeric powder derived from the rhizome of Curcuma longa, has been shown to inhibit the growth of various types of cancer cells by regulating cell proliferation and apoptosis. However, a need exists to design more effective analogs because of curcumin's poor intestinal absorption. EF-24 (diphenyl difluoroketone), the monoketone analog of curcumin, has shown good efficacy in anticancer screens. However, the effects of curcumin and EF-24 on salivary gland epidermoid carcinoma cells are not clearly established. The main goal of this study was to investigate the effects of curcumin and EF-24 on cell growth and induction of apoptosis in human salivary gland epidermoid carcinoma cells. Our studies showed that curcumin and EF-24 inhibited the growth of HTB-41 cells in a dose- and time-dependent manner, and the potency of EF-24 was > 34-fold that of curcumin. Treatment with curcumin or EF-24 resulted in nuclear condensation and fragmentation in HTB-41 cells, whereas the control HTB-41 cell nuclei retained their normal regular and oval shape. Curcumin and EF-24 promoted proteolytic cleavages of procaspase-3/-7/-9, resulting in an increase in the amount of cleaved caspase-3/-7/-9 in the HTB-41 cells. Caspase-3 and -7 activities were detected in viable HTB-41 cells treated with curcumin or EF-24. These results suggest that the curcumin and EF-24 inhibit cell proliferation and induce apoptosis in HTB-41 human salivary gland epidermoid carcinoma cells, and that they may have potential properties as an anti-cancer drug therapy.
추지민,강산하,송지현,한규현,신선영,양태영,최진정,홍성표 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.2
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of unknown etiology and is characterized by presence of variable pathogenic auto-antibodies and multiple organ involvement. Serositis is common in SLE, but peritoneal involvement is relatively rare. This is a case report of 28-year-old female who initially presented with abdominal pain and ascites. After ruling out many other possibilities such as liver cirrhosis, neoplasm, and infectious etiologies, we confirmed SLE with clinical features, serologic tests and radiological findings. To conclude, her abdominal pain and ascites were caused by lupus peritonitis. After administration of corticosteroid therapy, her symptoms fairly improved.
MicroRNA-27 Promotes Odontoblast Differentiation via Wnt1 Signaling
Ji-Ho Cho,Su-Gwan Kim,Byung-Sun Park,Dae-San Go,Joo-Cheol Park,Do Kyung Kim 대한구강생물학회 2015 International Journal of Oral Biology Vol.40 No.4
MicroRNA (miRNA, miR) is essential in regulating cell differentiation either by inhibiting mRNA translation or by inducing its degradation. However, the role of miRNA in odontoblastic cell differentiation is still unclear. In this study, we examined the molecular mechanism of miR-27-mediated regulation of odontoblast differentiation in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. The results of the present study demonstrated that the miR-27 expression increases significantly during MDPC-23 odontoblastic cell differentiation. Furthermore, miR-27 up-regulation promotes the differentiation of MDPC-23 cells and accelerates mineralization without cell proliferation. The over-expression of miR-27 significantly increased the expression levels of Wnt1 mRNA and protein. In addition, the results of target gene prediction revealed that Wnt1 mRNA has an miR-27 binding site in its 3’UTR, and is increased by miR-27. These results suggested that miR-27 promotes MDPC-23 odontoblastic cell differentiation by targeting Wnt1 signaling. Therefore, miR-27 is a critical odontoblastic differentiation molecular target for the development of miRNA based therapeutic agents in dental medicine.
( Sun Hwa Park ),( Ji Sun Park ),( Kyoung-hee Han ),( San-hui Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: To assess the feasibility of robotic single-site hysterectomy in clinical and economic aspects. Methods: Total 91 patients who underwent robotic hysterectomy in Wonju Severance Christian Hospital from July 2018 to July 2019 was enrolled retrospectively. All patients underwent total hysterectomy or subtotal hysterectomy with or without adnexal surgery using da Vinci Xi® system. Of total 91 patients, 31 patients underwent robotic single-site hysterectomy(RSSH) using Lapsingle® single port channel system, and 60 patients underwent robotic multi-port hysterectomy(RH) using 4-port system. Results: No cases of RSSH were converted to multi-port, laparoscopy or laparotomy. The patients characteristics showed no significant difference between RSSH group and RH group. The uterine weight of RSSH group was 323g [120-720g] and of RH group was 317g [80-653g], it had no significant difference (p=.286). Clinical outcomes except docking time (RSSH; 7.5 min [3-20 min] vs. RH; 10 min [5-26 min], p=.011) had no significant difference between 2 groups; including postoperative pain score on 2, 4, 6, 8, 12 hours after surgery, total operation time, console time, total hospital day, postoperative hemoglolin change. And the overall cost and actual cost paid by patients also had no significant difference. Conclusion: Robotic single-site hysterectomy is feasible in both clinical and economic aspects. Further prospective study should be needed.
Identification of Homer1 as a Potential Prognostic Marker for Intrahepatic Cholangiocarcinoma
Wu, San-Yun,Yu, Ming-Xia,Li, Xiao-Gai,Xu, Shu-Fang,Shen, Ji,Sun, Zhen,Zhou, Xin,Chen, Xing-Zhen,Tu, Jian-Cheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: The aim of the present study was to analyze whether Homer1 is a potential prognostic marker for intrahepatic cholangiocarcinoma (ICC). Materials and Methods: The expression of Homer1 in ICC tissue was detected with immunohistochemistry and levels of protein in ICC and paratumor tissues were evaluated by Western blotting. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. Results: Homer1 expression was high in 67.4% (58/86) of ICC samples, and there was significant difference between ICC and adjacent noncancerous tissues (p<0.001); high expression was associated with poor histologic differentiation (p=0.019), TNM stage (p=0.014), lymph node metastasis (p=0.040), and lymphatic invasion (p=0.025). On Kaplan-Meier analysis, a comparison of survival curves of low versus high expressors of Homer1 revealed a highly significant difference in OS (p=0.001) and DFS (p=0.006), indicating that high expression of Homer1 was linked with a worse prognosis. Multivariate analyses showed that Homer1 expression was an independent risk factor predicting overall survival[Hazard ratio(HR), 7.52; 95% confidence interval (CI), 2.63-21.47; p=0.002] and disease-free survival (HR, 11.56; 95%CI, 5.17-25.96; p<0.001) in ICC. Conclusions: Homer1 promotes lymphatic invasion and associates with lymph node metastasis and poor prognosis of ICC. The current study shows that Homer1 may be an independent prognostic factor for ICC patients after curative resection, and it provides an important basis for screening/treating high-risk patients.
분산전원용 인버터의 무효전력 제어를 통한 계통 연계지점의 전압 일정 제어 구현
권순형(Sun-Hyung Kwon),임지훈(Ji-Hoon Im),최형진(Hyeong-Jin Choi),강산(San Kang),송승호(Seung-Ho Song),최주엽(Ju-Yeop Choi),정승기(Seung-Gi Jeong),최익(Ick Choy) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.10
풍력, 태양광등 분산전원용 인버터의 운전중 출력이 변동하거나 부하의 크기가 변화함에 따라 분산전원이 연계된 지점의 전압이 변동하는 문제를 일으킬 수 있다. 이러한 문제를 효과적으로 해결하기 위하여 인버터의 무효분 전력을 조절하는 방법을 제안하고 시뮬레이션과 실험을 통해 제안된 방법의 유용성을 검증하였다. 측정된 연계지점 전압을 바탕으로 위상각을 계산하고 무효분 전류 지령값을 3가지 모드에 따라 변동시킴으로서 원하는 제어목적에 맞는 무효분 전력제어를 수행할 수 있다. 특히 피드백 전압 일정제어 모드의 경우 연계지점 전압 피드백값이 목표치를 추종하도록 무효분 전력을 자동으로 조절하는 기능을 갖추었다. 다수대의 분산전원이 병렬로 연결된 운전조건에서도 제안된 알고리즘이 효과적으로 동작함을 실험적으로 검증하였다.