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( Min-hyeok Cha ),( Sun Hee Kim ),( Seokhwan Kim ),( Woojung Lee ),( Hyo-sun Kwak ),( Young-min Chi ),( Gun-jo Woo ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.5
Acinetobacter strains are widely present in the environment. Some antimicrobial-resistant strains of this genus have been implicated in infections acquired in hospitals. Genetic similarities have been reported between Acinetobacter strains in nosocomial infections and those isolated from foods. However, the antimicrobial resistance of Acinetobacter strains in foods, such as meat, remains unclear. This study initially aimed to isolate Campylobacter strains; instead, strains of the genus Acinetobacter were isolated from meat products, and their antimicrobial resistance was investigated. In total, 58 Acinetobacter strains were isolated from 381 meat samples. Of these, 32 strains (38.6%) were from beef, 22 (26.5%) from pork, and 4 (4.8%) from duck meat. Antimicrobial susceptibility tests revealed that 12 strains were resistant to more than one antimicrobial agent, whereas two strains were multidrug-resistant; both strains were resistant to colistin. Cephalosporin antimicrobials showed high minimal inhibitory concentration against Acinetobacter strains. Resfinder analysis showed that one colistin-resistant strain carried mcr-4.3; this plasmid type was not confirmed, even when analyzed with PlasmidFinder. Analysis of the contig harboring mcr-4.3 using BLAST confirmed that this contig was related to mcr-4.3 of Acinetobacter baumannii. The increase in antimicrobial resistance in food production environments increases the resistance rate of Acinetobacter strains present in meat, inhibits the isolation of Campylobacter strains, and acts as a medium for the transmission of antimicrobial resistance in the environment. Therefore, further investigations are warranted to prevent the spread of antimicrobial resistance in food products.
Characterization of Metal Contacts to Two-Dimensional MoTe2
Min Hyeok Jo,신재철,Jae Eik Kim,Jae Gyun Lee,Seung Gyun Lim,Hyeon Jun Park,Yeol Gi Choi,Dae Hwa Joung,Dong Hwan Kim,Tae Wan Kim 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.5
Transition metal dichalcogenide (TMD) atomic layers are an atomically thin material in the form of MX2, where M is a transition metal atom (such as Mo or W) and X is a chalcogen atom (such as S, Se, or Te). Among them, MoTe2 is attractive because of its narrow band gap (i.e., 1 eV), leading to optical and electrical applications such as field-effect transistors, photodetectors, light- emitting diodes, and photovoltaics. The TMD atomic layers, however, suffer from the extremely high contact resistance of the metal electrodes. The formation of a low-resistance ohmic contact is essential to achieving good device performance. Here, we examined the contact resistance of the two-dimensional MoTe2 atomic tri-layers from transmission line model (TLM) measurements. 2H-phase MoTe2 atomic tri-layers were synthesized on a silicon dioxide/silicon substrate by using metal-organic chemical vapor deposition. The TLM pattern was fabricated on the tri-layers to examine the specific contact resistance of metals. This method is highly effective for minimizing the contact resistance of TMD atomic layers.
Recycling and LFA‐1‐dependent trafficking of ICAM‐1 to the immunological synapse
Jo, Jae‐,Hyeok,Kwon, Min‐,Sung,Choi, Hyang‐,Ok,Oh, Hyun‐,Mee,Kim, Hyang‐,Jin,Jun, Chang‐,Duk Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of cellular biochemistry Vol.111 No.5
<P><B>Abstract</B></P><P>Little is known about how adhesion molecules on APCs accumulate at immunological synapses. We show here that ICAM‐1 on APCs is continuously internalized and rapidly recycled back to the interface after antigen‐priming T‐cell contact. The internalization rate is high in APCs, including Raji B cells and dendritic cells, but low in endothelial cells. Internalization is significantly reduced by inhibitors of Na<SUP>+</SUP>/H<SUP>+</SUP> exchangers (NHEs), suggesting that members of the NHE‐family regulate this process. Once internalized, ICAM‐1 is co‐localized with MHC class II in the polarized recycling compartment. Surprisingly, not only ICAM‐1, but also MHC class II, is targeted to the immunological synapse through LFA‐1‐dependent adhesion. Cytosolic ICAM‐1 is highly mobile and forms a tubular structure. Inhibitors of microtubule or actin polymerization can reduce ICAM‐1 mobility, and thereby block accumulation at immunological synapses. Membrane ICAM‐1 also moves to the T‐cell contact zone, presumably through an active, cytoskeleton‐dependent mechanism. Collectively, these results demonstrate that ICAM‐1 can be transported to the immunological synapse through the recycling compartment. Furthermore, the high‐affinity state of LFA‐1 on T cells is critical to induce targeted movements of both ICAM‐1 and MHC class II to the immunological synapse on APCs. J. Cell. Biochem. 111: 1125–1137, 2010. © 2010 Wiley‐Liss, Inc.</P>
In Vitro Genotoxicity Assessment of a Novel Resveratrol Analogue, HS-1793
Min Ho Jeong,Kwangmo Yang,Chang Geun Lee,Dong Hyeok Jeong,You Soo Park,Yoo Jin Choi,Joong Sun Kim,Su Jung Oh,Soo Kyung Jeong,Wol Soon Jo 한국독성학회 2014 Toxicological Research Vol.30 No.3
Resveratrol has received considerable attention as a polyphenol with various biological effects such as anti-inflammatory, anti-oxidant, anti-mutagenic, anti-carcinogenic, and cardioprotective properties. As part of the overall safety assessment of HS-1793, a novel resveratrol analogue free from the restriction of metabolic instability and the high dose requirement of resveratrol, we assessed genotoxicity in three in vitro assays: a bacterial mutation assay, a comet assay, and a chromosomal aberration assay. In the bacterial reverse mutation assay, HS-1793 did not increase revertant colony numbers in S. typhimurium strains (TA98, TA100, TA1535 and TA1537) or an E. coli strain (WP2 uvrA) regardless of metabolic activation. HS-1793 showed no evidence of genotoxic activity such as DNA damage on L5178Y Tk<SUP>+/?</SUP> mouse lymphoma cells with or without the S9 mix in the in vitro comet assay. No statistically significant differences in the incidence of chromosomal aberrations following HS-1793 treatment was observed on Chinese hamster lung cells exposed with or without the S9 mix. These results provide additional evidence that HS-1793 is non-genotoxic at the dose tested in three standard tests and further supports the generally recognized as safe determination of HS-1793 during early drug development.
Label-free identification of individual bacteria using Fourier transform light scattering.
Jo, YoungJu,Jung, JaeHwang,Kim, Min-Hyeok,Park, HyunJoo,Kang, Suk-Jo,Park, YongKeun Optical Society of America 2015 Optics express Vol.23 No.12
<P>Rapid identification of bacterial species is crucial in medicine and food hygiene. In order to achieve rapid and label-free identification of bacterial species at the single bacterium level, we propose and experimentally demonstrate an optical method based on Fourier transform light scattering (FTLS) measurements and statistical classification. For individual rod-shaped bacteria belonging to four bacterial species (Listeria monocytogenes, Escherichia coli, Lactobacillus casei, and Bacillus subtilis), two-dimensional angle-resolved light scattering maps are precisely measured using FTLS technique. The scattering maps are then systematically analyzed, employing statistical classification in order to extract the unique fingerprint patterns for each species, so that a new unidentified bacterium can be identified by a single light scattering measurement. The single-bacterial and label-free nature of our method suggests wide applicability for rapid point-of-care bacterial diagnosis.</P>