서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

소아 재발성 호흡기 감염증에서 오라페론(Ora-feron) 치료 효과에 대한 연구

이재호,김종균 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

A prospective study was conducted to evaluate the effect of Oraferon on children with recurrent respiratory infection. Study population consisted of 28 children (Group I : 20 children with recurrent respiratory symptoms, Group II : 8 children with recurrent symptoms and nephrotic syndrome). All of patients received 500 milligram or 1000 milligram of Oraferon according to body weight, daily for 2 weeks to 12 weeks in out-patient clinic. The following clinical parameters were assessed according to the severity of cough, dyspnea, sputum in all of them. The mean score of 3 symptoms were highered following the therapy of Oraferon in the treated group. Oraferon worked as immunostinulant, improving the clinical situation in patients with recurrent respiratory infection. We considered that the Oraferon contributed to improve the symptoms of frequent upper respiratory infections and prevent the recurrece of upper respiratory infections in nephrotic syndrome as a coadjuvant therapy.

인산염계 내화물의 기계적 물성 및 내부식성에 대한 핵형성제 첨가효과

이덕용,이재춘,최광훈,김병균,신경숙 明知大學校 産業技術硏究所 1995 産業技術硏究所論文集 Vol.14 No.-

The effect of nucleants was studied on the mechanical property and corrosion resistance of phosphate refractories used for high temperature inorganic binder It was found that a mixture of TiO₂ and ZrO₂ nucleants yielded not only the best corresion resistant but the highest strength phosphate refractory. However, the effects of nucleants on the mechanical property of the refractories could not be identified in this study because each sample showed different porosity which was also presumed to affect the fracture strength of the refractory.

납기와 조립가능 시점을 고려한 병렬기계의 스케쥴링을 위한 발견적 해법

이동현,이경근,김재균,박창권,장길상 한국경영과학회 2000 한국경영과학회지 Vol.25 No.2

In this paper, we consider an n-job, non-preemptive and identical parallel machine scheduling problem of minimizing the sum of earliness and tardiness with different release times and due dates. In the real world, this problem is more realistic than the problems that release times equal to zero or due dates are common. The problem is proved to be NP-complete. Thus, a heuristic is developed to solve this problem. To illustrate its suitability, a proposed heuristic is compared with a genetic algorithm for a large number of randomly generated test problems. computational results show the effectiveness and efficiency of proposed heuristic. In summary, the proposed heuristic provides good solutions than genetic algorithm when the problem size is large.

Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

외주를 고려한 가공경로 선정에서의 유전알고리즘 접근

이규용,문치웅,김재균 한국경영과학회 2000 經營 科學 Vol.17 No.2

This paper addresses a problem of machining route selection in multi-stage process with machine group. The problem is considered the subcontracting and the production in-house such as regular and overtime work. The proposed model is formulated as a 0-1 integer programming constraining the avaliable time of each machine for planning period and total overtimes. The objective of the model is to minimize the sum of processing cost, overtime cost, and subcontracting cost. To solve this model, a genetic algorithm(GA) approach is developed. The effectiveness of the proposed GA approach is evaluated through comparisons with the optimal solution obtained from the branch and bound. In results, the same optimal solution is obtained from two methods at small size problem, and the consistent solution is provided by the GA approach at large size problem. The advantage of the GA approach is the flexibility into decision-making process because of providing multiple machining routes.

작업의 특성에 종속되는 병렬기계의 일정계획을 위한 발견적 기법

이동현,이경근,김재균,박창권,장길상 한국경영과학회 2000 經營 科學 Vol.17 No.1

In the real world, situations that some jobs need be processed only on certain limited machines frequently occur due to the capacity restrictions of machines such as tools, fixtures, or material handing equipment in this paper, we consider n-job, non-preemptive and m parallel machines scheduling problem having two machines group The objective function is to minimize the sum of earliness and tardiness with different release times and due dates The problems is formulated as a mixed integer programming problem The problem is proved to be NP-complete Thus, a heuristic is developed to solve this problem To illustrate its suitability and efficiency, a proposed heuristic is compared with a genetic algorithm and tabu search for a large number of randomly generated test problems in ship engine assembly shop Through the experimental results, it is showed that the proposed algorithm yields good solutions efficiently

골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

에스트로겐 투여가 난소절제로 유도된 백서의 골다공증에 미치는 효과에 관한 실험적 연구

허균행,김경욱,이재훈 단국대학교 치의학연구소 1994 논문집 Vol.6 No.2

Osteoporosis is a state of reduced bone mass per unit volume with a normal ratio of mineral to matrix. There were many methods for osteoporosis, and estrogen is one of them. In this study, 30 female rats were ovariectomized to make a state of estrogen deficiency and induce osteoporosis. After 13 weeks, 15 ovariectomized rats were injected 6 times with 60㎍/㎏ of estradiol by 1 week interval (experimental group). The remaining 15 ovariectomized rats were used as control group. According to the time schedule, both of them were sacrified and femur were harvested. Paraffin sections were stained with HematoxylinEosin staining and modified Gomori's Trichrome staining, and observed under light microscope. The results were as follows : 1. There were no significant bony changes between the experimental and control group of cancellous bone. 2. The density of cortical bone showed increasing with time in experimental group. 3. The resorption of cortical bone in experimental group was less than that of control group.

국산 Avana 인공치아와 외국산 ITI 인공치아의 악골조직내 적합성에 관한 비교연구

유재하,이지웅,백성흠,정원균,김종배 大韓顎顔面成形再建外科學會 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.6

The purpose of this article is to confirm the longterm biocompatibility of national Avana implant and international ITI implant in dogs. At the fourth month after extreaction of the mandibular third and fourth premolar in three dog, both implants were inserted using careful atraumatic technique and prosthetic abutments were applied onto the implants in three months. After that, the implants were examined by naked eye and radiographic image every three months during 1 year, for detection of the complications, such as, mobility, bone resorption and wound infection. At 1 year after application of prosthetic abutment, the dogs were sacrificed for the histopathologic analysis by light microscope. The results obtained were as follows; 1. All implants had the ralatively good prognosis without mobility, wound infection and moderate bone resoprtion, in clinical and radiological evaluation during one year. 2. The all histopathologic specimens at one year after application of prosthetic abutment onto the implants showed the distinct osseointegration between implant system and bone, with projection of new bone apposition onto the peri-implant tissue. But Avana implants had the less osseointegration than ITI implants in the cancellous and marrow layer of jaw bone. 3. The all histopathologic specimens at one year after application of prosthetic device showed the firm junction by dense connective tissue pattern between the implant and the gingival portion. But Avana implants had the less firmer junction than ITI implants. 4. The authors confirmed that Avana implant and ITI implant have more higher tissue biocompatibility in dental implantation, but ITI implant has the more osseointegration than the Avana implant.