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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
들잔디 성숙종자로부터 캘러스배양 및 식물체 재분화에 미치는 몇 가지 요인의 영향
이상훈,김범수,원성혜,조진기,김기용,박근제,성병렬,이효신,이병현 Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-
In an effort to optimize tissue culture responses of zoysiagrass (Zoysia japonica Steud.) for genetic transformation, factors affecting callus induction and plant regeneration were investigated. MS medium containing 3 ㎎/L 2,4-D was optimal for embryogenic callus induction from mature seed. The plant regeneration frequency of 73.3% was observed when embryogenic calli induced in this medium were transferred to N6 medium supplemented with 0.1 ㎎/L 2,4-D and 5 ㎎/L BA. Among several basic media, MS and N6 medium were optimal for callus induction and plant regeneration, respectively. Regenerated plants were grown normally when shoots transplanted to the soil. A rapid and efficient plant regeneration system established in this study will be useful for molecular breeding of turfgrass through genetic transformation.
李鉉凡,李熙碩,崔源弼 慶北大學校 1977 論文集 Vol.24 No.-
Present study was undertaken in order to clarify the species and infection rate of internal parasites in Korean native goats. Abomasum of 100 goats slaughtered in Daejun and abomasum, intestinal tracts, and pancreata of 40 goats slaughtered in Taegu prefecture were inspected. The parasites recovered were classified morphologically with following results. 1) A total of 7 species of parasite was identified. Their habitats and infection rates were as follows; Abomasum-Haemonchus contortus: 20% in Taegu and 42% in Daejun, and Trichostrongylus sp. : 2.5% in Taegu and 3% in Daejun. Small intestine-Moniezia expansa: 12.5%. Large intesine Oesophagostomum columbianum: 27.5%, Oesophagostomum venulosum: 17.5%, and Trichuris ovis: 5%. Pancreas-Eurytrema coelomaticum: 15%. 2) Characteristic nodule formation on the walls of cecum, colon, and ileum was observed in 5 out of 11 goats infected with Oesophagostomum columbianum. No nodule formation, however, was observable in goats infected with Oesophagostomum venulosum. 3) the maximum worm burdens of Oesophagostomum columbianum, Eurytrema coelomaticum, and Haemonchus contortus were higher (above 83) than those of the other parasites. 4) the numbers of female nematodes were greater than of male except Oesophagostomum venulosum.
모 주물공장 근로자의 작업공정별 분진폭로량, 자각증상 및 건강진단판정 비교
이범식,조영채,변정식,김동현,원선혜,김정윤 忠南大學校 環境問題硏究所 1995 環境硏究 Vol.13 No.-
The relationship among dust exposure dose, special health diagnosis results and subjective symptom questionaire survey for 109 casting foundry workers supervised by a local laber office has been studied from august to october 1993. Subjective symptom, dust exposure dose and health examination evaluation of respective working processes have been analized and concluded as follows; 1. Metal fume concentration in melting process measured 3.21±1.46㎎/㎥ is under threshould limit value(TLV;5.0㎎/㎥), casting sand dust measured in molding and desanding process is 5.8 ±3.41㎎/㎥ and 9.69 ±2.64㎎/㎥ which is 3-5 times higher than TLV(2.0㎎/㎥), metal fume, welding fume and metal dust in finishing process measured 9.34 ±1.32, 13.73 ±16.97 and 10.17 ±3.50㎎/㎥ respectively, which are also 2-3 times higher than TLV(5.0㎎/㎥). 2. The complain rate subjective symptoms appeal evaluated for finishing process are 35.9%, 46.2%, 27.2% and 42.2% for eye smptoms, respiractory, skin, general symptom respectively and the rates above express the highest values and the complain rates for melting process are 24.4%, 37.5% and 35.7% for eye smptoms, respiratory and mental system respectively and for molding and desanding it is 24.3%. 3. Perceived occupational disease rate is found 0.9% with are out of 109 worker surveyed who have been exposed in metal fume of finishing process. 4. 33.0% of workers surved are found to require close examination, the worker of hepatopathy suspected are 21.4% which is the highest and 3.7% for circulatory disturbance suspected. 5. The statistically significant variables in general chracteristics that affect health examination evaluation are smoking(P<0.001), respirator put-on (P<0.05) and working career(P<0.05). 6. Cough(P<0.001), "headache"(P<0.05) and "easily skin exchange by slight stimulation" (P<0.05) are statistically significant to the subjective symptom variables affect health examination evaluation.
이용두,고인범,김현희 제주대학교 해양연구소 1997 해양자원연구소연구보고 Vol.21 No.-
This study was performed to investigated the removal efficiency of BOD and SS from the retreated water of sewage effluent by upflow filtration system. Flow rate of sewage effluent were 80m/day. 150m/day. 200m/day and 300m/day. The removal rate of SS was above 90%. and independent on the flow rate. However. BOD removal rate decreased with the flow rate increase. And removal rate of BOD was 40-60%. In the results of experiment, it was considered that the treated water was possible to use as the graywater because it was suitable to Flush Toilet, Springkle -Water. Cleaning Car. etc.
Formocresol을 사용한 치수절단술시 Formaldehyde의 전신적 흡수, 분포 및 급성독성에 관한 연구
이범모,한세현 大韓小兒齒科學會 1990 大韓小兒齒科學會誌 Vol.17 No.1
Formaldehyde that is active constituent in fomaocresol used in pulpotomy is known astoxic agent that causes systemic toxicity. To determine the fate of ?? -formaldehyde which was absorbed following its application to pulpotomy sites, by-pass of posterior facial vein and cannulation of external carotid artery were established with 20G-polyethylene tube. Blood samples (0.2ml) were collectd in glass syringe before the pupotomy and then at 0, 3, 5, 10, 20, 30, 45, 60, 90 and 120 minutes there-after. Plasma was separated after centrifugation at 3000xg for 15 min and aliquots of plasma were counted by liquid scintillation counter. After liver, kidney, lung, heart, spleen, muscle, and socket were removed and solubilized with tissue solubilizer, the radioactivities in solutions were counted by liquid scintillation counter. The acute toxicity of formocresol wsa determined by BUN (Blood Urea Nitrogen), GOT (Glutamic Oxalacetic Transaminase) and OCT(Ornithine Carbamyl Transferase) assay in blood samples collected at 0, 2, 4, 6, 9 and 12 hours by means of cardiac puncture. The results were as follows: 1. The radioactivity of ?? -formaldegyde reached maximal value at 3-5 minutes and decreased thereafter. 2. About 8% of ?? -formaldehyde placed in the pulpotomy site was actually absorbed systemically until 2 hours. 3. About 50% of ?? -formaldegyde absorbed actually was distributed within 20 minutes. 4. The radioactivity of organ per gram was highest in the spleen and lowest in the muscle. 5. Total radioactivity of organ was highest in the liver and lowest in the heart. 6. There were no significant differences between control and experimental groups in BUN, GOT and OCT assay.
Systemic Lupus Erythematosus를 동반한 Multiple sclerosis
이지현,이기주,윤성호,부귀범,손현화,박유환,정춘해,김진호,정원영 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2
Multiple sclerosis and lupus erythematosus are chronic, potentially disabling diseases of unknown cause. It is a rare occasion that the finding of both diseases occurs in one patient. Because both diseases may affect the central nervous system, it may be difficult at times to differentiate symptoms of lupus erythematosus from those of multiple sclerosis. As far as we know, there was no case report of SLE in multilple sclerosis in Korea. We report a case of multiple sclerosis accompanied by SLE.