Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells

( Jae-sung Ryu ),( Kyu-tae Chang ),( Ju-taek Lee ),( Malg-um Lim ),( Hyun-ki Min ),( Yoon-ju Na ),( Su-bin Lee ),( Gislain Moussavou ),( Sun-uk Kim ),( Ji-su Kim ),( Kinarm Ko ),( Kisung Ko ),( Kyung- 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.6

The ACKNOWLEDGEMENTS should be corrected as follows, "This research was supported by a grant (Code# PJ0074922012) from the Korean Rural Development Administration, and has been supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education Science and Technology (2010-0022316 and KCG5401011), and the KRIBB/KRCF Research Initiative Program (NAP), Korea. The published article in this journal was a part of the 2013 Doctoral thesis of Jae-Sung Ryu submitted to Wonkwang University, Korea." and not "This research was supported by a grant (Code# PJ0074922012) from the Korean Rural Development Administration, and has been supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education Science and Technology (2010-0022316 and KCG5401011), and the KRIBB/KRCF Research Initiative Program (NAP), Korea."

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

항공이동통신로에서 M-ary PSK 신호에 대한 동일채널 간섭의 영향

고봉진,노재성,조성준 한국항공대학교 1993 論文集 Vol.31 No.-

본 논문에서는 잡음과 간섭이 존재하는 항공이동통신로에서 M-ary PSK 신호의 오율특성을 구하였다. 구한 결과로부터 신호 대 간섭비 (CIR)가 클수록 신호 성능이 향상되나 신호 대 간섭비 (CIR)가 20[dB] 이상이 되면 더 이상 향상되지 않는다. 또한 Rician 페이딩 환경하에서 직접파 대 반사파비 (K)가 작아질수록 신호성능은 더욱 열화된다. 직접파 대 반사파비 (K)가 10인 경우 오율 10-³을 달성하기 위해 필요한 QPSK 신호와 8PSK 신호의 신호 대 잡음비 (CNR)의 차는 약 5.5[dB]가 된다. 신호 대 간섭비 (CIR)가 35[dB], 직접파 대 반사파비 (K)가 10이 고 오율이 10-³일때는 8PSK 신호가 QPSK 신호보다 신호대 잡음비 (CNR)가 약 6[dB] 열화됨을 알 수 있다. In this paper, the error rate performance of M-ary PSK signal has been evaluated in the presence of AWGN and cochannel interference in the aeronautical mobile channel which is modeled by Rician fading channel. Generally the error rate performance improves as signal-to-interference ratio (CIR) increases. But above 20[dB] in CIR, the error rate performance hardly improves any more. In aeronautical mobile channel as direct component-to-diffuse component ratio (K) of received signal becomes smaller, the error rate performance degrades. The difference between two values of signal-to-noise ratio (CNR) needed in QPSK and 8PSK signals to achieve the error rate of 10-³ is about 5.5[dB] when K is 10 in the absence of interference. The QPSK signal outperforms 8PSK signal by 6[dB] in terms of CNR to achieve Pe=10-³ when CIR=35[dB] and K=10.

벌크 GaAs 반도체의 광 스위칭 특성

고성택,강민제,조경호 濟州大學校工科大學産業技術硏究所 1996 尖端技術硏究所論文集 Vol.7 No.2

A model for a gallium arsenide(GaAs:Si:Cu) photoconductive switch has been developed and solved to determine the performance of the device in bistable switch applications. Simulation studies are performed on a GaAs switch system composed of different density of deep levels to investigate the influence of deep traps in a photoconductive switch system. The computer results show that the initial electron occupation at the deep accepters controls the on-state conductivity of the switch. The required photon flux to turn off the switch is obtained from the computer simulation.

보릿짚의 수분함량 및 수확시기가 소각시 대기오염물질 발생에 미치는 영향

고지연,강항원,이재생,김춘송,박성태,김복진 한국환경농학회 2004 한국환경농학회지 Vol.23 No.2

영남지방 벼-보리 이모작답에서 가장 널리 시행되고 있는 보릿짚 처리방법인 소각이 대기환경에 미치는 영향을 소각시 발생하는 온난화가스, 대기오염가스 및 분진발생량을 중심으로 살펴보았다. 보릿짚 소각시 온난화가스 발생량은 CO₂376.8, CH₄ 1.56, N₂O 0.05 kg/10a 로서 CO₂의 발생량이 가장 많았으며, 대기 오염가스 중에는 유기물의 불완전 연소시 배출되는 CO발생량이 28.8 kg/10a로서 가장 많았다. 그 외 SO₂ H₂S, NH₃, NO등의 질소 및 황 함유 유해가스도 소량 발생되었고 발생된 PM 10 분진의 대부분은 인체에 미치는 영향이 PM 10보다 큰 PM 2.5로 이루어져 있었다. 또한 수확시기가 빠르거나 수분함량이 높은 보릿짚일수록 온난화가스 및 대기오염 가스의 발생량이 증가하고 소각 연기내 PM 10 분진중 PM 2.5의 미세분진 비중이 높았다. 수확적기로 알려진 출수 40일 이후의 보릿짚은 출수 후 40일된 보릿짚 소각시 발생하는 대기오염가스 발생량과 큰 차이가 없었다. This study was carried out to determine impacts of burning of barley straw produced from rice-barley double cropping paddy field on air quality by investigating emissions of greenhouse gases (CO₂, CH₄ and N₂O), air pollution gases (CO, SO₂, H₂S, NH₃ and NO) and particulate matters (PM 10 and PM 2.5). When the barley straw at a rate of 4.5 t/ha was burned at open status, the emitted GHGs amounts were CO₂ 376.8 kg/10a, CH₄ 1.56 and N₂O 0.06. The amount of CO emission was the largest among air pollution gases. These results showed that the range of 45~55% of total C in barley straw was emitted as CO₂-C, followed by CO-C (6.4~5.9%) and CH₄-C (0.5~0.7%). As far as moisture content in barley straw is concerned, the higher moisture content that the barley straw contains, the larger amount of air pollution gases and the higher portion of PM 2.5 in PM 10 were emitted when it burned. In case of harvesting time of barley straw, emission amounts of greenhouse, air pollution gases and PM 2.5 portion in PM 10 had tendency to increase when earlier harvested barley straw was burned.

선체상갑판 개구부의 응력집중에 관한 연구

고재용,윤순동,박성현 木浦海洋大學校 2000 論文集 Vol.8 No.1

In the ship structure, the stress concentration is to be occured at the corner of hatch opening under static and dynamic loading conditions. Recently, the ship structure design based on the fatigue strength analysis is increasingly demanded. Therefor, we analyzed the main deck hatch corner which was representative discontinuty of ship structure with ANSYS. According to the results, the stress concentration factor is lied from 1.68 to 6.41.

의약품중 잔류유기용매 시험법 확립에 관한 연구

고용석,강찬순,최보경,김혜수,홍정희,최명신,김상현,장성재,김길수 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

Headspace-GC(딘5-GC)를 이용하여 ICH 잔류웅매 가이드라인 class 1, 2에 속하는 28종의 잔류유기웅매 분석방법을 연군한 결과 SPB-5, BB-WAX column을 동시 이용하여 각각을 확인, 정량할 수 있었다.또한 염의 참가효과, 평형시간,평형온도가 headspace분석에 미치는 영향을 검토한 결과 평형 시간 30분,평형온도 85℃,Na₂SO₄Ig을 첨가하여 시험할 때 최적 부넉조건을 나타내었다. 회수율은 1,1-achloroethene(68.3%)를 제외하고 90.9 ~ 114.5%로 패체적으로 양호하였다. 따로 HS-GCJECD, DB-524 column을 이용하여 9종의 잔류유기용매에 대하여 각각의 검랸선을 작성하고 검출한계를 구하였다. 실제 의약품 원료 10종및 제제 5종에 적용시킨 결과 모두 불검출되었으며 본 시험법은 의약품중의 잔류유기용매 분석에 적용할 수 있는 방법이라고 판단된다. The headspace-fC/FID(HS -GC/FID) method was performed for test method developnlent of residu;31 organic solvents in pfrarmaceuticals. Using SPB-S and BB-WAXcolumn, 28 kinds of solvents iri ICH residual sof)·ents guidetine class 1, 2 couBd be individuallt-identified and quantitated. The foIBowing residoal soIYents were not detected by the headspaceinjection condition : N,N-Cmethylacetamide, N,N-dimeth)rlformamide, ethyfeneglycol, formamide,2-methoryethanot, N-rnethylpyrrolidone, suBforane. The effects of the addition of salts,equilibration time, and equilibration temperature on headspace analt·sis were invesugated. Theoptimum conditions weiFe obtained with addtion of Ifa2s04 19 as a salt, simultaneously. thetime and temperature of equitibration were 30min and 8i'f, respectivety. The recovery havefound between 90.9 and 114.5% except 1,1-dichloroethene(fi8.3%). Using DB-624 column &HS-GC/:ECD method, 9 kinds of residual solvents could be individually identified andfuantitated. This HS-GC method can be applied to test the residua3 organic solvent in thepharmaceuticals.

법랑질 접착에 대한 습윤 효과

고근호,조영곤,진철희,유상훈,김종욱,박병철,기영재,최희영,김종진 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.3

This study evaluated the microleakage and interfacial gap between enamel and composite resin under the dry and wet condition of the enamel surface, V shaped class 5 cavities were prepared on the occlusal portion of extracted human molars. Samples were divided into three groups: D group (air dry for 10-15s), BD group (blot dry with moist cotton pellet), and DR group (air dry for 10-15s and rewet with Aqua-Prep F for 20s). Cavities were filled using Aelitefil composite resin after applied One-Step. Microleakage was tested by 2% methylene blue dye solution and the data were statistically analysed by Kruskal-Wallis test and Mann-Whitney test. Also Enamel-resin interface was observed under SEM. Group BD showed statistically lower microleakage than group D (p〈0.05). but there was no statistically significant difference between group BD and DR (p)0.05). At the enamel-resin interface, group D showed the gap of 2 ㎛ thickness, but group BD and DR showed close adaptation. In conclusion, the use of blot dry and rewetting agent (Aqua-Prep F) resulted in decreased microleakage and improved adhesion between enamel and resin when using One-Step.

냉간성형상의 휨성능과 설계기준식에의 적용

이명재,고상기,이현석 中央大學校 建設環境硏究所 1998 環境科學硏究 Vol.9 No.1

The bending capacity of cold-formed steel channel members was investigated by tests with eighteen specimens which were made with three different types of section shape. Pure bending moment adn three point bending were used for loading condition. Experimental results were compared with local and lateral -torsional bucking strength predictions based on suggested design formula of cold-formed steel members. The results leads to the following conclusions ; (1) The specimens have unavoidable initial crookedness which affects bending capacity because they consist of thin-walled section. (2) The single section such as Lip-C channel and C channel is symmetric for bending axis, nevertheless, I-shaped section which is built up is more stable than single section. (3) The bending strength of cold-formed steel members was satisfied with the suggested design formula in case of pure bending and three point bending.

다결정 실리콘 트렌지스터의 이온 샤워 도핑과 엑사이머 레이저 activation에 관한 연구

고무순,盧在相 弘益大學校 科學技術硏究所 2000 科學技術硏究論文集 Vol.11 No.-

Ion implantation being used in the fabrication process of semi-conductor is utilized for the formation of S/D. But It is difficult to apply to large area glass substrate in the process of TFT-LCD. Also It demands high temperature for the recovery of damage after ion implantation. Therefore, ion shower doping which is non-mass separate and dope directly large ion beam without scanning by D.C voltage is the promising method. In this study, we are going to make clear of material characteristics change after ion shower doping and predict the dominant ion species in ion beam generating according to processing condition of ISD. Also we have proceeded a study for minimizing degradation of gate electrode in laser activation and perfect removal of implant damage and effective impurity activation.