노치 형상 및 냉각속도에 따른 Zr-2.5Nb 압력관의 DHC거동

김상재,김영석,임경수,김성수,정용무 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.1

The objective of this study is to investigate the delayed hydride cracking (DHC) velocity and the incubation time for the water-quenched and furnace-cooled Zr-2.5Nb tube with the different radius of a notch tip. DHC tests were carried out at constant K_1 of 20 MPa√m and 250℃ on the cantilever beam (CB) specimens subjected to furnace cooling or water quenching after electrolytic charging with 57 or 72 ppm hydrogen, respectively. An acoustic emission sensor was attached to the CB specimens to detect the incubation time before the start of DHC. The shape of the notch tip changed from the fatigue crack to the dull crack with its radius ranging from 0.1 to 0.15 mm. The DHC incubation time increased remarkably with the increasing radius of the notch tip, which appeared more strikingly on the furnace-cooled CB specimens than on the water-quenched ones. However, both furnace-cooled and water-quenched CB specimens indicated little change in the DHC velocity with the radius of the notch tip unless their notch tip exceeded 0.125mm. These results demonstrate that the uncleation rate of hydrides at the notch tip determines the incubation time and the DHC velocity becomes constant after the concentration of hydrogen at the notch tip reaches the terminal solid solubility for dissolution (TSSD). This observation agrees well with Kim's DHC model. A difference in the incubation time and the DHC velocity between the furnace-cooled and water-quenched specimens is discussed in terms of the uncleation rate of hydrides at the notch tip and the hysteresis of hydrogen solubility.

우리나라 지역 직업성질환 감시체계의 현황과 전망

임종한,장성실,김성아,문재동,채창호,홍윤철,김수영,김진석,김영욱,한상환,이혜숙,원종욱,송동빈,하은희,강성규 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

기존의 특수건강진단과 작업환경측정을 통한 직업병 관리가 진폐증, 소음성난청 등의 소수 특정질환에 국한되고 실제 직업병 발생 규모 파악이나 신종 직업병의 발견에 한계를 보인다는 사실은 산업의학전문가들 사이에서도 공감을 이루고 있다. 미국과 영국 등에서의 직업성질환 감시체계에 대한 경험은 우리 나라의 직업성질환 감시체계 구축에도 새로운 자극제가 되면서, 1998년이후 인천, 대전, 여천, 구미, 부울경 지역에서 지역 직업성질환감시체계를 산업보건관리의 중요한 시스템으로 구축하려는 노력이 확산되고 있다. 새로이 구축되어지는 이들 지역 직업성질환 감시체계는 감시하고자 하는 대상질환, 활용 가능한 인적자원 및 자료원, 지역 의료체계의 특수성 등에 따라서 목적과 방법을 달리하면서 독특한 형태로 발전을 하고 있다. 각 지역단위 감시체계들이 그 상황에 맞게 독특한 목적과 전략들을 발전 시키면서도, 향후 발전할 국가적인 차원의 직업성질환 감시체계 구축을 위하여 직업성질환 감시의 기본 전략 등을 공유하는 등의 노력이 필요하다. 환례 정의 및 기본적인 등록 서식의 공유, 직업성질환 감시 자료원의 발굴, 공동의 정보 네트워크 및 직업성질환 감시 데이터베이스 구축 등 직업성질환 감시활동을 지원하기 위한 여러 기초 인프라 구축에 힘을 모아야 할 것이다. 우리 나라에서 직업성질환 감시체계를 성공적으로 구축하기 위해서는 수집된 자료의 질 관리를 위한 직업성질환 감시의 원칙 제정과 감시 전략의 공유 등이 필요하며, 전국적인 직업성질환 감시체계의 하부구조라고 할 수 있는 지역감시체계의 기초 토대 마련과 강화작업이 절실하게 필요하다.

시스템 가설재의 구조성능 평가에 관한 연구

김성수,안용선,박재형,이재연 牧園大學校 建築·都市硏究센터 1999 建築·都市環境硏究 Vol.7 No.-

This paper describes analysis and test procedures for the estimation of structural performance of SSPS system(Systematic Steel Pipe supporting system) developed through previous researches. Section of each members which composes proposed SSPS system has large influence on weight and capacity of steel pipe supports. Therefore, parameter analysis using the program will be first performed to decide the shapes and details of SSPS system that is light-weighted for easy carrying, setup, dismantling and has high capacity. For evaluation of structural performance of proposed SSPS system, several experiments is carried out under various assembling conditions.

해조류 용매별 추출물의 항돌연변이원성

김봉오,박제석,오명철,현재석,김재하,오창경,김수현 濟州大學校工科大學産業技術硏究所 1996 尖端技術硏究所論文集 Vol.7 No.2

톳, 미역 및 다시마를 용매별로 추출하여 이들 추출물의 항돌연변이원성을 검색하였다. 톳 용매별 추출물의 MMS에 대한 항돌연변이 효과는 TA100 균주에서 헥산, 에탄올, 에칠에테르 추출물 순으로 높았고, TA102 균주에서 헥산, 에칠에테르, 에탄올 순으로 높았으나, 미역 및 다시마 추출물은 항돌연변이원성이 거의 없었다. ICR191에 대한 항돌연변이 효과는 시험된 모든 시료에 대한 에탄을 추출물이 높은 항돌연변이 효과를 나타내었고, 에칠에테르와 헥산 추출물은 물 추출물보다도 낮은 효과를 나타냈다. 그러나 톳 추출물은 시험된 모든 용매 추출물에서 60% 이상의 높은 항돌연변이 원성을 나타내어 ICR-191에 의해 유도되는 돌연변이 원성을 저해하는 물질이 수용성 및 비수용성에 걸쳐 다양함을 나타내었다. 한편, 미역, 다시마 및 톳 추출물의 sodium azide에 대한 항돌연변이원성은 없는 것으로 나타났다. Desmutagenic effects against methyl methanesulfonate(MMS)-, 2-methoxy-6-chloro-9-〔3-[2-chloroethyl〕aminopropylamino〕acridine(ICR191)- and sodium azide-induced mutations by the extracts from Hizikia fusiforme. Laminaria japonica and Undaria pinnatifida with different solvents were investigated. The solvent extracts from Hizikia fusiforme were the highest desmutagenic effect against MMS in n-hexane and against ICR191 in ethanol extract. but no against sodium azide in all solvent extracts tested. While the solvent extracts from Undaria pinnatifida and Laminaria japonica were the highest against ICR191 in ethanol extract. but no against sodium azide and MMS in all solvent extracts tested. Moreover. all the solvent extracts from Laminaria japonica were inhibited 60% or more ICR191-induced mutations.

都市街路樹의 環境汚染에 關한 硏究 : 慶南地域을 中心으로 Especially in Gyeongnam Province

金在生,金点秀 慶尙大學校 1990 論文集 Vol.29 No.1

慶南 地域의 主要 都市인 馬山市와 昌原市, 忠武市, 三千浦市, 普州市, 金海市 等 6個 都市의 18個 區間에 있는 은행나무와 버즘나무, 히마라야시아. 벚나무 等의 4個 樹種의 잎에 含有되어 있는 硫黃 과 重金?(Fe, Mn. Cu,Zn, Cd, Pb)의 含量과 은행나무 잎과 士?中에 含有되어 있는 硫黃 과 重金屬 含量 相互間의 相關關係를 調査하여 본 結果는 다음과 같다. 1.잎에 있어서의 硫黃의 含量을 보면 은행나무는 0.32~0.63%, 히마라야시다는 0.13~0.18%, 버즘나무는 0.37~0.44%, 벚나무는 0.18%이었으며, 都市別로는 馬山市가 第一 높았고, 다음은 普州市의 順이었다.士?에 있어서는 馬山市는 158~691ppm, 昌原市는 158~ 691ppm, 忠武市는 226~691ppm, 三千浦市는 113~872ppm, 普州市는 271~533ppm, 金海市는 892ppm으로서 三千浦市와 金海市가 높게 나타났었다. 2.잎에 있어서의 Fe含量은 은행나무는 159~448ppm, 벚나무는 435ppm , 버즘나무는 209~305ppm. 히마라야시다는 156~180ppm으로서 은행나무가 第一많은 量을 含有하고 있었다. 土壤에서의 Fe含量은 馬山市가 5.8~48.8ppm, 昌原市가 34.2~54.4ppm, 忠武市가 2.9~26.1~54.3 ppm, 金海市가 27.3ppm으로서, 特히 工團??의 含量이 높은 便이었다. 3.Mn의含量은 히마라야시다가 167~488.5ppm, 벗나무가 182ppm, 버즘나무가 50.5~70.7ppm,은행나무가 16~39.5ppm의 順으로서 히마라야시다가 第一많은 量을 含有하고 있었다. 土壤에서의 Mn의 含量은 馬山市가 7.5~27.2ppm, 昌原市가 24.2~29.2ppm, 忠武市가 9.9~12.4ppm, 三千浦市가 5.4~18.2ppm, 普州市가 5.3~164ppm, 金海市가 24.2ppm으로서 昌原市와 馬山市가 많은 量을 含有하고 있었다. 4.Cu의含量은 잎에선는 4~8,5ppm ppm에서는 0.8~9.2ppm을 含有하고 있어서 낮은 便이었으며, Zn의 含量은 잎에서는 11.5~98.5ppm 土壤에서量은 잎에서는 0.46~1.51ppm,土壤에서는 0.08~3.70ppm을 含有하고 있어서 大體的으로 적게 含有하고 있는 便이었다. 5.은행나무 잎과 그 周邊 土壤에서의相關關係는 Fe만이 正의 相關을 보였고 5%水準에서 有意性이 認定되었다.또한 은행나무 잎에서의 성분간에는 Cu와 Zn 間에는 正의 相關을 보였고 1% 水準에서 有意性이 認定되었고 硫黃과 Fe,硫黃과 Cu, Fe와 Cu間에는 正의 相關,Zn과 Pb間에는 負의 相關을 보였으며 이들 모두 5%水準에서 有義性이 認定되었다 This study was undertaken to investigate the environmental pollution of Urban Trees(Ginkgo biloba, Platanus orientalis, Gedrus deodra, Prunus serrulata vr spontanea) in the main cities of Gyeongnam. The investigated details were Total Sulfer and the Heavy Metals(Fe, Mn, Cu, Zn, Cd, Pb)in the leaves and soils, and correlation between pollutants of Ginkgo biloda leaves and the soils, and correlation among the pollutants in Ginkgo biloba leaves. The results were summarized as follows; 1. Total Sulfer contents in the leaves were ranges of 0.32~0.63% in Ginkgo biloba, 0.37~ 0.44% in Platanus orientalis. 0.13~0.18% in Gedrus deodara ,and 0.18% in Prunus serrlata var spontanea. In regional groups. Masan cty was the highest. and Chinju city was the next yo highest. Total Sulfer contents in soils were ranges of 158~691ppm in Masan city. 158~691ppm in Changwon city. 226~691ppm in Chungmu city. 113~872ppm in Samchonpo city. 271~533ppm in Chinju city, and 829ppm in Kimhai. and they were highly shown in Samchonopo city and Kimhai city generally. 2.Fe contents in leaves were 159~448ppm in Ginkgo biloba, 435ppm in Prunus serrulata var. spontanea 209~305ppm in Plalanus orientalis . and 156~180ppm in Cedrus deodara. and they were the highest in Ginkgo biloba.In soils, they were 5.8~48.8pp in Masan city, 34.2~54.4ppm in Chinju city.and 27.3ppm in Kimhai city. Especiaslly, they were tendencious that they were high around the insusrial complex. 3.Mn contents in the leaves were 167~488.5ppm in Cedrus deodara. 182ppm in Prunus serrulata var spantanea. 50.5~70.0ppm in Platanus orientalis. and 16.0~39.5ppm in Ginkgo biloba. Its contents in soils were 7.5~27.2ppm in Masan city.24.2~29.2ppm in Changwon city , 9.9~12.4ppm in Chungmu city. 5.4~18.2ppm in Samchanpo city, 5.3~16.4ppm in Chinju city. and24.2ppm in Kimhai city. 4.Cu contents in the leaves and soils were range of 4~8.5ppm, and 0.8~9.2ppm respectively. Zn contents were 11.5~98.5ppm,and 1.8~30.1ppm. Pb contents were o,46~1.51 ppm. and 0.08~3.70ppm. Generally, they were low in all investigated sites. 5.The correlations of the pollutants between the leaves of Ginkgo biloba and the soils were positive and significant at 5% level in only Fe contents. The correlations of Heavy Metals contained in the leaves of Ginkgo biloba were highly positive and significant at 1% level between Cu and Zn and at 5% level between Total Sulfer and Fe, Total Sulfer and Cu and Fe and Cu. repectively , and were negative and significant at 5% level between Zn and Pb.

폐선암조직에서 Neutral Ribonuclease의 분리와 성상에 관한 연구

김응수,고재경,지행옥 한양대학교 의과대학 1993 한양의대 학술지 Vol.13 No.1

Concentrations of nucleic acids and proteins were determined in adenocarcinoma tissue of the lung and were compared with those in the control lung tissue. Also studied were properties of the neutral RNase specific to the lung cancer to investigate the possible role of the RNase in process involved in carcinogenesis of adenocarcinoma of the lung. DNA and protein centents were unchanged, but RNA content was increased in adenocarcinoma tissue of the lung. Neutral RNase activity was unchanged in the cancer tissue, indicating that the RNase could not be used as a marker for the lung cancer. Proteins and neutral RNase in adenocarcinoma tissue of the lung were separated by a DEAE-cellulose column chromatography into 7peaks each, of which the peak I neutral RNase isozyme was not found in the control lung tissue. This indicated that the peak I neutral RNase was specific to the adenocarcinoma of the lung. The peak I neutral RNase isolated from the adenocarcinoma tissue of the lung did not hydrolyze single stranded (ss) polydeoxyribonucleotides and double stranded (ds) polynucleotides, but hydrolyzed ss polyribonucleotides. The enzyme was observed to be highly active toward poly C, poly U and RNA, indicating that the RNase appeared to be mixed type of secretory and nonseretory RNase. The peak I RNase was not active toward A-A and G-G linkages, but unusually highly active toward A-C and A-U linkages (4 to 6 fold as active as C-C linkage). These results indicated that the peak I neutral RNase isolated from the adenocarcinoma of the lung was (1)specific to the lung cancer. (2) mixed type of seretory and nonsecretory enzymes, (3) unusually highly active toward A-C and A-U linkages of ss polyribonucleotides and RNA, suggesting that the RNase might play roles in processes involved in carcinogenesis and suppression of cancer.

한약과 양약의 약물상호작용에 관한 연구(제1보) : Nicardipine과 청혈단의 상호작용 Effects of CHUNGHYULDAN on the Pharmacokinetics and Pharmacodydnamics of Nicardipine in Rats

김남재,진성민,최혁재,주수만,송보완,김종우 한국병원약사회 2002 병원약사회지 Vol.19 No.4

The influence of single and repeated oral pretreatment of CHUNG-HYUL-DAN(CHD). a widely used Korean traditional herbal medicines prescribed for hypertension and hyperlipidemia, on the pharmacokinetics and pharmacodynamics of a calcium channel blocker, nicardipine after oral administration of nicardipine was investigated in rats. The single pretreatment of CHD significantly increased area under the plasma concentration-time curve(AUC_(0-8h), but did not influence the time to reach the maximum peak plasma concentration(T_(max)), the maximum peak plasma concentration(C_(max)), terminal elimination half-life(t_(1/2) or the elimination rate constant(λ) for nicardipine. And, C_(max) and AUC_(0-8h) for nicardipine were significantly increased by with 1-week repeated pretreatment with CHD, but the other parameters were not significantly different from those of control. Also, the extent of the lowering effect of nicardipine on blood pressure in rats was significantly increased after oral administration of nicardipine with single and repeated oral pretreatment with CHD. These results indicated that single and 1-week repeated oral pretreatment with CHD should inhibit the metabolism of nicardipine in rats.

건축공사시방서에서의 KS규격의 국제인증방안에 관한 연구

김경식,이재섭,김용수,이규진,조용훈,최완철,전재열,이현수,구재동,이기환 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

The purpose of this research is make out construction specifications for International Construction. Using off-shore products incur cost increase and longer delivery term of construction. and inconvenient on International Construction. Expand the range of additional local products conforming to performance. Life Cycle Cost. maintainability. operability. user's acceptability, etc.. And this study is suggest the standard formats and the techniques for construction specification.

난소암조직 Acid Deoxyribonuclease의 분리와 성상에 관한 연구

김두상,김영신,고재경,한중수 한양대학교 의과대학 1992 한양의대 학술지 Vol.12 No.1

In order to find out a possible role of acid deoxyribonuclease (DNase) in carcinogenesis of the ovary, activity of the enzyme was measured and the nature of the enzyme was studied in serous cystadenocarcinoma and endodermal sinus tumor of the ovary following the purification of the acid DNase in the tumor tissue of the ovary. (1)The acid DNase activity was greatly increased in the tumor tissues of the ovary, serous cystadenocarcinoma and endodermal sinus tumor tissues, while neutral and alkaline DNase activities were unchanged in the tumor tissues. This may indicate that the acid DNase can be used as a biochemical marker for the ovary tumors. (2)Proteins in the tumor tissues of the ovary were separated by a DEAE-cellulose column chromatography into 7 peak, respectively, of which one peak protein each appeared to be specific for serous cystadenocarcinoma and endodermal sinus tumor. (3)Acid DNases in the tumor tissues of the ovary were isolated into a single peak, respectively. The size of peak in the tumor tissues was greater than that in the control tissue of the ovary, indicating that the acid DNases in the tumor tissues were activated, but not specific for the tumors. (4)Acid DNases in the tumor tissues of the ovary were partially purified by centrifugation and a DEAE-cellulose column chromatography. The purified enzyme was highly active against double stranded DNA (ds-DNA), even though some activity was found against single stranded DNA (ss DNA). Observations that acid DNase from serous cystadenocarcinoma tissue was highly active and specific to ds DNA compared with ss DNA suggested that the enzyme might play a role in transforming normal ovarian cells into cancer cells.

빌라조경 설계사례에 관한 연구 : Case Study of Jang-chung Dong Villa

김동찬,이윤수,유재설,박익수,임동민,임상재 경희대학교 부설 디자인연구원 1998 예술· 디자인학연구 Vol.1 No.1

The goal of this study is to propose a plan for the Jang-Chung Dong Villa. This Villa is located on Jang-Chung Dong Jung-Gu, Seoul. And, this place is where high-class residential area. This Site area covers about 1925.6m². This base idea of this plan is to provide a community of dwelling houses with identity and amenity in outdoor spaces in order to create the high-class environment of outdoor spaces. Design principles are established as follow; to make spaces for flexibility in the garden related activities, to provide many chances to contact with nature, and to feel pride in the villa life.