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朱守良 전북대학교 동북아법연구소 2019 동북아법연구 Vol.13 No.1
In the tide of criminal integration, the relationship between criminal law and criminal policy is getting closer and closer. As an important part of the application of criminal law, the interaction between criminal law interpretation and criminal policy is also increasingly frequent. Criminal policy, as a national strategy for crime prevention and a response mechanism for tackling crime problems, embodies the value concept of overview of the country. Only by following the purposeful guidance of criminal policy can criminal law play its due role, but this guiding function must be carried out under the restraint of the principle of legality of crime and the principle of balanced crime, while still considering the reality of criminal policy, only in this way can we realize the transformation to respond to criminal law and embody the requirements of a country ruled by law.
Inhibitory Effects of 6-Gingerol on Cytochrome P450 in Human Liver Microsomes
주수연,임영채 대한임상약리학회 2011 Translational and Clinical Pharmacology Vol.19 No.1
a 배경: 일상 식이 생활에서 흔히 쓰이는 생강(ginger)의 한 성분인 6-gingerol은 질병 치료 과정 중에 사용하는 약물과 상호 작용을 일으킬 수 있다. 그러나 인체 간 대사 효소인 시토크롬 P450 활성도에 대한 6- gingerol의 효과는 아직 알려져 있지 않다. 본 연구에서는 인체 간 미세소체에서 6-gingerol이 시토크롬 P450대사 효소에 미치는 억제 효과를 연구하고자 하였다. 방법: 인체 간 미세소체 모델을 이용하여 다양한 농도의 6-gingerol과 각각의 CYP450에 특이적인 기질을 함께 배양하였으며, 각각의 대사물을 HPLC로 측정하였다. 본 연구에서 사용된 CYP효소에 의해 촉매 되는 반응에는 CYP1A2에 의한 phenacetin O-deethylation, CYP2C9에 의한 tolbutamide 4-hydroxyltion, CYP2C 19에 의한 S-mephenytoin 4’-hydroxylation, CYP2D6에 의한 dextromethorphan O-demethylation, CYP2E1에 의한 chlorzoxazone 6-hydroxylation, 그리고 CYP3A4에 의한 midazolam 1-hydroxylation이었다. 결과: 6-gingerol은 IC_50가 100 μM을 상회할 정도로 CYP2C9, CYP2D6, CYP2E1 그리고 CYP3A4의 활성도에 큰 영향을 미치지 않았다. 그러나 6-gingerol은 CYP 2C19과 CYP 1A2에 대하여 Ki 수치가 각각 13 μM과 29 μM이 될 정도로 강한 억제 효과를 나타내었다. CYP1A2에 대하여 6-gingerol은 상경적인 형태의 억제를 초래하였다. 결론: 이러한 결과는 6-gingerol이 CYP1A2과 CYP2C19의 활성도를 잠재적으로 억제할 수 있음을 시사하였다.
韓·美 군사동맹체제에 대한 再評價 : 한국측 영향변수를 중심으로 Focused on the Korea-Side Factors
朱秀基 단국대학교 미소연구소 1989 미소연구 Vol.3 No.-
During the decade of 1980s, Korea had been undergone, domestically and internationally, a great deal of changes. In the domestic front, the democratization movement and its aftermath have created a totally new climate of politics, meanwhile the rapid evolvement of international affairs and the Korean initiative of "Nordpolitik(i.e., Northern Policy)" have presented a rather different environment of international politics. Particularly, the ROK-US relations passed a period of transition in the 1980s, and it clearly appears that the Republic of Korea and the United States can no help changing their existing format of interactions in the 1990s. The primary purpose of this study is to prove into the future pattern of ROK_US relationships for the 1990s. To do so, the study reviews the historical ups-and-downs in the past and present patterns and looks into the future framework of desirability for the Republic of Korea and the United States. Then, the study analyzes the relevant factors of importance in order to evaluate the development of ROK_US military alliance system. The selected factors are certainly pertained to the both countries, but they are viewed from the Korean side only in present analyses. The following three political-military factors are analyzed: ⅰ)the role and function of U.S. military troop in Korea, ⅱ) the question of transferring the "operational control" of ROK-US Combined Forces Command to Korea, and ⅲ) the problem of sharing the defense cost ant burden with reference to the role, risk and alliance responsibility in the joint military command system. The two additional factors analyzed are: the trade friction and pressure deriving from the enfeeblement of American economy and the growing trade surplus of Korea with the United States and the anti-American sentiment stemming from the re-evaluation of America and her role in the modern Korean history. The former is an economical one and the latter is a social one; however, these factors undoubtedly play a highly significant role in the future development of ROK-US military alliance relationship. It is true that the ROK-US relations have been characterized by the Korea's dependence on America-sometimes called as the patron-client relationship, in which Korea played a junior partnership. However, due to the Korea's economic growth, the emergence of nationalism, and the rise of national self-esteem and pride, the republic of Korea and the United States appear to have entered into an age of the mutually beneficial partner-relationship of inter-dependence, in which the two countries can harmoniously pursue their own national interests. In conclusion, for the sake of a more mature ROK-US relations, Korea needs to develop her own capabilities of democratization, continuous economic growth, national self-defense posture, and diplomatic skill in international politics. If not, Korea can not be expected to play the role of equal partnership in the ROK-US military alliance relationship.