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서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
Distribution of Aquaporins (Water Channels) in the Rat Salivary Glands
정지연(Ji-Yeon Jung),한창룡(Chang-Ryoung Han),정연진(Yeon-Jin Jeong),오원만(Won-Mann Oh),김미원(Mi-Won Kim1),김선헌(Sun-Hun Kim),김옥준(Ok-Joon Kim),김현진(Huyn-Jin Kim),고정태(Jeong-Tae Koh),최홍란(Hong-Ran Choi),김원재(Won-Jae Kim) 대한해부학회 2002 Anatomy & Cell Biology Vol.35 No.3
침샘은 하루 1.5 l의 침을 분비하며, 일반적으로 침샘에서 수분이동은 능동적 염분 이동에 따른 삼투현상에 의해 일어난다. 따라서 침샘에서 높은 수분투과성으로 인해 수분통로 단백인 aquaporin (AQP)들이 풍부하게 존재할 수 있다. 지금까지침샘에 4가지 형태의 AQP이 존재한다고 알려져 있지만 침샘에서 정확한 위치와 수분 이동에 대한 각 AQP들의 역할은 아직 확실치 않다. 본 연구는 300 g 정도의 흰쥐를 pentobarbital sodium (50 mg/kg, IP) 마취하에서 carbarchol (10 μg/kg)을 복강 내 투여한 후 AQP들의 역할과 분포를 면역조직화학방법으로 조사하였다. AQP1은 침샘의 미세혈관의 내피세포와 샘세포와 샘관 주위에 존재하는 근육상피세포에 존재하였다. AQP4는 침샘관의 마지막 부위인 배출관에 존재하였다. AQP5는 주로 장액세포의 바닥가쪽과 세포사이 분비소관을 포함한 세포꼭대기쪽막 에 존재하였으며 콜린성 분비 자극으로 세포꼭대기쪽막으로 이동되어 밀집되었다. AQP5는 모든 침샘의 사이관과 줄무늬 관에도 존재하였으며 점액세포는 약하게 존재하였다. AQP8은 AQP5처럼 장액세포의 바닥쪽막과 세포사이 분비소관을 포함한 세포꼭대기쪽막에 존재하였으며 콜린성 침분비 자극으로 세포꼭대기쪽막쪽으로 이동되어 밀집되었다. 이상의 실험결과는 AQP5와 AQP8이 장액세포에서 일차 침 형성시 일어나는 수분이동의 주된 통로임을 시사하였다. The salivary glands produce 1.5 l of fluid per day. As in other organs, the general paradigm in the salivary glands is that water movement occurs secondary to osmotic driving forces created by active salt transport. Therefore, high water permeability in salivary glands is expected to need a variety of aquaporin (AQP), a water channel. Although four AQPs have been known to reside in salivary glands, the precise location and roles of AQPs have been not well examined. This study is aimed to investigate the distribution of AQPs in 3 major salivary glands and their changes after cholinergic stimulation using immunohistochemical study in Sprague Dawley rats weighing 300 g under pentobarbital sodium anesthesia. AQP1 was localized in the endothelial cells of all salivary capillary vessels and the myoepithelial cells. AQP4 was demonstrated in the epithelium of the excretory ductal cells of all salivary glands. AQP5 and 8 were abundantly present in the basolateral membrane and apical membranes of the serous acini including intercellular secretory canaliculi, whereas AQP5 was weakly present in mucous acini. In addition, AQP5 was found in the epithelium of the intercalated and striated ducts. Upon stimulation of carbachol (10 μg/kg, I.P). AQP5 and 8 tended to translocate from basolateral membrane to the apical membrane, appearing as clusters of dots. These results suggest that AQP5 and 8 are the candidate molecules responsible for the water movement in salivary acinar cells.
자매에서 발생한 중증 마이코플라즈마 폐렴에서 스테로이드 치료
김도희,이경일,김명숙,윤유숙,황자영,임정우,강진한,이준성 대한감염학회 2009 감염과 화학요법 Vol.41 No.3
Numerous evidences support the pathogenesis that M. pneumonias pneumonia is associated with cell-mediat-ed immune reaction. We report 2 cases of severe M. pneumoniae pneumonia in previously healthy sisters, who were both admitted during an epidemic of M. pneumoniae pneumonia. The elder sister, who was 16 years old, was admitted with M. pneumoniae pneumonia. She showed no response to treatment with clarithroycin and levo-floxacin, and eventually progressed to severe ARDS, requiring mechanical ventilation. After treatment with hydrocortisone (200 mg/day), there were rapid improvements in clinical manifestations and chest radiographic findings. The younger sister, who was 14 years old, was admitted 10 days later, Presenting with fever but no pneumonic lesions on chest radiograph. Just like her sister, the infection showed no response to clarithromycin. Fever persisted and pneumonic consolidation with mild pleural effusion was noticed in the left lower lobe on the 5th hospital-day. After treatment with oral prednisolone (1 mg/kg), she showed rapid defervescence and on the 8th hospital day, no pneumonic lesions were detectable on chest radiograph. Given the fact that the pathogenesis of pneumonia and extrapulmonary manifestations in M. pneumoniae infection is immune-mediated, an immuno-suppressive therapy would be validated for selected patients with M. pneumoniae infections.
전산모형과 지리정보시스템을 결합한 Wed 기반의 유역 및 하수도 관리시스템의 개발
김준현,박형춘,한영한 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A
A Web based watershed and sewer management system was developed for the analysis of stormwater runoff and sewer flow, and for optimal operation of sewer works using ArcView and SWMM. SWMM and ArcView were dynamically linked together using Avenue and Visual Basic in order to construct user-friendly management system. The developed system was applied to Choonchun city to verify its utilities. All the relevant field data were analyzed on the basis of developed system, and the modeling of runoff and sewer flow was implemented using RUNOFF and TRANSPORT blocks in SWMM. This system was connected to the management system of surface and subsurface environment management system in order to develop an integrated environmental mangament system. Futhermore. this system will be a critical part of overall control system of sewer works including sewer line and wastewater treatment plant. As this system can provide comprehensive prediction of flow and pollution profiles and analytical tool equipped with Web-GIS, it could serve widely as a tool not only for optimal mangament, but also for decision support system to examine the efficiency of planning and implementation of sewer projects.
춘천시의 지하 저장 탱크의 예비적 위해성 평가를 위한 설치 현황 분석 및 지리정보시스템의 적용
김준현,한영한,이종춘,권영성,이광연 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.A
In this study, the preliminary risk assessment for the underground storage tanks(UST) in Chunchon city was implemented using the geographical information system(GIS). The estimation variables, such as the installation year, storage capacity, the distances from streams, and from groundwater pumping wells, were selected to estimate the relative risk levels. The weighting factors were given to all the estimation variables. Cumulative scores were induced by the combination of al1 the scores of the corresponding variables using the buffering technique and the overlay analysis in ArcView. Using the these process, the relative risk level of each UST was estimated. Some sites in this study are simplified and reduced because the number of useable data are limited or too enormous. Thus the selection of the comprehensive estimation variables and the proper weighting values are required for the future study. The methodology in this study could be served not only for the preliminary risk assessment of UST but also for the selection of the proper location of new and old UST. And, it can be used for the effective management system of UST.
복합재료 이론에 의한 2차원 상판 구조물의 정확하고 간단한 해석
김준민,한봉구 서울산업대학교 2005 논문집 Vol.54 No.2
대부분의 건설기술자들은 강판형교나 콘크리트 교량을 단위 폭을 가진 보로 해석 하나 이러한 구조물은 엄연히 복합재료로 이루어진 판(plate) 구조이다. 이러한 구조물은 균등단면에 등분포하중을 받고 4변 단순 지지된 경우가 아니면 정확한 해석이 불가능하다. 복합 재료의 이론은 일반 기술자들이 이해하기 힘드나, 본 논문에서는 이러한 문제를 비교적 쉽게 정확히 해석하는 방법을 제시하고, 예로서 3경간 연속 판 교량과 포스트텐션된 강교의 해석을 보여준다.
김한성,최현준,주미,장선희,곽지은,김철남 인제대학교 2006 仁濟醫學 Vol.27 No.-
Typical serous cystadenoma of pancreas is formed by many microcysts, of which diameter are less than 2cm. Recently, rare variants are also reported as macrocystic, unicystic, or multicentric. Macrocystic serous cystadenoma is diffcult to differentiate from pseudocyst, mucinous cystadenoma and other cystic mass having macrocysts. As these lesions have different symptoms, methods of treatment, and prognoses, it is important to diagnose and treat correctly. We report 2 cases which diagnosed as macrocystic serous cystadenoma with stressing scarcity value and clinical importance.