인천지역 TDI 노출 작업자에서 직업성천식 유병율

김형렬,김철우,홍윤철,전형준,김치년,김현수,이지나,신주연,고동희,노재훈 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.2

목적 : TDI는 직업성천식을 일으키는 대표적인 물질로 알려져 있다. 과거 TDI에 노출된 작업자들의 천식 발생률을 5~6%가량 보고하였고, 국내에서도 2-20%에 이르는 유병율을 보고한바 있다. 작업환경이 많이 개선되고, 노출량이 감소된 최근에도 TDI에 의한 직업성천식에 대한 보고가 많이 이루어지고 있어, 이에 대한 적극적인 조사와 진단과정을 통해 유병율을 구하고 질병발생의 변화양상을 파악해 보고자 하였다. 방법 : 인천지역에서 특수건강진단을 수행하는 2개 기관의 TDI 노출 근로자 400여명 중, 사업장의 규모가 50인 이상이며 사업주가 연구진행을 허락한 사업장에서 근무하는 근로자 중 직접적으로 TDI에 노출되는 작업에 종사하는 근로자 170명을 연구대상으로 하였다. 이들에 대해 설문지와 산업의학의사의 면담을 통한 작업관련성 평가를 근거로 정밀대상자를 선정하고 이들에 대해 메타콜린 유발시험, TDI 유발시험 등을 수행하여 직업성천식을 확인하였다. 결과 : 설문조사 결과 11명이 직업과 관련하여 천식증상을 보이는 것으로 나타났고(6.9%), 이중 7명에서 메타콜린 유발검사 양성소견을 보였다. TDI에 의한 특이유발시험 결과 1명에서 양성반응이 나타나, 이 집단에서 TDI에 의한 직업성천식의 유병율은 0.58%였다. 결론 : 과거 국내연구에서 TDI에 의한 직업성천식의 유병율이 2~20%에 이르렀던 데 비해, 본 연구에서는 0.58%로 나타났다. 이는 국외 논문에서도 나타나는 경향으로 작업장 노출량 감소로 점차 발생률이 감소하는 양상을 보이고 있다. 그러나 이미 증상이 나타난 근로자들이 부서를 옮기거나, 직장을 그만둠으로 인해 그 유병율이 과소평가되었을 가능성도 있다고 판단된다. Objecdives: This study was carried out to estimate the prevalence of isocyanate-induced occupational asthma in toluene diisocyanate (TDI) exposed workers. Methods: We examined 170 workers who had been directly exposed to TDI through a medical questionnaire, physical examination, and pulmonary function test. Based on screening examination, workers with suspected occupational asthma were selected for further evaluation such as methacholine and TDI challenge tests. Results: Eleven (6.9%) among 170 workers complained of symptoms of occupational asthma. and 7 among these 11 symptomatic workers showed positive responses to the methacholine challenge test (4.1 %). One spray painter was confirmed as having the TDI induced occupational asthma following a positive response to TDI challenge test. Conclusions: The prevalence of TDI-induced asthma was at 0.58% was lower than that for former studies (2-20%). Improved workplace environment, lower level of TDI exposure compared to the past, and the healthy workers effect may have contributed to this low rate of asthma prevalence in workers with TDI exposure.

분편 인플루엔자백신(split influenza vaccine)의 임상효과 및 면역원성에 관한 연구

우흥정,김동림,정희진,천병철,이주연,안정배,김지희,박찬,신영규,김우주,김민자,박승철 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.1

목적 : 아단위 인플루엔자 백신 접종 후 백신의 인플루엔자 예방효과, 인플루엔자 방어 항체형성, 인플루엔자 백신의 안전성을 조사하고자 하였다. 방법 : 총 571명을 대상으로 인플루엔자 백신 접종을 하였고, 이들 접종자에서 인플루엔자 양질환의 이환을 조사하여 인플루엔자 백신의 인플루엔자예방효과를 알아보았고, 백신의 접종 전 및 접종 4주 후 혈청에서 혈구응집억제물(Hemagglutination Inhibition : HAI) 항체 검사를 실시하여 백신의 방어항체생성을 조사하였고, 백신의 안전성을 알아보기 위해 백신접종 후 1주일 이내의 부작용을 조사하였다. 결과 :백신 접종군과 백신 비접종군에서 인플루엔자 양 질환의 이환을 조사한 결과 접종군 28.35%, 비접종군 35.88%으로 나왔으며, p 값이 0.001로 통계적으로 접종군에서 유의하게 낮았고, 인플루엔자 양 질환의 예방 효과는 20.97%를 보였다. 백신의 방어항체 형성의 평가를 위해 유럽의 인플루엔자 백신 허가 기준을 조사하였는데 B/Guangdong/5/94균주의 백신접종 후 항체가 40이상의 비율을 제외한 다른 기준은 모두 만족 시켰다. 부작용은 전체 조사자 521명중 149명(29%)으로 주로 접종 부위의 국소 부작용을 호소했고, 전신 부작용은 2% 내외였으며 특별히 심각한 부작용은 발견되지 않았다. 결론 : 분편 인플루엔자 백신은 인플루엔자양질환의 예방과 방어항체생성에 효과 있으며 안전한 것으로 사료된다. Background : The safety and effectiveness of influenza vaccine are well known in developed country. The influenza vaccination has been recommended as one of the tentative immunization schedule for indicated persons since 1997 in Korea. But there are still no available data about them, even though nearly 5 million doses of influenza vaccine were used in 1997-1998 season. So it is immediately needed to investigate the safety. efficacy and immunogenicity of influenza vaccine among Korean. Methods : We studied the clinical efficacy of influenza vaccine by monitoring Occurrence of influenza-like illness in influenza risk group(vaccination ; 300, non-vaccination; 215) from December in 1997 to March in 1998. We used the split quadrivalent influenza vaccine containing 15 microgram of hemagglutinin of A/Beijing/262/95(HlNl), A/Wuhan/359/95(H3N2), B/Mie/1/93 and B/Guangdong/5/94. Hemagglutination inhibition(HA1) antibody titers were determined before immunization and 1 months after vaccination And we evaluated adverse effect of influenza vaccination at 7 days after vaccination. Results : Influenza vaccination was associated with si@icant reductions in influenza-like spptoms(vaccination group; 28.35%, non-vaccination group, 35.88%, p=0.001). The preventive effect of influenza-like i3lne.s among influenza risk goup was 20.97%. And immunogenicity of influenza A and B exceeded all of the European licensure criteria for immunogenicity except postvaccination proportion of titers 240 of B/Guangdong/5/94 strain. And the adverse effects were mainly local injection site problem and no serious adverse effect was noted. Conclusion : Split influenza vaccine is safe, inmunogenic and eff'tive in influenza risk group in Korea.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

인삼 선발계통의 지역적응성 검정

Bong Jae Seong,Sun Ick Kim,Ka Soon Lee,Moo Geun Jee,Su Dong Kim,A Reum Kwon,Hyun Ho Kim1,Young Chang Kim 한국약용작물학회 2017 한국약용작물학술대회 발표집 Vol.2017 No.05

Background : For cultivation of varieties of ginseng, the pure line selection method, which is to select the best among those cultivated in farms for pedigree breeding, replicated yield trials and regional adaptation trials before registering as a new variety, is widely used. Although there are 25 registered varieties of ginseng in Korea, the quality of ginseng is declining together with the amount of harvest being decreased by 15 - 20% due to the heat injuries and diseases from the warming & abnormal climate. Thus, the needs for development of disaster-resistant varieties with better chances of surviving through high temperature, salts and disease are increasing. Therefore, this study is to cultivate disaster-resistant varieties among those selected for their disaster tolerance and salt tolerance through regional adaptation trials. Methods and Results : As a result of examining the growth characteristics of the selected 2 - 5 year old varieties used in the study, among the 5-year old crops, Goryeo 4 and Eumseong 5 showed superior growth in both above and below aerial parts, and among the 4-year old crops, Eumseong 11 and Cheonryang showed superior growth while the growth in the below aerial parts were satisfactory in the order of Cheonryang > Eumseong 10 > Eumseong 11 > Eumseong 9. Among the 3-year old crops, the most superior growth in both above and below aerial parts was observed in Eumseong 14 with the weight of the below aerial part, root diameter and taproot length at 13.8 g, 11.8 ㎝ and 6.2 ㎝ respectively. Among the 2-year old crops, Eumseong 10 showed the most superior growth in both above and below aerial parts. Conclusion : Based on the above results, Goryeo 4 and Eumseong 5 among the 5-year old crops, Eumseong 11 among the 4-year old crops, Eumseong 14 among the 3-year old crops and Eumseon 10 among the 2-year old crops showed the most superior growth among the selected varieties. The growth characteristics of both above and below aerial parts in each year will continuously be monitored.

건전지의 본질안전 방폭성 평가에 관한 연구

지승욱,이광식,이동인,박원주,이춘하,김하호 嶺南大學校 工業技術硏究所 1997 工業技術硏究所論文集 Vol.25 No.1

Ignitability of explosive gas mixture by spark of dry cell in case of short circuit by accident was studied for the purpose of evaluation of intrinsically safe characteristics of dry cell that manufactured in Korea. IEC type spark test apparatus, 21±2[vol%] of hydrogen-air mixture, and dry cell that produced in Korea was used for the experiment. The result of this research could be used for design, manufacturing and using the intrinsically safe electrical apparatus.

심하게 변위된 유전치 치근파절의 보존적 접근

김지영,이광희,김대업,라지영,이동진 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.3

유치열에서의 치근파절은 유치열의 손상 유형 중 2∼7% 정도를 차지하고 생리적 치근흡수가 시작하는 3∼4세 쯤 흔히 나타난다. 파절선의 위치에 따라 치근단 ⅓,중간 ⅓ ,치경부⅓으로 분류되며 치경부 ⅓에서의 치근파절이 예후가 가장 불량하다. 유치의 치근파절이 발생한 경우 파절편의 변위가 적고 감염의 소견이 없으면 영구치의 경우와 같이 2∼3개월의 선부자고정으로 치료할 수 있으나,파절편의 동요 및 변위가 심하거나 선부자고정을 할 수 없을 때에는 치관부 파절편은 제거하고 영구치배의 안전을 위해 치근부 파절편은 잔존시킨다. 본 증례는 유전치의 치근파절이 발생하여 치관부 파절편의 변위가 섬한 경우에서 발치하지 않고 정복 후 선부자 고정을 1∼3개월 간 시행하고,파절편의 동요,동통,치수괴사,감염 등의 증상없이 치유되는 양호한 결과를 얻었기에 보고하고자 한다. Root fracture of primary teeth is relatively uncommon because the more pliable alveolar bone allows displacement of the tooth. Root fracture of primary teeth is occupied 2∼7% in trauma pattern of primary teeth. A horizontal root fracture is classified based on the location of the fracture in relation to the root tip : the apical third, middle third, or cervical third of the root. The prognosis worsens the further cervically the fracture has occurrer. Root fracture of primary teeth should be treated by splinting the incisor to the adjacent normal teeth with a resin-wire splint for 8∼12 weeks. However, if a portion of the root is abscessed or extremely mobile, it can be extracted, and the remaining root fragment will resorb normally. For coronal third fracture in primary teeth, the coronal third is extracted, leaving the apical portion of the root to resorb normally. These root fracture cases of primary teeth were treated by resin-wire splinting despite extremely mobile coronal fragment. Even though they seems like healing well, They need to be monitored regularly until their successors erupt.

웹 학습 싸이트에서 링크 제시 기법의 효과

김동식,김지일,한지호 한국교육정보방송학회 2001 교육정보미디어연구 Vol.7 No.3

본 연구에서는 링크 제시 기법이 학습자의 학습 능력에 따라 상호작용 빈도와 웹 학습 싸이트에 대한 태도 및 네비게이션 패턴에 어떠한 영향을 미치는가를 규명하고자 하였다. 링크의 제시 기법에서 적응적 제시기법이란 하이퍼 공간에서 링크의 제시를 변화시킴으로써 학습자의 학습 구조 파악과 탐색을 지원하기 위한 기법이다. 이중에서 가장 많이 사용되는 기법이 학습자의 현재 학습목표와 관련이 없거나, “적절한” 내용과 관련이 없는 링크를 숨김으로써 학습자의 방향상실을 줄이고자 하는 링크 숨기기 기법이다. 연구 가설들을 검증하기 위해 서울시내에 위치한 N 초등학교 6학년 2개 학급을 무선적으로 선정해서 실험집단과 통제집단에 각각 1학급씩 40명을 배정한 후 실험집단은 링크 숨기기 기법이 적용된 프로그램 으로 학습을 진행하였으며, 통제집단은 동일한 주제를 가지고 제작된 링크 일반 제시 기법의 프로그램으로 학습을 진행하였다. 연구 결과 링크 숨기기 기법을 적용한 집단이 링크 일반 제시 기법을 적용한 집단보다는 웹 학습 싸이트에 대한 태도에 있어 좀 더 긍정적이었다는 결과가 검증되었고, 링크 숨기기 기법을 적용한 집단이 링크 일반 제시 기법을 적용한 집단에 비해 네비게이션 패턴에 있어 학습의 핵심 노드를 집중적으로 학습한 결과를 보였다. In the web-based learning site, learner may interact learning contents using a variety of links. Thus, ways of providing the link take an important role in supporting effective learning of web-based learning environments. The purposes of this study are to analyze the effects of linking techniques on the frequency of interaction, learner's attitude toward the learning environment and navigating pattern with learner's levels of relevant prior knowledge. This study utilized two types of linking technique : general linking technique and link hiding technique. In order to test the effects of selected independent variables on the dependent measures, two types of web site applying the linking techniques were developed. The content of two web-based learning programs were same except the linking types. The hypotheses were formulated as follows. First, there would be the significant differences in the interaction frequency between linking techniques and learner's levels of relevant prior knowledge. Second, there would be the significant differences in the learner's attitudes toward web-based learning site between linking techniques and learner's levels of relevant prior knowledge. Third, there would be the significant differences in the navigating pattern between a link hiding technique and a general linking technique. To verify these hypotheses, the subjects of this study were 80 6th grade students selected into 2 classes of elementary school located in Seoul. The subjects were classified into two groups : 40 students of a class were participated in web-based learning situation given by program which applied to general linking technique, and another 40 students of a class were participated in web-based learning situation given by program which applied to link hiding technique. In order to verify the effects of the experiment, the instruments used in this study were the Nodal Frequencies and Propositions Analysis, the Learning Attitude Test for Web-based Learning Site, the Audit Trail Tree Pattern Analysis. The experiment had been lasted for one week from May 29 to June 3 in 2000. To testify the effects of this experiment, tests were examined and their results were compared with each other. For statistical analysis, ANOVA procedure was applied by using the SPSS(version 8.0). Major findings of this study may be summarized as follows. First, there were not the significant differences in the interacting frequencies between general linking technique and link hiding technique(F=0.29, p>.05). But, there were the significant differences in learner's attitude toward web-based learning site between general linking technique and link hiding technique(F=5.26, p<.05). Second, there were the significant differences in the learner's attitude between superior learners and inferior learners(F=4.10, p<.05). And, there were the significant differences in the interaction frequencies between superior learners and inferior learners(F=33.21, p<.05). Third, there were the different appearance in the navigating patterns between general linking technique and link hiding technique. In conclusion, the link hiding technique was more effective than general linking technique to get a desirable learning attitude toward web-based learning site. And learner who had been navigating by using link hiding technique was seen more effective learning pattern. This study is only an initial to solve the problem of ease of link in web-based learning site. Further studies will be required across cognitive linking strategies, adaptive linking techniques, and intellectual linking techniques.

장기간 운동이 노인들의 심혈관계 기능 변화에 미치는 효과

지용석,김동진,유신환 대한스포츠의학회 2004 대한스포츠의학회지 Vol.22 No.1

The purpose of this study was to investigate the change of related factors in cardiovascular function variables after long duration regular exercise programs. The subjects of this study were 40 older man and women residing Seoul-Seniors-Tower. All of subjects divided to four groups, exercise group 20(man = 10, women = 10) was participating in an exercise program for 3 years, and the other group or non-exercise group 20(man = 10, women = 10) was not in that program. In the results, Changes of cardiovascular function were significantly improved in peak oxygen uptake, ventilation, rest blood pressure of cardiovascular function variables in male or female exercise groups after 3 years' exercise program. Also, we have been known to the facts that although the cardiopulmonary variables of men are superior to those of women, if being exercised for a long time, the women's cardiopulmonary variables(e.g. Endurance time, HRrest, SBPrest, SBPmax, DBPrest, RPPrest, and RPPmax) would not different from those of the men especially in old ages. As a conclusion, we could know that not only the regular exercise might increase or change almost the cardiovascular function variables except for V ˙O2max, Ventilation, and HRmax of elderly people, but also the sex's differences were vanished in endurance time, HRrest, SBPrest, SBPmax, DBPrest, RPPrest and RPPmax between males and females. Therefore, we might tell that exercise programs could provide an excellent parameters for enforcing or keeping the cardiovascular functions of elderly people.

국내 부산물 다염화비폐닐(PCBs) 배출량 예비 평가

김경미,조규탁,이지윤,이지은,이동수 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.2

The main objectives of this study were to identify from literature review the potential sources and to provide a preliminary national emission inventory for the unintentionally produced polychlorinated biphenyls(PCBs) (i.e., by-product PCBs). In Korea, fuel combustion, waste combustion, thermal industrial processes, and transportation were identified as potential sources of by-product PCBs. According to the availability of the emission factors and/or activity data, emission inventory could be assessed only for fuel combustion, waste combustion, steel industry, non-ferrous industry, and non-metallurgical industry. The total national emission of by-product PCBs was estimated to be 1087kg for the year 2000. The preliminary estimation further indicated that the steel manufacturing was the single dominant emission category, contributing 93% to the total emission. Of the steel manufacturing processes, the contribution of the electric are furnace was about 80% of the total emission. Due to high uncertainty associated with both the emission factors and activity statistics, the emission estimates in this study are likely to contain significant errors. However, the results of the present work could serve the first step toward future efforts to establish national source and emission inventories of by-product PCBs.

관동맥 우회로술 중 경식도 심초음파도로 관찰한 도부타민 투여후와 우회로술후의 좌심실 국소벽운동

김희열,김종진,윤호중,유기동,박지원,이길환,노태호,채장성,김재형,홍순조,최규보 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8