Protective Effects of N-acetylcystenine and Selenium against Doxorubicin Toxicity in Rats

Yeo-sung Yoon,Sun-don Kim,Min-hye Lee,Heung-shik S.Lee,In-se Lee,Je-kyung Sung,Eun-sung Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Effects of N-acetylcysteine and Selenium against Doxorubicin Toxicity in RatsEun-sung Park, Sun-don Kim1, Min-hye Lee, Heung-shik S. Lee, In-se Lee, Je-kyung Sung and Yeo-sung Yoon*

Dissolved Air Flotation(DAF) 접촉조의 수리동력학적 조건이 입자의 제거에 미치는 영향

유제선,김성훈,신은허,박희경 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1

Hydrodynamic conditions for optimum solids capture within the contact zone, which are governed by the geometry and flow, are not yet well understood. In this research, dimensionless parameters which represent hydrodynamic conditions in the contact zone were derived, using the Buckingham π theorem. Those parameters are Reynolds No. (Re), Froude No. (Fr), Weber No. (We), Local Weber No., and Bubble Capacity No. (Bc). The particle removal rate was investigated by changing each value of the dimensionless parameters. The experimental results indicate that particle removal rate, when gravity dominates and the flow is semi-turbulent (Fr < 0.3, Re < 8000), is higher than when inertia dominates and flow is turbulent. For the We, higher removal rates were obtained in the range of the We < 40. Relative to the Local We, smaller bubbles which are influenced more by surface tension than inertia, demonstrated a higher particle removal rate than larger bubbles. For the Bc, the optimal range is from 0.3 to 0.5. We suggest that these dimensionless parameters can be used to diagnose the performance of and to design a DAF reactor.

레니텍^(�) 정(말레인산 에날라프릴, 10mg)에 대한 에나레이스 정의 생물학적 동등성

조성희,하용화,홍성제,서성훈,류재환,김동현,이경태 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

The purpose of present study was to evaluate the bioequivalence of two enalapril maleate tablets, Renitec^(™) (MSD Korea Ltd.) and Enalace ^(™) (Welfide Korea Ltd.), according to the guidelines of Korea Food Drug Administration (KFDA). Twenty-four normal male volunteers, 22.33±2.55 year in age and 66.54±8.30 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containint 10 ㎎ of enal-april maleate per tablet wre orally administered, blood was taken at predetermined time intervals and concentrations of enalapril in plasma were determined using LC-MS-MS. Pharmacokinetic parameters such as AUC_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t) and C_(max) untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transfored data were acceptance range of log0.8 to log1.25(e.g., log1.02∼log1.14 and log1.03∼log1.19 for AUC_(t) and C_(max), respectively). The major parameters, AUC_(t) and C_(max), met the criteria of KDFA for bioequivalence indicating that Enalace^(™) tablet is bioequivalent to Renitec^(™) tablet.

우심방과 우심실의 거대 심장 혈관종 1예

김제열,조상호,김건일,허경림,김현숙,조구영,최영진,이원용,임종윤 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Cardiac tumors, especially the primary tumors involving any part of the heart are extremely rare and its relative incidence has been reported to be approximately 0.02%. We report a patient with huge cardiac hemangioma who complained of shortness of breath, general weakness, and dizziness, Imaging study by echocardiography and computed tomography of thorax revealed a huge lobulating mass like a bunch of grapes in the right chamber of heart. The surgical exploration of thorax was performed and a histological diagnosis of spindle cell hemangioma was obtained by microscopy. The patient was treated by surgical resection of the tumor and doing well after surgery. Our experience indicated that prompt diagnosis and treatment of cardiac hemangioma is imperative for patients' prognosis.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

養液栽培 管理方法에 關한 硏究

金炅濟,林相喆 東國大學校 1989 論文集 Vol.28 No.-

This study was conducted in 1984 and 1985 to utilize the simplified cultural equipments and find the simplified cultural methods in nutrient solution culture. Results obtained were as follows : 1. material cost of equipment it lowest priced in water culture and highest priced in rice-charcoal culture made of stylofoam. 2. ratio of culture bed to total cost ranges from 37.2% to 51.3%. 3. although circulating system was more effective than air comp, the air comp is usuable in case of small simplified cultural practice. 4. incase of spray culture, highly concentration of solution were promotive to rapid growth and more yield in cucumber and tomato.

합성섬유보강 콘크리트의 구속수축균열 제어특성연구

박제선,윤경구,이주형,최성용,김태환 강원대학교 부설 석재복합신소재 제품연구센터 1999 석재연 논문집 Vol.4 No.-

최근에 폴리프로필렌 섬유를 첨가하여 콘크리트의 인성을 증가시키고, 균열에 대한 저항성을 향상시키고자 하는 노력이 계속되어 왔다. 그러나 첨가된 섬유의 구조에 대한 이해부족으로 인하여 연구자들간에 실험결과에 대한 해석이 상이한 경우가 많았다. 이러한 연구의 일환으로 섬유의 첨가에 따른 건조수축 균열의 조절 가능성을 분석하기 위하여 섬유의 첨가에 따른 유동성과 건조수축의 변화를 조사하였다. 섬유의 첨가에 따른 유동성의 변화와 건조수축을 측정하기 위한 강제링 시편을 제작하였다. 본 연구에서는 섬유를 첨가한 콘크리트의 역학적 거동특성인 압축강도, 휨강도, 인성, 그리고 균열특성을 실험적으로 규명하고자 하였다. 본 연구는 강도 및 건조수축특성을 규명하기 위하여 수행되었고 섬유의 영향으로 인한 건조수축특성을 예견할 수 있다. Polypropylene Fibers have been used to increase the toughness of concrete and to increase the resistance to crack formation. However, there are many contradictory argument about the effectiveness of the fiber due to the lack of knowledge about the mechanism of fiber in concrete. In order to study the effect of fibers on possible crack control, the effects of fibers on workability and drying shrinkage have been studied. The workability change due to the addition of fibers has been studied, and full size concrete steel ring specimen have been cast at field to investigate the effect of fibers on the shrinkage properties. This laboratory have been performed to obtain the properties of pp fiber reinforced concrete such as compressive, flexural strength, toughness, slump, drying shrinkage crack and drying shrinkage characteristics. The present study was performed clarify the strength and drying shrinkage properties. From these results, we can expect the effect of the admixtures of polypropylene fiber for concrete and mortar about strength and drying shrinkage properties.

燻炭栽培時의 給液時間이 오이와 토마토의 生育과 收量에 미치는 영향

林相喆,金炅濟 동국대학교 대학원 1989 大學院硏究論集-東國大學校 大學院 Vol.19 No.-

This study was conducted to investigate the effect of supplying interval of solution on the growth of cucumber and Tomato in nutri-culture. The major results obtaince were as follows. 1. Cucumber 1) Plant growth in early stage, as well as total yield, was the best in 30∼30 treatment. 2) First harvesting date was 7 and 12 days earlier in 30∼30 treatment than in 30∼90, 30∼150 treatment. 3) It can be recommended that the optimum supplying time of solution in cucumber should be 30∼30 until middle stage to promote the growth and then 30∼90. 2. Tomato 1) As the supplying time increased, over growth was obseued but retarded growth was found in 30∼150 treatment. 2) The plant height and stem diameter were good 30∼90 treatment and total yield of that treatment was similar to 30∼30 treatment. 3) Suitable supplying interval of solution in tomato was 30∼90 from early to late stages constantly.

전산유체 기법을 이용한 DAF 부상조에서의 수리 특성 고찰

김성훈,유제선,김영미,박희경 대한상하수도학회 2002 상하수도학회지 Vol.16 No.4

Dissolved air flotation is a solid-liquid separation process that uses fine rising bubbles to remove particles in water. DAF is found most effective in treating algae and lower density flocs that are hard to remove in sedimentation process. Some researcher reports the results of an experimental study which examined the flow within the flotation zone of a DAF tank (ONeill at al., 1997). I would be concluded that, in general, the flow within flotation zone is robust and that differences in the performance of individual DAF tanks must be the result of processes occurring within the contact zones of these tank, not as the result of flotation processes. In this research, the authors thought that the efficiency of the DAF process is strongly related to bubble size. It means bubble rising velocity at the air injection nozzle is most important factor of DAF process. However, bubble movement in DAF tank is somewhat complicate, so it is hard to make up conceptual model through simple mass balance as other researchers did (Leppinen at. al., 2000). For the modeling of turbulent 2-phase flow in the tank, the standard k-ε model was used in CFD code because it is widely accepted and the coefficients for the model are well established. This model uses the eddy-viscosity hypothesis for the turbulence. As the result of this study, the authors concluded that bubble size and its rising velocity is very important factor of DAF process and the recycle ratio must be also consider for the flotation zone parameter. Also, For the improved model, relation between turbulent intensity and bubble-particle attachment must be studied.

Methicillin내성 포도 구균의 기타 항균제에 대한 감수성

이경수,이제철,설성용 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.1

A total of 204 strains of Staphylococcus aueus isolates in 1987, 1988, and 1989 were studied for the frequency of methicillin-resistant S. aureus (MRSA) and antimicrobial susceptibility and also were examined for oxacillin screening tst and change of minimal inhibitory concentration (MIC) of methicillin at the various conditions. When S. aureus were incubated on the agar media supplemented with 4% NaCl at 35℃ for 72 hours, 33(16.2%) of 204 strains were resistant to methicillin. In oxacillin screening test, oxacillin resistance was found in 33 (16.2%) of the 204 strains. Compared to the MIC of methicillin, oxacillin screenigng positive strains were not same strains of methicillin resistant S. aureus. Total frequency of MRSA was 24 (11.8%) of 204 strains. The frequencies of MRSA in 1987, 1988, and 1989 were 12 strains (9%), 11 strains (16.9%), and 1 strain(20%), respectively and MRSA increased yearly. All MRSA had multiple antibiotic resistance from 9 to 15 tested antibiotics and resistance to 12 antibiotics was the most predominant. All MRSA were resistant to kanamycin, gentamicin, penicillin and cefoxitin. More than 75% MRSA were resistant to amikacin, cefotaxime, cephalothin, tetracycline, rifampin and erythromycin. All MRSA were susceptible to minocycline, vancomycin and trimethoprim-sulfamethoxazole. More than 75% MRSA strains were susceptible to norfloxacin, ciprofloxacin and doxycycline.