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Protective Effects of N-acetylcystenine and Selenium against Doxorubicin Toxicity in Rats
Yeo-sung Yoon,Sun-don Kim,Min-hye Lee,Heung-shik S.Lee,In-se Lee,Je-kyung Sung,Eun-sung Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2
Effects of N-acetylcysteine and Selenium against Doxorubicin Toxicity in RatsEun-sung Park, Sun-don Kim1, Min-hye Lee, Heung-shik S. Lee, In-se Lee, Je-kyung Sung and Yeo-sung Yoon*
Yoon, Yeo Cho,Hwang, Jin-Teak,Sung, Mi-Jeong,Wang, Shuaiyu,Munkhtugs, Davaatseren,Rhyu, Mee-Ra,Park, Jae-Ho Published for International Union of Biochemistry 2012 Biofactors Vol.38 No.5
<P>Luteolin is a flavonoid in many fruits and vegetables. Although luteolin has important biological functions, including antioxidant, anti-inflammatory, antimicrobial, and neuroprotective activities, little is known about the functions of luteolin in the olfactory system. Various odorants can be detected and distinguished by using several molecular processes, including the binding of odorants to odorant receptors, activation of adenylyl cyclase (AC), changes of cyclic adenosine monophosphate (cAMP) and Ca(2+) levels in olfactory sensory neurons, as well as changes in membrane potentials and the transmission of electric signals to the brain. Because AC-cAMP signal transduction plays a pivotal role in the olfactory system, we evaluated the effects of luteolin on the AC-cAMP pathway that had been stimulated by the odorant eugenol. We demonstrated that eugenol caused an upregulation of the cAMP level and the phosphorylation of phosphokinase A (PKA, a downstream target of cAMP) in human embryonic kidney 293 (HEK293) cells expressing the murine eugenol receptor. This upregulation significantly decreased in the presence of luteolin, suggesting that luteolin inhibited the odorant-induced production of cAMP and affected the downstream phosphorylation of PKA.</P>
COVID-19 Vaccine Induced Systemic Inflammatory Response Syndrome
( Sang-heon Kim ),( Soo Jin Lee ),( Sung Jun Chung ),( Yoomi Yeo ),( Hyun Lee ),( Tai Sun Park ),( Dong Won Park ),( Ji-Yong Moon ),( Tae-hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
To protect people from coronavirus disease 2019 (COVID-19), various types of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and administered. Adverse reactions to COVID-19 vaccines include various local and systemic adverse reactions which may occur immediately or weeks later. Here we report a case of systemic inflammatory response syndrome induced by COVID-19 vaccine. A 65-year-old man with a history of hypertension presented with 5 days of fever. On admission, he was febrile to 38.3℃ with mild dyspnea when experiencing febrile sensation. Six days ago, he was vaccinated with the BNT162b2 mRNA COVID-19 vaccine. Fever with chill developed one day after vaccination and persisted. Chest radiography and a CT scan showed bilateral pleural effusion. Abdomen CT showed interstitial edematous pancreatitis at pancreas tail and perinephric infiltration. PET/CT revealed diffuse hypermetabolic infiltration or activity in mediastinal fat tissue, pericardial and peritoneal thickening. Laboratory Results documented leukocytosis, elevated levels of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and C-reactive protein. There was no evidence of possible infectious diseases or rheumatic diseases after a full examination and consultation with the specialists. With the administration of high-dose oral corticosteroids, fever and pleural effusion disappeared gradually. These findings suggest systemic inflammatory response syndrome induced by COVID-19 mRNA vaccine.
Persistence of Chinese Milk Vetch(Astragalus sinicus L.) Seed in Naturally Reseeded CMV-Rice Field
Sang-Yeol Kim,Sung-Hwan Oh,Jong-Hee Lee,Jun-Hyeon Cho,Kuk-Hyun Jeong,Ji-Yoon Lee,Sung-Tae Park,You-Chun Song,Un-Sang Yeo,Jeong-Il Kim,Hang-Won Kang 한국작물학회 2010 한국작물학회 학술발표대회 논문집 Vol.2010 No.04
Field experiments were conducted to investigate persistence of Chinese milk vetch(CMV) seed under naturally reseeded CMV-rice cropping systems during the period of 2007~2009. Persistence of the CMV seeds were evaluated in the naturally reseeded CMV-rice field on different tillage methods and soil depths based on the seed number recovered and the seed longevity in soil. Field observation in the naturally reseeded CMV rice field showed that as many as 917~2,185 CMV seeds m-2 were found from 0~15cm soil depth in the rotary tillage and 250~10,105 CMV seeds in minimum tillage rice cultivation in autumn. The recovered seed germinated 25~33%, 23~43% but still had high percentage of hard seed having 64~72% and 51~77%. Field experiment showed that the CMV seedling still emerged even after 2 years of continuous destructive killing of emerged CMV plant by rotary tillage in naturally reseeded CMV-rice field, indicating that CMV seeds persistent at least two years in rice field.
Yoon, Yeo-Taek,Lee, Sang-Shin,Lee, Byoung-Su Elsevier 2012 Photonics and nanostructures Vol.10 No.1
<P><B>Highlights</B></P><P>► We propose a highly efficient visible wavelength filter enabling a homogeneous integration with an image sensor, which can be fabricated by employing an advanced standard 90-nm CMOS process. ► We design and implement the proposed device incorporating a metallic subwavelength grating embedded in a CMOS image sensor. ► We analyze the characteristics of the visible wavelength filter by referring to the practical metal-grating structures.</P> <P><B>Abstract</B></P><P>A highly efficient visible wavelength filter enabling a homogeneous integration with an image sensor was proposed and manufactured by employing a standard 90-nm CMOS process. A one dimensional subwavelength Al grating overlaid with an oxide film was built on top of an image sensor to serve as a low-pass wavelength filter; a microlens was then formed atop the filter to achieve beam focusing. The structural parameters for the filter were: a grating pitch of 300nm, a grating height of 170nm, and a 150-nm thick oxide overlay. The overall transmission was observed to reach up to 80% in the visible band with a decent roll-off near ∼700nm. Finally, the discrepancy between the observed and calculated result was accounted for by appropriately modeling the implemented metallic grating structure, accompanying an undercut sidewall.</P>
Yoon, Young-Cheol,Kim, Kyeong-Hwan,Lee, Sang-Ho,Yeo, Donghun Elsevier 2018 Energy and buildings Vol.174 No.-
<P><B>Abstract</B></P> <P>This study presents a sustainable design method that optimizes the embodied energy and carbon dioxide (CO<SUB>2</SUB>) emissions of a reinforced concrete (RC) column. Conventionally, the design of RC structures has been focused on the minimization of construction costs while satisfying the structural design code. Recently, however, sustainability aspect in structural design has drawn big attention to structural engineers, especially for structure life cycle assessment. Therefore, it is crucial to understand the relationship between construction costs and consumption of energy including CO<SUB>2</SUB> emissions, in the design process of RC structures. In the sustainable design process, the objective functions for the cost, embodied energy, and CO<SUB>2</SUB> emissions were set and numerous optimization analyses for various loading conditions were conducted as the failure mode of RC columns varies according to the eccentricity involving the axial forces and moment. A thorough investigation of the optimization analysis results shows that, when a 10% cost increase is assumed, the embodied energy and CO<SUB>2</SUB> emissions might undergo an overall reduction of up to 22% and 63%, respectively. As a result, the proposed design method enables the embodied energy and CO<SUB>2</SUB> emissions to be effectively optimized in the conventional design process of RC columns.</P>
Yoon, Yeo Min,Han, Yong-Seok,Yun, Chul Won,Lee, Jun Hee,Kim, Rang,Lee, Sang Hun MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.10
<P>Mesenchymal stem cells (MSC) could be a candidate for cell-based therapy in chronic kidney disease (CKD); however, the uremic toxin in patients with CKD restricts the therapeutic efficacy of MSCs. To address this problem, we explored the effect of pioglitazone as a measure against exposure to the uremic toxin <I>P</I>-cresol (PC) in MSCs. Under PC exposure conditions, apoptosis of MSCs was induced, as well as PC-induced dysfunction of mitochondria by augmentation of mitofusion, reduction of mitophagy, and inactivation of mitochondrial complexes I and IV. Treatment of MSCs with pioglitazone significantly inhibited PC-induced apoptosis. Pioglitazone also prevented PC-induced mitofusion and increased mitophagy against PC exposure through up-regulation of phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK-1). Furthermore, pioglitazone protected against PC-induced mitochondrial dysfunction by increasing the cytochrome c oxidase subunit 4 (COX4) level and activating complexes I and IV, resulting in enhancement of proliferation. In particular, activation of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) regulated the pioglitazone-mediated up-regulation of PINK-1. These results indicate that pioglitazone protects MSCs against PC-induced accumulated mitochondrial dysfunction via the NF-κB–PINK-1 axis under <I>P</I>-cresol exposure conditions. Our study suggests that pioglitazone-treated MSCs could be a candidate for MSC-based therapy in patients with CKD.</P>