18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

생약추출물 유도형 Nitric Oxide Synthase 저해활성 검색

류재하,이소영,박재현,이화진,장세란,은진희,김남이,정연수,장미경,최영은,이숙현,손행자,안한나,고혜진 숙명여자대학교 약학연구소 2001 약학논문집-숙명여자대학교 Vol.17 No.-

Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS: cNOS and iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of herbal drugs which have been used for the treatment of inflammation in oriental medicine. We have screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among the 81 kinds of extracts of herbal drugs, 34 extracts showed potent inhibitory activity of NO production above 50% at the concentration of 50 (μg/ml. The inhibitory activities of NO production were also evaluated for several solvent fractions at three different concentrations. Especially, hexane soluble fractions of Agrimonia pilosa, Hydrangea serrata, Machilus thunbergii, Prunella vulgaris, Saussurea lappa, Tussilago farfara, and ethyl acetate soluble fractions of Angelica gigas, Ostericum koreanum, Torilis japonica, Perilla frutescence showed moderate activity at 10 and/ or 25 (μg/ml. These fractions are promising candidates for the study of the activity-guided chromatographic purification of active compounds.

영양표시정착화사업(Ⅱ) : 식품참고량설정에 관한 연구 Study on the Establishement of the Reference Amount in Foods

김대병,장영미,김인복,이혜영,장재희,김보영,이정구,김창민,정해랑 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 영양표시에서 1회분량 및 영양소함량표시의 기준으로 사용되는 "식픔창고량"에 관한 연구를 수행하므로써 합리적이고 일관성있는 영양표시기준 개선을 위한 기초자료로 활용코자 하였다. 이를 위하여 미국 및 캐나다를 중심으로 제외국의 현황 및 식품참고량 설정방법을 조사 ·연구 하으며 제도도입 및 개선 방안을 강구하였파. 또한, 시판 제품의 영양료시현황 및 음료류 둥의 포장단위 등을 피악하여 식품참고량설정을 위한 기초자료로 활용코자 하였다. 앞으로 국민건강 ·영양조사자료의 체계적인 통계분석, 가공식품의 섭취량조사 등을 통하여 우리나라 국민의 1인 1회 섭취량자료의 축적이 선행되어야 할 것이다. The purpose of this ?roject is to study on the reference amounts customarily consumed per eating occasion to improve the nutrition labelling standards. We Performed to study on the methodology to establish the reference amounts on the basis of the review on the advanced counITy's status. And we investigated the packaged unit ofprocessed foods. Further study is needed to establlsh the customarily consumed amount per eating occasionthrough the statistical analysis of nationwide food consumption data. Our results will be helpful information to improve nutrition labelling system in Korea.

산업자재용 폴리에스터 섬유의 강도 향상에 관한 연구

박영신,남영식,정상영,최재호,장기혁,박원호,Park, Young-Shin,Nam, Young-Sik,Jung, Sang-Young,Choi, Jae-Ho,Jang, Ki-Hyuk,Park, Won-Ho 한국섬유공학회 2012 한국섬유공학회지 Vol.49 No.1

In this work, effects of total draw ratio change on the mechanical properties of polyester fibers were studied. The process parameter was a total draw ratio and the draw ratios that were used ranged from 6.6 to 7.0. Tensile properties are determined from the tensile tester, and crystallite parameters from the density measurement and X-ray diffraction were discussed with the different total draw ratios. The tenacity, young's modulus and crystallinity were increased to 10.6 g/d, 123.2 g/d and 42.1%, respectively, with increase in the total draw ratio. The relations between total draw ratio and mechanical properties of high tenacity polyester fiber were discussed.

천연염료를 이용한 무늬염법

장영호,이재범 한국공예학회 1999 조형디자인연구 Vol.2 No.2

The natural dye substance largely consists of plant, animal and minerals materials, which we can easily and naturally be obtained all around us. It has been widely used all around the world for numerous years. The natural dye substance appears to have a lot of benefits that enable the dyed material to show natural merits which in turn enables the dyed materials to exhibit their natural colors. It may have a little bit of a damaging effect on the human body itself. , in comparison to the synthetic substances. It also causes hardly any environmental pollution because of the natural chemicals and costs much less to dispose of. on the other hand it also has disadvantages, that is it's difficult to get various kinds of patterns on the cloth. The dyeing process is done by full saturation, which is only available for commercial use because of the low ratio of dyeing success. The product of the dye substance is limited, the reliability of the dyed material is low, and it is easy to make dark and light colors. For the reasons mentioned above, the use of the natural dye is decreasing except for special uses. Nowadays it is very difficult to come across this method because of he appearance of synthetic dye substances. The dyeing process by saturation into the natural dye substance is done by putting the material, ready for dyeing, into the dye-water once or several times repeatedly. It also has several problems, which include, the complexity of the dyeing process, the low reliability of the dyeing substance and the dependence on manual work done by observing with the naked eye. Eventually, these problems caused the slow down of industrialization. Furthermore, the mixed use of dye substances and it's catalyst caused to develop the natural dye substance and to increase the dye's adhesiveness to the material. Those are the disadvantages of it's use. This is the method to study silk screen printing by using natural dye substance to make a specific patterns on the clothing using various methods. The silk screen printing needs to have the material dyed by the saturation method. Then the silk screen is printed by subtracting the colors to make another shade of color without using any additional dye substance. It only uses the natural dye substance mixture and it's catalyst. It will help to print specific patterns on the material. Therefore it's effects are available for using in various kinds of silk screen printing and to make different kinds of patterns equal to the natural dye substance method, which is both saturating and then printing.

R.F. magnetron sputtering법으로 제조한 LaCoO₃박막의 가스감지 특성

장재영,신정호,김정규,박기철,전춘배 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

LaCoO_(3)(LCO) thin film sensors were fabricated on an alumina substrate by the r.f. magnetron sputtering. By varying the annealing temperature of the LCO films from 600℃ to 1000℃, we investigated X-ray diffraction pattern, electrical properties, and gas sensing properties of the films. The crystallinity was improved and the activation energy was increased with increasing the annealing temperature. The sensitivity of the LCO films for NH_(3) and CO gases was also increased with the annealing temperature. Sensing properties of LCO thin films were improved when the measuring temperature was 350℃ or more.

Ionized Calcium 과 Chitosan 정제의 안정성에 관한 연구

장윤정,김현주,김영일,양재헌 又石大學校 1998 論文集 Vol.20 No.-

Recently, chitosan has being fiocused on not only the role of a potential and natural resource with antibacterial or antifungal effect but also the natural controller of releasing of drugs or principle actives. Calcium is one of the most important minerals of human that concerned with the intra-or inter-cellular function. But ionized calcium, prepared from shell through the condition of high temperature, own the antibacterial effects. We prepared the mixed tablet of chitosan and ionized calcium with several additives such as starch paste, ethylcellulose(EC), hydroxypropylmethylcelullose(HPMC) or hydroxyprophylcellulose(HPC). Each formulation with a additive was adopted as a challenger to modify of release profiles of calcium. Finally following both cationic properties, chitosan & ionized calcium, the mucoadhesive effects in the oral cavity are favorable to introduce for chewable tablet. The similar patterns of contents of calcium, disintegration time, hardness, weigth variation were showed following the preparation with each additive. The dissolution profiles of starch paste preparation was more slower than other preparations. It was as the order as HPMC, HPC, EC. The stabilities of tablet of each formulation was creditable in the period of 4 weeks under the condition of 50℃ and 75% of humidity. The contents of calcium, disintegration time, hardness were not changed significantly. Ionized calcium and chitosan mixed tablet may increase the antibacterial effects and the release patterns of calcium could changed successfully by several addives.

관상동맥경화증 환자에서 전곡섭취가 지질과산화 및 혈중 인슐린과 호모씨스테인 농도에 미치는 영향

장양수,이종호,엄영람,조은영,바현영,황재관,여익현 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

도심지역 이동통신의 전파특성 모델

장자영,노순국,박종천,김재섭,박성렬,박창균 조선대학교 동력자원연구소 1996 動力資源硏究所誌 Vol.18 No.1

To predict accurately an antenna radiation pattern is very important for determining of a service area, base-station location, cell design. In this paper, we have calculated a propagation prediction data of Hata, Egri, Carey, Free Space Loss model by a computer simulation in Kwang-ju downtown, and the data is compared with field test data. As a results, Hata and Egri model are approached to field test data, but considerable errors are detected.Conclusively, we believe that the most accurate prediction model must propose to improve the radio propagation environments for the specified region. For resolve these problems, we are proposed a mew experimental radio wave propagation predict model.

LaCrO₃후막 소자의 가스에 대한 감지 특성

장재영,박기철,신정호,김정규 慶尙大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.14 No.-

LaCrOa₃ thick-film sensors were fabricated on an alumina substrate by the screen printing method. The sensitivities for gases were investigated by varying the heat treatment temperatures of the films. The sensitivities of LaCrO₃ thick-film for ?? and NH₃ gases were better than those for CO and NO gases. The best condition of heat treatment was 450℃ and the optimal operating temperature of LaCrO₃ thick-film for the highest sensitivity was 400℃. Sensitivities of LaCrO₃ thick-film about at 3000ppm for ?? and NH₃gases were 85% and 95%, respectively.