Serum and Cerebrospinal Fluid Neuron-Specific Enolase for Diagnosis of Tuberculous Meningitis

송태진,김원주,최영철,이경열 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.6

Purpose: Late diagnosis and treatment lead to high mortality and poor prognosis in tuberculous meningitis (TbM). A rapid and accurate diagnosis is necessary for a good prognosis. Neuron-specific enolase (NSE) has been investigated as a biochemical marker of nervous tissue damage. In the present study, the usefulness of NSE was evaluated, and a cut-off value for the differential diagnosis of TbM was proposed. Materials and Methods: Patient charts were reviewed for levels of serum and cerebrospinal fluid (CSF) NSE, obtained from a diagnostic CSF study of samples in age- and gender-matched TbM (n=15), aseptic meningitis (n=28) and control (n=37) patients. Results: CSF/serum NSE ratio was higher in the TbM group than those of the control and aseptic groups (p=0.001). In binary logistic regression,CSF white blood cell count and CSF/serum NSE ratio were significant factors for diagnosis of TbM. When the cut-off value of the CSF/serum NSE ratio was 1.21, the sensitivity was 86.7% and the specificity was 75.4%. Conclusion: The CSF/serum NSE ratio could be a useful parameter for the early diagnosis of TbM. In addition, the authors of the present study suggest a cut-off value of 1.21 for CSF/serum NSE ratio.

Marginal fit of anterior 3-unit fixed partial zirconia restorations using different CAD/CAM systems

송태진,권택가,양재호,한중석,이재봉,김성훈,여인성 대한치과보철학회 2013 The Journal of Advanced Prosthodontics Vol.5 No.3

PURPOSE. Few studies have investigated the marginal accuracy of 3-unit zirconia fixed partial dentures (FPDs) fabricated by computer-aided design/computer-aided manufacturing (CAD/CAM) system. The purpose of this study was to compare the marginal fit of zirconia FPDs made using two CAD/CAM systems with that of metalceramic FPDs. MATERIALS AND METHODS. Artificial resin maxillary central and lateral incisors were prepared for 3-unit FPDs and fixed in yellow stone. This model was duplicated to epoxy resin die. On the resin die, 15 three-unit FPDs were fabricated per group (45 in total): Group A, zirconia 3-unit FPDs made with the Everest system; Group B, zirconia 3-unit FPDs made with the Lava system; and Group C, metal-ceramic 3-unit FPDs. They were cemented to resin dies with resin cement. After removal of pontic, each retainer was separated and observed under a microscope (Presize 440C). Marginal gaps of experimental groups were analyzed using oneway ANOVA and Duncan test. RESULTS. Mean marginal gaps of 3-unit FPDs were 60.46 μm for the Everest group, 78.71 μm for the Lava group, and 81.32 μm for the metal-ceramic group. The Everest group demonstrated significantly smaller marginal gap than the Lava and the metal-ceramic groups (P<.05). The marginal gap did not significantly differ between the Lava and the metal-ceramic groups (P>.05). CONCLUSION. The marginal gaps of anterior 3-unit zirconia FPD differed according to CAD/CAM systems, but still fell within clinically acceptable ranges compared with conventional metal-ceramic restoration.

듀시엔형 근이영양증과 베커 근이영양증 환자의 심장 기능 평가

송태진,최영철 대한신경과학회 2007 대한신경과학회지 Vol.25 No.4

Background: Cardiac problems are common and are a major cause of death in both Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). Early diagnosis and proper management are very important for prolonging life expectancy, improving mobility and the quality of life in dystrophinopathic patients. The object of this study was to assess the cardiac dysfunction in dystrophinopathic patients. Methods: We reviewed the clinical and laboratory findings of 53 male patients with DMD/BMD. The diagnosis was based on clinical criteria suggested by the European neuromuscular center, dystrophin gene analysis and immunohistochemistry of dystrophinopathic patients. We investigated 12-lead electrocardiography (EKG) findings, cardiac echocardiography findings and exon deletion analysis of dystrophin by multiplex polymerase chain reaction. Results: The mean age of 53 patients was 20.98±7.85 years old. On EKG findings of DMD/BMD patients, 50 patients (94.3%) revealed abnormal findings (DMD 36 [94.7%]/BMD 14 [93.3%]). Of the forty nine patients investigated by cardiac echocardiography, 25 patients (51.1%) showed abnormal echocardiographic findings (DMD 18 [51.4%]/BMD 7 [50.0%]), 18 patients (36.7%) had dilated cardiomyopathy, and 7 (14.3%) patients had cardiac symptoms (DMD 4 [11.4%] /BMD 3 [21.4%] numbers). There was no difference in the neurological disability score between normal echocardiographic finding patients and abnormal patients. On DNA analysis by multiplex PCR, the proximal exon deletion of dystrophin genes (exon 1-30) has a significant association with cardiac involvement compared to those of distal exon deletion (exon 31-60) (p=0.034). Conclusions: Because DMD/BMD patients mostly have affected cardiac dysfunctions without clinical symptoms, early diagnosis and appropriate management of asymptomatic cardiac dysfunctions is very important. J Korean Neurol Assoc 25(4):515-520, 2007

뇌혈관조영술에서 연질막 곁순환이 관찰된 급성 중간대뇌동맥경색 환자의 액체감쇠반전회복 뇌자기공명영상에서 보이는 고신호강도 혈관

송태진,서경임,서상현,이경열 대한신경과학회 2010 대한신경과학회지 Vol.28 No.2

Hyperintense vessels are frequently observed on fluid-attenuated inversion recovery imaging in acute ischemic stroke patients. Some investigators suggest that a hyperintense vessel sign in patients with middle cerebral arterial occlusion results from collateral blood flow originating in neighboring arterial territories, especially via pial collaterals. We report two cases of acute proximal middle cerebral arterial infarction that exhibited hyperintense vessels signs on fluid-attenuated inversion recovery imaging accompanying pial collaterals as confirmed by cerebral angiography.

In-vehicle 교통안전 경고정보 제공에 따른 운전자 반응특성 분석

송태진,오철,오주택,이청원 대한교통학회 2009 대한교통학회지 Vol.27 No.5

One of the effective countermeasures for preventing traffic accidents is to provide traffic safety warning information to drivers. Provision of warning information would lead to safer driving to avoid accident occurrence. This study investigated the effects of in-vehicle warning information on driver's behavior. A variety of warning information contents using text, sound, and pictograms were prepared for the field experiments. Individual vehicle speed and acceleration data, which represent quantitative drivers’ behavior in response to in-vehicle warning information, were collected using differential global positioning systems (DGPS). Statistical analyses including ANOVA and Tukey's pairwise comparison were conducted. It is expected that the results could be invaluable for designing more effective warning information. 본 연구에서는 실시간 주행환경에서 전방의 위험상황에 대해 운전자가 효과적으로 반응 할 수 있는 교통안전 경고정보 컨텐츠 도출을 위한 연구를 수행하였다. 차내 단말기를 통해 제공되는 경고정보 유형에 따른 운전자 반응특성을 분석하였다. 운전자 반응특성자료를 수집하기 위하여 DGPS를 장착한 실험차량을 이용하여 개별차량 주행궤적을 수집하여 속도 및 가감속도를 산출하였다. 차내 경고정보 유형은 사고위험성과 직접적인 연관이 있는 긴급영향권과 긴급영향권에 진입하는 차량에게 위험발생의 사전정보를 제공하기 위한 일반영향권으로 분류하였다. 컨텐츠는 시각적 정보인 Text, 이미지와 청각적 정보인 경고음, 그리고 음성 메시지를 고려하여 다양한 시나리오를 제작하여 현장실험에 활용하였다. 분석 결과 긴급영향권에서는 음성+이미지+text와 경고음+text로 구성된 경고정보를 제공하는 것이 가장 효과적인 것으로 분석되었으며, 일반영향권에서는 경고음+음성+이미지+text로 구성된 경고정보를 제공하는 것이 가장 효과적인 것으로 나타났다. 본 연구 결과는 향후 운전자의 반응특성을 고려한 보다 효과적인 실시간 경고정보를 설계하기 위한 유용한 정보로 활용 될 것으로 기대된다.

[Symposium] Duodenum Malignant Neoplasm

송태진 대한외과학회 2011 대한외과학회 학술대회 초록집 Vol.2011 No.11

유혈관종성 섬유성 조직구종

송태진,천영덕,조용걸,김승주,조민영,목영재,최상용,황정웅,구범환 대한외과학회 2001 대한외과학회 학술대회 초록집 Vol.2001 No.11

Tensile Deformation Behaviors of tEmpered Martensitic Steels (초)

송태진,곽재현,김한수,( B. C. De Cooman ) 대한금속ㆍ재료학회 2009 대한금속재료학회 학술대회 개요집 Vol.2009 No.1

Oncolytic Viral Therapy to Solid Tumors; modified HSV and Vaccinia Virus

송태진 대한외과학회 2012 대한외과학회 학술대회 초록집 Vol.2012 No.11

Distribution of Cerebral Microbleeds Determines Their Association with Impaired Kidney Function

송태진,김진권,이혜선,남정모,남효석,김영대,허지회 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.3

Background and Purpose Cerebral microbleeds (CMBs) are associated with various pathologies of the cerebral small vessels according to their distribution (i.e., cerebral amyloid angiopathyor hypertensive angiopathy). We investigated the association between CMB location and kidneyfunction in acute ischemic stroke patients. Methods We enrolled 1669 consecutive patients with acute ischemic stroke who underwentgradient-recalled echo brain magnetic resonance imaging. Kidney function was determined usingthe estimated glomerular filtration rate (eGFR). CMBs were classified into strictly lobar, strictlynonlobar (i.e., only deep or infratentorial), and a combination of both lobar and nonlobar. Multinomial logistic regression analyses were used to determine the factors associated with the existence of CMBs according to their location. Results The patients were aged 66±12 years (mean±standard deviation), and 61.9% (1033/1669) of them were male. CMBs were found in 27.0% (452/1669) of the patients. The strokesubtypes of small-artery occlusion and cardioembolism occurred more frequently in those withstrictly nonlobar CMBs (10.8%) and strictly lobar CMBs (48.8%), respectively. The mean eGFRwas lower in the strictly nonlobar CMBs group (72±28 mL/min/1.73 m2) and the both lobar andnonlobar CMBs group (72±25 mL/min/1.73 m2) than in the no-CMBs group (86±29 mL/min/1.73 m2). Multivariate multinomial logistic regression revealed that eGFR <60 mL/min/1.73 m2was independently related to strictly nonlobar CMBs (odds ratio=2.63, p=0.001). Conclusions Impaired kidney function is associated with strictly nonlobar CMBs. Our findingsindicate that the distribution of CMBs should be considered when evaluating their relationshipsor prognoses.