Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

저작근에 전이된 신세포암 1예

정재현;황인성;유지형;성락희;노충희;정재용 인제대학교 2011 仁濟醫學 Vol.32 No.-

Renal cell carcinoma is the third most common neoplasia of the genitourinary tract. Its most common type, representing 60% of the cases, is the clear cell carcinoma, with an incidence peak between 50 and 70 years. Metastases are present at the time of diagnosis in approximately 30% of the patients, the major sites being lungs, bones, skin, liver, and brain. But distant metastasis of malignant neoplasm to the masseter muscle is extremely rare. We report a case of renal cell carcinoma (RCC) metastasizing to the masseter muscle.

異常氣象이 벼의 生育과 收量에 미치는 影響

鄭炳官,金容在,金東觀 全南大學校 農業科學技術硏究所 1997 農業科學技術硏究 Vol.32 No.-

1980年度 벼 減數分裂期의 異常低溫과 寡照現象 등 異常氣候條件에서 標高別에 따른 品種別 및 移秧期別로 全羅南道 求禮郡 山間地域의 一般 農家畓에서 生育의 進展度와 이에따른 主要 形質들의 變化를 調査分析한 結果를 要約하면 다음과 같다. 1. 出穗 遲延現象은 日本型에 비하여 統一系型이 그리고 早植에 比하여 晩植이 顯著하였고, 이 現象은 標高가 높아짐에 따라 더욱 심하였으며, 標高 100m씩 높아짐에 따라 平均 5日이 遲延되었다. 2. 生育의 進展抑制에 따라 主要 形質들의 變化는 品種 및 移秧期에 따라 差가 있었으나, 標高가 100m씩 높아짐에 따라 平均 4.5㎝가 짧아졌으나, 穗長은 增減變化가 없었다. 3. ㎡當 穗數는 標高 200m 以下에서는 增減變化가 없었으나, 200m 以上에서는 14∼16%가 減少하였고, 4. 穗當粒數 및 登熟率은 標高 100m씩 높아짐에 따라 각각 15粒 및 6.7%가 平均的으로 減少 하였으며, 5. 玄米種은 早植의 경우 400m 以上의 高標高에서 78%, 200∼400m에서 41∼67%가 減 收하였으나 晩植의 경우 300m 以上의 高標高에서 78%가 減收하였다. This study was carried out to improved the rice cultivation method under unusual weather condition such as low temperature and deficiency of sunshine hours of meiosis stage of rice in 1980. Investigation was taken with different varieties, transplanting time and altitude in farm land. Investigation region was mountainous area in Ku-Rae, Chonnam Province, Heading time was remarkable delay in the Tong-il pedigree. It was 5 days delay average according to raise of 100m altitude and culm length was observed 4.5㎝ shortage too but panicle length did not any change. The decreasing of panicle number(14∼16%), ripened grain(6.7%) was observed according to the raise of 100m altitude and brown rice yield was decreased of 41% in the 150∼200m, of 57% in the 200∼300m, of 67% in 300∼400m and 78% over the 400m altitude in early planting because of the decreasing of yield components when compared with those of plain land. But decreasing degree of yield was observed 78% over the 300m altitude when was planted late.

오수처리 시설용 원격 계측 및 제어 장치의 개발

이문용,정재학,곽철규 嶺南大學校 工業技術硏究所 2001 工業技術硏究所論文集 Vol.29 No.2

The research for development of remote monitoring and control system composed three stages of research categories. At the first stage, we decided the suitable instrumentation devices for interface between H/W systems and waste water treatment facility, and at the second stage. We developed the software package for remote monitoring system and data transmission system including data receipt system via wired telephone line. At the final stage we developed local control system for auto-process control of waste water treatment facilities. For the first stage of research we developed the a drawing of design the instrumentation and selected optimal sensors for monitoring basic important data. After the first stage research we developed the software package with Graphic User Interface with on-line real time data monitoring graphic view windows and data acquisition. Finally we developed the hardware, one-board microcomputer with CPU and suitable size of ram, and interface of modem. The developed system will be composed as a commercial product.

Dense Kondo 계인 CeTe의 광학적 성질

정명화,김재민,권용성 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.1

Dense Kondo계인 CeTe와 정상금속인 LaTe의 크기 양질인 단결정을 개선된 Bridgeman방법으로 성장시켰다. 이 단결정을 이용하여 0.05∼8eV의 광범위한 에너지 영역에서 반사율을 측정하여, Kramers-Kronig변환을 통해 광학전도도를 얻었다. 광학전도도의 스펙트럼을 분석한 결과, CeTe와 LaTe의 경우 모두 p-d 전이에 의한 두 개의 피크가 3.6eV와 5.1eV에서 발견되었다. 이 두 피크의 형성 mechanism은 5d-band의 입방결정장에 의한 것임을 알았다. 그리고 CeTe의 경우는 LaTe에 없었던 4f-5d전이에 의한 피크가 0.4eV에서 발견되었다. 이는 XPS 스펙트럼으로부터 얻은 bare 4f-전자의 binding 에너지(약 1.5eV)에 비해 매우 작은 값이다. 이 편차는 local field를 고려한 Lorentz모델을 적용함으로서 잘 설명되었다. 또한, localization의 정도로 약 0.4의 값을 얻었다. 끝으로, 띠내전이의 해석으로부터 LaTe의 경우보다 CeTe의 경우가 전도전자의 유효질량이 무겁다는 사실을 얻었다. 이것으로부터 CeTe의 여기상태인 Γ_8와 전도전자 간의 Kondo 교환상호작용의 에너지가 매우 크다는 것을 알았다. We had grown the high quality single crystals of dense Kondo system CeTe and normal metal LaTe by using the advanced Bridgeman method. The reflectivities of the single crystals were measured in wide energy range from 0.05 to 8eV, and their optical conductivities were obtained using Kramers-Kronig transformation. By the result of their optical conductivity spectra, two peaks due to p-d transition were discovered at about 3.6 and 5.1eV, respectively. The double peaks were explained by cubic crystalline electric field. And in case of CeTe, extraordinary peak due to f-d transition, which LaTe had not, was appeared around 0.4eV. This value was well explained by the Lorentz model considering the local field. The degree of screening due to conduction electrons was evaluated to be about 0.4. The effective mass of conduction electron of CeTe was large compared with that of LaTe. From this, we could obtain the fact that in CeTe, Kondo exchange energy between conduction electron and excited Γ_8 state was very large

급성 포름알데히드 가스 흡입에 의한 흰쥐 후각상피의 형태학적 변화

백선용,전재기,문용석,황승영,노환중,고의경,왕수건 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.3

알고리즘 의존적 임계값 적용방법을 이용한 키 수열 생성 기법

정성용,이재도 대구보건대학 2002 대구보건대학 論文集 Vol.22 No.-

As part of efforts to improve the problems of LFSR keystream being weak to periodicity and correlation attacks, research are being increased to generate keystream for stream cyptosystem using features of the chaos signal. However, lacking is the research aimed to generate keystream sufficient the balance and randomness characteristics and analyze the characteristics of ciphertext in the generating of chaos keystream. This paper suggests an algorithm. Thus, as we use the method forapplying the threshold dependent on the algorithm with the problems of arbitrary threshold application improved. The test results confirm that the keystream generated through the suggested algorithm improved its balance and randomness features.