Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

초·중·고 학생들의 과학 지식 성취 수준 추이 분석을 위한 종단적 연구

권재술,최병순,권치순,양일호,이경호,김지나 한국교원대학교 과학교육연구소 1999 청람과학교육연구논총 Vol.9 No.1

학생의 과학 지식 성취도에 대한 장기간의 경향성은 과학 교육 정책의 효율성을 점검하는데 매우 중요한 요인이다. 그러나 지금까지 우리 나라 학생들의 학업 성취도의 경향성을 이해해보려는 진지한 노력이 현실적으로 거의 없었다. 최근까지 한국교원대학교 과학교육연구소에서는 전국에 있는 초·중·고 학생들을 대상으로 학생들의 과학 지식 성취도를 알아보기 위한 연구를 진행시켜왔다. 연구의 첫 단계에서는 평가 문항을 개발하였다. 두 번째 단계에서는 개발된 문항을 전국적으로 투입하고 그 결과를 수집하여 2년간의 변화를 분석하는 것으로써, 이 논문은 두 번째 단계에 관한 내용을 담고있다. 이 연구에서는 권재술 등(1998)이 개발한 국가 수준의 과학 지식 평가 도구를 일부 수정하여 사용하였다. 1997년에는 전국적으로 8,766명의 학생을, 1999년에는 4,398명의 학생을 조사 대상으로 하였다. 조사 대상은 지역별, 성별 등을 고려하여 우리 나라 전체 학생의 모집단을 대표할 수 있는 표본으로 선정되었다. 연구 결과, 2년 동안 초·중·고 학생들의 과학 지식 성취 수준의 서로 다른 변화를 확인할 수 있었다. 초등학생의 경우는 성취도가 감소하였으나, 고등학생의 경우는 증가하였고 중학생의 경우는 두 시기에 의미 있는 차이가 없었다. 과학 지식 영역의 하위 영역별 분석 결과를 보면, 초등학생의 경우 개념 체계에 대한 지식 수준을 유의미하게 향상되었으나, 사실과 원리에 관한 지식 수준은 낮아졌다. 반면 고등학생의 경우는 지식 수준이 향상되었으며 특히, 사실 영역에서 크게 향상 되었다. 연구에서는 이 자료를 성별, 지역별, 행동 목표 수준 그리고 검사 문항의 상황 등으로도 나누어서 분석하였다. 한국교원대학교 과학교육연구소에서 개발한 과학 성취 수준 점검 시스템은 국가 수준에서 학생들의 과학성취도를 점검하는데 효과적인 도구가 될 것이다. The long term trend of studensts' science achievement is a very important factor to check the effectiveness of science educational policy. However, up to date no such effort to understand the trend of Korean students' science achievement has been put into action. Recently, the Science Education Center in Korea National University of Education has been attempted to collect nation wide data for students' science achievement. The first part of the effort was to develop item pools. This study was the second part to collect nation wide data and to check any change during the two year time interval. In this study, the item pools developed by Kwon et. al.(1998) were used with some modification. The data were collected two times; February 1997 and March 1999. The subjects collected nationally were 8,766 students in 1997 and were 4,398 in 1999. The subjects were collected randomly but stratified by region and sex. As the results, the trends of achievement change during the two years were different from elementary to high school. The achievement scores were decreased in elementary schools and increased in high school. In case of middle schools, the change was not significant. However, even in elementary schools the knowledge on theory was increased significantly while knowledge on facts and principles were decreased. In contrast, the knowledge on fact showed the most increase in high schools. In this study, the data were analysed in light of region, sex, behavioral objective levels(ability) and context of test items. The science achievement monitoring system developed by the Science Education Center in Korea National University of Education can be an effective tool for monitoring students' achievement on the national level.

아동의 사회적 문제해결능력과 어머니의 대화형태와의 관계연구

김재림,백은주,신유림,심미경,이혜경 연세대학교 생활과학대학 1985 婦學 Vol.18 No.-

The present study investigated the relationship between the social problem solving ability of children and the language patterns of their mothers. The subjects included 193 nine year­olds (185 girls, 108 boys), and 230 twelve year­olds (115 girls, 115 boys). The instruments used were a language patterns test for the mother and IPA (Interpersonal Problem Solving Ability Test) for children. Major finding from this study were: ⑴ the correlation between the social problem solving ability of children and the language patterns of their mothers was not statistically significant, ⑵ the language patterns of the mothers were significantly different by child's sex; for boys, mother used more ordered language patterns and for girls, mothers used more ordered language patterns and for girls, mothers used more human­oriented language patterns, ⑶ the social problem solving ability of children were significantly different by child's age; 12­year­olds exhibited higher ability than 9­year­olds.

공동주택의 장수명화 및 재생을 위한 IHCS 표준모델 개발 : 개념 및 특성을 중심으로 With a focus of Concept and Character

최경석,강재식,양관섭,이승언 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

Recently Excessive national resources, energy losses and social·economical problems are induced by reconstruction apartment housing which was constructed about 20 years and is enough to keep one's residence structurally. Especially, the greatest obstruction in longevity & recycling technology of apartment housing is the current Ondol system of wet process integrated structures. Also the current Ondol system is difficult to improve due to its character of material and process. The object of this study is to develop IHCS(Infill Heating & Cooling System) standard model with prefabricated & dry process that shall be the substitution for the current wet Ondol system.

과학학습에서 불일치 상황에 대면한 초등학생의 인지갈등 측정 도구 개발

박상석,이경호,김정환,권혁구,권재술 한국교원대학교 과학교육연구소 1999 청람과학교육연구논총 Vol.9 No.1

The purpose of this study was to develop an Instrument for the Measurement of Cognitive Conflict Levels of students who confronted with an anomalous situation in science learning. Anomalous situation is generated when students' prediction is disconsistent with the observed fact. In this study, the researchers identified 4 components of cognitive conflict and developed three items for each component. The items were developed and revised by four pilot tests. In the first pilot test, 55 elementary school students participated in the test. In the second pilot test, 88 students of the 5th and 6th grader participated in the test. The instrument of measuring cognitive conflict levels was given to the subjects right after demonstrating anomalous situation. For the demonstration, two different problem situations were developed: one was a pulley problem and the other was electric bulbs in parallel. Answered reasons for each items were analyzed to assess students' understanding on each items. In third pilot test, 125 elementary school students participated in the test. A factor analysis of the responses was carried out and reliability of the test was assessed by calculating internal consistency values. The items were finalized by three pilot tests. After 1 month after the third pilot test, researchers conducted the finalized test items to 323 students of the 5th and 6th grader. The final instrument showed moderate reliability (Cronbach-α 0.82∼0.87) and good content validity(0.93). A factor analysis of the response was carried out. 4 main factors completely coincided with 4 components that we supposed to be the conducts of cognitive conflict. The instrument can provide a means for both teachers and researchers to assess the cognitive conflict of a large number of students within a single class period. The results can be used by teachers to better understand the process of conceptual change of their students and to match instruction and materials accordingly.

견/합성섬유 혼방품의 1욕염색(Ⅶ) : 견/아크릴로니트릴 섬유 혼방품의 염색거동 Adsorption Behavior of Silk/Acrylonitrile Fiber

金公朱,김경수,전재홍,이화선 全北大學校 1995 論文集 Vol.40 No.-

In one bath dyeing system of silk/acrylonitrile(acryl) fabric with acid/disperse dyes and acid/cation dyes, adsorption behavior of acid dyes, disperse dyes and cation dyes on silk and acryl fabrics were examined. In the dyeing of acryl with the C. I. Disperse Red 19(Red 19) and The C. I. Disperse Red 60(Red 60), dye uptake with Red 19 was higher than that with Red 60. When the silk and acryl fabric were dyed with C. I. Basic Red 27(Red 27), dye uptake on the acryl was higher than that on the silk. When the silk/acryl fabric was dyed with Red 19 and Basic 27, solid shade could be obtained with Red 19 but could not be obtained with Basic 27. In the dyeing of silk/acryl fabric dyed with Blue 80/Red 27 and C. I. Acid Blue 113(Blue 113)/C. I. Basic Blue 116(Blue 116), compatibility could be obtained with Blue 80/Red 27 but that could not be obtained with Blue 113/Blue 116.

Gene Expression Analysis of Anticancer Drug Induced Hepatotoxicity Using cDNA Microarray

Lee, Gyoung-Jae,Kim, Yang-Suk,Jung, Jin-Wook,Hwang, Seung-Yong,Park, Joon-Suk,Kang, Kyung-Sun,Lee, Yong-Soon,Chon, Man-Suk,Chon, Kum-Jin,Kang, Jong-Soo,Kim, Dong-Hyean,Park, Young-Keun The Korean Society of Toxicogenomics and Toxicopro 2006 Molecular & cellular toxicology Vol.2 No.2

Tamoxifen (TAM), a non-steroidal anti estrogen anticancer drug and chemopreventive agent for breast cancer, have caused cholestasis in liver. The potent hepatocarcinogenicity of this drug has been reported. Methotrexate (MTX) is dihydrofolate reductase inhibitor which interfaces with the synthesis for urine nucleotide and dTMP. And it may cause atrophy, necrosis and steatosis in liver. These two anticancer drug have well-known hepatotoxicity. So, in this study we compare the gene expression pattern of antitumor agent TAM and MTX, using the cDNA microarray. We have used 4.8 K cDNA microarray to identify hepatotoxicity-related genes in 5-week-old male Sprague-Dawley (SD) rats. Confirm the pattern of gene expression, we have used Real time PCR for targeted gene. In the case of MTX, Protease related gene (Ctse, Ctsk) and Protein kinase (Pctk 1) have shown specific expression pattern. And in the case of TAM, apoptosis related gene (Pdcd 8) and signal transduction related gene (kdr) have significantly up regulated during treatment time. Gene related with growth factor, lipid synthesis, chemokins were significantly changed. From the result of this study, the information about influence of TAM and MTX to hepatoxicity will provide.

Preparation and Characteristics of Cellulose Acetate Based Nanocomposites Reinforced with Cellulose Nanocrystals (CNCs)(셀룰로오스 나노크리스탈 강화 셀룰로오스 아세테이트 나노복합소재 제조 및 특성)

( Jae-gyoung Gwon ),( Dan-bee Lee ),( Hye-jung Cho ),( Sun-young Lee ) 한국목재공학회 2018 목재공학 Vol.46 No.5

셀룰로오스 아세테이트(cellulose acetate, CA)는 높은 투명도와 열 저항성을 갖고 있어 복합소재 개발에 많이 응용되고 있다. 본 연구에서는 CA 복합재의 기계적 강도 개선을 위해 셀룰로오스 나노크리스탈 (cellulose nanocrystals, CNCs)을 강화제로 첨가하였다. CA 수지 내부에 CNCs의 고른 분산을 위해 선 분산(predispersion)법 적용 후, 압출 및 사출하는 제조 방식으로 CA 복합재를 제조하였다. 기계적 특성 분석 결과, CNCs를 3 wt% 첨가하였을 때 강화효과(reinforcing effect)로 인해 최대 인장강도와 굴곡강도 값을 보임을 확인하였다. 열중량 분석법을 이용한 열분해 거동 분석을 통해 황산 처리된 CNCs의 첨가는 CA 복합소재의 열안정성을 약간 감소시키는 결과를 얻었다. Cellulose acetate (CA) has been widely utilized for composite materials due to its high transparency and thermal resistance. In this study, CNCs (cellulose nanocrystals) were reinforced in CA nanocomposites for fortifying mechanical properties of the composites. In addition, CA nanocomposites reinforced with CNCs were manufactured by extrusion/ injection processes applied with CNC-predispersion method for achieving a high dispersion level of CNCs in the CA matrix. According to the analysis of mechanical properties, the CA nanocomposite with 3 wt% CNCs has the highest tensile and flexural strengths due to the reinforcing effect of CNC nanoparticles. Thermogravimetric analysis (TGA) showed that the addition of acid hydrolyzed CNCs slightly lowered the initial pyrolysis temperature of CA nanocomposite.

Comparative Analysis of Korean and Japanese Strains of Pseudomonas syringae pv. actinidiae Causing Bacterial Canker of Kiwifruit

Lee, Jae-Hong,Kim, Jung-Ho,Kim, Gyoung-Hee,Jung, Jae-Sung,Hur, Jae-Sung,Koh, Young-Jin The Korean Society of Plant Pathology 2005 Plant Pathology Journal Vol.21 No.2

Genomic and phenotypic characteristics of the bacterial strains of Pseudomonas syringae pv. actinidiae and P. syringae pv. syringae collected from several kiwifruit orchards of Korea were investigated and compared with those from Japan to elucidate their phylogenic relationships. All the strains of P. syringae pv. actinidiae and pv. syringae tested were sensitive to copper sulfate but Korean and Japanese strains showed quite different responses to streptomycin. Korean strains were sensitive to streptomycin, but most of the Japanese strains of P. syringae pv. actinidiae were highly resistant to streptomycin. Japanese strains were also relatively more resistant to oxytetracycline than Korean strains. Plasmid profiles were not valuable to distinguish Korean strains of P. syringae pv. actinidiae frombJapanese strains. One or more indigenous plasmids with more than 15 kb in size were detected in all strains of P. syringae pv. actinidiae, but the number and sizes of plasmids harbored in P. syringae pv. actinidiae were variable among the strains regardless of their geographic origins. There also observed no significant relationship among resistance levels of the strains of P. syringae pv. actinidiae to antibiotics, their pathogenicity and plasmid profiles. RAPD profiles were useful to analyze the strains of P. syringae pv. actinidiae and pv. syringae. All the strains of P. syringae pv. actinidiae fell into a wide cluster separated from the strains of P. syringae pv. syringae, but Korean strains of P. syringae pv. actinidiae were separated from Japanese strains. The results support that Korean and Japanese strains of P. syringae pv. actinidiae may have different phylogenic origins.

Development of a prognosis‐prediction model incorporating genetic polymorphism with pathologic stage in stage I non‐small cell lung cancer: A multicenter study

Lee, Won Kee,Lee, Shin Yup,Choi, Jin Eun,Seok, Yangki,Lee, Eung Bae,Lee, Hyun Cheol,Kang, Hyo‐,Gyoung,Yoo, Seung Soo,Lee, Myung Hoon,Cho, Sukki,Jheon, Sanghoon,Kim, Young Chul,Oh, In Jae,Na, Koo John WileySons Australia, Ltd 2017 Thoracic cancer Vol.8 No.3

<P><B>Background</B></P><P>This multicenter study was performed to develop a prognosis‐prediction model incorporating genetic polymorphism with pathologic stage for surgically treated non‐small cell lung cancer (NSCLC) patients.</P><P><B>Methods</B></P><P>A replication study including 720 patients and a panel of eight single nucleotide polymorphisms (SNPs), which predicted the prognosis of surgically treated NSCLC in our previous study, was conducted. Using the combined cohort of current and previous studies including 1534 patients, a nomogram for predicting overall survival was made using Cox proportional hazards regression.</P><P><B>Results</B></P><P>Among the eight SNPs, C3 rs2287845, GNB2L1 (alias RACK1), and rs3756585 were significantly associated with overall survival. A nomogram was constructed based on pathologic stage and the genotypes of the two SNPs, and the risk score was calculated for each patient in the combined cohort. Using the prognosis‐prediction model, we categorized patients into low, intermediate, and high‐risk groups, which had greater accuracy in predictive ability (log‐rank statistics = 54.66) than the conventional tumor node metastasis staging (log‐rank statistics = 39.56). Next, we generated a prognosis‐prediction model for stage I to identify a subgroup of potential candidates for adjuvant chemotherapy. Notably, 97 out of 499 stage IB patients were classified as high‐risk patients with a similar prognosis to stage II patients, suggesting the benefit of adjuvant chemotherapy.</P><P><B>Conclusions</B></P><P>This prognosis‐prediction model incorporating genetic polymorphism with pathologic stage may lead to more precise prognostication in surgically resected NSCLC patients. In particular, this model may be useful in selecting a subgroup of stage IB patients who may benefit from adjuvant chemotherapy.</P>