고요산혈증의 위험인자 : 아산시 지역 주민을 대상으로

김용배,장원기,황보영,김화성,안규동,이병국,이용진,이종은,이준숙,이찬구,이한정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Objective : Serum uric acid has now been identified as a marker for a number of metabolic and hemodynamic abnormalities. The aim of this study is to evaluate risk factors which influence hyperuricemia in the citizens of Asan. Method : The study design was cross-sectional and research subjects were 1086 citizens of Asan. General characteristics, cigarette smoking, alcohol consumption, and past history were obtained by interview using a structural questionnaire. Also, we measured height, weight and blood pressure, and serum uric acid of the subjects. Results : The mean serum uric acid level was 5.27 ㎎/㎗ in men and 4.01 ㎎/㎗, in women, In the multiple logistic regression analysis, statically significant risk factors of hyperuhcemia were gender, body mass index, blood lead concentration, and serum creatinine. Conclusion : Our results suggest that gender, body mass index, blood lead concentration, and serum creatinine might be the most important risk factors of hyperurcemia. Education program as well as routine check-up for serum uric acid was highly recommended for the effective prevention of hyperuricemia.

DAP 신념에 근거한 유아과학 교수·학습모형의 현장적용 효과

이정화,이미은 미래유아교육학회 2003 미래유아교육학회지 Vol.10 No.4

DAP(Developmentally Appropriate Practice)는 유아교육실제의 질을 진단ㆍ평가하는 타당한 기준으로 인정받고 있을 뿐 아니라 유아교육과정의 설계나 프로그램 개발에 고려해야 할 준거로 널리 활용되고 있다. 본 연구는 DAP 신법에 근거하여 만들어진 절차화된 유아과학 교수ㆍ학습모형(이정화, 2002)을 유아교육 현장에 적용하여 그 효과를 검증해 보고자 하였다. 이를 위해 연구자들은 두 가지 교수학습방법(DAP 신념에 근거한 유아과학 수업모형과 전통적 수업모형)을 적용한 과학활동 프로그램을 구성, 처치한 후 유아들의 과학적 호기심 및 과학적 과정 기능의 향상 정도를 살펴보았다. 연구결과 DAP 신념에 근거한 절차화된 유아과학 교수ㆍ학습모형에 의한 과학활동 프로그램에 참여한 유아들이 전통적 교수법에 의한 과학활동 프로그램에 참여한 유아들보다 유의하게 높은 향상을 보였음이 확인되었다. The purpose of this study was to examine the effects of a developmently appropriate model of teaching science(DAP model) which is developed by Lee Jeong-Hwa(2002) on children’s curiosity and scientific process skills. Two research questions were made from the review of the literature, as follows ; 1. Are there any differences in science curiosity between children in an experimental and a control group? 2. Are there any differences in science process skills between children in an experimental and a control group? To answer the questions, forty five-year-old children attending a preschool in Busan participated in this study. They were randomly assigned to either an experimental or a control group. Children in the experimental group, took part in eight 40~45 minute sessions of science program based on the DAP model; whereas, their counterparts in the same sessions of a traditional science program. After the sessions of each program, all children were tested on the science processing skill test and the science curiosity test. The children who took the DAP model received higher achievement than their counterparts on curiosity and scientific process skills. From the results, the researchers suggest to apply the DAP model of teaching science for young children in the education field.

1995-96년 한반도 남동부 지역의 미소지진 자료를 이용한 지각구조 모델의 비교 연구

이기화,정태웅,Lee, Gi Hwa,Jeong, Tae Ung 한국지구물리물리탐사학회 1999 지구물리 Vol.2 No.1

한국자원연구소 지진관측망의 1995-96년 미소지진 자료를 바탕으로 한반도 남동지역의 지각구조에 대하여, Lee (1979), 김상조·김소구(1983), 김성균·정부흥(1985)의 세 지각 모델 중 어느 것이 잔차의 최소자승을 만족하는지 검증하였다. 세 모델 잔차의 뚜렷한 차이가 관찰되지 않았으나, Lee 의 지각 모델이 약간 깊은 진원을 산출하는 경향이 있다. 한반도 지각의 층상구조는 아직 명백하지 않으므로 앞으로 더 많은 자연지진 자료 또는 인공지진 자료를 통해서 규명되어져야 한다. Using the microearthquake data acquired from 1995 to 1996 through the seismic network operated by the Korea Institute of Geology, Mining & Materials (KIGAM), the three P-wave velocity models proposed by Lee (1979), Kim·Kim (1983) and Kim·Jung (1985) concerning the structure of the southeastern part of the Korean peninsula were examined in terms of the least square errors of the P-wave arrival times. The three models do not differ significantly in arrival time residuals except that the Lee's model gives slightly deeper focuses than the others. The layering of the crust of the peninsula is not clear as yet and to be studied by more earthquake and explosion data in the future.

Plant regeneration from callus of Iris odaesanensis Y. N. Lee native to Korea via organogenesis

Bae, Kee-Hwa,Yoo, Kyoung-Hwa,Lee, Mi-Hyun,Jeong, Jae-Hun,Choi, Yong-Eui,Yoon, Eui-Soo The Korean Society of Plant Biotechnology 2013 식물생명공학회지 Vol.40 No.3

Iris odaesanensis Y. N. Lee. is an important endangered and native plant belonging to the family Iridaceae in Korea. This study describes a method for rapid micropropagation of this species via from leaf, rhizome and root explants derived calli. Leaf, rhizome and root explants were cultured on Murashige and Skoog (MS) medium supplemented with 2,4-dichlorophenoxy acetic acid (2,4-D) for callus induction. Rhizome explants yielded calli at a frequency of 72% when cultured at 1.0 mg/l 2,4-D. Calli were maintained at 1.0 mg/l 2,4-D. These calli were transferred to MS medium supplemented with 0, 0.5, 1.0, and 2.0 mg/l 2,4-D in combination with 0, 0.5, 1.0, and 3.0 mg/l BA for adventitious shoot induction. The highest number of adventitious shoot (228.9 per petri-dish) were formed at 1.0 mg/l 2,4-D and 1.0 mg/l BA. WPM medium was the best to convert calli into plantlets, where up to 98.2% of calli were regenerated into plantlets. This in vitro propagation protocol should be useful for conservation of this endangered plant.

화병(火病)을 동반한 갱년기 환자 치험 5례

송유림 ( Yu-rim Song ),박경미 ( Kyung-mi Park ),양승정 ( Seung-jeong Yang ),이은규 ( Eun-kyu Lee ),김혜화 ( Hye-hwa Kim ),조성희 ( Seong-hee Cho ) 대한한방부인과학회 2016 大韓韓方婦人科學會誌 Vol.29 No.4

Objectives: The purpose of this study is to evaluate the effects of Korean traditional treatments for Climacteric Syndrome Patients with Hwa-Byung. Methods: From February 2015 to May 2015, We treated 5 Cases Patients with Korean traditional treatments for a month. We measured treatment effects by Menopause Rating Scale (MRS), Beck`s Depression Inventory (BDI), Visual Analogue Scale (VAS) and Digital Infrared Thermal Imaging (DITI). Results: After treatment, First, the scores of MRS, BDI were decreased. Second, the symptoms such as hot flush, pantalgia, palpitation, insomnia, fatigue were significantly improved. Also, the difference of ?中 (CV17, Danjung) and 關元 (CV4, Guanyuan) temperatures were significantly decreased after treatment. Conclusions: This study suggests that Korean traditional treatments such as Gamicheonglijagam-hwan, acupuncture, moxibustion are effective on Climacteric Syndrome Patients with Hwa-Byung.

청간소요산으로 호전된 설통 환자 3례

김연진,양승보,김정화,이상화,조승연,박성욱,박정미,고창남,Kim, Yeon-jin,Yang, Seung-bo,Kim, Jeong-hwa,Lee, Sang-hwa,Cho, Seung-yeon,Park, Seong-uk,Park, Jung-mi,Ko, Chang-nam 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.4

Objectives: This clinical study reports the effects of Cheonggansoyo-san (CSS) on three patients with glossodynia. Methods: Three patients with glossodynia were treated with CSS (i.e., an herbal medicine) and acupuncture. Numeric rating scales (NRSs) for glossodynia and dry mouth and hwa-byung questionnaire scores were evaluated, and the results from heart rate variability (HRV) evaluations were analyzed. Results: After treatment with CSS, three patients' glossodynia symptoms, such as burning sensations, tingling, and numbness of the tongue, were improved. NRS ratings for glossodynia and dry mouth and the hwa-byung questionnaire scores also improved, and HRV parameters were closer to the normal range. Conclusion: Cheonggansoyo-san could be used to treat glossodynia.

일회통과 관류실험시 물의 수송 : 관류액의 종류와 삼투압의 영향 Effects of Some Perfusates and Their Osmolality

이정화,이현주,용철순,오두만 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-

The single pass perfusion experiments were performed in anesthetized rata to investigate the effects of perfusates and their osmolality on the water transport and to determine the correlation between the extent of water transport and the volume change of perfusate. Phenol red was used as a nonabsorbable marker. In normal rats, when perfused at a flow rate of 0.5 ml/min 2-(N-morpholino) ethanesulfonic acid (MES) aid Sorensen's phosphate hullers showed minimal net water transport as 0.125 and 0.173 %/cm of intestinal length, respecetively. Hypotonic perfusate of 200 mOsm㎏ of water and hypertonic perfusate of 400 mOsm/㎏ of water generated significant water transport compared with isotonic perfusate of 300 mOsn/㎏ of water. There was a linear correlation between the attent of water transport and the volume change of perfusate, suggesting that the volume change can be used as a measure of water transport.

한국인에서 도파민 D4 수용체 다형성과 Novelty Seeking 성격 특성의 연관성

이헌정,이홍석,강화연,김린,이민수,서광윤,변영찬 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.4

연구목적 : 저자들은 한국인에서 도파민 D4 수용체(DRD4) 유전자의 다형성과 성격의 관련성을 알아보고자 본 연구를 시행하였다. 방 법 : 173명의 건강한 한국인 여자 청소년(13.88±0.29세)을 대상으로 하여 성격 기질 설문지(Temperament and Character Inventory : TCI)를 작성하도록 하였으며, 이들에서 DRD4 exon Ⅲ 48-bp VNTR(variable numbers of tandem repeats) 다형성을 분석하였다. 결 과 : DRD4 exon Ⅲ Vntr에서 긴 대립유전자(≥5 repeats)를 가진 군이 긴 대립유전자를 가지지 않은군에 비하여 Novelty Seeking 척도 점수가 유의하게 높았다(t=2.11,p=0.037). 결 론 : 본 연구 결과는 DRD4-exon Ⅲ의 긴 대립유전자가 Novelty Seeking 성격과 관련이 있다는 기존의 외국에서의 연구결과를 다시금 확인해주는 것이다. Objectives : We investigated the relationship of personality traits with dopamine D4 receptor(DRD4) exon Ⅲ polymorphism in a Korean population. Methods : We analysed DRD4 exon Ⅲ 48-bp repeats polymorphism in 173 Korean heakthy female adolescents(age=13.88±0.29years) who also completed Temperament and Charater Inventory(TCI). Results : Novelty seeking score of the TCI was significantly higher in the subjects with DRD4 long alleles(≥5 repeats) compares with the subjects without these (t=2.11, p=0.037). Conclusion : The present study supports the previous reports that long repeats of the DRD4-exon Ⅲ polymorphism are relatedwith Novelty Seeking personality.

고속핵에서 GABA가 동맥압에 미치는 영향

이정헌,오기화,안동국,박재식 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : NTS (nucleus tractus solitarius)는 압감수성 반사 구심성 신경이 처음 시냅스를 형성하는 곳으로 동맥압 조절에 중요한 역할을 한다. NTS에서 어떤 특정 물질이 동맥압 조절에 관여하는지는 정확히 밝혀지지는 않았지만, NTS에 존재하는 많은 물질들이 이들 과정에 관여하고 있다. 그중 하나인 GABA성 약물이 NTS에서 순환계에 미치는 영향을 구명하고자 본 실험을 시행하였으며 아울러 반대편 NTS를 lidocaine으로 억제하였을 경우의 변화를 관찰하여 NTS에서 신경회로 일단을 밝히고자 하였다. 대상 및 방법 : 실험동물은 체중 300-500g 되는 숫컷 Wistar쥐를 사용하였다. 동맥압 측정과 약물 주입을 위하여 대퇴 동정맥에 삽관하였다. 이어서 기관지절개술을 시행하였으며 체온을 36-37℃ 되게 열판을 이용하여 조절하였다. 쥐를 뇌 정위 고정 장치에 두고 머리를 45°숙여 NTS를 노출시킨 다음 약물을 10초간에 걸쳐 80nl주입하였다. 결과 : 인공 뇌척수액을 주입하면 동맥압의 변화가 거의 없었으나 동량의 GABA를 NTS에 주입하면 동맥압이 증가하였다. GABA에 의해 동맥압이 증가된 상태에서 반대측 NTS에 lidocaine을 주입하여 한쪽 기능을 억제시키면 동맥압이 더욱 증가하였다. 또한 lidocaine주입 후 반대쪽의 건전한 NTS에 GABA를 재차 주입하면 동맥압 증가가 적었다. 그리고 GABA를 NTS에 주입 후 정맥으로 nitroprusside를 주입하면 GABA 주입이 없는 대조군에 비해 동맥압 감소가 더 컸으며, lidocaine으로 마취하여 한쪽 NTS의 기능을 차단한 후 반대쪽 건전한 NTS에 GABA를 주입한 경우는 동맥압 감소가 적었다. 동일한 방법으로 lidocaine을 주입한 후 phenylephrine으로 승압을 시키면 동맥압 증가가 적었다. 압감수성 반사는 NTS에 GABA를 주입하거나 또는 반대편 NTS를 lidocaine으로 마취하여 기능을 억제시킨 경우에 둔화되었다. 결론: NTS에서 GABA가 동맥압의 조절 인자로 작용하며, 양쪽 NTS는 상호작용하고 있는 것으로 보인다. The nucleus tractus solitarius (NTS), the site of termination within the brain of baroreceptor afferent fibers, has been shown to be involved in the regulation of arterial pressure (AP). Many neuroactive substances present within the NTS have been shown to be involved in this process, although the manner in which any specific neurotransmitter acts physiologically in the regulation of AP has not been completely elucidated. The present study was intended to clarify the mechanism of action of GABA in the NTS and also to examine the cardiovascular response to inhibition of the contralateral NTS by lidocaine. Male Wistar rats weighing 300-500 g were employed for the experiment. The femoral artery and vein were cannulated to record the arterial pressure (AP) and to inject nitroprusside or phenylephrine, respectively. The tracheotomy was performed and body temperature was kept to 36-37℃. Rats were mounted in a stereotaxic frame with the head flexed downward to an angle of 45°. After the NTS was exposed. GABA or lidocaine was microinjected into the NTS in a volume of 80 nl over 10 seconds through a glass micropipette (outer diameter of the tip 50 ㎛) connected to a 1 ㎕ Hamilton microsyringe. The results obtained are summarized as follows. Microinjection of artificial CSF into the ipsilateral NTS did not alter basal AP. In contrast, microinjection of the same volume of GABA into the NTS produced a significant increase in the AP. The results presented thus far indicated that the volume injected did not affect AP. In animals with elevated AP by GABA injection, injection-of lidocaine into the contralateral NTS resulted in a further increase in AP. After the contralateral NTS was inhibited with lidocaine. injection of GABA into the NTS produced a less increase in AP. After microinjection of GABA into the NTS, the nitroprusside administered i.v. accentuated the increase of AP but not after microinjection of lidocaine into the contralateral NTS. Similar results were obtained with i.v. injection of phenylephrine after pretreatment of lidocaine into the NTS. The baroreflex sensitivity was reduced by microinjection of GABA into the NTS or microinjection of lidocaine into the contralateral NTS. These results suggest that alterations in GABA-mediated neural transmission in the NTS contribute to the regulation of AP and the NTS of both sides have a mutual interaction.

외래환자를 위한 시간제한 집단정신치료

이후경,차정화,윤성철,김정일 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : 최근 외래집단정신치료는 전통적인 장기치료에서 단기치료나 시간제한치료로 전환되고 있는 추세다. 단기는 보통 10∼40회 걸쳐 실시되는 것에 비해 시간제한(time-limited)은 시작부터 종결시기 및 횟수를 미리 정해놓고 실시한다. 이는 치료자와 환자간에 가능성 있는 구체적인 치료목표를 설정하고 적극적인 공동작업을 통하여 정해진 기간에 효과적인 치료결과를 가져올 수 있기 때문에 효율적인 치료방법으로 점차 부상되는 있는 양식이다. 본 논문의 연구목표는 다음과 같다 ① 정신과의원 외래환자를 대상으로 시간제한 집단정신치료를 시행하여 치료효과와 치료요인을 조사한다. ② 집단정신치료 시행과정에 나타나는 특징을 살펴본다. ③ 본 집단정신치료의 적절성과 타당성을 검증하여, 현재 한국 의료상황에 맞는 저비용, 고효율적인 모델로서 정착시켜 외래치료를 보다 효과적으로 할 수 있는 기반을 마련하다. 방 법 : 본 연구는 2000년 4월부터 동년 7월까지 매주 1회, 한번에 70∼80분씩, 총 12회 걸쳐 실시되었다. 실험군은 정신과의원 외래환자중 기능수준이 높은 정신병환자를 대상으로 하였다. 대조군은 비슷한 나이, 성별, 진단군, 유병기간을 일대일 짝을 지어 선정하였다. 각각8명이 참여하였다. 평가도구는 BDI, STAI,MMPI, 이화방어기제를 사전, 사후에 실시하였고, 매회 마다 13가지 치료요인 척도를 실시하였으며, 총평가 설문지를 마지막에 실시하였다. 결 과 : BDI는 실험군에서 대조군에 비하여 유의미하게 감소하였다. STAI-S는 실험군, 대조군 모두에서 차이가 없었고, STAI-T는 실험군에서 대조군에 비하여 유의미하게 감소하였다. MMPI는 실험군에서 대조군에 비하여 통계적으로 유의미하게 감소하였지만, 사전-사후 변화량에 대한 집단간 검사에서 유의미하지 않았다. 이는 두 군에 동일하게 노출된 약물치료와 지지치료의 영향으로 추측된다. 이화방어기제는 실험군에서만 미성숙 방어기제와 신경증적 방어기제의 유의미한 감소를 보였다. 치료요인은 초기, 중기, 말기로 나누어 비교했을 때, 전 회기에 걸쳐 실존적 인자가 1위를 차지하였고, 카타르시스, 치료자동일시, 보편성, 집단응집력이 내내 상위를 차지하였다. 초기, 중기에 중하위를 차지하였던 대인관계학습은 말기에 2위를 기록하였다. 총평가 설문에서 참여자의 100%에서 도움 받은 것으로 보고하였고, 75%에서 생활의 변화를 보고하였으며, 75%에서 재참여 의사를 밝혔다. 결 론 : 외래환자들에게 단순히 약물치료와 지지치료만을 시행하는 것에 덧붙여 시간제한 집단정신치료를 시행할 때 증상호전뿐만 아니라 성격변화의 효과도 가져오는 것으로 나타났다. 또한 참여자들의 집단정신치료에 대한 만족도도 매우 높은 것으로 나타났다. 집단정신치료는 정신치료에 뿌리를 두면서 이에 필적하는 치료효과가 있는 것으로 공인된 치료양식이다. 의약분업 및 의료비 감축 등의 급변하는 현 의료환경에서 집단정신치료와 시간제한치료가 정신치료와 장기치료만큼 효과 있으면서 저비용, 고효율적인 양식으로서 정착될 수 있을 것이다. Objectives : Recently, the outpatient group psychotherapy has been changed from traditional long-term therapy to short-term or time-limited therapy. The termination time and session numbers are given from start line in the time-limited therapy while 10 to 40 sessions are needed in the short-term therapy. And therapist and patients come to an agreement of the accomplishable therapeutic goal and work together actively. The time-limited group psychotherapy is being accepted newly as an efficient therapeutic modality because effective therapeutic outcomes within given time have been reported. The objectives of this study are as follows ; firstly, we examine the therapeutic outcomes and the therapeutic factors after performing the time-limited group psychotherapy for outpatients in the psychiatric clinic ; secondly, we analyze the characteristics showed in the process of study ; lastly, we verify the feasibility and the validity of this group psychotherapy and then establish the basis of the effective outpatient therapy that would be settled down as an applicable treatment modality economically and efficiently in the current medical environment of Korea. Methods : This study was performed weekly in total 12 sessions from July 1999, April 2000 to and each session took 70-80 minutes. The experimental group were composed of the highly-functioning psychotic patients among outpatients in the psychiatric clinic. The control group were composed of the similar patients through one-to-one matching of age, sex, diagnosis, and duration of illness. The participants were 8 patients each. BDI(Beck Depression Inventory), STAI(Spielbergs State-Trait Anxiety Inventory), MMPI(Minnesota Multiphasic Personality Inventory), and EDMT(Ewha Defence Mechanism Test)as the evaluation scales were performed before and after treatment. And 13-therapeutic factors scale was performed just after each session and the self-report total assessment questionnaire was performed only in experimental group at the end of this study. Results : The mean score of BDI was decreased significantly in experimental group in comparison with control group. The mean score of STAI-S was not changed significantly in both group, and the mean score of STAI-T was decreased in experimental group in comparison with control group. The mean score of MMPI was decreased significantly in experimental group in comparison with control group, but the comparison of difference scores(post-treatment score-pre-treatment score) between the experimental and control group was not decreased significantly. This result may come from psychopharmacotherapy and individual supportive psychotherapy given equally to both group. The mean scores of immature defence and neurotic defence in EDMT were decreased significantly in experimental group compared with control group. Comparing the therapeutic factors to divide into the first, middle, and the last stage, existential factor was ranked first, and catharsis, identification with therapist, universality, and group cohesiveness were ranked high in all stages. Interpersonal learning was ranked first in the last stage altinough being ranked low in the first and middle stage. The total assessment questionnaires about group psychotherapy were reported that 100% of participants were helped, 75% of participants were changed in their lives, and 75% of participants had minds to join this kind of program again if given for them. Conclusions : This result shows that not only symptom relief but also personality change was achieved when the time-limited group psychotherapy was practiced in addition to simple psychophamarcotherapy and individual supportive psychotherapy for outpatients. The degree of satisfaction for group psychotherapy of participants were evaluated highly. Group psychotherapy has been accepted in public as therapeutic modality that must be as equally effective as psychotherapy although group psychotherapy derives from individual psychotherapy. In out current medical environment that has been changed suddenly by the separation of medical practice and pharmaceutical dispensing and the decrease of medical fee, group psychotherapy or time-limited therapy would be settled down as low-expense and high-efficiency therapeutic modalities that were as equally effective as individual psychotherapy or long-term therapy