http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hung-Chun Fu,Jen-Ruei Chen,Min-Yu Chen,Keng-Fu Hsu,Wen-Fang Cheng,An Jen Chiang,Yu-Min Ke,Yu-Chieh Chen,Yin-Yi Chang,Chia-Yen Huang,Chieh-Yi Kang,Yuan-Yee Kan,Sheng-Mou Hsiao,Ming-Shyen Yen 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.5
Objective: Choice of hysterectomy and adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid endometrial cancer (EEC) is still controversial. Aims of this study were to evaluate survival benefits and adverse effects of different hysterectomies with or without adjuvant radiotherapy (RT), and to identify prognostic factors. Methods: The patients at 14 member hospitals of the Taiwanese Gynecologic Oncology Group from 1992 to 2013 were retrospectively investigated. Patients were divided into simple hysterectomy (SH) alone, SH with RT, radical hysterectomy (RH) alone, and RH with RT groups. Endpoints were recurrence-free survival (RFS), overall survival (OS), disease-specific survival (DSS), adverse effects and prognostic factors for survival. Results: Total of 246 patients were enrolled. The 5-year RFS, OS, DSS and recurrence rates for the entire cohort were 89.5%, 94.3%, 96.2% and 10.2%, respectively. Patients receiving RH had more adverse effects including blood loss (p<0.001), recurrent urinary tract infections (p=0.013), and leg lymphedema (p=0.038). Age over 50-year (HR=9.2; 95% confidence interval [CI], 1.2–70.9) and grade 3 histology (HR=7.28; 95% CI, 1.45–36.6) were independent predictors of OS. Grade 3 histology was an independent predictor of RFS (HR=5.13; 95% CI, 1.38–19.1) and DSS (HR=5.97; 95% CI, 1.06–58.7). Patients receiving adjuvant RT had lower locoregional recurrence (p=0.046), but no impact on survival. Conclusion: Different treatment modalities yield similar survival outcomes. Patients receiving SH with RT had lower locoregional recurrent with acceptable morbidity. Age and tumor grading remained significant predictors for survival among patients with FIGO 2009 stage II EEC.
Optimization on Ready-Mixed Concrete Dispatching Problem via Sliding Time Window Searching
Machine Hsie,Chun Yen Huang,Wen-Ta Hsiao,Ming-Yen Wu,YuanChi Liu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.8
The dispatching of ready-mixed concrete (RMC) is usually scheduled manually and difficult tomeet the demand of construction sites. The inefficient dispatching plan causes concretedefects of discontinuous casting (cold joint formation) or long on-site queuing (concrete earlyhardening inside RMC truck). The RMC dispatching literature focus on optimizing thedispatching intervals to minimize RMC truck on-site queuing, system operation costs of RMCplant and construction sites, or tradeoff. The previous research methods include mixed-integerlinear programming (MILP) and evolutionary algorithms. They have the limitations of providingoptimal solutions or computation efficiency. This paper develops a Binary Linear programmingwith Sliding Time-Window (BLSTW) to overcome these limitations. The BLSTW model subtlydetermines the dispatch of RMC trucks through binary variables incorporated into sliding timewindow search approach. Two perspectives, from the RMC plant supplier and constructionsite demanders, are discussed respectively. Three case studies are conducted to verify theefficiency improvement of the developed model including one largescale example of 25 sites. The comparisons made with two cited results shows the superior of the developed model.
Studying the Strain Effect on Silicon Atomic Wires
Shu-Tong Chang,Shu-Hui Liao,Hsiao-Chun Huang,Chee-Wee Liu,Chung-Yi Lin 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.6
The transport properties of a Si3 atomic wire system, which is formed by a Si3 cluster connected to two lithium electrodes with bias applied, is studied using the simulator Virtual NanoLab that is constructed based on the non-equilibrium Green’s function (NEGF) scheme. We investigated the Si3 atomic wire system under three strain conditions (tensile, compressive and shear). Different trends in the I-V characteristics are observed for the three cases at various applied biases. The transmission spectrum T(E, Vb), as a function of energy and applied biases, are analyzed. The interactions among eigenstates of the molecular projected self-consistent Hamiltonian (MPSH) strongly affect the transport properties of the system.
Jing-Han Chen,Chi-Te Liang,Chun-Feng Huang,Da-Ren Hang,David A. Ritchie,J. C. Hsiao,Jyun-Ying Lin,Michelle Y. Simmons,Ming-Gu Lin,S. H. Lo,Tsai-Yu Huang 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.3
By applying a magnetic field perpendicular to GaAs/AlGaAs two-dimensional electron systems (2DESs), we study the low-field Landau quantization when the thermal damping is reduced with decreasing temperature. Magneto-oscillations following the Shubnikov-de Haas (SdH) formula are observed even when their amplitudes are so large that the deviation to such a formula is expected. Our experimental results show the importance of the positive magneto-resistance to the extension of the SdH formula under the damping induced by the disorder.
Tests of reinforced concrete deep beams
Wen-Yao Lu,Hsin-Tai Hsiao,Chun-Liang Chen,Shu-Min Huang,Ming-Che Lin 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.15 No.3
This study reports the test results of twelve reinforced concrete deep beams. The deep beams were tested with loads applied through and supported by columns. The main variables studied were the shear span-to-depth ratios, and the horizontal and vertical stirrups. The shear strengths can be effectively enhanced for deep beams reinforced with both horizontal and vertical stirrups. The test results indicate the shear strengths of deep beams increase with the decrease of the shear span-to-depth ratios. The normalized shear strengths of the deep beams did not increase proportionally with an increase in effective depth. An analytical method for predicting the shear strengths of deep beams is proposed in this study. The shear strengths predicted by the proposed method and the strut-and-tie model of the ACI Code are compared with available test results. The comparison shows the proposed method can predict the shear strengths of reinforced concrete deep beams more accurately than the strut-and-tie model of the ACI Code.
Shu-Hua Yang,Kai-Chiang Yang,Chih-Wei Chen,Ting-Chun Huang,Yuanhui Sun,Ming-Hsiao Hu 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.5
Study Design: In vitro cell culture study. Purpose: This study aims to investigate the impact of transforming growth factor-beta1 (TGF-β1) and lovastatin on differentiating human mesenchymal stem cells (MSCs) toward nucleus pulposus (NP)-like phenotype. Overview of Literature: MSCs offer a cell source to the cell-based therapy for intervertebral disc degeneration. TGF-β1 is used to induce MSCs to differentiate into NP-like cells; however, an undesired expression of collagen type I has been reported. Statins reportedly stimulate expression of bone morphogenetic protein-2 (BMP-2) and promote the chondrogenic phenotype to NP cells. However, the effects of statins with or without TGF-β1 on the differentiation of MSCs into NP-like cells remain unclear. Methods: Human MSCs were treated with TGF-β1 alone, lovastatin alone, and simultaneous or sequential treatment with TGF-β1 and lovastatin. After the proposed stimulation, the total RNA was extracted to assess the expression profile of NP cells-specific genes. Hematoxylin–eosin staining was used for examining the microscopic morphology. Furthermore, we detected the syntheses of S-100 protein, aggrecan , and collagen type II in the extracellular matrix using immunohistochemical staining. Results: Simultaneous or sequential treatment of TGF-β1 and lovastatin could further augment the BMP-2 overexpression compared with lovastatin-alone treatment. However, the mRNA expression of aggrecan and collagen type II was not compatible with the expression level of BMP-2 . Immunohistochemical studies revealed compatible production of aggrecan, collagen type II , and S-100 protein in all three groups treated with lovastatin. Cells in groups treated with lovastatin were less populated than that in the group treated with TGF-β1 alone. Conclusions: This study demonstrates a promising role of lovastatin in inducing human MSCs into NP-like cells. However, further optimization of cell density before lovastatin treatment, treatment duration, and combination with TGF-β1 are warranted to attain better stimulatory effects.
Wang Hui-Ching,Moi Sin-Hua,Chan Leong-Perng,Wu Chun-Chieh,Du Jeng-Shiun,Liu Pei-Lin,Chou Meng-Chun,Wu Che-Wei,Huang Chih-Jen,Hsiao Hui-Hua,Pan Mei-Ren,Chen Li-Tzong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Personalized genetic profiling has focused on improving treatment efficacy and predicting risk stratification by identifying mutated genes and selecting targeted agents according to genetic testing. Therefore, we evaluated the role of genetic profiling and tumor mutation burden (TMB) using next-generation sequencing in patients with head and neck squamous cell carcinoma (HNSC). The relapse mutation signature (RMS) and chromatin remodeling mutation signature (CRMS) were explored to predict the risk of relapse in patients with HNSC treated with concurrent chemoradiotherapy (CCRT) with platinum-based chemotherapy. Patients in the high RMS and CRMS groups showed significantly shorter relapse-free survival than those in the low RMS and CRMS groups, respectively (p < 0.001 and p = 0.006). Multivariate Cox regression analysis showed that extranodal extension, CCRT response, and three somatic mutation profiles (TMB, RMS, and CRMS) were independent risk predictors for HNSC relapse. The predictive nomogram showed satisfactory performance in predicting relapse-free survival in patients with HNSC treated with CCRT.