A Phase II Study on Continuous Infusional Paclitaxel and 5-Fu as First-line Chemotherapy for Patients with Advanced Esophageal Cancer

Gu, Ming,Li, Su-Yi,Huang, Xin-En,Lin, Yan,Cheng, Hong-Yan,Liu, Lin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Objective: This study was performed to evaluated the efficacy and safety of continuous infusional paclitaxel and 5-Fu as first-line chemotherapy in patients with advanced esophageal squamous cell cancer (ESCC). Methods: A total of 22 patients with advanced esophageal squamous cell cancer with no indications for surgery and radiation therapy, or recurrent patients were enrolled from October 2008 to November 2010. All were treated with PTX 20 $mg/m^2$ was administered through a 16 hours continuous intravenous infusion on days 1 to 3, 8 and 9. DDP 3.75 $mg/m^2$ was given on days 1 to 4 and 8 to 11, continuous infusional 5-FU over 24-hours on days 1 to 5 and 8 to 12 at a dose of 375 $mg/m^2$, and folacin 60 mg orally synchronized with 5-Fu. The treatment was repeated every 21 days for at least two cycles. Results: 22 cases of all enrolled patients could be evaluated for the effect of treatment: 2 cases were CR, 9 cases PR, 5 cases SD and 2 cases PD, giving an overall response rate of 68.2%(15/22). The median time to progression was 7.0 months. The adverse reactions related to chemotherapy were tolerable; the most common toxic effects were marrow depression, alopecia, and fatigue. Conclusion: Low-dose continuous infusional PTX over 16-hours and 5-fu over 24-hours is a promising regimen with good tolerability in treating patients with advanced esophageal squamous cell cancer.

GPR12 Selections of the Metabolites from an Endophytic Streptomyces sp. Asociated with Cistanches deserticola

Lin, Zhen-Jian,Lu, Xiao-Ming,Zhu, Tian-Jiao,Fang, Yu-Chun,Gu, Qian-Qun,Zhu, Weiming 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9

An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma.. Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.

Quality of Life and Radiotherapy Complications of Chinese Nasopharyngeal Carcinoma Patients at Different 3DCRT Stages

Gu, Mo-Fa,Su, Yong,Chen, Xin-Lin,He, Wei-Ling,He, Zhen-Yu,Li, Jian-Jun,Chen, Miao-Qiu,Mo, Chuan-Wei,Xu, Qian,Diao, Yuan-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

Purpose: the study aimed to compare the quality of life (QOL) and radiotherapy complications among Chinese nasopharyngeal carcinoma (NPC) patients at different 3-dimensional conformal radiotherapy (3DCRT) stages adjusting for other variables. Methods: 511 NPC patients at different 3DCRT stages were enrolled. They were interviewed regarding SF-36, complications and socio-demographic variables and cancer- or treatment-related variables. Analysis of covariance (ANCOVA) based on SF-36, complications scores as dependent variables, 3DCRT stages as independent variables, and other variables as covariate were established. Results: The influencing factors of PCS included 3DCRT stages and age group. The influencing factors of MCS included 3DCRT stages and income. Most QOL scores of NPC patients were significantly associated with 3DCRT stage, after accounting for other variables. QOL scores of the patients receiving 3DCRT were the lowest, QOL scores of people after 3DCRT gradually increased. PCS scores of people greater than 5 years after 3DCRT was improved to or even better than the level before 3DCRT. The complications with significantly different scores of patients at different 3DCRT status included xerostomia, throat ache, hypogeusia, caries, hearing loss, snuffles. Conclusions: Clinicians should pay more attention to older NPC patients and patients with lower income. When patients receive 3DCRT, measures should be taken to reduce radiation injury to improve the patients' QOL.

The Gender-Sensitive Social Risk Factors for Internet Addiction in College Undergraduate Students

Xia Lin,Jing-yan Gu,Wan-jun Guo,Ya-jing Meng,Hui-yao Wang,Xiao-jing Li,Wei Deng,Lian-sheng Zhao,Xiao-hong Ma,Ming-li Li,Ting Chen,S,K,Cheng,Tao Li 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.7

Objective The current study aims to explore precipitating and social risk factors for internet addiction (IA) in university undergraduate students, and to provide evidence for interventions and the early prevention of IA in different genders. Methods Four thousand eight hundred and fifty-eight college sophomores completed an online survey on their internet use-related behaviours and social risk factors. Results We found that more male (8.3%) than female students (5.4%) had moderate and severe IA. The main online activity in the moderate and severe IA groups was online gaming in males and online streaming in females. Roommates engaging in similar internetbased entertainment was a risk factor of IA only for males, while not being in a romantic relationship was a risk factor of IA for females only. Infatuation with the internet before college and adjustment problems for college life were shared risk factors for both genders in the mild and moderate IA groups. Conclusion IA was a common phenomenon in college students with shared and unique precipitating and social risk factors in males and females. The gender-sensitive risk factors for IA warranted earlier and individualized intervention and prevention strategies for IA in this population.

A new rotational force model for quasi-steady theory of plate-like windborne debris in uniform flow

Huatan Lin,Peng Huang,Ming Gu 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.35 No.2

The force coefficients of rotating plates in the acceleration stage will vary with rotation rate from 0 to stable rotation rate w0, which are important for quasi-steady theory of plate-like windborne debris to simulate the trajectory. In this paper, a wind tunnel experiment is carried out to study the effects of geometry and the Reynolds number on the variations of mean force coefficients of rotating plates. The rotational lift coefficients are sensitive to both geometry effect and Reynolds number effect, while the rotational drag and moment coefficients are only sensitive to geometry effect. In addition, new empirical formulas for the rotational lift coefficient and moment coefficients are proposed. Its accuracy is verified by comparing the predicted results with existing test data. Based on the experimental data of rotating plates, a new rotational force model for quasi-steady theory, which can be applied to a wider scope, is proposed to calculate the trajectory of plate-like windborne debris. The results show that the new model provides a better match with the tested trajectories than previous quasi-steady theories.

Manufacturing quality assurance for a rotate vector reducer with vibration technology

Jingjun Gu,Dishan Huang,Jing Tan,Jinlei Liu,Song Wang,Ming Li,Lin Xiao 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.5

To improve the product quality of rotate vector (RV) reducer at a low cost, a kind of vibration technology is introduced to investigate the quality assurance of RV. It includes a torsional vibration test to assess the vibration performance of the reducer and vibration analysis to recognize the manufacturing defects in the reducer’s mechanical components. The mechanical components with manufacturing defects are diagnosed through the signal processing on torsional vibration and defect characteristics recognition, and they are removed from the RV reducer by a reassembling process. As a result, the dynamic behavior of the reducer is evidently improved, the torsional vibration of the reducer is kept within a low level, and the feedback control is realized for product quality during the production process. Therefore, the presented vibration technology is highly recommended to the manufacture quality assurance of RV reducers applied in an industrial robot.

Optimization of multiple tuned mass dampers for large-span roof structures subjected to wind loads

Zhou, Xuanyi,Lin, Yongjian,Gu, Ming Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.20 No.3

For controlling the vibration of specific building structure with large span, a practical method for the design of MTMD was developed according to the characteristics of structures subjected to wind loads. Based on the model of analyzing wind-induced response of large-span structure with MTMD, the optimization method of multiple tuned mass dampers for large-span roof structures subjected to wind loads was established, in which the applicable requirements for strength and fatigue life of TMD spring were considered. According to the method, the controlled modes and placements of TMDs in MTMD were determined through the quantitative analysis on modal contribution to the wind-induced dynamic response of structure. To explore the characteristics of MTMD, the parametric analysis on the effects of mass ratio, damping ratio, central tuning frequency ratio and frequency range of MTMD, was performed in the study. Then the parameters of MTMD were optimized through genetic algorithm and the optimized MTMD showed good dynamic characteristics. The robustness of the optimized MTMD was also investigated.

Application of physical vapor deposition process to modify activated carbon fibers for ozone reduction

Yu-Chih Lin,Chung-Liang Chang,Tser-Sheng Lin,Hsunling Bai,Ming-Gu Yan,Fu-Hsiang Ko,Chia-Tien Wu,Cheng-Hsiung Huang 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.3

This study utilized the activated carbon fiber (ACF) modified with metal catalyst via physical vapor deposition (PVD) process (ACF/PVD) to diminish ozone. Furthermore, the ozone removal efficiency of ACF/PVD was compared with that of original ACF and ACF modified with metal catalyst via impregnation process (ACF/impregnation). In addition to the kinds of coated metal and the inlet ozone concentrations, the effects of the coating thickness and the reaction temperature on ACF/PVD for ozone removal were also examined. The results indicate that the ozone removal efficiency of ACF/PVD is better than that of original ACF and ACF/impregnation. The ozone removal efficiency of different metal-coated ACF/PVD in the superior order is gold (Au), and manganese (Mn). The increase of Au-coated thickness (3 nm to 80 nm) on ACF/PVD will enhance the ozone removal. However, when the Mn-coated thickness on ACF/PVD is larger than 15 nm, the ozone removal efficiency displays a declining trend. Furthermore, a higher reaction temperature will result in a better ozone removal of ACF/PVD and the original ACF.

GPR12 Selections of the Metabolites from an Endophytic Streptomyces sp. Asociated with Cistanches deserticola

Zhen-Jian Lin,Xiao-Ming Lu,Tian-Jiao Zhu,Yu-Chun Fang,Qian-Qun Gu,Weiming Zhu 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9

An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma..Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.

Experimental study and FE analysis of tile roofs under simulated strong wind impact

Huang, Peng,Lin, Huatan,Hu, Feng,Gu, Ming Techno-Press 2018 Wind and Structures, An International Journal (WAS Vol.26 No.2

A large number of low-rise buildings experienced serious roof covering failures under strong wind while few suffered structural damage. Clay and concrete tiles are two main kinds of roof covering. For the tile roof system, few researches were carried out based on Finite Element (FE) analysis due to the difficulty in the simulation of the interface between the tiles and the roof sheathing (the bonding materials, foam or mortar). In this paper, the FE analysis of a single clay or concrete tile with foam-set or mortar-set were built with the interface simulated by the equivalent nonlinear springs based on the mechanical uplift and displacement tests, and they were expanded into the whole roof. A detailed wind tunnel test was carried out at Tongji University to acquire the wind loads on these two kinds of roof tiles, and then the test data were fed into the FE analysis. For the purpose of validation and calibration, the results of FE analysis were compared with the full-scale performance ofthe tile roofs under simulated strong wind impact through one-of-a-kind Wall of Wind (WoW) apparatus at Florida International University. The results are consistent with the WoW test that the roof of concrete tiles with mortar-set provided the highest resistance, and the material defects or improper construction practices are the key factors to induce the roof tiles' failure. Meanwhile, the staggered setting of concrete tiles would help develop an interlocking mechanism between the tiles and increase their resistance.