[논문]부산광역시 지하철역의 오염물질 농도 변화에 관한 연구

이화운,박종길,장난심,이희령,김희만 부산대학교 환경문제연구소 2004 環境硏究報 Vol.22 No.-

on the variation of Air Pollutants concentration in Subway Station at Busan Metropolitan City

위암과 식도암이 병발된 다발성 원발성 악성종양 1예

박사영,이나영,이효진,이선영,최진혁,이순남,심강섭,성순희,한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3

Multiple primary cancer means that more that two cancers occur independently in an individual. Recently, the incidence of multiple primary cancer has increased with lengthened survival, of cancer patients, development of new diagnostic technique and increased clinical evaluation. We report a patient who had adenocarcinoma of stomach combined with squamous cell carcinoma of esophagus simultaneously.

[trans-FeCl_2(O=PPh_3)_4]^+ [FeCl_4]^-·toluene 합성 및 구조

박희숙,박병규,이순원 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.2

The reaction of FeCl_3(PPh_3)_2, Ⅰ, with 2,6-diisopropylaniline in the presence of magnesium gave an ionic salt [FeCl_2(O=PPh_3)_4]·C_6H_5CH_3, Ⅱ. This product has been characterized by ^1H-NMR and single crystal X-ray crystallography. Crystal data for Ⅱ: Monoclinic, space group Cc, a = 31.499(6)Å, b = 14.796(4)Å, c = 18.033(4)Å, β = 116.87(1)°, Z = 4, R(wR_2) = 0.0692(0.1717).

외과적 보조의 급속상악확장술 : 치험 5예 REPORT OF 5 CASES

박충열,이용욱,송종운,김영운,박홍주,오희균,유선열,이기현,황현식 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Five adults (3 cases of bilateral posterior crossbite, 2 cases of unilateral posterior crossbite) with intermaxillary discrepancy of over 5㎜ due to maxillary transverse deficiency were treated by surgically assisted rapid maxillary expansion (SARME). Bilateral maxillary horizontal osteotomies, osteotomies of pterygomaxillary junction and anterior lateral nasal wall, ans anterior palatal osteotomy were performed in 4 cases, and unilateral osteotomies in 1case, followed by palatal expansion with tooth-borne orthopedic applicance. No significant complication was observed. The mean palatal expansion was 7.2㎜ (5.8∼10.0㎜) in the maxillary first molar region. During the mean follow-up period of 4 years (5 months∼8 years 7 months), no recurrence of crossbite was observed in all cases. The SARME seemed to be a simple, stable, and reliable procedure for achieving a permanent increase of over 5㎜ in skeletal maxillary transverse width of adults.

Porphyromonas endodontalis의 침투에 따른 혈관 내피세포의 유전자 발현

공희정,최경규,박상혁,이진용,최기운 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.6

During the last two decades, there has been an increasing interest in the impact of oral health on atherosclerosis and subsequent cardiovascular disease (CVD). To date, some periodontal pathogens including Porphyromonas gingivalis (P. gingivalis) have been reported to be relevant to CVD. Porphyromonas endodontalis (P. endodontalis), which shares approximately 87% sequence homology with P. gingivalis, is mostly found within infected root canals. However, recent studies reveal that this pathogen also resides in the dental plaque or periodontal pocket in patients with periodontitis. It has been shown that P. endodontalis invades human coronary artery endothelial cells (HCAEC) and coronary artery smooth muscle cells (CASMC). To evaluate whether P. endodontalis can participate in the progression of atherosclerosis and CVD, we examined the changes in transcriptional gene expression profiles of HCAEC responding to invaion by P. endodontalis in this study. The following results were obtained. 1. Porphyromonas endodontalis was invasive of HCAEC. 2. According to the microarray analysis, there were 625 genes upregulated more than two-folds, while there were 154 genes downregulated by half. 3. Upregulated genes were relevant to inflammatory cytokines, apoptosis, coagulation and immune response. Enhanced expression of MMP-1 was also noticeable. 4. The transcription profiles of the 10 selected genes examined by real-time PCR agreed well with those observed in the microarray analysis. Thus, these results show that P. endodontalis presents the potential to trigger and augment atherosclerosis leading to CVD. 본 연구에서는 Porphyromonas endodontalis와 죽상경화증 및 심혈관질환과의 관계를 알아보기 위해, P. endodontalis가 사람의 관상동맥 내피세포에 침투했을 때 나타나는 유전자 발현의 변화를 microarray와 real-time PCR로 측정하였고, 발현이 증가된 유전자 중에서 죽상경화증과 연관된 유전자들이 관련 KEGG pathway 상에서 유의성 있는 영향을 미치는지를 분석하여 다음과 같은 결과를 얻었다. 1. Porphyromonas endodontalis는 사람의 관상동맥 내피세포에 침투하였다. 2. Microarray 분석결과, 대조군보다 발현이 2배 이상 증가된 유전자는 625개였고, 1/2이하로 감소된 유전자는 154개였다. 3. 발현이 2배 이상 증가된 유전자 중에는 염증성 cytokine 및 chemokine, 세포자멸사, 혈액응고와 면역반응 관련 유전자들이 포함되었다. 4. Microarray 분석결과를 확인하기 위해 발현이 2배 이상 증가된 유전자 중에서 10개의 유전자를 선택하여 real-time PCR을 시행하였고, 그 결과 microarray에서와 마찬가지로 발현 정도가 대조군보다 모두 높게 나타났다. 따라서 P. endodontalis가 사람의 관상동맥 내피세포에 만성적으로 작용했을 때, 심혈관질환에서 중요한 부분을 차지하는 죽상경화증을 유발하는 위험 요소 중의 하나로 작용할 수 있을 것으로 판단된다. 이와 관련된 자세한 기전을 이해하기 위해서는 앞으로 더 많은 연구가 필요할 것으로 보인다.

프로스타글란딘 E₁에칠에스테르의 외용 리오겔 제제 설계

양성운,이진교,이지은,김희규,박혜숙,김종석,최한곤,용철순,최영욱 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

External lyogels containing prostaglandin E₁ethyl ester(PGE₁-EE), a produrg of prostaglandin E₁(PGE₁) as a therapeutic agent for erectile dysfunction, were formulated to overcome the aqueous instability and enhance the percutaneous absorption. Lyogels of PGE₁-EE were prepared with ethanol (EtOH)/proplyene glycol (PG) cosolvent system as a vehicle, cineol as an enhancer, and hydroxypropylcellusose as a gelling agent. In vitro percutaneous absorption studies were performed to determine the rate of PGE₁ absorption through rat or hairless mouse skin. The permeability of PGE₁-EE lyogel with enhancer was 16-fold greater than that of lyogel without enhancer. Cosolvent produced 9-fold increase in percutaneous absorption. Pharmacodynamic effects of lyogels were evaluated in mature male cats in terms of intracavernosal pressure (ICP). Lyogles containing 0.01% of PGE₁-EE showed higher ICP compared to intraurethral preparation of PGE₁(1%) and enhancer-free control lyogel. The shelf-life (t_(10%) of lyogel at refrigerated condition (4℃) was calculated as 928 days, which is 4.2 times longer than that of control hydrogel. As a result, PGE₁-EE was formulated successfully to a lyogel system with a selective enhancer and cosolvent system for the topical delivery of PGE₁.

靜穩太陽年의 黑點活動과 서울地區 地磁氣 수직分力과의 關係

沈雲澤,朴喜椿 成均館大學校 1966 論文集 Vol.11 No.-

우리 나라에서 地磁氣수직分力의 測定 및 太陽黑點의 觀測은 國際靜穩太陽年(1964∼65)에 國際機構에 加入하므로서 始作되었다. 우리는 이 論文에서 1965年度에 成均天文臺의 12.5inch Equatorial Reflector에 依해 觀測된 黑點 活動과 地磁氣 測定分科에서 Ruska-VR-Type magnetometer에 依해 Geomagnetic Coord.26.9°N 187.9°E(Geographical Coord, 37°35′N 127°03′E)에서 測定한 地磁氣 수직分力을 Analysis하여 서울 地方에서 Sq variation과 Sunspot Relative No와의 關係와 SD variation과 Sunspot Relative No 및 大陽黑點群의 C.M.P. 通過와의 關係를 求하였다. 그 結果를 보면 Sq variation이 Sunspot Relative No와 線形關係를 갖이며 SD variation이 Sunspot Relative No가 極大를 이룬 翌月에 極大를 이루어 서로 잘 對應되고 있으며 이 原因을 살펴보니 大黑點群이 C.M.P.를 많이 通過한 翌月에 SD variation이 極大를 이룸을 볼 수 있었다. This study has the purpose of describing the relations with the solar activies and geomagnetic vertical components for international quite sun year at Seoul area. The number of relative sunspot values derived for the reflector telescope with 12.5 inchs aperture and the type 348 receiver, and the sunspot groups are classified by Zu¨rich classifications. The geomagnetic vertical compoment is measured by the division of geomagnetism with Rusk-VR-type magnetometer. The following conclussion are obtained. 1. The sunspot relative number and Sq's monthly variation have linearlity; R=7.9Sq+14.4 2. The SD's monthly variation have the greatest phenomena when the sunspot relative number reached to the greatest, there are occured its phenomena at next month when a large sunspot groups passed to center of meridian planes. This periodic variation have the difference of a month with the sunspot activities and SD variation.

Osteotome Sinus Floor Elevation Procedure를 이용한 임프란트 매식

송종운,조용기,박홍주,김영운,오희균,유선열 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.2

Maxillary sinus has an anatomic limitation to bone support available for dental implant. When there is less than 10㎜ of bone remaining between the upper alveolar ridge crest and the maxillary sinus floor, bone augmentation should be considered. In 1994, Summers reported two sinus floor elevation techniques of limmediate implant insertion, using osteotomes, for patients who have at least 5㎜ of bone remaining between the alveolar ridge crest and the maxillary sinus floor. One technique is osteotome sinus floor elevation (OSFE) procedure in which uses osteotomes to elevate the sinus floor. The other is bone-added OSFE (BAOSFE) procedure in which bone graft is added into osteotomy site. Both procedures conserve all of the remaining bone and selectively displace it upward, thereby raising sinus floor. This study was aimed to evaluate the long-term success rate of implants which had been placed by osteotome sinus floor elevation procedure. Between February 1996 and June 1998, 10 implants were placed using OSFE or BAOSFE procedures in 6 patients who had at least 6㎜ of bone remaining between the alveolar ridge crest and the sinus floor. OSFE procedures were performed in patiens, 2∼4㎜ sinus floor elevation was needed, whereas BAOSFE procedures were done in patines, more than 4㎜ sinus floor elevation was needed. During the mean follow-up period of 4 years 4 months (3 years 6 months ∼ 5 years 9 months), no implant was failed and all patients showed good functional results. OSFE and BAOSFE procedures seemed technically easier and less invasive compared to conventional sinus lift procedure. And both procedure have good success rate.

부산광역시 지하공간의 CO 대기질 평가

이화운,박종길,장난심,이희령,김희만 한국환경과학회 2003 한국환경과학회지 Vol.12 No.1

With increasing population denities in cities, underground facilities and entertainment are proliferating at a rapid pace in efforts to maximize the use of land. The purpose of this study is to evaluate CO concentration level of subway stations having underground platforms in Busan Metropolitan City, from September to November 2000, over seven times. The places of inquiry include Yongsan-dong station. The samplings were conducted at three point of each station, i.e. gate ticket gates, and platforms. The component of CO concentration is the main elements of indoor air quality evaluation. The total concentrations and average concentration of CO were the higher at the average concentration of CO were the higher at the Somyon station. The distribution of CO concentrations at each station, generally was higher at gate than ticket gates platforms. The I?O ratios(I-platforms, O-gates) were expressed highly than 1 at the Yongsan-dong station, Busan station, Nampo-dong station and were lower 1 at others.

척수 경막외 혈관 기형에 의한 재발성 척수병증

오동호,김희태,박운규,이영주,김승현,김주한,김명호,박문향 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5