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Dong‑Jun Kwon,Sung‑Min Park,Il‑Jun Kwon,Joung‑Man Park,Euigyung Jeong 한국탄소학회 2019 Carbon Letters Vol.29 No.2
This study provides an economical and effective method to improve the interlaminar properties of carbon fiber-reinforced polymers (CFRPs) using aluminum trihydroxide (ATH) microparticles. ATH microparticles are cheap and are expected to show good affinity to epoxies in the matrix and sizing agents of the carbon fibers owing to the presence of three hydroxyl groups. In addition, ATH particles are reported to improve the mechanical properties of polymers when used as the reinforcement. In this study, ATH microparticles of various sizes, 1.5, 10, and 20 μm, were used to improve the interlaminar properties of the CFRPs. ATH particles with a size of 1.5 μm improved the tensile properties of the ATH/epoxy resin and did not significantly alter the curing behavior. The interfacial adhesion between the carbon fiber and the epoxy resin was also improved, and the impregnation of the resin mixture remained similar to that of the neat resin, resulting in no significant void and defect formation. Considering the above results, the resulting 1.5 μm ATH-reinforced CFRP showed improved interlaminar properties compared to CFRP without ATH. However, 10 and 20 μm ATH-reinforced CFRPs showed deteriorated interlaminar properties due to the diminished tensile properties of the resin itself and resin impregnation, which resulted in more voids and defects, despite the interfacial adhesion between the fiber and the matrix resin.
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Dong‑Jun Lee,Taesoo Kwon,Chang‑Kug Kim,Young‑Joo Seol,Dong‑Suk Park,Tae‑Ho Lee,Byung‑Ohg Ahn 한국유전학회 2020 Genes & Genomics Vol.42 No.11
Background Sequence variations such as single nucleotide polymorphisms are markers for genetic diseases and breeding. Therefore, identifying sequence variations is one of the main objectives of several genome projects. Although most genomeproject consortiums provide standard operation procedures for sequence variation detection methods, there may be differencesin the results because of human selection or error. Objective To standardize the procedure for sequence variation detection and help researchers who are not formally trainedin bioinformatics, we developed the NGS_SNPAnalyzer, a desktop software and fully automated graphical pipeline. Methods The NGS_SNPAnalyzer is implemented using JavaFX (version 1.8); therefore, it is not limited to any operatingsystem (OS). The tools employed in the NGS_SNPAnalyzer were compiled on Microsoft Windows (version 7, 10) andUbuntu Linux (version 16.04, 17.0.4). Results The NGS_SNPAnalyzer not only includes the functionalities for variant calling and annotation but also providesquality control, mapping, and filtering details to support all procedures from next-generation sequencing (NGS) data to variantvisualization. It can be executed using pre-set pipelines and options and customized via user-specified options. Additionally,the NGS_SNPAnalyzer provides a user-friendly graphical interface and can be installed on any OS that supports JAVA. Conclusions Although there are several pipelines and visualization tools available for NGS data analysis, we developedthe NGS_SNPAnalyzer to provide the user with an easy-to-use interface. The benchmark test results indicate that theNGS_SNPAnayzer achieves better performance than other open source tools.
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권동현 ( Dong Hyun Kwon ),김호준 ( Ho Jun Kim ),이명종 ( Myeong Jong Lee ),송미영 ( Mi Young Song ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.2
Objectives: The purpose of this study is to investigate interaction and safety in administering herb-medicine with warfarin. Methods :For this study, we selected 19 patients who have been taking warfarin, from the ones that have been transferred from western hospital to oriental hospital. During their stay in the oriental hospital, we gave herb-medicine in addition to warfarin. Then we gathered informations and data on sex, age, main indications, and International Normalized Ratio(INR) values of selected patients through Electronic Medical Records(EMR) of Dong-Guk university hospital. Accordingly, we compiled all of the above data for a period of 10 days prior and 10 days post admission(western hospital period and oriental hospital period, respectively)Results and Conclusions :The statistical analysis of the data have revealed that there was no significant change of INR values after giving herb-medicine with warfarin(p=0.586). The result shows that administration of herb-medicine with warfarin is safe and has little drug interaction. However, this study was carried out on small sample size and the interaction with other drugs and various kinds of herb-medicine was not considered. Although we attained a restrictive result from this study, we are able to suggest the safety about co-administration of herb-medicine and warfarin.
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권준택,김형기,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1
Cytochrome P4502E1 (CYP2E1) is inducible by ethyl alcohol and activates procarcinogenic N-nitrosodimethylamine (NDMA), benzene, urethane and other lower molecular weight compound. CYP2E1 is also involved in metabolism of certain drugs, for example, alcohol, acetaminophen, tamoxifen, theophylline, fluorinated anesthetics, and chlorozoxazone. CYP2E1 activity was shown to be polymorphically distributed in humans and has been suggested to play a role in hepatocellular carcinoma and alcoholic related disorders. Although genetic predisposition to alcoholism and alcoholic liver disease has been reported, genetic susceptibility to alcoholic pancreatitis is still a matter of debate. The aims of this study were to investigate the allelic frequency of CYP2E1 Rsa I polymorphism in Koreans. We investigated the frequency distribution of CYP2E1 Rsa I polymorphism in 212 unrelated healthy Koreans and 42 hepatocellular carcinoma patients. Detection of the CYP2E1 alleles was performed by polymerase chain reaction and restriction fragment length analysis. The genomic DNA was isolated from peripheral blood with conventional phenol: chloroform extraction method. The allelic frequencies of c1 and c2 in healthy volunteers were 0.85 and 0.15, respectively. The rare type (c2/c2) of CYP2E1 Rsa I polymorphism was 0.005 in healthy volunteers.
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흰쥐에서 탄수화물 종류가 운동시 당 및 지질대사에 미치는 영향
권태동,전중기,민경선,김형렬,장응찬 대구대학교 기초과학연구소 1998 基礎科學硏究 Vol.15 No.2
The purpose of this study was to investigate the effects of glucose, sucrose, and glucose polymer(GP) ingestion on the carbohydrate and lipid metabolism during treadmill running in rats. Rats were randomly assigned to normal, control and carbohydrate groups. Carbohydrate group was divided into glucose, sucrose and GP ingested rats. The experiment was carried out after overnight fasting. Rats were administrated either normal saline(control) or carbohydrates solutions of formulated glucose(6%), sucrose(6%) and GP(6%) via polyethlene tube to stomach before treadmill run. Exercise was loaded by a treadmill run at the speed of 1 km/hour for 30, 60 and 120 minutes. The results of experiment were as follows: Plasma glucose levels were decreased in proportion to the exercise time in control, but increased at treadmill run 30 minutes and then gradually decreased with the lapse of the exercise time in carbohydrates compared with normal rats. It decreased in control, glucose, sucrose and GP compared with normal rats in decreasing order at treadmill run 120 minutes(% change of plasma glucose level of control, glucose, sucrose and GP compared with normal rats were 67, 74, 87 and 91 in plasma glucose level at treadmill run 120 min., respectively). Plasma lactate levels were increased by the exercise loading compared with normal in control and carbohydrates ingested rats. It increased in control, sucrose and GP in increasing order compared with normal rats, at treadmill run 120 minutes(% change of plasma lactate level of control, glucose, sucrose and GP compared with normal rats were 167, 185, 149 and 114 in plasma lactate level at treadmill run 120 min., respectively). Plasma FFA levels had tendency to increase by the exercise loading compared with normal in control and carbohydrates ingested rats. It showed increase in the sucrose, glucose, GP and control rats in Increasing order compared with normal rats at treadmill run 120 minutes(% change of plasma FFA level of control, glucose, sucrose and GP compared with normal rats were 151, 153, 166 and 152 in plasma FFA level at treadmill run 120 min., respectively). Plasma acetoacetate levels were higher in control compared with carbohydrates ingested rats at treadmill run 30, 60 and 120 minutes. Plasma beta-hydroxybutyrate levels increased by exercise compared with normal rats in control and carbohydrates ingested rats at treadmill run 30, 60, 120 minutes. Plasma insulin levels were decreased in proportion to the exercise time in control compared with normal rats, but in carbohydrates ingested rats increased at treadmill run 30 minutes and then gradually deceased with the lapse of the exercise time compared with normal. In carbohydrates ingested rats, plasma insulin levies were higher than control. Hematocrit did not show any difference between control and carbohydrates rats at treadmill run 30, 60 and 120 minutes. From these experimental results, it is suggested that the exhaustion of skeletal muscle glycogen, the hypoglycemia, the overproduction of lactate and dehydration is delayed in carbohydrates ingested rats. GP of the carbohydrates is considered as the most effective for these effects. Therefore, intake of carbohydrates before exercise, especially GP seems to increase performance in the prolonged moderate exercise.
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權炳善,鄭東熙,梅崎輝尙,寺尾寬行,井之上準 順天大學校 農業科學硏究所 1992 農業科學硏究 Vol.6 No.-
In order to obtain basic informations on F_1 hybrids of rape which are suitable at the southern part of Japan, 10 hybrids were grown from Oct. 1990 to Jun. 1991 at faculty agriculture, Kyushu University, Fukuoka, 812, Japan, and the evaluations were conducted using heterosis which were comparison between the performance of F_1 and that of parental average and heterobeltiosis which were comparison between the performance of F_1 and that of better parent. All the 10 crosses showed high degree of heterosis and heterobeltiosis in plant height and the maximum increase over better parent was 21%. Ten crosses showed high degree of heterosis and a crosses showed greater ear length than better parents. In case of number of branches per plant, all 10 crosses exceeded the parents. In case of number of brnches per plant, all 10 crosses exceeded the parental average and 8 crosses showed grater number of branches per plant than better parents. All the 10 crosses showed high degree of heterosis and heterobeltiosis in the number of pods per plant and the maximum increase over better parent was 7%. The performance of F_1 for pod length was similar to that of parental average and better parents. Pod setting density of all 10 hybrids was high degree of heterosis and heterobeltiosis of parental average and better parents. Some degree of heterosis and heterobeltiosis were observed in seed seeting rate only in 7 crosses. All the 10 hybrids produced higher garin yield than higher parent and the maximum increase over higher parent was 67%. Hybrids between early parent and late parent showed late flowering and falling blossoms date. However, in a crosses betwen late parents, the F_1 flowered 2 days earlier than the parents.
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소목 천연 염색에 관한 연구 Ⅰ : 정제 알루미늄 화합물들의 매염효과에 대하여 Mordanting Effect of Purified Aluminum Compounds
권민수,전동원,최인려,김종준 服飾文化學會 2004 服飾文化硏究 Vol.12 No.5
Currently, as mordants, heavy metals are being used in dyeing process in order to improve dye uptake and dye fastness. These chemicals, however, are mostly harmful to human body and the environment along with the pollution by effluent. Traditionally, rice straw ash solution, lime, etc. have been used as mordants in order to improve the effects on dye uptake and color fastness of dyestuffs. The study of natural mordants would, therefore, be vital to the development and succession of our traditional dyeing methods. In this study, as a preliminary step toward the use of rice straw ash solution for the nautral dyeing using Caesalpinia sappan, several aluminum compounds were employed as mordants. When the purified aluminum compounds were used, on the basis of unmordanted cotton fabric, the WS values of the pre-mordanted and simultaneously mordanted fabrics increased by 2 or 3 times, while those of the post-mordanted fabrics decreased.
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