Four Poems by Kim Chun-su

Kim Chun-su The Academy of Korean Studies 1967 Korea Journal Vol.7 No.10

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 이트라코나졸 액과 플루코나졸 시럽의 예방 효과 : 전향적, 무작위, 비교 임상시험

최수미,이동건,최정현,박선희,엄기성,김유진,김희제,민창기,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2005 감염과 화학요법 Vol.37 No.2

목적 : 조혈모세포이식 환자에서 호중구 감소 기간 동안 이트라코나졸 액(ITZS)과 플루코나졸 시럽(FCZS)의 진균 감염에 대한 예방 효과를 전향적으로 비교해 보고자 하였다. 재료 및 방법 : 2001년 8월부터 2002년 6월까지 가톨릭 조혈모세포이식센터에 입원하여 동종 조혈모세포이식을 받은 만 18세 이상의 환자들을 각각 ITZS와 FCZS군으로 무작위 배정하여 침습성 진균 감염 발생과 약제 관련 부작용을 전향적으로 조사하였다. 결과 : ITZS군에 40명, FCZS군에 38명이 배정되었고, FCZS군 환자의 평균 나이가 더 많았다. 시험 약제 평균투여기간은 ITZS군 16.4일, FCZS군 21.9일로 ITZS군이 더 짧았다. 이는 ITZS군에서 소화기 부작용으로 인한 약제 중단이 더 많았기 때문으로 보인다. 시험 약제 투여 후 총 빌리루빈 수치의 유의한 증가가 관찰되었으나, 약제 관련 부작용은 모든 환자에서 가역적이었다. 호중구감소 기간동안 표재성 진균 감염은 두 군에서 모두 발생하지 않았고, 침습성 진균 감염은 ITZS군 5명(12.5%), FCZS군 8명(21.1%)으로 FCZS군에서 많았으나, 통계학적으로 유의하지 않았고, 사망률에도 유의한 차이는 없었다. 결론 : 침습성 진균 감염에 대한 이트라코나졸 액과플루코라졸 시럽의 예방 효과에 유의한 차이는 없었으나, 앞으로 더 많은 환자를 대상으로 잘 짝지어진 대조군 연구가 필요할 것으로 보인다. 부작용 중 간독성과 관련하여 이식시 투여되는 여러 약제들과의 상호작용에 대한 연구도 필요할 것이다. Background : Though fluconazole is widely used for antifungal prophylaxis, it is ineffective against mould infections including Aspergillus species. Itraconazole has a broader spectrum than fluconazole but the capsule form shows erratic bioavailability in neutropenic patients. In this study, we compared itraconazole oral solution (ITZS) with fluconazole syrup (FCZS) for the prevention of invasive fungal infection (IFI) in allogeneic hematopoietic stem cell transplant recipients. Materials and Methods : Adults receiving allogeneic hematopoietic stem cell transplantation (HSCT) from september 2001 to June 2002, were randomly allocated to either the ITZS group or the FCZS group. We prospectively evaluated the safety and efficacy of each drug. Results : Out of 78 patients (40 patients in the ITZS group and 38 patients in the FCZS group) who were eligible for this study, 37 patients completed the course of prophylaxis without any evidence of IFI. The mean duration of prophylaxis was 16.4 days for the ITZS group and 21.9 days for the FCZS group (P<0.006). Drug-related adverse events occurred in 28 patients (70.0%) and 19 patients (50.0%) in the ITZS group and the FCZS group, respectively. Common adverse events of ITZS were nausea, vomiting, and diarrhea. Drug-related reversible hepatotoxicity occurred in 4 patients in the ITZS group. There was a significant elevation of total bilirubin level in the ITZS group. The incidence of suspected IFI occurred in 5 patients (12.5%) who received ITZS, compared with 8 (21.1%) who received FCZS (P=0.372). There were no proven IFIs or superficial (oral/vaginal) fungal infections in both groups. Overall mortality was not different between the two groups (2.5% in the ITZS group versus 5.3% in the FCZS group, P=0.610). Conclusion : ITZS and FCZS showed similar protection against IFI during pre-engraftment period. Poor tolerability due to gastrointestinal troubles of ITZS might limit its success as prophylactic therapy. Well matched controlled study with large number of patients will be required in the future.

들깨(Perilla) 品種改良 및 育成에 관한 硏究(Ⅰ) : 施肥水準 및 栽植密度 試驗 Effect of Fertilizer application and Planting density on Perilla

金正基,孫賢秀,安始榮,鄭大守 東亞大學校 1978 東亞論叢 Vol.15 No.2

1977年 本大學校 農科大學에서 들깨栽培에 대한 施肥適量 및 栽培密植密度에 관한 試驗을 實施한 결과는 다음과 같았다. 1. ?酸質 肥料는 10a當 7kg을 施用하는 것이 效果的이었다. 2. 可里 肥料는 10a當 3kg을 施用하는 것이 들깨의 收量을 높여 주었다. 3. 本試驗에서 石?의 施用效果는 별로 없었다. 4. 들깨의 栽植密度는 60cm X 20cm가 가장 收量이 높았다. Factorial experiment was carried out in to determine the adequated amount of fertilizer and planting density for perilla breeding, and the results obtained were as follows; 1) 7kg per 10a of P²O fertilization was found reasonable. 2) 3kg per 10a of potash fertilization was effective for increasing the yields of perilla seed. 3) No effect was recognized in clcim application. 4) Adequate planting density was 60cmX20cm in order to increase the yields.

가설재해의 원인 분석과 안전성 개선방안에 관한 연구

김용수,소용성,김천학 중앙대학교 건설환경연구소 2001 環境科學硏究 Vol.12 No.2

본 연구는 통계자료를 통해 건설재해 및 가설재해에 관한 현황을 조사하고, 가설재 제조 및 임대 · 유통업체와 가설재 사용업체를 중심으로 가설재 사용실태에 대한 설문조사 및 사례조사를 실시하여 가설재 사용실태에 관한 가설재해의 원인을 파악하고 가설재해 예방에 관한 개선방안을 제시하였고, 그 결과는 다음과 같다. 1.가설재 제조 및 임대 · 유통업체의 경우 가설재 제조 및 임대 · 유통업체의 문제점은 불량 가설재의 불법유통으로 인한 가설재 제조업체의 경영악화와 영세 가설재 임대 · 유통업체의 난립으로 인한 유통과정에서의 가설재 품질저하 그리고, 가설재 성능 검정제도의 미흡으로 나타났다. 그에 대한 개선방안으로는 가설재 제조업체의 제도적인 육성, 임대 · 유통업체에 대한 허가기준 강화, 그리고 가설재 성능 검정제도의 보완과 재사용가설재의 명확한 사용기준 마련을 들 수 있다 2.가설재 사용업체의 경우 가설재 사용업체의 문제점은 원청업체의 가설재에 대한 하도급업체로의 비용전가와 가설재 반입 및 사용시 형식적인 품질검사로 나타났다. 그에 대한 개선방안으로는 가설재에 대한 비용을 설계이전 단계에서부터 계획에 포함, 전 공정에 대한 품질검사 절차의 모델화, 그리고 현재 유통되고 있는 기존의 불량 가설재에 대한 자발적인 폐기의 유도를 들 수 있다. This study aims to find the cause of temporary work accidents and suggests a improvement plan for the prevention of accidents in temporary works. For this purpose, the following research methods were used: statistical analysis of construction accidents, questionnaire survey, and a case study. As conclusions, causes of temporary work accidents were showed and a improvement plan for the prevention of the accidents in temporary works was suggested for the 2 groups: (1) temporary material manufacturers, lease and sales companies, (2) construction companies which use those temporary materials

진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과

정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.

국민건강실천운동의 효과적 추진방안

김수춘 韓國保健敎育學會 1991 보건교육건강증진학회지 Vol.8 No.1

In accordance with the rapid industrialization in Korea, there have been remarkable changes in the health environment. The major changes are: the change of disease structure, the aging of population structure, the diversification of health needs and the increase of health care costs. Because most of health problems stems from the environment, national health policy should be conducted according to the environmental changes. It is necessary for the voluntary organizations as well as the government ones to plan and participate the national health promotion movement on a national level so as to make the people form the attitude that health promotion is better than cure. Also, it is desirable that national health promotion movement be implemented gradually especially by four steps, 1) preparation step ; 2) enlightenment step : 3) implementation step : 4) evaluation step.

우리나라 논 관개용 지하수 수질 특성

김진호,조광래,임수정,이경자,경기천,엄미정,김희권,김찬용,이영한,이신찬,윤순강 한국환경농학회 2003 한국환경농학회지 Vol.22 No.4

This study was carried out to evaluate the status of the groundwater quality for paddy fields irrigation in Korea. Water samples were collected at 130 sites throughout the country. Samples were collected at three seasons-April, July and October-in 2000. According to our survey, the groundwater was found to be suitable for irrigation purpose. Average EC was shown 0.286 dS/m. Nitrate-nitrogen and Cl^(-) concentration was 5.6 ㎎/L, 32.95 ㎎/L which satisfied the Korean Standards for Irrigation Water. Nitrate-nitrogen concentration in each province was shown as following orders: Jeju (11.17 ㎎/L) > Chungnam (8.16 ㎎/L) > Gyeongbuk (6.64 ㎎/L) > Gyounggi (5.91 ㎎/L) > Chungnam (4.95 ㎎/L) > Gyeongnam (3.91 mgk) > Jeonbuk (3.50 ㎎/L) > Jeonnam (3.27 ㎎/L) > Gangwon (2.91 ㎎/L). The concentration by sampling seasons were October (6.62 ㎎/L) > July (5.88 mg&) > April (4.78㎎/L). As the soil of Jeju Province is usually derived from volcanic ash soils mainly used for upland drops, it may influence the nitrate-nitrogen concentration of groundwater. The amount of rainfall also influence the water quality. But the COD_(Cr), were shown April (3.17㎎/L) > July (2.91 ㎎/L) > October (2.40 ㎎/L), it is highly related in the basal dose of organic matter fertilizers. This study demonstrated that groundwater quality was suitable for irrigation, but continuous monitoring is recommended for agricultural policy and developing OECD agricultural environment indicators.

물리치료사들의 대체의료에 관한 인식도 조사

김영희,김기열,배주환,김상수,남철현 경산대학교 보건복지연구소 2000 保健福祉硏究 Vol.5 No.-

This study was conducted to examine physical therapists' awareness of alternative medicine and their treatment. 250 physical therapists who were working in Daegu were selected as subjects of this study. Data were collected from February 21, 2000 to March 31, 2000. The results of this study are summarized as follows. 1. Among 218 respondents, 72.7% of them directly experienced alternative medicine. According to general characteristics of the respondents, 79.0% of them who were in thirties had experiences in alternative medicine. 83.3% of the respondents who had worked for above twenty years experienced alternative medicine and 90.0% of the respondents who were working in Oriental medical clinics had experiences in it. 79.8% of the respondents who had been married experienced alternative medicine and 88.4% of them who were Buddhists had experience in it. 2. The sources of information on alternative medicine were newspapers and broadcast (22.9%), seminars of related associations (22.5%), and Books (20.0%). 3. The respondents experienced alternative medicine for the purpose of treating their chronic diseases (67.0%), improving their energy and quality of life (20.5%), and improving their weak physical constitution (13.4%). 4. According to the respondents' trust in alternative medicine, 40.8% of them trusted chiropractic, while 25.2% of them trusted massage and finger-pressure therapy. 19.7% of them trusted taping therapy and 15.1% of them trusted sports massage. 5. 67.0% of the respondents treated patients by alter native medicine in the hospitals and clinics. In the case of treatment methods by alternative medicine, 35.3% of them gave patients the massage and finger-pressure. 33.0% of them adopted taping therapy and 24.3% of them tried to treat patients by chiropractic. 17.0% of them applied moxacautery, while 15.1% of them gave patients the sports massage. 6. The respondents adopted alternative medicine to treat following diseases: lumbago (57.5%), shoulder pain (51.8%), sciatica (39.9%), arthritis (36.2%), headache (31.1%), hypertension (24.3%), diseases of the peripheral nervous system (22.4%), diseases of digestive organ (14.6%), insomnia (12.3%), obesity (8.7%), stroke (5.5%), allergy and skin diseases (4.1%), cystitis (3.6%). 7. According to their motives of concern about alternative medicine, 59.1% of them were interested in it because they expected additional effect which could be obtained from it in parallel with Western medicine. 16.7% of them were concerned about alternative medicine because they lacked ability to solve patients' clinical problems, while 15.3% of them were interested in it because they acknowledged the effect of it. 8.9% of them had interest in alternative medicine because they were dissatisfied with medical and scientific approach of Western medicine. 8. 73.4% of the respondents thought that alternative medicine needed to be introduced in the college/university curriculum

부산지역 IT기업의 특성이 수출성과에 미치는 영향에 관한 연구

김미정,박경은,이춘수 한국관세학회 2009 관세학회지 Vol.10 No.1

According to the empirical results, it was found out that the R&D capability of a company's characteristics, overseas market experience and export immersion from the CEO's characteristics directly affected the qualitative export results. This study also found out that the R&D capability of a company's characteristics, export immersion from the CEO's characteristics and government overseas marketing support policy characteristics directly affected the qualitative export results. Therefore, a high R&D capability played a key role in quick market entrance and performance creation of technology oriented IT companies that have less market experience and insufficient business resources.