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신찬석 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.3
In animals, microRNAs (miRNAs) and small interfering RNAs (siRNAs) repress expression of protein coding genes by assembling distinct RNA-induced silencing complexes (RISCs). It has previously been shown that passenger-strand cleavage is the predominant mechanism when siRNA duplexes are loaded into Argonaute2 (Ago2)-containing RISC, while an unwinding bypass mechanism is favored for miRNA duplexes with mismatches. Here I present experimental data indicating that some mammalian miRNAs are assembled into Ago2-containing RISC by cleaving their corresponding miRNA star strands. This phenomenon may depend on the secondary structure near the scissile phosphate of the miRNA duplex. In addition, I show that ATP is not required for star-strand cleavage in this process. Taken together, the data here provide insight into the miRNA-loading mechanisms in mammals.
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Mechanism for Unfaulting of an Extrinsic Frank Loop with <112> Edges by Glide Dislocations
신찬선,Hyun-Ha Jin,심재혁,Jun Hyun Kwon,Thak Sang Byun 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.4
The interaction between dislocations and radiation defects plays a critical role in the formation of a clear channel, which results in a heterogeneous, localized plastic deformation of irradiated materials. We applied a molecular dynamics method to simulate the interaction between an extrinsic Frank loop, which is the dominant radiation defects of austenitic steels and glide dislocations to investigate the mechanism of defect elimination. We found that two dislocations in two different parallel slip planes played cooperatively to remove the defect. This finding implies that a group of dislocations is responsible for a cleared channel by moving in a group and eliminating the defects.
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