정상 성인에서 운동이 혈중 Cortisol과 포도당 및 전해질 농도에 미치는 효과

정진상,정순열,안태순,고성은 최신의학사 1993 最新醫學 Vol.36 No.7

좌심실 이완기 장애 평가에서 Atrioventricular Plane Displacement의 임상적 중요성

정연손,조구영,이태유,김근숙,최창순,류제헌,최민호,박우정,임종윤,이영 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.12

급성하벽심근경색에서 전흉부유도 ST절 하강의 의의

정병천,배호상,곽동훈,김영태,배용학,황종현,임현주,류재근,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 급성하벽심근경색증 환자에서 심전도상 흔히 동반되는 전흉부유도 ST절 하강의 의의를 알아보았다. 방법 : 심근경색후 24시간에서 48시간에 얻은 심전도를 기준으로 52명의 급성하벽심근경색증 환자를 전흉부유도에서 ST절의 하강이 있는 군과 없는 군으로 나누었으며 심도자, 관상동맥조영술, 심초음파도 및 방사성 핵종을 이용한 좌심구혈율 측정 등을 시행하였다. 결과 : 1) 좌심실확장기말압은 전흉부유도에서 ST절의 하강이 있는 경우에서 16.9±5.33mmHg로 없는 경우의 11.0±4.02mmHg보다 유의하게 높았다(p<0.05). 그러나 운동량 및 좌심구혈을은 흥부 유도상 ST절의 하강이 있는 경우 7.6±3.0 METs 및 53.9±9.1%로 없는 경우의 9.1±2.7 METs 및 54.6±9.5%보다 낮았으나 통계적 유의성은 없었다(p=0.180, p=0.823). 2) 관상동맥조영술상 전흉부 ST절의 하강이 동반된 군에서는 유의한 좌전하행지나 좌회선지의 협착이 있는 경우가 60.9% 및 57.9%로 ST절의 하강이 없는 군에서의 34.5% 및 7.7%와 비교해 좌관상동맥에 협착이 동반된 경우가 많았다(p=0.050, p=0.001). 3) 관상동맥조영술상 세 혈관질환의 빈도는 흉부유도상 ST절의 하강을 보인 23예에서 10예로 ST절 하강이 없었던 29예중 2예에 비하여 유의하게 많았고(P=0.007), 단 혈관질환의 빈도는 ST절의 하강을 보인 군에서 23예중 5예로 ST절 하강이 없었던 29예중 17예에 비하여 유의하게 적었다(P=0.002). 두 혈관질환의 경우에는 각각 8예와 10예로 양군간에 유의한 차이가 없었다. 4) 흉부유도상 ST절 하강의 빈도는 단 혈관질환 22예 중 5예에서, 두 혈관질환 18예중 8예, 세 혈관질환 12예 중 10예에서 관찰되어 협착이 있는 관상동맥의 수가 많을수록 ST절의 하강이 나타나는 빈도가 많음을 보였다(p=0.00308). 그러나 흉부유도상 나타난 ST절의 하강을 모두 합하여 구한 ST절 하강의 합은 협착이 있는 관상동맥의 수와 통계적인 유의성이 없었다. 5) 심초음파도상 좌심실 하벽의 벽운동은 ST절 하강을 보인 군에서는 akinesia가 83.3%, hypokinesia가 11.1%, 정상 벽운동이 5.6%로, ST절 하강이 없었던 군에서의 dyskinesia가 3.6%, akinesia가 39.3%, hypokinesia가 25.0%, 정상 벽운동이 32.1%와 비교하여 ST절의 하강이 있는 군에서 유의하게 벽운동의 장애가 빈번함을 보였다(p=0.03891). 그러나 좌심실전벽, 측벽 및 중격부위에서는 유의한 벽운동의 차이가 없었다. 결론 : 급성하벽심근경색증 환자의 전흉부유도에서 ST절의 하강이 동반되는 경우 다혈관 질환의 가능성이 높으며 좌심실확장기말압이 상승되었고 운동능력은 감소되어 있었다. 또한 심초음파도상 좌심실하벽의 벽운동장애도 심하였다. 따라서 전흉부 ST절의 하강을 동반한 급성하벽심근경색증 환자는 전흉부유도에 ST절 하강이 없는 경우보다 예후가 불량할 것으로 생각되며, 보다 적극적인 치료가 필요할 것으로 생각된다. The purpose of this study was to determine the significance of precordial ST segment depression appearing during acute inferior myocardial infarction and to assess the correlation of that with angiographic finding. 52 patients were allocated into two groups based on the existence of precordial ST segment depression : 23 patients with ST segment depression and 29 patients without ST segment depression. The extent of coronary artery disease as well as the prevalence of significant stenosis (≥70%) in left anterior descending artery were more frequent in patients showing precordial ST segment depression than in patients not showing them (p=0.050) and the result were similar in cases of left circumplex artery (p=0.001). On echocrdiographic examination of left ventricular (LV) wall motion, it showed more severely decreased inferior LV wall motion in patients showing precordial ST segment depression than in patients not showing them (p=0.03891) even though the other segment of LV wall motion didn't show the statistical difference between both groups. The other cardiac parameters such as LVEDP, exercise amount (METs) and ejection fraction were tend to showing bad profile in patients with precordial ST segment depression. From the above results, we could deduce that patients with precordial ST segment depression have relatively large infarction or concomitant left coronary artery disease, so they need more caution and intensive theraphy.

韓國在來山羊의 胎兒 및 新生仔의 後肢骨成長에 關한 硏究

鄭敬泰,金鐘涉 慶尙大學校 1991 論文集 Vol.30 No.2

This study was conducted to investigate the skeletal growth of pelvic limb and girdles during fetal growth and neonates in Korean native goats. The length and ossification of the pelvic limb bones were observed at 60, 90 and 120 days of gestation and neonates. The results were as follows : 1. The length of hip bone of fetuses at 60, 90, 120 days of gestation and neonates was 1.34±0.610, 2.99±0.18, 5.03±0.20 and 6.67±0.21cm, respectively. 2. The length of femur of fetuses at 60, 90, 120 days of gestation and neonates was 1.11±0.06, 2.95±0.12, 5.06±0.17 and 6.08±0.34cm, respectively. 3. The length os tibia of fetuses at 60, 90, 120 days of gestation and neonates was 1.19±0.10, 3.31±0.28, 5.38±0.25 and 7.16±0.24cm, respectively. 4. The length of metatarsal bones of fetuses at 60, 90, 120 days of gestation and neonates was 0.81±0.06, 1.89±0.14, 3.43±0.08 and 4.54±0.18cm, respectively. 5. The length of pelvic limb bones was in the order of tibia, femur and metatarsal bones throughout the period of fetal growth and at neonatal period. 6. During the fetal growth period ilium was longer than metatarsal bones, but at neonatal period the ilium became shorter. 7. The ossification of ilium, femur and tibia was observed at 60 dyas of gestation. 8. The ossification of ischium, talus, calcaneous, metatarsal bones and phalanges was observed at 90 days of gestation. 9. The ossification of pubis, the central-4th and the 2nd-3rd tarsal bones was observed at 120 days of gestation. 10. The ossification of patella and the first tarsal bone was observed at neonatal period.

정상 성인에서 등척성 운동과 등장성 운동이 신체대사에 미치는 효과

안태순,정순열,정진상 건국대학교 1995 學術誌 Vol.39 No.2

This study was undertaken to investigate effects of isometric and isotonic exercise on the plasma levels of creatine phosphokinase (CPK), total cholestrol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), glucose, and cortisol and heart rate (HR) in twenty healthy adults. Prior to the exercise the baseline level was taken from blood sampling after resting for thirty minutes. The subjects were divided Into two groups by ten ; one for isometric, the other for isotonic exercise. Physical exercise was performed by twenty minutes a day for 5 days. As compared with the baseline level, the plasma cortisol level increased significantly after isometric exercise and the plasma CPK level increased significantly after isotonic exercise (p<0.05). There is no significant change in the levels of plasma TC, TG, HDL, LDL, and glucose after exorcise in both groups. Heart rate increased more rapidly in isometric exercise than in isotonic exercise (p<0.05). Key words : isometric exercise, isotonic exercise

후박 및 은행엽 추출물을 함유한 치약의 임상 및 미생물학적 효과에 관한 연구

김태일,염혜리,류인철,배기환,정종평 충남대학교 약학대학 의약품개발연구소 1996 藥學論文集 Vol.12 No.-

Previous studies have shown that Magnoliae cortex and Ginkgo biloba extracts were showed on the antimicrobial and anti-inflammatory action, in vitro. The purpose of this study was to evaluate on the effect of antimicrobial and anti-inflammatory activity of Magnoliae cortex and Ginkgo biloba extracts containing dentifrice in gingivitis. 70 subjects with gingivitis were divided into an experimental group which performed normal oral hygiene procedure with Magnoliae cortex and Ginkgo biloba extracts containing dentifrice and a control group which also performed normal oral hygiene procedure with the same dentifrice without the natural extracts and completed a double-blind, cross-over study. At baseline and 3 weeks, subjects were assayed for clinical study by plaque index, gingival index, pocket depth, GCF rate, and microbiological study by subgingival dental plaque bacterial morphotypes by phase contrast microscopy, total anaerobes, total aerobes, Black pigmented bacteroides, A-actionomycetemcomitans, A.viscosus, C.rectus, S.sanguis, P.gingivalis, P.intermedia by bacterial culture and immunofluorescence microscopy. After 3 weeks using their respective dentifrices, reductions in the clinical indices of subjects were similar between the experimental dentifrice group and a control dentifrice group except for statistically significant much reductions in PI, GI, and GCF rate in the experimental dentifrice group as compared to control dentifrice group. Also statistically significant reductions in the motile rods and Spirochetes were found in both experimental group to compare with control group, however statistically much reduction in total anaerobes, Black pigmented bacteroides, and P.gingivalis, P.intermedia were found in the experimental dentifrice group as compared to control dentifrice group. This results indicates that Magnoliae cortex and Ginkgo biloba extracts containing dentifrice might be useful for elimination of gingival inflammation.

Bicycle Ergometer 작업을 시작한 직후의 심박수와 산소섭취량의 변동

김순태,정종원,이달영 가톨릭대학산업의학센타 산업의학연구소 1974 韓國의 産業醫學 Vol.13 No.1

In order to examine the responses of heart rate and oxygen uptake during the first minutes of bicycle ergometer work with different loads, we measured the heart rate and oxygen uptake on 975, 100, 125, 150, 175, 200 and 225 watts. The results obtained were as follows: 1. Time required for reaching a steady state of heart rate and oxygen uptake was delayed with increasing work loads and it was more significant in case of oxygen uptake. 2. Statistically significant difference was existed in heart rate among different work loads of ergometer cycling except between 125 and 150 watts and between 200 and 225 watts. 3. Statistically significant difference was existed in oxygen uptake among different work loads, especially within 1 minute after onset of ergometer cycling. 4. The changes in the rates of increase of heart rate( HR%) and oxygen uptake( VO₂%) during the work, which were calculated as percentage to the values at 3 minutes after onset of ergometer cycling showed approximately the same pattern regardless of work loads, and the rate of increase was greater in heart rate than in oxygen uptake within 1 minute after onset of ergometer cycling.

상추(Lactuca sativa L.)의 ACAT 억제 Diterpenoid, Phytol : 식용 식물자원으로부터 활성물질의 탐색 Development of Biologically Active Compound from Edible Plant Sources

장태오,방면호,송명종,홍윤희,김지영,정대균,배동근,권병목,김영국,이현선,김인호,백남인 한국농화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.1

Propylthiouracil에 의한 중증 급성간염 1예

임종주,심미령,이명수,김태현,오석규,안선호,박무림,김남호,박병현,조성구 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2

PTU에 의한 간염의 발생은 매우 드물게 발생하는 것으로 알려져 있으나 저자들은 Graves씨 병으로 진단 받고 propylthiouracil 투여를 받고있던 환자에서 중증의 급성 간염이 발생한 1예를 경험하였기에 보고하는 바이다. Propylthiouracil is widely used to treat patients with hyperthyroidism. This drug has been associated with severe hepatotoxicity rarely. We presented the case of jaundice and profound liver dysfunction from a 23-year old woman treated with propylthiouracil for hyperthyroidism. Viral, metabolic, and autoimmune liver disease could be excluded and liver biopsy revealed a pattern of acute hepatitis. After discontinuing the drug, there was a progressive resolution of hepatic symptoms and decrease in biochemical data of the liver. Despite propylthiouracil induced hepatitis in rare case, patients receiving propylthiouracil are exposed to develope severe hepatotoxicity. Therefore it might be advisable to monitor level of the transaminase on regular base from patients receiving propylthiouracil.

地黃잎의 給與가 離乳仔兎의 發育에 미치는 效果

姜奉泰,鄭鉉丞,郭鐘瀅 진주산업대학교 1968 論文集 Vol.2 No.-

地黃잎을 Chinchilla 種 離乳仔兎에 10%, 20%, 30%生草와 代置하여 各各 4頭에 給與하여 다음과 같은 結果를 얻었다. 1.增體量은 對照區에 比하여 10% 地黃잎 代置區는 有意的으로 우수하였으며, 20%, 30% 代置區는 不良하였다. 2.飼料利用性도 10% 地黃잎 代置區는 對照區보다 優良하였다. 3.嗜好性은 10% 地黃잎 代置區가 가장 우수하였으나, 20%, 30% 代置區는 對照區보다 不良하였다. 4.健康狀態는 모두 良好하였으며, 10% 地黃잎 代置區가 가장 활발하였다. 以上 本試驗의 結果로써 地黃잎 10% 代置가 仔兎의 成長에 有效함을 認定할 수 있었다. This experiment was conducted to determine the effect of Jiwhang`s leaf on weanling rabbits. Heaf of Jiwhang substitude with 10%(T_1), 20%(T_2), 30%(T_3) for grass in ration was fed with basal ration. The experimental results obtained were as follows; 1)In weight gain T_1 lot showed more gain (P.<0.05) than that in the control. T_2 lot, T_3 lot showed less gain than that in the control. 2)Feed efficiency of T_1 lot was also higher than that in any other lots. But T_2 lot, T_3 lot respectively showed less feed efficiency than that in the control. 3)T_1 lot was most palatable to rabbits. But T_2 lot, T_3 lot respectivly showed less palatability than that in the control. 4)All of the rabbits used in experimental period were in good health. T_1 lot was most vigorous. From the above mentioned results of this experiment it was estimated that the ration substituted with 10% of Jiwhang1s leaf was effective for rabbits.