굽힘모우멘트를 받는 혼합형모드의 외부크랙에 대한 응력확대계수

이치우,김태규 慶南大學校 附設 工業技術硏究所 1986 硏究論文集 Vol.4 No.-

파괴역학에서 크랙첨단부근의 응력분포는 응력확대계수로 표시함은 잘 알려진 사실이다. 임의의 경사각을 가지는 혼합형모드(Mixed Mode)에 대해서 외부직선크랙, 반원형외부크랙, 외부노치크랙을 갖는 판이 순수굽힘, 3점굽힘, 등분포하중을 받는 경우에 대한 해석을 광탄성적인 방법(Photoelastic Method)으로써 응력확대계수를 결정하였다.. 특히 외부직선크랙을 가진 판이 개구형모드(Opening Mode) 상태에서 순수굽힘 및 3점굽힘을 받을때의 결과는 Gross, Srawley, Wilson 등이 연구한 경계분할법(Boundary Collocation Method)과 잘 일치함을 관찰할 수 있었다. The stress distribution in the vicinty of the crack tip in Fracture Mechanics ordinary indicated by stress intensity factors K which have been Proposed by Irwin. In the analysis of stress intensity factors, there are many theoretical and experimental method. This paper was stuided for stress intensity factors of a steet with inclined crack of a subjected to pure bending moment, 3-points bending moment and Uniform distributed load by photoelastic method. The results of this method, the stress intensity factors subjected to pure bending moment and 3-points bending moment were very coincided result of the Gross and Srawley by Boundary Collocation method.

급성 신우신염이 선행된 Escherichia coli 농흉 1예

차치운,조준형,김미진,오윤정,연재우,이성규,오미정,채지영,김수연 대한감염학회 2009 감염과 화학요법 Vol.41 No.5

We experienced a case of acute pyelonephritis which progressed to Escherichia coli bacteremia and later complicated by empyema in a 65-year-old female. She was successfully treated with intravenous antibiotic therapy and percutaneous drainage of empyema.

GIS를 이용한 주암호 유역의 오염부하량 산정

김철,김석규,이치열 호남대학교 산업기술연구소 2001 산업기술연구논문집 Vol.9 No.-

광주 · 전남의 상수원인 주암호 유역을 연구대상지역으로 선정하여 GIS를 이용하여 수질 오염부하량을 계산하였다. 계산방법은 점오염원 부하량과 비점오염원 부하량을 나누어서 산정하였는데, 점오염원 부하량은 생활하수, 축산폐수, 산업폐수, 양어장폐수, 식당과 숙박업소의 배출수 등을 고려하여 원단위를 이용하여 산정하였고, 비점오염원 부하량은 SCS의 유출곡선지수(CN)를 기초로 해서 산정한 유출량과 환경부에서 우리나라 유역의 특성에 맞게 제시한 토지이용별 기대평균농도(EMC)를 적용하여 산정하였다. 계산된 점오염원 부하량과 비점오염원 부하량을 합하여 전체 오염부하량을 산정하였다. Juam Lake, which is the source of water supply to Chonnam province and Kwangju city was selected as a research site and water quality pollutant loads were calculated in this site. Point source pollutant loads and nonpoint source pollutant loads were calculated respectively. Point source pollutant loads were estimated using the unit pollutant loads of residence wastewater, farm wastewater, industrial wastewater, fish-farmer wastewater, wastewater of restaurants and lodgings presented by the Ministry of Environment, The direct runoff based on SCS Curve Number method was multiplied by Expected Mean Concentration to give nonpoint source pollutant loads. Total pollutant loads were calculated by summing up point and nonpoint source pollutant loads.

신공법에 의해 제조한 흑삼의 아토피 억제효과

김의검,이지현,신귀남,조수현,김룡국,이지숙,박용진,윤치영,송규용 충남대학교 약학대학 의약품개발연구소 2008 藥學論文集 Vol.23 No.-

The purpose of this study was to investigate the effects of crude saponin fraction of black ginseng(SFBG) on atopic dermatitis in vitro. The house dust mite(Dermatophagoides pteronissinus, DP) plays a key role in the pathogenesis of allergic diseases, including atopic dermatitis and asthma. Monocyte chemo-attractant protein 1(MCP-1/CCL2)/interleukin-6(IL-6)/IL-8(CXCL8) plays a pivotal role in mediating the infiltration of various cells into the skin of atopic dermatitis. We found that SFBG potently suppressed the elevated production of MCP-1, IL-6 and IL-8 induced by D. pteronissinus extract(DpE) treatment in the human monocytic cell line, THP-1 cells. Also, SFBG potently suppressed the elevated production of IL-6 and IL-8 induced by DpE treatment in the human eosinophilic cell line, EoL-1 cells. These results suggest that SFBG have an anti-atopic property, and that in future further development of main effective constituents in SFBG can provide a novel therapeutic agent for atopic dermatitis.

2009년 인플루엔자 대유행 중 인플루엔자 진료소 방문자의 연령 분포 변화

김백남,곽이경,문치숙,김연숙,김의석,배인규,염준섭,이창섭,허지안 대한감염학회 2010 감염과 화학요법 Vol.42 No.2

The pandemic influenza (H1N1 2009) virus, after being introduced in Korea in April, 2009, spread rapidly nationwide in mid-2009. This study was conducted to characterize trend in age distribution of visitors to Flu-clinics during the pandemic. Demographic, clinical and laboratory data of visitors to flu clinic from Week 36 to 52 (August 30 to December 26) of 2009 were retrieved and collected from electronic databases at 9 hospitals. Visitors 0-6, 7-12, 13-18, 19-29, 30-64, and 65 years or more of age were classified into group I to VI, respectively. A total of 107,467 visitors were seen at Flu-clinics for a 17-week study period. Of those, 32,485 were laboratory-confirmed. Antivirals were prescribed for 62,533 visitors. Numbers of visits, prescriptions of antivirals, and laboratory-confirmed cases of the pandemic influenza (H1N1 2009) peaked at Week 44. A large number of visits by group II and III were followed by those of group I and V, especially around the peak. Numbers of visits by group VI were lowest in all hospitals. In some hospitals, higher number of visits lasted longer in children than in adults while vice versa in other hospitals depending on the location. In summary, the pandemic influenza (H1N1 2009) was presumed to peak in late October and involved majorly children and students in Korea. Unique age distribution of visitors to flu clinic was observed in some hospitals.

알코올 의존과 후보 유전자들간의 연관성 연구

정인원,김헌,홍주봉,지경환,이규영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 알코올 대사와 중추신경계내의 알코올 작용부위와 관련한 일부 후보유전자들이 알코올 의존과 관련이 있는지를 확인하고자 하였다. 방 법 : DSM-IV로 진단된 알코올 의존 환자 128명과 정상 대조군 128명을 대상으로 후보 유전자들의 다형성을 중합효소 연쇄반응과 제한효소처리법을 이용하여 동정하였다. 여기서 분리된 대립유전자와 유전자형에 따른 빈도의 차이를 유전자별로 각각 비교하였으며, 알코올 의존에 작용하는 서로 다른 유전자들에 의한 영향력을 배제하기 위하여 logistic regression 분석을 적용하였다. 결 과 : 알코올 의존군에서는 ALDH_2 유전자의 NN(wild type)형이 정상대조군에 비하여 유의하게 많았다(chi-square test, p<0.001). logistic regression analysis를 통하여 다른 유전자들에 의한 영향을 보정한 상태에서 ALDH_2가 NN(wild type)인 경우 다른 아형에 비하여 알코올 의존에 대한 odds ratio는 130.312이며 그 신뢰구간은 (17.22, 986.43)이었다. 한편, ASA는 N-glycosylation 부위에 변이형 대립유전자를 갖고 있는 경우(AG or GG)는 wild type에 비하여 알코올 의존에 대한 위험도는 2.344배이며 그 95% 신뢰구간은 (1.128, 4.871)이었다. 결 론 : 알코올 의존과 ALDH_2 유전자간에는 밀접한 연관성이 확인되었다. 또한 다른 유전자들은 개별 연관분석에서 의미있는 연관성이 관찰되지는 않았지만 logistic regression analysis를 통하여 N-glycosylation 부위에 다형성이 있는 ASA 유전자가 알코올 의존과 관련이 있음을 시사하였다. Objectives : This study was to explore the association between alcohol dependence and five candidate genes related to the metabolism of alcohol and the enzymes of the suspected sites in CNS. Methods : The genotype and allele frequencies of five candidate genes in 128 male hospitalized patients who met DSM-IV criteria for alcohol dependence were compared with 128 age-matched healthy male control subjects using polymerase chain reaction and restriction fragment length polymorphism. A logistic regression analysis was applied in order to exclude the reciprocal interactions among five candidate genes. Results : The NN genotype frequency of the ALDH_2 gene was significantly higher in alcoholic patients than in control subjects(chi-square test, p<0.001). No difference in frequency was found in the other four genes. In a logistic regression analysis, the odds ratio for alcohol dependence in the NN genotype of the ALDH_2 gene and AG or GG genotypes of the N glycosylation site on the ASA gene were 130.312(95% confidence interval, 17.22-986.43) and 2.344(95% confidence interval. 1.128-4.871), respectively. Conclusion : The result reiterates the association of the ALDH_2 gene polyporphism and the alcohol dependence. Logistic regression analysis additionally suggested that the N-glycosylation site on the ASA gene was associated with alcohol dependence.

Development of Multi-Analytical Method for Particulate Matter of Environmental Samples Using Nuclear Track Technique

Chi-Gyu Lee,Joonki Kim,Junghwan Park 한국방사성폐기물학회 2021 한국방사성폐기물학회 학술논문요약집 Vol.2021 No.06

소간세포암의 진단과 치료 및 예후

이상우,김윤환,이재원,김경수,박미라,박동규,이성준,이구,김광희,김창덕,최재현,류호상,전훈재,송치욱,서성옥,엄숭호,현진해,진윤태 대한간학회 1998 Clinical and Molecular Hepatology(대한간학회지) Vol.4 No.4

Background/ Aims : Cases of small hepatocellular carcinoma (HCC) have been increasing with the progress of diagnostic methods . In t his study the screening methods for early diagnos is of HCC were re-evaluated, and comparative ther apeutic analyses were perfomed. Methods : A total of 110 pat ients with small HCC ($lt; 5 cm and $lt; 4 nodules ) were retrospectively analyzed. The patients were divided into four treatment groups ; unt reated group (No T x, n=12), transarterial-oily-chemoembolization group (TOCE, n=43), combined treatment group of percutaneous ethanol injection and TOCE (CEI, n=22), OP group ( OP, n=33). Results : Small HCC occupied 22.6% of t ot al HCC cases . Only one thir d of small HCC cases were detected during the regular screening. In this group, Alpha- fet oprotein as say pr ovided a diagnostic clue in 50% of cases, ultras onography in 71%, and the combination of both in 88%. Five year s ur vival rat e and 5- year non- recurrence rate in small HCC was 29% and 37% respectively. Comparative ther apeutic analys es showed t hat CEI and OP gave a bet t er s ur vival t han T OCE in Child gr ade A. CEI prolonged survival in Child grade B wher eas TOCE did not . Only TOCE was tried and did not improve the survival in Child grade C. Conclus i on : 1) A more strict screening is needed in high risk group of HCC. 2) As a first line of treatment in small HCC, OP or CEI can be selected in Child grade A, and CEI in Child grade B. In Child grade C, a less invasive treatment (PEIT , microwave coagulat ion therapy) should be investigated. (Korean J Hepatol 1998;4:365 380)

Position of Source Leaf Affects Translocation and Distribution of C14 Photo-Assimilates in Tomato

Sang-Gyu Lee(이상규),Chi-Won Lee(이치원),Dong-Kum Park(박동금),Yun-Chan Heo(허윤찬),Kyung-Sup Park(박경섭) 한국원예학회 2004 한국원예학회 학술발표요지 Vol.2004 No.5

수박과 오이의 탄수화물 전류 특성

이상규(Sang-Gyu Lee),박동금(Dong-Kum Park),허윤찬(Yun-Chan Heo),박경섭(Kyung-Sup Park),이치원(Chi-Won Lee) 한국원예학회 2004 한국원예학회 학술발표요지 Vol.2004 No.10