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김의검,이지현,신귀남,조수현,김룡국,이지숙,박용진,윤치영,송규용 충남대학교 약학대학 의약품개발연구소 2008 藥學論文集 Vol.23 No.-
The purpose of this study was to investigate the effects of crude saponin fraction of black ginseng(SFBG) on atopic dermatitis in vitro. The house dust mite(Dermatophagoides pteronissinus, DP) plays a key role in the pathogenesis of allergic diseases, including atopic dermatitis and asthma. Monocyte chemo-attractant protein 1(MCP-1/CCL2)/interleukin-6(IL-6)/IL-8(CXCL8) plays a pivotal role in mediating the infiltration of various cells into the skin of atopic dermatitis. We found that SFBG potently suppressed the elevated production of MCP-1, IL-6 and IL-8 induced by D. pteronissinus extract(DpE) treatment in the human monocytic cell line, THP-1 cells. Also, SFBG potently suppressed the elevated production of IL-6 and IL-8 induced by DpE treatment in the human eosinophilic cell line, EoL-1 cells. These results suggest that SFBG have an anti-atopic property, and that in future further development of main effective constituents in SFBG can provide a novel therapeutic agent for atopic dermatitis.
이지현,이재호,김현관,김의검,신귀남,조수현,명창선,김동희,윤미영,최용석,김성훈,송규용,Lee, Jee-Hyun,Lee, Jae-Ho,Kim, Hyun-Kwan,Kim, Eui-Geom,Shen, Gui-nan,Cho, Soo-Hyun,Myung, Chang-Seon,Kim, Dong-Hee,Yun, Mi-Young,Choi, Yong-Seok,Kim, Su 대한약학회 2006 약학회지 Vol.50 No.5
A novel series of 4-senecioyloxymethyl-6,7-dimethoxycoumarin, isolated from Crinum latifolium, was prepared by reacting 4-bromomethyl or 4-bromomethyl-6,7- dimethoxycoumarin with various carboxylic acids and examined for their anti-angiogenic activities in human umbilical vein endothelial cells (HUVECs). Among them, 4e, 4f, 4g and 4i with noncyclic moiety exhibited potent anti-angiogenic activity. However, compounds with cyclic moiety such as phenyl, pyridinyl, thiophenyl and furanyl group did not exhibit any anti-angiogenic activity. Also, compounds 4f and 4g which exhibited strong anti-angiogenic activity in a dose-dependent manner showed antitumor activity.
참당귀(Angelica gigas) 뿌리 추출물로부터 (+)-Decursinol의 대량 제조 방법
이지현(Jee-Hyun Lee),최용석(Yong-Seok Choi),김주환(Joo-Hwan Kim),정혜광(Hye-Gwang Jeong),김동희(Dong-Hee Kim),윤미영(Mi-Yong Yun),김진숙(Jin-Sook Kim),이상한(Sang-Han Lee),조수현(Soo-Hyun Cho),신귀남(Gui-Nam Chen),김의검(Eui-Geom Kim 대한약학회 2006 약학회지 Vol.50 No.3
The purpose of this study is to develop a mass preparation method of (+)-decursinol from Angelica gigas roots. Recently, it has been shown that (+)-decursin, (+)-decursinol angelate and its analogues, isolated from Angelica gigas root, exhibit various biological activities such as antitumor, antibacterial and neuroprotective activities. The contents of these compounds, ester form of (+)-decursinol, is very high in the Angelica gigas roots, whereas the content of (+)-decursinol itself is very low. Therefore, (+)-decursinol which can be used as starting material to synthesize various its analogues was easily prepared from decursin analogues in the Angelica gigas roots. In order to achieve such aim, the Ether-Fr, of the ethanol extract of Angelica gigas root was hydrolysed with various alkalis and solvents. As a result, the order of (+)-decursinol preparation was 1) NaOH, KOH, 2) K2CO3, and 3) NaHCO3 as alkali. Also, the yield of (+)-decursinol was higher in diethyl ether than any other solvent conditions. From 1kg of dried Angelica gigas roots, we could obtain 27.4g of (+)-decursinol as a pure white solid.