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아미노산 투여가 운동중 싸이클선수의 젖산 및 심박수에 미치는 영향
이승국,유병렬,김문희,김완조,이선장 韓國體育大學校附屬 體育科學硏究所 1992 韓國體育大學校附屬 體育科學硏究所論文集 Vol.11 No.1
The purpose of the study was to determine whether a 15.6mg.Kg ??' does of glutamate given one hour prior to incremental exercise test would reduce the lactate formation. Five well trained cyclists served as subjects in this experiment which included a placebo and glutamate trial. The subjects initially work on treadmill 200m/min for 3 minutes and here increased the workload by 20m/min every 3minutes until exhaustion. Blood lactate were collected from finger-tip. Subjects in the glutamate trial showed significantly lower lactate formation during exercise then they did in the placebo trial. In both groups no significant difference was found on heart rate. During the recovery lactate and heart, rate were unaltered in either the glutamate or placebo trials. In summary, glutamate ingestion may reduce lactate formation resultly improvement of performance.
Ionizing 방사선이 MOS 소자에 미치는 영향에 관한 연구
김말문,한병국,배인호,김인수,유승권 嶺南大學校 基礎科學硏究所 1990 基礎科學硏究 Vol.10 No.-
The analysis of a simple model for radiation-induced space charge buildup in the SiO₂layers of MOS(Metal-Oxide-Semiconductor) is carried out. The model assumes that holeelectron pairs are created in SiO₂layer by the radition and that some of the electrons thus created drift out of SiO₂layer under action of an applied potential across the oxide, V??while corresponding holes become trapped. in these experiments, MOS capacitors having 1100Å and 1950Å SiO₂thickness are exposed to X-ray. Both p-and n-type substrate and Al metal electrodes are used to evaluate characteristics of radiation induced positive charges. From the results of these experiments △V ?? and the number of holes trapped in SiO₂layer strongly depend on oxide thickness, electric field across the oxide layer and absorbed dose. Alwayys C-V(Capacitance-Volage) curve shifts negatively without any relation to substrate types and applied voltage during radiation. This means that trapped charges in the oxide are always positive.
Byung Kuk Yoo,Joo Cheol Shim,김충락,정영인,박제민,김성곤,김지훈,Young Min Lee,Eun Soo Moon,Do Hoon Kwon,이병대 대한신경정신의학회 2012 PSYCHIATRY INVESTIGATION Vol.9 No.4
Objective 1) To investigate the relationship between NrCAM polymorphisms and methamphetamine abuse in an ethnically homogenous Korean population. 2) To further support our findings by investigating the association among NrCAM gene variants, certain personality traits, and addictive symptoms of methamphetamine abusers. Methods Thirty-seven male methamphetamine abusers (age=43.3±7.8) and30 non-users (16 men, 14 women; age=59.8±10.4) were recruited. Ten single nucleotide polymorphisms (SNPs) in the NrCAM gene were assayed to compare genotype distributions between the 2 groups. Personality characteristics were measured using the Temperament and Character Inventory (TCI) and the NEO Personality Inventory, Revised (NEO PI-R). Addictive symptoms were assessed using the Diagnostic Interview for Genetic Studies (DIGS) and reviews of the subject’s medical records. ResultsaaAmong the 10 SNPs in the NrCAM gene, the frequency of the TA genotype at rs1990162 was significantly lower in methamphetamine abusers compared to non-users (p=0.042). In the 3 NrCAM gene SNPs (rs381318, rs2072546, and rs6954366), the distribution of genotypes and alleles were significantly associated with some traits in the TCI and NEO PI-R. Genotypes and alleles at 5 gene SNPs (rs2142325, rs381318, rs1269621, rs1269634, and rs1990162) were associated with certain addictive symptom dimensions in the patients. Conclusion These findings support the idea that NrCAM is associated with genetic susceptibility of methamphetamine abuse and is also associated with certain personality characteristics that may increase disturbed addictive behavior.
유병국(Byung-Kuk Yoo),임기영(Ki-Young Lim) 대한사회정신의학회 2005 사회정신의학 Vol.10 No.2
목 적: 많은 병사들이 군 부적응의 문제를 보임에도 불구하고 군부적응의 요인들에 대한 간헐적인 연구들은 이루어져 왔으나, 군 병원에 입원을 요하는 심각한 적응장애 환자들에 대한 연구는 이루어지지 않았다. 이에 국군 ○○병원에 입원한 적응장애 환자들을 대상으로 일반 병사와 비교하여 어떤 정신병리상의 차이가 있는지를 평가해보고자 하였다. 방 법: 2004년 6월 1일부터 2005년 2월 28일까지 국군○○병원에 입원한 환자들 중에서 정신과 전문의(5인)에 의해서 적응장애로 진단되어진 환자 102명을 연구대상으로 하였다. 대조군은 2004년 12월 1일 현재 국군○○병원 본부 근무대에 소속된 장병 116명을 저 계급자 순으로 무작위로 선발하였다. 두 군에 대하여 소정의 설문지를 작성하도록 하였다. 1) K-Social Avoidance & Distress(이하 K-SAD라 지칭) 사회적 상황에서 불안을 경험하는 정도와 잠재적으로 혐오하는 사회적 상황을 회피하려는 경향을 측정하며 진위형 28문항으로 되어있다. 2) Barret Impulsiveness Scale 11판(이하 BIS-11 이라 지칭) 무계획, 운동, 인지에 관한 충동성을 측정하며 23문항으로 구성되어 있다. 3) Symptom Checklist -90-Revision(이하 SCL-90-R 이라 지칭) 9개 증상차원, 90개 문항으로 구성되어 있으며 신체화, 강박증, 대인민감성, 우울, 불안 등에 관한 문항으로 구성되어 있다. 결 과: K-SAD 점수가 적응장애 환자군에서(102.12±25.16) 대조군에(75.59±16.69) 비해 유의한 결과를 보였다(p<0.05). 적응 장애 환자군에서 총충동성(57.70±10.64), 인지충동성(22.67±4.60), 운동충동성(18.09±4.32), 무계획 충동성(16.94±3.16) 모든 항목에서 정상대조군의 총 충동성(50.28±8.34), 인지충동성(20.27±3.39), 운동충동성(14.83±3.66), 무계획 충동성 (15.16±2.80)과 비교하여 유의미한 결과를 보였다(p<0.05). SCL-90-R 검사에서 신체화 척도를 포함하여 적응장애 환자군 에서(62.31±15.19) 정상 대조군(47.26±8.20)에 비해 모든 척도에서 유의미한 결과를 보였다(p<0.05). 결 론: 국군 ○○병원에 입원중인 102명의 적응장애 환자군이 116명의 정상 대조군에 비해 통계학적으로 더 높은(p<0.05) 사회불 안을 느끼고 있었으며 인지, 운동, 무계획 충동성 모두에서 통계학적으로 더 높은(p<0.05) 충동성향을 보였고, SCL-90-R 검사에서 신체화 척도를 포함한 9가지 소척도 모두에서 통계학적으로 의미 있는(p<0.05) 결과를 보였다.
( Yoo Jin Lee ),( Woo Jin Chung ),( Yu Jin Hah ),( Hyung Ki Lee ),( Ho Young Lee ),( Jae Seok Hwang ),( Byung Kuk Jang ),( Kyung Sik Park ),( Kwang Bum Cho ),( Eun Soo Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background/Aim: Transjugular Intrahepatic Portosystemic Shunt (TIPS) has been undergone for control of gastric variceal bleeding. But, TIPS has some limitations as hepatic encephalopathy or shunt occlusion, etc. Balloon Occluded Retrograde Transvenous Obliteration (BRTO) also has been undergone for these patients. So, we compared the effectiveness and safety of TIPS and BRTO for control of gastric variceal bleeding. Methods: Between January 2003 and February 2012, TIPS or BRTO have been undergone for gastric variceal bleeding. All patients had patent portal veins on preprocedural computed tomography. The patient who failed BRTO underwent TIPS for rescue therapy. Data regarding technical success, rebleeding, hepatic encephalopathy and survival were analyzed by Chisquare test and Kaplan-Meier method with Log-rank test. Results: 1. Among 100 patients, 32 patients underwent TIPS and 68 underwent BRTO. Technical success was achieved in 96.9% (31/32) in TIPS group and 86.8% (59/68) in BRTO group. There was no statistical difference of age, sex distribution, and Child-Pugh class in each group. 2. Early rebleeding within 5 days after procedure were 18.8% (6/32), 4.4%(3/68) (p=0.019) and late rebleeding after 5 days were 18.8% (6/32), 1.5% (1/68) in each group (p=0.002). 3. Hepatic encephalopathy was developed or aggravated in 53.1% (17/32), 4.4%(3/68) (p<0.001). 4. After procedure, Child-Pugh class was aggravated in 50% (16/32) and 19.1% (13/68) (p=0.004). 5. The survival time were 45.4 in TIPS and 62.3 months in BRTO group (p=0.04). 6. Procedure related complications did not have statistical difference in each group. Conclusion: BRTO can more effectively control of gastric variceal bleeding with less worsening of Child-Pugh class, hepatic encephalopathy, relatively decreased rebleeding rate and longer survival period than TIPS. So, if the patients who have ceased gastric variceal bleeding in the presence of gastrorenal shunt, BRTO may be considered as initial therapeutic procedure for control of gastric variceal bleeding.
( Yoo Jin Lee ),( Woo Jin Chung ),( Yu Jin Hah ),( Hyung Ki Lee ),( Ho Young Lee ),( Jae Seok Hwang ),( Byung Kuk Jang ),( Kyung Sik Park ),( Kwang Bum Cho ),( Eun Soo Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background/Aim: Transjugular Intrahepatic Portosystemic Shunt (TIPS) has been undergone for control of gastric variceal bleeding. But, TIPS has some limitations as hepatic encephalopathy or shunt occlusion, etc. Balloon Occluded Retrograde Transvenous Obliteration (BRTO) also has been undergone for these patients. So, we compared the effectiveness and safety of TIPS and BRTO for control of gastric variceal bleeding. Methods: Between January 2003 and February 2012, TIPS or BRTO have been undergone for gastric variceal bleeding. All patients had patent portal veins on preprocedural computed tomography. The patient who failed BRTO underwent TIPS for rescue therapy. Data regarding technical success, rebleeding, hepatic encephalopathy and survival were analyzed by Chisquare test and Kaplan-Meier method with Log-rank test. Results: 1. Among 100 patients, 32 patients underwent TIPS and 68 underwent BRTO. Technical success was achieved in 96.9% (31/32) in TIPS group and 86.8% (59/68) in BRTO group. There was no statistical difference of age, sex distribution, and Child-Pugh class in each group. 2. Early rebleeding within 5 days after procedure were 18.8% (6/32), 4.4%(3/68) (p=0.019) and late rebleeding after 5 days were 18.8% (6/32), 1.5% (1/68) in each group (p=0.002). 3. Hepatic encephalopathy was developed or aggravated in 53.1% (17/32), 4.4%(3/68) (p<0.001). 4. After procedure, Child-Pugh class was aggravated in 50% (16/32) and 19.1% (13/68) (p=0.004). 5. The survival time were 45.4 in TIPS and 62.3 months in BRTO group (p=0.04). 6. Procedure related complications did not have statistical difference in each group. Conclusion: BRTO can more effectively control of gastric variceal bleeding with less worsening of Child-Pugh class, hepatic encephalopathy, relatively decreased rebleeding rate and longer survival period than TIPS. So, if the patients who have ceased gastric variceal bleeding in the presence of gastrorenal shunt, BRTO may be considered as initial therapeutic procedure for control of gastric variceal bleeding.