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( Hyun Jung Kim ),( Sung Kyun Na ),( Young Min Choi ),( Hoe Soo Jang ),( Young Nam Kim ),( Eun Kwang Choi ),( Hyun Woo Kim ),( Byung-cheol Song ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Entecavir (ETV) and tenofovir (TDF) are most commonly used anti-viral agents for the treatment of chronic B hepatitis (CHB). We evaluated renal safety between two antiviral agents. Methods: Of 549 patients who received ETV or TDF as a first-line treatment, 285 patients (ETV, n=139 vs. TDF, n=146) were analyzed retrospectively. We compared the frequency of renal impairment, defined by creatinine increase (ł 0.3mg/dL) or GFR reduction (ł 15%) and GFR change at 2 years. Results: The frequency of creatinine increase was 0.8% and 9.2% in ETV and TDF groups, respectively (p=0.002). The frequency of GFR reduction (ł 15%) was higher in TDF group (14.2%) than in ETV group (6.8%) (p=0.048) The frequency of renal impairment at 2 years was higher in TDF group compared with ETV groups (17.0% vs. 6.8%, p=0.01). TDF treatment, baseline albumin, GFR and diabetes mellitus were independent risk factors for renal impairment. The GFR decreased from 76.6 ml/min/1.73m2 to 74.0 ml/min/1.73m2 in ETV group (p<0.0001) and from 76.2 ml/min/1.73m2 to 72.0 ml/min/1.73m2 in TDF group (p< 0.0001). GFR change between two groups was not different at 2 years. (p=0.16) In subgroups with high GFR ( > 76 ml/min/1.73m2), GFR was not different between two groups at 2 years. (p=0.97) However, in patients with low GFR (< 76 ml/min/1.73m2), GFR was higher in ETV group than in TDF groups. (p=0.005) at 2 years. Conclusions: TDF treatment might be associated with renal function deterioration. Therefore, before choosing antiviral agents, efficacy and risk factors for renal impairment should and should be considered.
Medicinal Chemistry : Quantitative Determination of Diterpenoids from the Roots of Aralia cordata
( Min Kyun Na ),( Ki Hwan Bae ),( Young Ho Kim ),( Jae Sue Choi ),( Byung Sun Min ),( Ik Soo Lee ),( Jong Keun Son ),( Tran Manh Hung ),( Mi Hee Woo ),( Mi Kyoung Lee ) 영남대학교 약품개발연구소 2009 영남대학교 약품개발연구소 연구업적집 Vol.19 No.-
( Min Kyun Na ),( Yong Tae Jeong ),( Xian Li ),( Fansi Jin ),( Seung Lark Hwang ),( Geum Jin Kim ),( Ju Hye Yang ),( Young Chae Chang ),( Dong Soo Kim ),( Cheorl Ho Kim ),( Hyeun Wook Chang ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
The effect of butanol extracts of the skin of Anguilla japonica (BESA) on endoplasmic reticulum (ER) stress-induced insulin resistance in L6 myotubes was investigated. Western blotting revealed that BESA increased phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase, and stimulated glucose uptake in L6 myotubes. Stimulation of AMPK and glucose uptake by BESA were significantly (p<0.05) reduced by siRNA LKB1 or siRNA AMPK, compared with controls, suggesting that enhanced glucose uptake by BESA was predominantly accomplished via an LKB1-mediated AMPK activation pathway. In addition, BESA effectively reduced phosphorylation of ER stress markers, RNA-activated protein kinaselike ER resident kinase, JNK, and significantly (p<0.01) increased glucose uptake via AMPK activation in tunicamycin-treated L6 myotubes, compared with controls. Improvement of insulin sensitivity under ER stress conditions by BESA is predominantly accomplished via an LKB1- AMPK-dependent pathway.