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진영욱,정진은,조훈기,강우,정재우 한국기술교육대학교 2006 論文集 Vol.13 No.1
A test bench which is consisted of roots blower, air flow meter, driving unit for VGT actuator, transmitters for temperature and pressure, and the rotational speed sensor was developed to evaluate the characteristics of the VGT system. Measurements using VGT of the 2.0 L diesel engine were carried out. The corrected mass flow rate and the pressure ratio for the compressor of the VGT are related directly with the rotational speed, but they are independent of the rack position of the VGT. The pressure ratio and the corrected mass flow rate of the turbine of the VGT are related directly with the rack position of the VGT, but they don't have any relation with the rotational speed. The mechanical efficiency of the VGT is higher than the conventional turbocharger in the wide range. The efficiency at the 0.03 kg/s of the mass flow rate is 4.36 times as high as that of the conventional turbocharger. These data will be used to develop the new engine equipped with the VGT system.
한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률
조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4
Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.
이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
경유돌공 부위에서 전기신경자극기를 이용한 안면경련 환자의 치료
정창우,민진혜,이규탁 관동대학교 의과학연구소 2000 關東醫大學術誌 Vol.4 No.1
Facial spasm is the most common in middle aged women, which is a distressing condition characterized by involuntary, intermittent, unilateral twitching of the muscles innervated by the facial nerve. There are various treatments for facial spam, such as neurovascular decompression, local injection of botulinum, facial nerve compression at stylomastoid foramen and facial nerve block with O'Brien method. There are the same clinical problems associated with the reported procedure in pain clinic, such as severe pain and recurrence of spasm. In this paper, we report the modified facial nerve block using electric nerve stimulator at the stylomastoid foramen. This new technique will be able to reduce the pain and the discomfort during facial nerve block, and reduced the recurrence of facial spasm.
정병호,조원제,천승훈,박면지,유진철,천문우 朝鮮大學校 1998 藥學硏究誌 Vol.19 No.2
For the development of antifungal agents. modification of naftifine which exhibits significant antimycotic activity was performed by replacing the naphthalene ring of it to hetero cyclic rings such as morpholine. benzothiazole. piperidine and pyridine derivatives. The synthesized compounds were tested in vitro antifungal activity against five different fungi with naftifine as a comparative antimycotic molecule. From the biological evaluation two compounds. (E)-N-(3-phenyl-2-propenyl)-N-(4-piperidinylmethyl)amine(3d) and (E)-N-(3-phenyl-2-propenyl)-N-(3-pyndylmethyl)amine(3D) showed relatively noticeable activity(MIC=50㎍/㎖). On the other hand. the other compounds had no activity.
의료정책의 정치경제학 : 건강보험 약가 정책을 중심으로 Korea's Drug Pricing Policy Reform
정우진 한국정책학회 2002 韓國政策學會報 Vol.11 No.4
본 연구는 의료정책이 정치·행정·경제의 상호작용에 의해서 변동된다는 것을 보이기 위해 최근 전임 보건복지부장관의 이임 연설로 부각된 건강보험 약가 정책의 정책변동과정을 정치경제학적 시각에서 규명하였다. 이 사례연구를 통하여 과거 '정부 고시가 상환제도'에서는 경제적 요인과 행정적 요인이 상호 작용하면서 정치적 균형을 이루고 있었으나, 신 정부 출범 이후 정치적 요인과 경제적(외교적)요인으로 인해 균형이 파괴되었고 관료의 포획 등 행정적 요인이 주도적 역할을 하면서 '개별 실거래가 상환제도' 및 'A-7 가격 결정제도'의 보험약가 정책변동이 초래되었다는 사실을 확인할 수 있었다. 따라서 인구 고령화, 국민소득 증가, 소비자 주권의식 강화, 삶의 질 향사 욕구 증대로 계속 확대일로에 있는 의료정책 부문은 정치, 경제, 외교, 행정이 복잡하게 상호 작용하는 영역이고 주무부처인 보건복지부 조직과 관련 직능이익단체의 성격 및 상호관련성이 독특하므로 이 부문의 정책학 연구는 보다 정교한 접근이 필요하다는 정책학적 시사점을 도출할 수 있었다. The article examines Korea drug pricing policy reform. The reform was motivated by a desire to enhance the efficiency and transparency of the dung against the backdrop of lack of public support, resistance of various interest print reform agenda-Korea ended up with a drug pricing policy in favor of interest groups, at the cost of heavier general public and fiscal burden. Our study suggests that health policy involves complex decision making, heavily affected by political, economic, and even diplomatic relationships. Without, controlling these, it is difficult to achieve the policy goal of bettering the publics welfare.
정원우,이윤종,강용희,윤일희,이우붕,손종경,김중욱,강동진,권용주 慶北大學校 師範大學 科學敎育硏究所 1999 科學敎育硏究誌 Vol.23 No.-
The purpose of this study is to investigate the status of the experimental and practical education in high school general science. The present status and reasonable management of the experimental and practical education in high school general science were evaluated by the questionaires. To do this, 146 science teachers in Korea are administered questionaires. The frequency of the experimental and practical items in the seven kind of general science text books were investigated. The problems and the reasonable management for experimental and practical education were proposed in this paper.
유아용 조제 분유가 치태 pH에 미치는 영향에 관한 연구
정우진,이상훈,한세현 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1
Infant formula in nursing bottle, with inappropriate feeding habits, is major factor associated with the development of nursing caries. Although each infant formula has different carbohydrate and protein composition, studies comparing cariogenic potential of many Korean-branded infant formulas are deficient. In addition, it is on the point of being difficult to evaluate the cariogenecity of milk due to development of many infant formulas. In this study, to evaluate the cariogenic potential of many infant formulas, after oral rinse with six Korean-branded infant formulas(three milk based formulas, one soy based formula and two specific formulas for infants with allergy to milk protein and with lactose intolerance) for ten adult volunteers(eight males and two females), plaque pH change was measured with In vivo/In vitro combination technique and results were as follows. 1. All six different kinds of Korean-branded commercial infant formulas dropped the plaque pH significantly(p<0.05) and at an hour after rinse, plaque pH was not recovered in most of subjects. 2. Soy based infant formula and casein-hydrolyzated infant formula containing no casein dropped the plaque pH significantly more than milk based infant formula containing casein(p<0.05). 3. In the milk protein of infant formulas, casein had more effect on buffering the pH change of the infant formula than whey protein and casein-hydrolyzated infant formula had a refuced effect of casein. 4. In infant formulas with similar protien composition, infant formula containing sucrose dropped plaque pH more than infant formula containing lactose, but there was no significant difference(p>0.05).