비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구

한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.

BMB Reports : Connexin32 inhibits gastric carcinogenesis through cell cycle arrest and altered expression of p21^Cip1 and p27^Kip1

( Hyang Jee ),( Su Hyung Lee ),( Jun Won Park ),( Bo Ram Lee ),( Ki Taek Nam ),( Dae Yong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2013 BMB Reports Vol.46 No.1

Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition, after Cx32 overexpression in the human gastric cancer cell line AGS, cell proliferation, cell cycle analyses, and p21^Cip1 and p27^Kip1 expression levels were examined by bromodeoxyuridine assay, flow cytometry, real-time RT-PCR, and western blotting. Immunohistochemical study noted a strong inverse correlation between Cx32 and Ki67 expression pattern as well as their location. In vitro, overexpression of Cx32 in AGS cells inhibited cell proliferation significantly. G1 arrest, up-regulation of cell cycle-regulatory proteins p21^Cip1 and p27^Kip1 was also found at both mRNA and protein levels. Taken together, Cx32 plays some roles in gastric cancer development by inhibiting gastric cancer cell proliferation through cell cycle arrest and cell cycle regulatory proteins. [BMB Reports 2013; 46(1): 25-30]

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

中風病辨證診斷標準에 의한 臨床的 硏究

任長信,文祥官,高昌男,權正男,曺基湖,金永錫,裵亨燮,李京燮 경희대학교 1997 慶熙醫學 Vol.13 No.3

시각장애인용 음성합성기에 대한 사용자 요구분석

이희연,홍기형 이화여자대학교 특수교육연구소 2012 특수교육 Vol.11 No.2

본 연구의 목적은 시각장애인용 보조기기인 스크린리더에 사용되는 음성합성기에 대한 사용자의 요구분석 사항을 파악하여 고품질의 합성음을 개발하여 멀티미디어 환경 내에서 시각 장애인들의 지식정보 접근성을 높이고, 스크린리더 등의 전용 프로그램의 기능을 보완 ·강화하여 교육 및 사회 참여의 기회를 확대하여 전반적인 삶의 질을 향상하는데 있다. 컴퓨터와 스크린 리더의 사용에 익숙한 총 다섯 명의 참가자가 본 연구를 위한 핵심집단 면담연구에 참여했으며, 참가자의 요구분석 내용들은 상향식 접근방법(bottom-up approach)을 통하여 분석되었다. 시각장애인들의 음성합성기에 대한 요구분석들을 분석한 결과, (1) 청취 시의 피로도 개선, (2) 합성음의 명료도 개선, (3) 자연스러운 합성음에 대한 요구, (4) 남성 음색의 합성음에 대한 요구, (5) 잡음 발생 최소화, (6) 포네틱(phonetic) 기능에 대한 요구, (7) 정보유형에 따른 차별화된 속도 제공 등의 요구를 파악할 수 있었다. 이러한 결과에 근거하여 다양한 남성 음색의 명료하고 자연스러운 음성합성기를 개발하고, 이에 대한 시각장애인들의 장기간에 걸친 사용성 및 만족도를 평가하는 후속 연구가 요구된다. The purpose of this study was to examine usability and needs for speech synthesizer used in a screen reader which is an assistive technology device for the blind in order to (1) improve web accessibility in multimedia environment, (2) enhance the quality of a screen reader, (3) expand educational and vocational opportunities, and (4) improve the overall quality of life for the blind. Participants were five individuals (three men and two women) who were blind between the ages of thirty five to forty nine years old, and all of them were good at using computers, keyboards, and screen reader programs. After each participant was participated in the nonsense-word dictation task and the sentence listening task presented at two different speeds, they were engaged in a focus group interview to examine their preferences, needs, interests, and other opinions regarding the synthesized speech. The results of this study were analyzed into following categories using a bottom-up approach. Participants’ needs for the speech synthesizer were (1) reduction of fatigue while listening synthesized speech for a long time, (2) improvement of the intelligibility of the synthesized speech, (3) use of natural and comfortable synthesized speech, (4) use of low tone of voice (male voice tone), (5) removal of background noises or high-frequency noises, (6) addition of the phonetic reading function, and (7) differentiated speed of synthesized speech based on the type of information. The first priority of the speech synthesizer users’ was to minimize fatigue level while listening a synthesized speech. Further research needs to be directed to examine usability and needs for the updated speech synthesizer through a long-term usability testing.

복숭아심식나방(Carposina niponesis Walsingham)의 發育에 미치는 溫度의 影響에 關한 硏究

李昌喜,玄在善,金基滉 서울大學校 農科大學 1982 서울대농학연구지 Vol.7 No.2

The peach fruit moth, Carposina niponensis Walsingham, was reared under verious temperatures; 20℃, 25℃, 30℃, and room condition. The effect of the rearing temperatures on the development were examined. The results obtained are as follows: 1. The seasonal change of the damaged fruits of apple was examined. The damaged fruits increased greatly in August, when the number of apple fruits had stabllized. It seemed to have two generations in an year in Suweon area according to the seasonal change of the damaged fruits. 2. The adult longevity of peach fruit moth decreased at high temperatures, and ovipositional periods were shorter at 30℃ compared with the lower temperatures tested, suggesting that such a high temperature hasten the sexual maturity of the adult. The longevity of the female was longer than that of the male. 3. No significant effects of the temperatures on the number of eggs laid by a female were observed in the temperature range from 20℃ to 30℃, and they were ranged 85∼170 eggs. 4. The median of days required for the completion of the various life stages were 6.9∼12.1 days for eggs, 15.8∼26.0 days for larvae, and 11.3∼20.0 daus for pupae, depending on the rearing temperatures. The velocity of development in eggs and larvae increased linearly at temperature range from 20℃ to 30℃, while there seemed to be slight retardation of development for the pupae at 20℃. The velocity of development was greater with higher temperatures. 5. The calculated developmental threshold temperatures were 6.6℃ for eggs, 5.4℃ for larvae, and 6.4℃ for pupae, and overall developmental threshold temperature was estimated as 60℃. 6. The estimated values of the total effective temperatures were 150∼170 day degrees for pupae, and overall total effective temperature would be 790∼850 day degrees based on the overall threshold temperature of 6℃. 7. A predietion formula was suggested as Y=-2.419X+105.257, where Y: Number of days required to complete a life cycle. X: Temperature treated, based on the total effective temperature.

麥門冬과 五味子가 Asthma model 內의 Cytokine IL-4, IL-5, IL-6에 미치는 影響

李同生,鄭熙才,李珩九,鄭昇杞 경희대학교 2000 慶熙醫學 Vol.16 No.2

정신과 외래환자의 약물치료 반응과 심박동 변이의 변화 양상

이상규,이홍석,김인주,김형태,김도훈,손봉기 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objectives : The purpose of this study was to investigate the change of heart rate variability after antidepressant treatment in depressed or anxious patients. We tried to find the usefulness of heart rate variability as a predictive marker of response to pharmacological treatments in the psychiatric field. Methods : Forty-seven patients with major depression, anxiety disorder, and somatoform disorder were treated over 4 weeks with antidepressants and were then classified as responders or nonresponders according to Hamilton depression scales or CGI scores. The HRV variables were measured and compared among the responders/nonresponders and the matched normal control. Results : The responders group exhibited low heart rate, low PSI, high SDNN, RMSSD, HRV index, NN50, pNN50, LNTP, LNLF, and LNHF compared with the nonresponders after 4 weeks antidepressant treatment. However, no significant differencein HRV vanables was observed between the responders group after treatment and the nonnal control group and the responsegroup after treatment. Conclusion : These results indicate that HRV variables would are normalized after successful antidepressant treatment and it that HRV has some possible uses as a predicting marker of antidepressant response.

화상 처리 기술을 이용한 공기 가압식 인젝터의 분무 특성 분석

이기형,정해영 漢陽大學校 工學技術硏究所 1998 工學技術論文集 Vol.7 No.1

본 연구에서는 공기 가압식 인젝터의 분무 특성과 보조 공기압에 따른 분무 특성에 의한 영향을 분석하였다. 분무 분리각, 분무 도달력, 분무 도달거리, 자우터 평균 입경 등의 분무 특성은 인젝터와 최상의 엔진 성능을 실현하기 위해 필요한 흡기 포트의 최적 설계에 매우 중요한 인자이다. 이러한 분무 특성을 파악하기 위해 거시 분무 구조를 가시화하고, 분무 미립화 과정은 그림자 촬영법과 디지털 화상 처리법을 이용하여 정량화하였다. 실험을 통하여 공기 가압식 인젝터와 공기 보조 어댑터를 설계시 필요한 유용한 설계 인자를 파악할 수 있었으며 본 논문에 상세한 내용을 기술하였다. An experimental study is carried out to analyze spray characteristics for air-shrouded injector and to see the effects of air shrouding pressure differential on the spray characteristics. The spray characteristics including spray angle, targeting capability, penetration, and SMD(Sauter Mean Diameter) are very important for injector and intake port design to achieve best engine performance. The global spray structure are visualized and spray atomization processes were quantified using shadow graphy method and image processing algorithm. Effective spray characteristics to design air-shrouded injector is derived from this experimentation and described in more detail in this thesis.

합기도 체육관 선정에 대한 학부모의 의식 조사

이기세,정형진,신원 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

Students' parents' attitude survey about hapkido stamp choice, To this research contributes to activate hapkido gymnasium supplying pebulum to operate hapkido gymnasium investigating essential factors that students' parents choose, result that study is as following. 1. It appeared highest that respond that path that know about hapkido gymnasium which go present knew through children's friend. 2. To go to hapkido gymnasium is direct influenced to fathers appeared highest and motive that begin exercise is for health preservation and it appeared highest that respond. 3. Appeared that leader is thought most heftily at gymnasium choice, and education contents of stamp make aware of pride appeared high 4. To problem that parents is worried, 'Safety problem' the highest response do, and distance about 500m sides from the house to hapkido gymnasium are most. Also, walking (walk) appeared by the most things by transfer method, Gymnasium operation is demonstrating worry that show industrialize phase through quantitative public information through large scale and modern interior in past small scale and is [Ban to profit management contest than body and moral education. Therefore, seek more qualitative elevation than quantitative development, and is considered by thing which induction of various program and induction of practice method that safety is guaranteed are urgentest.