Trirutile type 고체촉매를 이용한 olefin의 에폭시화 반응에 관한 연구

조영범,안광현 慶熙大學校 材料科學技術硏究所 2000 材料科學技術硏究論集 Vol.13 No.-

과산화수소를 이용한 알켄의 산화 반응에서 trirutile type 고체 산화물이 효과적으로 촉매 역할하는 것을 관찰할 수 있었다. 특별히 HNbMoO_(6), LiNbMoO_(6) 및 HNbWO_(6)등이 좋은 촉매효과를 보여주었다.

뇌 아밀로이드 혈관병과 고혈압성 뇌출혈의 감별에 있어서 Apolipoprotein Eε4와 점상 출혈 분포의 유용성

김용범,이광호,이수주,나덕렬,조수진,정진상,이원용 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

개질재를 혼입한 재생아스콘의 역학적 특성에 관한 실험적 연구

박승범,조광연,조청휘,김정환,채용주 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

This paper presents the results of an experimental study on the mechanical properties of modified recycling asphalt concrete. Research has been performed to obtain the characteristics of the modified recycling asphalt concrete such as marshall test, indirect tensile test, resilient modulus and wheel tracking test by varying contents of modifier (SBS, SBR) and recycled aggregate(30, 50, 70%). Modified recycling asphalt concrete showed better performance than new asphalt concrete in dynamic stability. Each quality property of the modified recycling asphalt concrete satisfied requirement of pavement construction specification.

강섬유보강 콘크리트 슬래브의 내력 및 균열특성에 관한 실험적 연구

박승범,조광연,장석호,김부일 忠南大學校 産業技術硏究所 1997 산업기술연구논문집 Vol.12 No.2

This Study is aimed to investigate the effect of load and deflection on steel fiber reinforced concrete slab. Slabs were made with Hooked and Straight types steel fiber and compared a change of steel fiber contents and fiber type. Test were carried out to evaluate the first crack load, maximum load and deflection of slab. AT this result, the first crack load, maximum load and energy absorption capacity were increased remarkably as steel fiber contents were increased. And we found that the deflection of slab at same load were decreased as steel fiber contents were increased, too. As the aspect ratio was increased, the first crack load, maximum load and energy absorption capacity were increased.

동일한 시료에 대한 국내 기관간의 STR 분석결과 비교 : STR 유전자좌 분석법의 표준화 설정을 위하여

박종태,신경진,양윤석,우광만,이숭덕,이승환,이정빈,정연보,조승희,한길로,한면수,홍승범 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

This paper described a collaborative exercise intended to see what kinds of short tandem repeat (STR) loci are used in different DNA typing laboratories in Korea and to compare their results for the demonstration whether uniformity of DNA profiling results from different laboratory could be achieved in Korea Laboratories were asked to test five tissue DNAs using methods routinely used in each laboratory and to report the results to the coordinating laboratory. The exercise demonstrated that each laboratory was using different STR loci for the typing with different STR numbers,2 VNTRS,36 STRs and amelogenin in total, and the direct comparison of the results from all the laboratory for the 18 loci could not be done as only one laboratory submitted typing results. Among 21 loci for which several laboratories submitted typing results, results for 14 loci were the same and results for the other 7 loci were different depending on the participating laboratory. D1S80, F13A01, D16S539, D21S11, D18S51, D3S1744 were the loci with different typing results. Even in the cases where commercial kits were used, the results were not the same depending on the machines used, that is the capillary electrophoresis or the gel based electrophoresis. The reason for the different results, points about the standardization of the methods arid the profiling data were described.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

단기간 탄수화물 섭취가 유도선수들의 운동수행력에 미치는 효과

남광우(Nam Kwang-Woo),전승훈(Jeon Seung-Hoon),김범수(Kim Bum-Soo),조준용(CHo Jun-Yong),조인호(Cho In-Ho) 한국체육과학회 2008 한국체육과학회지 Vol.17 No.3

The purpose of this study was to investigate the effects of carbohydrate supplementation on rating of Perceived Exertion (RPE), CK(creatine kinase), LDH(Lactate dehydrogenase), plasma insulin, glucose, and isokinetic contraction in elite judokas who have performed regular judo training for 2-3 years. For this study, elite judokas (male, n=10) were voluntarily participated in two different experiment trials. During experiments period, elite judokas were supplemented both placebo(P) and carbohydrate(CHO)) by double blinded trial. Serum CK level was significantly decreased after CHO supplementation. Interestingly, RPE level was significantly lower after CHO supplementation. There was no different both insulin and glucose concentration in both supplementation trial. Isokinetic muscle power (total, mean) was slightly higher in CHO trial, but not in placebo trial. In conclusion, Elite judokas who have performed long period regular training developed overreaching phase. but this syndrome might be alleviated by CHO supplementation during training session.

The Management of Endoscopic Retrograde Cholangiopancreatography-Related Duodenal Perforation

Kwang Bum Cho 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.4

Uneventful duodenal perforation during endoscopic retrograde cholangiopancreatography (ERCP) is an uncommon but occasionally fatal complication. ERCP-related perforations may occur during sphincterotomy and improper manipulation of the equipment and scope. Traditionally, duodenal perforation has been treated with early surgical repair. Recently, nonoperative early endoscopic management techniques including clips or fibrin glue have been reported. In the present paper we review the literature pertaining to the treatment of perforations.

Single Oral Dose Toxicity Test of Persicae Semen Aqueous Extracts in Mice

Cho, Hun-Bum,Park, Ji-Ha,Seo, Bu-Il,Cho, Su-Yeon,Park, Kyu-Ryul,Choi, Seung-Hoon,Han, Chang-Kyun,Song, Chang-Hyun,Park, Soo-Jin,Ku, Sae-Kwang The Korea Association of Herbology 2013 大韓本草學會誌 Vol.28 No.3

Objectives : This study was to evaluate the single dose toxicity of Persicae Semen (PS) in ICR mice. Methods : Aqueous extracts of PS (Yield = 18.60%) were administered as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) guidelines (2009-116, 2009). Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 12 principle organs were examined. Results : Amygdalin contents in PS aqueous extracts were detected as $32.50{\pm}5.96{\mu}g/ml$. We could not find any PS extracts treatment related mortalities, clinical signs, changes on the body and organ weights, gross and histopathological observations up to 2,000 mg/kg in both female and male mice, except for transient and slight loss of locomotion detected in female and male mice treated with 2,000 mg/kg. In addition, pharmacological immunomodulatory effects related findings were also demonstrated in 2,000mg/kg treated female and male mice as hypertrophy and hyperplasia of lymphoid cells in the submandibular lymph nodes. Conclusions : Based on the results of this experiment, the approximate lethal dose (ALD) of PS extracts after single oral treatment in female and male mice were considered above 2,000 mg/kg, respectively. It should be carefully used in clinics because the possibilities of respiratory or neurological disorders were observed when administered over 2,000 mg/kg of PS extract related to amygdalin.

How to reduce fistula formation after self-expandable metallic stent insertion for treating malignant esophageal stricture?

Kwang Bum Cho 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.6

EDITORIAL