국내산 중하(Metapenaeus joyneri) 내 주알레르겐 규명 : 가열 및 소화액에 의한 변화

윤성호,김현아,김현미,최정희,서창희,남동호,김윤근,민경업,박해심 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection

Chun, Yoon-Keun,Ha, Joo-hun,Hong-Jung-Woo,Oh, Soo-Myung,Kim, Sung-Soo 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Yoon-Keun Chun¹,Joohun Ha□Hong-Jung Woo□, Soo Myung Oh□,Sung Soo Kim□ ¹Department of Molecular Biology, College of Medicine,²Department of Surgery, college of Medicine,³Department of Internal Medicine, College of Oriental Medicine,and ⁴East-Weat Medical Reserch Institute,Kyung Hee University, Seoul, Korea. The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection. Proceedings of International Symposium on East-West Medicine, Seoul. 212-230, 1999. -Hepatitis B is caused by hepadnavirus. Hepatitis B virus replicates through 3.5kb pregenomic RNA intermediate which is regulated by core promoter. Pathogenesis of hepatitis B virus has been bilieved the result of host immune response. But recently many studies have reported that high level of viral replication caused by mutation in core promoter might result in severs hepatitis. But these studies were performed in vitro, not in vivo. So there is yet debate about which factor, viral of host factor, is more important in pathogenesis of hepatitis B virus. So we measured real viral replication level in 204 chronic hepatitis B patients by quantifying HBV DNA from sera by our novel PCR-based more sensitive method, and compared these results with ALT level measured from same sera, which indicates liver cell damage. Surprisingly there are no significant correlation between HBV DNA quantity and ALT level. Then we cloned core promoter region. In SSCP, we found that many viral mutants coexist in one patient. Base on SSCP result, we chose main viral core promoter type in each patients, which is thought to determine overall viral replication level in this patient. Main type of core promoter region of each 41 patients were directly sequenced. And with these we measured promoter activity by luciferase assay system and compared promoter activity with on another. We found tha there were some differences in promoter activity according to core promoter sequences. And we constructed replication-competent viral constructs with core promoter from 41 patients and Transfected these into HepG2 cell and measured HBV DNA by southern blot. There were also differences in HBV DNA quantity according to core promoter sequences. On these all results we investigated correlation between the effect of HBV core promoter on viral replication in vitro and HBN DNA quantity, ALT level from sera of each patients. We found there is no significant correlation among them. As a result, we concluded that in determining severity chronic hepatitis B patients, host factors of each patient is more important rather than replicative activity of virus itself.

전경대원에서 발생한 결핵의 임상 양상

문창기,박상준,조민구,김영중,김소연,김윤권,정준오,안석진,김은실,서승오,김지훈,최원제,이윤영,박형기,최규영,김현근 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background: The purpose of this study was to document the incidence and clinical characteristics of patients with tuberculosis (TB) in combat and auxiliary police, living in a group, in Korea where the incidence rate of active TB in a general population is higher than in Western countries. Materials and Methods:We retrospectively reviewed the medical records of all tuberculosis patients diagnosed at National Police Hospital from January 2002 through December 2004. Results:In 2002-2004, a total of 156 cases of tuberculosis were identified with the mean (Standard deviation) age of 20.6 (±1.0) years. Of these, 134 (85.9%) patients were registered as new cases, 11 (7.1%) as relapse, 2 (1.3%) as failure, 5 (3.1%) as treatment-after-default cases whereas 4 (2.6 %) patients were not included in any categories. Average annual new TB rate and smear-positive TB rate were 86.5/10^(5) and 17.4/10^(5) person-years, respectively. In 12 of 31 smear-positive cases, time from onset of symptoms to diagnosis was more than 30 days. Two multidrug-resistance TB cases were identified and two suspected outbreak episodes of TB had occurred during 3 years. Conclusion:There was no statistically significant difference in the incidence rate of new cases of TB between the general population aged 20 to 29 years and combat and auxiliary police in Korea. 배경 : 국내 결핵의 발생은 감소 추세에 있으나 여전히 후진국형 발생양상을 보이고 있다. 특히 집단생활을 하는 젊은이들에서 발생하는 결핵의 유행이 간헐적으로 알려지고 있어 우려를 낳고 있다. 이에 저자들은 최근 전경대원의 결핵 발병 양상에 대해 알아보고자 본 연구를 시행하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 3년간 경찰병원에서 결핵 진료를 받은 전경대원의 의무기록을 후향적으로 분석하여 연도별 결핵 신환발생률, 도말양성결핵 신환율, 진단 지연, 집단발병, 다제내성결핵을 조사하였다. 결과 : 연도별 결핵 신환자 수(10만명당 발생추정치)는 2002년 50명(83.6명), 2003년 42명(83.7명), 2004년 42명(93.5명)이었고 도말양성 폐결핵 신환자 수는 2002년 10명(16.7명), 2003년 11명(21.9명), 2004년 6명(13.4명)이었다. 3년간 도말양성 폐결핵 환자는 31명이 있었고 그 중 12명은 호흡기 증상 발생 30일이 지나서 진단을 받았다. 다제내성 결핵은 2명이 있었으며 결핵의 집단발병이 의심되는 사례는 2차례 있었다. 결론 : 전경대원과 20-29세 연령군 일반인의 결핵 신환발생률, 도말양성 폐결핵 발생률의 통계적으로 유의한 차이는 없었다.

호산구성 간농양 54예의 임상상

강혜련,권혁수,송우정,이상민,김태범,박혜경,장윤석,김윤근,조상헌,민경업,김유영 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

Phenylhydrazine으로 處置한 토끼 赤血球의 Lactate Dehydrogenase Isozymes의 活性度에 關하여

金良均,朴在允,車鍾希,高光三,李根培 조선의대 1983 The Medical Journal of Chosun University Vol.8 No.1

하안면부에서 입술의 돌출 정도와 안면 비대칭의 인지도에 관한 연구

김규선,김영진,이근혜,김영호,국윤아 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.6

교정 치료를 하고자 하는 가장 큰 동기 중의 하나는 좋은 안면을 얻고자 하는 것이므로 교정 치료 후 안면부에 나타나는 변화에 대한 환자들의 인지도를 이해하는 것은 교정 치료의 진단과 치료 계획 수립에 매우 중요한 일이다. 이에 본 연구는 정면 및 측모에서 하 안면부위의 입술의 위치와 안면 비대칭의 변화에 관하여 인지할 수 있는 최소한의 변화량을 알아보고자 균형 잡힌 비율을 지닌 가상의 정모와 측모 사진을 컴퓨터 영상으로 제작한 후 입술의 위치는 Ricketts의 E-line을 기준으로, 안면의 비대칭은 턱 끝의 중앙 지점을 기준으로 각각 1, 2, 3, 4 mm 변화시킨 디지털 영상을 이용하여 40명의 미술학도를 관찰자로 인지도 조사를 하였다. 연구 결과 환자가 입술의 위치와 비대칭의 변화를 인지하기 위해서는 측모에서 최소한 2 mm 이상, 정모에서 3 mm 이상의 변화가 필요하였으며 하 안면부 변화에 대한 인지도는 정모에서보다 측모 변화에 대한 인지도가 높았다. 또한 변화에 대한 사전 정보는 변화에 대한 인지율을 현저하게 높여 주었다. Objective: While one of the most prevailing motivations for seeking orthodontic treatment is to achieve good facial esthetics, understanding the level of a person's perception to the changes that have occurred on the face after orthodontic treatment is critical to the process of orthodontic diagnosis and treatment planing. Methods: 40 students attending art school participated in determining the level of their perception of changed lip position and facial asymmetry. Computer-graphic frontal face and facial profile photographs with balanced proportions were used to evaluate the level of a participant's perception of the changes in facial asymmetry and in lip position. Results: Change of lip position over 2 mm and over a 3 mm change of facial asymmetry was perceived significantly. Conclusion: The results indicated that at least a 2 mm change of lip position was needed to be perceived after orthodontic treatment. The level of perception of the change in facial asymmetry was lower than that of the change in lip position. Information about facial changes given prior to the evaluation enhanced the level of perception.

사회제도와 레크리에이션의 관계에 관한 연구

김윤숙,이근모 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

As modem civilization advances very highly, our way of living is changing. In particular, industrialized society, which provides us with "increase of leisure time", has a strong effect on ethical and moral aspects of our life. In addition, it is regarded as a new research subject. Good use of leisure can save human deprivation and self alienation, but bad use of leisure will cause them. Therefore, in modem society, recreation, which plays a role in re-education for humanization, is getting more and more significant. Recreation tendencies and problems of modem society are being mentioned in many different points of view. But there are few paper which have investigate recreational phenomena through sociological approaches. So this, as away of sociological study, aims at criticizing and analyzing the relationship between social regulations of politics, economy, culture, religion, ethic, recreation and goes to the conclusion that the recreation is a kind of social phenomenon.

카이토산을 이용한 방사성스트론튬 오염의 치료

김지열,송호천,양광희,최근희,채기문,범희승,김광윤 대한방사선 방어학회 1994 방사선방어학회지 Vol.19 No.3

본 연구에서는 마우스에 이미 오염된 방사성스트론튬(Sr-85)을 제거하는데 수용성카이토산이 어느정도 효과가 있는지 알아보고자 하였다. Sr-85를 정맥주사한 경우 주사후 1일째의 체내 잔류량은 72.9 ±5.7%, 5일째는 57.7 ±1.9%, 7일째는 54.2 ±1.4%로 서서히 감소하였으며, Sr-85를 복강내 주사한 경우는 주사후 5일째 54.4 ±1.2%, 15일째 50.6 ±0.8%로 정맥주사에 비해 낮은 잔류량을 보였다(5일째 잔류량의 비교, P<0.05), 0.3% 수용성카이토산을 1회 정맥주사해준 제21군 및 10% 수용성카이토산을 식이중에 섞어 먹인 제5군은 각각의 대조군에 비해 체내 잔류방사능의 차이가 없었으나 (P>0.05), 0.3% 수용성카이토산을 3일간 정맥주사한 제3군과 3% 수용성카이토산을 이틀 간격으로 15일간 복강내 주사한 제6군에서는 각각의 대조군에 비해 낮은 잔류방사능을 보였다. (P<0.01). 결론적으로 수용성카이토산을 연속적으로 정맥투여하거나 복강내 투여하는 경우에는 스트론튬의 골대사촉진 또는 골중의 스트론튬과의 반응등을 통해 그 배출을 촉진시킬 것으로 사료되었다. The aim of the present study was to elucidate the effect of the water soluble chitosans on the removal of contaminated radiostrontium(Sr-85) from the bone of mice. The remaining radioactivities in intravenously injected controls(group 1) were higher than in intraperitoneally injected controls (group 4, P<0.01). The % retention at day 5 were 57.7 ±1.9%, 54.4 ±1.2%, respectively. Single intravenous injection of 0.3% water soluble chitosan and continuous oral ingestion of 10% water soluble chitosan for 15 days were ineffective on the removal of contaminated radiostrontiums. Multiple intravenous or intraperitoneal injections of water soluble chitosan effectively removed contaminated radiostrontiums (P<0.01 vs controls). In conclusion, water soluble chitosan might remove once incorporated radiostrontium from bones of mice. further studies were needed to elucidate the mechanism of the removal.

PECVD에 의해 제조된 Sb-doped SnO₂박막의 광학적성질

김근수,윤석영,김광호 부산대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.58 No.-

플라즈마를 이용한 화학증착법 (PECVD)으로 Corning glass 1737 기판에 Sb-doped SnO2 박막을 증착하였다. 플라즈마 화학증착시 반응변수에 따른 박막의 결정상, 표면형상 및 광투과도를 XRD, SEM, AFM 과 그리고 UV-VIS-NIR Spectrophotometer를 이용하여 분석하였다. Thermal CVD에 비해 PECVD법은 박막의 증착속도를 향상시켰고, 박막의 표면형상을 보다 균일하게 하였다. 반응온도 450℃, 유입가스비 R=1.12, RF power 30W에서 결정성과 광투과도가 비교적 뛰어난 Sb-doped tin oxide films을 얻을 수 있었다. Sb-doped tin oxide films were deposited on Coming glass 1737 substrate by plasma enhanced chemical vapor deposition (PECVD) technique. The films deposited at different reaction parameters were investigated by using XRD, SEM, AFM, and UV-VIS-NIR Spectrophotometer. Compared to thermal CVD,PECVD effectively enhanced the deposition rate and smoothed the surface of tin oxide films. Sb-doped tin oxide films which have a relatively good crystallinity and photo-transmission were obtained at deposition temperature 450℃, input gas ratio R=1.12, and RF power 30W.

21세기 삶의 질 향상을 위한 레크리에이션 운동에 관한 연구

김윤숙,이근모 釜山大學校 師範大學 1998 교사교육연구 Vol.35 No.-

As modern civilization advances very highly, our way of living is changing. In particular, industrialized society, which provides us with "increse of leisure time," has a strong effect on ethical and moral aspects of our life. In addition, it is regarded as a new research subject. Good use of leisure can save human deprivation and self alienation, but bad use of leisure will cause them. Therefore, in modern society, recreation, which plays a role in re-education for humanization, is getting more and more significant. Therefore, the purpose of this study was as follows : This study investigated the direction and task for activating recreational movement. For example, in the direction and task for activating recreational movement investigated to livelihood, organization, space, polity of recreation. And, It proposed task for activating recreational movement in field of servitude society, one's place of work, school, social welfare to progress Quality of Life in 21st Century.