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공통데이터 모델과 임상 데이터 웨어하우스를 이용한 Fimasartan과 Losartan의 약물 유발 간 손상의 발생 비교: 단일 의료기관 후향적 코호트 연구
강혜련,윤진,김현지,고예희,이시연,안경민,정지웅,이지향,김광수 대한약물역학위해관리학회 2024 약물역학위해관리학회지 Vol.16 No.1
: Fimasartan, an angiotensin II receptor blocker (ARB) with superior potency and longer-lasting effects than losartan, demonstrates a good safety profile. However, recent case reports have emerged, linking fimasartan to hepatotoxicity. The aim of the study is to compare the occurrence of liver injury induced by fimasartan. Methods: Patients prescribed with fimasartan and losartan from 2011 to 2021 were identified from electronic health recordbased Common Data Model (CDM) of Seoul National University Hospital. Using clinical data warehouse, clinical information was collected and employed to cross-reference the results retrieved from the CDM. To assess causality and compare the incidence of drug-induced liver injury (DILI), 100 randomly selected patients with liver function abnormalities were evaluated. Results: The CDM analysis included 3,063 patients on fimasartan and 9,688 patients on losartan, among which 302 patients (2.37%) exhibited liver function abnormalities within the first year of ARB therapy. Specifically, 107 (3.49%) patients on fimasartan showed elevated serum alanine aminotransferase or aspartate aminotransferase, compared to 195 (2.01%) patients on losartan. However, when causality was assessed, patients with causality graded as probable or certain did not show any significant difference between the two medications. Conclusion: Although patients taking fimasartan exhibited a slightly higher incidence of mild liver enzyme elevations, this study did not find a significant difference in the occurrence of DILI. Consequently, fimasartan is less safe than losartan in terms of hepatotoxicity cannot be asserted. However, similar to other ARBs, fimasartan poses a risk of DILI, underscoring the importance of monitoring liver function tests to promote safer use of the medication. (PeRM 2024;16:79-89)
러시아 지방엘리트의 지속성과 변화 : 재임기간별 연방주체 수장들의 특성을 중심으로
강혜련 동북아시아문화학회 2008 동북아 문화연구 Vol.1 No.16
This study is to explore the changes and continuities of regional political elites in Russia by categorizing them into four groups on the basis of the length of their incumbency. The study also leads us to a couple of findings. First, drastic changes could be identified in both initial period of Eltsin's and Putin's rule. Second, such technocrats as economic elites those based on banks and industrial sectors, those from judicial sectors and intelligency branches emerged as a ruling class, while the first generation of regional elites became regional heads. This could be one of most conspicuous changes that were introduced under Putin. Third, new faces emerged in the process of institutional changes that had been caused by negotiations between Moscow and federal subjects.
강혜련 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6
This study aims at tracing the relation of participation in dance activity to personality characteristics on the assumption of the theoretical relation between the experience in the process of socialization and the formation of personality. To accomplish such a research purpose, first it compares the personality characteristics between participant group in dance activity and the group of general students, second the personality characteristics according to the career of dance activity among the participants in dance activity. The objects of this research are 150 students participating in dance activity and 160 general students with the population of girl students attending middle schools and high schools in Seoul. Collected data was performed with the statistical methods including t-test, reduction capacity, analysis and post test depending on the goals of research. This study obtains the following conclusions through the data analysis based on the above methods and procedures. First, as a result of comparing the personality characteristics between the participating group in dance activity and general students group, the students participating in dance activity show higher tendency in consideration and less emotional stability than non-participating students and there is a significant difference between in male orientation and sociality between two groups. Second, as a result of comparing the personality characteristics by careers between two groups, the group with more careers are less in male orientation, stability, sociality and consideration than the group with less career of participation in dance activity and there is a significant difference between two group. And there is no significant difference between two groups in the factors of activity.
강혜련 연세대학교 동서문제연구원 2000 유라시아연구 Vol.1 No.1
이 글은 옐친시기 러시아대통령의 제도, 개인, 측근집단에 대한 고찰을 통해 러시아대통령제의 특성과 러시아민주주의의 과도기적 성격을 조명하는 데에 목적이 있다. 제도적 측면에서 러시아대통령제는 삼권분립 구도를 넘어서는 막강한 대통령의 위상, 구소련적 유산을 바탕으로 한 대통령과 행정부의 관계의 특이성 및 대통령기구의 독자적인 권력기구로서의 활동가능성, 의회 및 정당과의 관계에서 지나친 권력불균형구조 등이 특징으로 나타난다. 이러한 대통령제의 특성은 대중적 정치인으로서 탁월한 감각을 갖고 있었지만 새로운 체제의 정착을 본격적으로 실행하는 데에서는 한계를 노정한 옐친의 지도자로서의 자질, 주요한 정치엘리트 충원메카니즘의 하나였다고 할 수 있는 옐친의 측근집단 형성과 결합하면서 실질적인 권력기구로서 대통령을 이루는 근간이 되었다. 옐친시대의 유산은 뿌친체제의 출발점이 되는데 권력핵심부의 확립과 정치적 안정이라는 과제에 부딪치면서 옐친에 의해 의도된 막강한 대통령의 위상이 이후 제도적 반전을 거쳐 어떻게 재정립될 것인라는 문제가 뿌친체제의 성격을 가름짓는 핵심인 초점이 될 것이다.