한국인에서 구강상피세포를 이용한 발암물질 대사효소의 유전자 다형성에 관한 연구

최민아,박해준,정원윤,이재원,이정복,박광균 대한암예방학회 2002 Journal of cancer prevention Vol.7 No.3

N-Oxyldiethylenebenzothiazole-2-sulfenamide의-S-N= 결합에 대한 전기화학적 환원

金海珍,鄭根鎬,崔圭源,金日光,林善英 원광대학교기초자연과학연구소 1992 基礎科學硏究誌 Vol.11 No.3

N-Oxyldiethylenebenzothiazole-2-sulfenamide(ODBS ; 가황촉진제)의 전기화학적 환원을 직류와 시차펄스 폴라로그래피 순환 전압전류법, 조절전위 전기량법으로 연구하였다. ODBS의 전극환원과정은 단일 환원파(-1.86 volts vs. Ag/0.1M AgNO₃ in AN)에서 비가역으로 3전자가 이동하는 E-C-E-C 반응메카니즘으로 진행되었다. 조절전위 전기분해 결과 sulfenamide(-S-N=) 결합이 끊어지고 mercaptobenzothiazole(MBT)과 benzothiazole disulfide(MBT dimer) 그리고 유리된 sulfur 등이 생성물로 얻어졌다. pH 변화에 따른 폴라로그램의 해석과 생성물 분석의 결과를 바탕으로하여 전기화학적 반응 메카니즘을 제안하였다. The electrochemical reduction of N-oxyldiethylenebenzothiazole-2-sulfenamide(ODBS; vulcanization accelerator) was investigated by direct current polarography, differential pulse polarography, cyclic voltammetry and controlled potential coulometry. The irreversible electrode reduction of ODBS proceeded E-C-E-C reaction mechanism by three electrons transfer with irreversible one wave(-1.86 volts vs. Ag/0.1M AgNO₃ in AN). As the results of controlled potential electrolysis, mercaptobenzothiazole(MBT), benzothiazole disulfide(MBT dimer) and extricated sulfur were products which followed by cleavage of the sulfenamide(-S-N=) bond. Upon the basis of products analysis and polarogram interpretation with pH variable, electrochemical reaction mechanism was suggested.

공공부문 정보시스템의 하드웨어 용량산정 방식 설정을 위한 실증적 연구

정해용,나종회,최광돈 한국정보사회진흥원 2005 정보화정책 Vol.12 No.3

2002년도부터 2006년도까지의 국가정보화촉진계획인『e-Korea Vision 2006』에 의하면 과거 수년 동안 정보시스템에 대한 투자액은 급격하게 증가하고 있으며, 정보시스템에 대한 투자액의 50%이상은 하드웨어 구축에 소요되는 비용인 것으로 분석되고 있다. 따라서 정보시스템 구축∙운영에 소요되는 하드웨어 규모를 적정하게 산정하는 작업은 효과적인 정보화 투자를 위한 필수불가결한 작업으로 인식되고 있으며, 이를 통하여 자원낭비를 최소화하고 기회비용을 절감할 수 있다는 점에서 그 중요성이 증대되고 있다. 이러한 관점에서 본 연구에서는 공공부문에서의 정보시스템 구축∙운영에 필요한 하드웨어 용량을 객관적으로 산정할 수 있도록 용량산정식 및 용량산정식에 포함될 항목들을 실증적으로 제시하였다. 즉, 업무중심의 정보시스템 프로젝트 단위별로 CPU 및 메모리와 하드디스크의 용량을 산출하는데 고려해야 할 항목들과 이러한 항목들을 통하여 적정 용량을 산정할 수 있는 용량 산정식을 도출하였다. 이론적 문헌검토와 SI업체 및 하드웨어 공급업체의 사이징 전문가들의 경험적 노하우 등을 통하여 기존에 활용되고 있는 용량산정식에 근거하여 기준이론을 설정하고 이를 현장의 실무전문가들을 대상으로 설문조사 및 전문가 집단토의 방식을 통하여 타당도를 검증하였다. 본 연구의 주요 의의로는 공공기관의 현장실무 전문가 및 공급업체의 용량산정 전문가들을 대상으로 실행적 측면에서 CPU(Web/WAS용 및 OLTP용), 메모리, 디스크에 대한 용량산정식 및 각 용량산정식에 포함되어야 할 항목들이 실증적으로 도출되고 전문가 집단토의를 통하여 확인함으로써 객관성을 확보한 용량산정식을 제시하였다는 점이다.

응급실환자 내원행태 및 중증도에 관한 조사 연구

유순규,최혜경,김광한 서울보건대학 1999 서울보건대학 부설 병원경영연구소 논문집 Vol.4 No.2

To solve the problem of tertiary emergency medical center. overcrowding and long hospital stay. it is very important to analyze arrival pattern of the emergency patients who visited tertiary emergency medical center and to reviewed 312 cases of patients who visited the four places emergency medical center which emergency medicine department specialist always stays in. of Seoul and Suwon teritory, from March 1 to May 31. 1997. The results were as follow : 1. Considering sexual distribution, male patients were 60.3% and female patients were 39.7% and the most common age group was 2th decade. 2. The result of symptom severity classification of patients coming emergency medical center was urgent patients 12.8%, emergency patients 29.8%, non-emergency patients 57.4% 3. The peak time of patient's enterance in emergency medical center was between 8: 00PM and 12:00 PM(26.7%), and most patients visited between 4:00 PM and 12:00 PM (out patients coming time) 4. In a week. Monday was the most crowding day (25.0%) 5. The most patients who visited emergency medical center needed surgical care due to injury & poisoning(27.9%) and second disease of them had circulatory system (17.6%) 6. The admission rate was 42.9% and 46.4% of admitted patients were non-emergency patients. 7. The rate of the urgent patients making use of 119 ambulance was 62.5%. emergency patients rate was 47.3% 8. The treatment result of patients in emergency medical center trended improving of urgent patients(improvement rate was 72.5%)

심한 변비와 복부팽만으로 발견된 소아 크론병 1예

성명순,강석정,최광해 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Crohn's disease is a chronic inflammatory bowel disease that mainly affects children and young adults, Its cause remains unknown. The incidence of pediatric Crohn's disease is increasing, so it is important for clinicians to be aware of the presentation of this disease in the pediatric population The majority of patients complain of abdominal pain (72%), with only 25% Presenting with the 'classical triad' of abdominal pain, weight loss, and diarrhea. Many children with Crohn's disease present in a 'non-classical' manner, with vague complaints such as lethargy or anorexia, which may be associated with only mild abdominal discomfort Other symptoms include fever, nausea, vomiting, growth retardation, malnutrition, delayed Puberty, Psychiatric symptoms, arthropathy, and erythema nodosum. Severe constipation and abdominal distension are uncommon symptoms at diagnosis. We report a case of pediatric Crohn's disease, which was diagnosed after the patient presented with severe constipation and abdominal distension.

영아의 혀에 발생한 유아조직 1례

이희정,윤은실,최준혁,최광해 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Tongue tumors of pediatric patients are the most common soft tissue tumor of pediatric oral and maxillofacial tumors. There are many kind of pediatric tongue lesions such as hemangioma, lymphangioma, papilloma, and cyst. Most of these lesions are benign, but malignant tumors of tongue may be occurred. Therefore, malignancy should be ruled out Sometimes, tongue lesions are present with dyspnea, dysphagia, dyarthria, bleeding, or cosmetic problem. We experienced a case of chronic inflammatory mass on posterior 1/3 of symptom occurred because of tongue mass effect. The tongue mass was confirmed as granulation tissue by microscopic examination After excision of tongue mass, she had no problem with swallowing and breathing.

소아의 위장관 이물질에 대한 임상적 고찰

이보형,이현경,김미정,최광해 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: The accidental swallowing of foreign body is a common problem in the children. Ingested foreign bodies may be managed by endoscopy, observation, or surgery. So we analyzed the methods of removal, type, location and complications of foreign bodies. Materials and Methods: This report reviewed 37 cases of ingested foreign body in the gastrointestinal tract at the Department of Pediatrics, Yeungnam University Hospital between January 1997 and April 2001. Results: The age ranged from 8 months to 8 years. The most prevalent age group was between 1 year and 2 years of age(19%). The male to female ratio was 2.1:1 with 25 male and 12 female patients. The type of foreign bodies were coins in 20 cases(54%), nail in 4 cases(11%), key in 4 cases(11%), pin in 2 cases(5.5%), necklace in 2 cases(5.5%) and others. The locations of foreign bodies were upper esophagus in 12 cases(32.5%), lower esophagus in 4 cases(10.8%), stomach in 16 cases(43.2%), small bowel in 5 cases(13.5%). 4. Presenting symptoms were variable with asymptomatic(59.4%), vomiting(19.0%), epigastric pain(8.1%), dysphagia(5.4%) and others. The methods for removal of foreign bodies included 20 cases of endoscopic removal(54.0%), 3 cases of spontaneous removal(8.1%) and there was no surgical removal. 14 cases(37.9%) did not confirmed removal of foreign body because of no revisit of our hospital. Endoscopic finding of patients were normal(15 cases), ulceration(2 cases), erosion(1 case), inflammation(1 case) , mucosal scratch(1 case). Conclusion: It appears that the endoscopic approach is the preferable method for the removal of upper gastrointestinal foreign bodies in the children.

울산지역 초, 중, 고등학생들의 자기 체형에 대한 인식 및 불만족도에 대한 조사

홍찬의,홍성완,정철주,이동진,최광해 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Background : In this study, we examined body image perception and dissatisfaction with weight and height in children and adolescents, according to age and body mass index. Additionally, we compared our findings with those of previous studies concerning eating disorders. Materials and Methods : In July and August 2008, 1,501 students were sampled from elementary, middle, and high schools in Ulsan and assessed using self-completion questionnaires. We used the Korean version of the Eating Attitude Test-26 (EAT-26) to screen for eating risk groups Participants were stratified by grade, gender, and body mass index. Results : 1) Dissatisfaction with height, weight, and body image was greater in the older group. 2) Dissatisfaction with weight and body image was greater in the heavier group. 3) EAT-26 scores and the number of individuals at high risk for eating disorders were higher in the female group than in the male group. Conclusion : The EAT-26 score in this study was similar to those found in Previous Westem studies. 2) There were a number of high-risk individuals in the female group, with a tendency toward earlier Presentation. Continuous health management and prevention programs are required.

NMR Study of Hydrogen Exchange in the DNA Decamer Duplexes Containing the -10 galP1 Promoter Sequence

Choi, Kwang-Ho,Lee, Eun-Hae,Kim, Hee-Eun,Lee, Yeon-Mi,Lee, Ae-Ree,Park, Jin-Wan,Choi, Myong-Yong,Lee, Joon-Hwa Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.5

Cytotoxicity of a Novel Biphenolic Compound, Bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane against Human Tumor Cells In vitro

Choi, Sang-Un,Kim, Kwang-Hee,Kim, Nam-Young,Choi, Eun-Jung,Lee, Chong-Ock,Son, Kwang-Hee,Kim, Sung-Uk,Bok, Song-Hae,Kim, Young-Kook The Pharmaceutical Society of Korea 1996 Archives of Pharmacal Research Vol.19 No.4

Phenolic compounds are prevalent as toxins or environmental pollutants, but they are also widely used as drugs for various purpose including anticancer agent. A novel biphenolic compound, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane (GERI-BPO02-A) was isolated from the fermentation broth of Aspergillus fumigatus F93 previously, and it has revealed cytotoxicity against human solid tumor cells. Its effective doses that cause 50% inhibition of cell growth in vitro against non-small cell lung cancer cell A549, ovarian cancer cell SK-OV-3, skin cancer cell SK-MEL-2 and central nerve system cancer cell XF498 were 8.24, 10.60, 8.83, $9.85\mug/ml$ respectively. GERI-BPO02-A has also revealed cytotoxicity against P-glycoproteinexpressed human colon cancer cell HCT15 and its multidrug-resistant subline HCT15/CL02, and its cytotoxicity was not affected by P-glycoprotein. We have also tested cytotoxicities of structurally related compounds of GERI-BPO02-A such as diphenylmethane, 1,1-bis(3,4dimethylphenyl)ethane, 2,2-diphenylpropane, 2-benzylpyridine, 3-benzylpyridine, $4,4^I-di-tert-butylphenyl$, bibenzyl, $2,2^I-dimethylbibenzyl$, cis-stilbene, trans-stilbene, 3-tert-butyl-4-hydroxy-5-methylphenyisulfide, sulfadiazine and sulfisomidine for studying of structure and activity relationship, and from these data we could suppose that hydroxyl group of GERI-BPO02A conducted important role in its cytotoxicity.