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윤은실 샘터사 2005 월간 샘터 Vol.427 No.-

비만아에서 비알코올성 지방간염의 위험요인

윤은실,박용훈,최광해,Yun, Eun-Sil,Park, Yong-Hun,Choi, Kwang-Hae 대한소아소화기영양학회 2007 Pediatric gastroenterology, hepatology & nutrition Vol.10 No.2

목 적: 비만 인구 증가와 함께 비알코올성 지방간염의 유병율이 증가하고 있어 이에 대한 관심이 높아지고 있지만, 비만아 중 비알코올성 지방간염 발생의 위험요인에 대한 연구는 별로 없는 실정이어서, 비만아 중 비알코올성 지방간염을 예측할 수 있는 위험 요인을 알아보고자 하였다. 방 법: 영남대학교 병원 소아 비만 클리닉을 방문한 비만아 84명을 대상으로 하였으며, ALT 40 IU/L 이하 (Group 1), 41 IU/L 이상(Group 2)로 나누었으며, 간염이 있는 경우에는 다른 원인에 의한 간염은 배제 시켰으며 나이와 총콜레스테롤, 고밀도와 저밀도 지단백 콜레스테롤, 중성지방, 비만도, 체지방률을 비교하고 빈도를 분석하였다. 결 과: 연령, 총콜레스테롤, 고밀도와 저밀도 지단백 콜레스테롤, 중성지방, 비만도, 체지방율의 평균을 비교하였을 때 1군에서는 연령이 $10.5{\pm}1.6$세, 2군은 $10.7{\pm}2.0$세였으며, 총콜레스테롤은 1군에서 $183.0{\pm}29.1$ mg/dL, 2군에서 $183.7{\pm}31.3$ mg/dL였고, 고밀도 지단백 콜레스테롤은 1군, 2군 각각 $53.0{\pm}10.2$ mg/dL, $55.7{\pm}13.0$ mg/dL, 저밀도 지단백 콜레스테롤은 1군에서 $113.4{\pm}30.2$ mg/dL, 2군에서 $113.0{\pm}30.0$ mg/dL, 중성지방은 1군에서 $99.4{\pm}62.9$ mg/dL, 2군에서 $114.2{\pm}47.3$ mg/dL, 비만도는 1군에서 $44.7{\pm}12.2%$, 2군에서 $47.9{\pm}15.1%$, 체지방률은 각각 $32.7{\pm}5.0%$, $34.0{\pm}4.8%$로 두 군 간에 통계적으로 유의한 차이가 없었으나, 이상지혈증의 분포는 총콜레스테롤, 고밀도와 저밀도 지단백 콜레스테롤은 두 군에서 통계적으로 유의한 차이가 없었으나, 중성지방은 110 mg/dL 이상인 경우가 1군에서 13명(28.9%), 2군에서 21명(53.8%)으로 2군에서 통계적으로 유의하게 많았다(p-value=0.023). 결 론: 비만아에서 비알코올성 지방간염을 예측할 수 있는 위험요인으로 중성지방이 유용할 것으로 생각된다. Purpose: Obesity has recently emerged as a significant health problem in the pediatric population, and the prevalence of non-alcoholic fatty liver disease is increasing in tandem with a significant rise in childhood obesity. Therefore, this study was conducted to clarify the risk factors of non-alcoholic steatohepatitis in obese children. Methods: We enrolled 84 obese children who visited the pediatric obesity clinic at Yeung-Nam university hospital. The patients were divided into two groups based on their alanine aminotransferase (ALT) level (separated at 40 IU/L), and the mean of ages, total cholesterol levels, HDL-cholesterol levels, LDL-cholesterol levels, triglyceride (TG) levels, as well as the mean obesity index, and body fat percentage of the two groups were then compared. Results: When the mean of ages ($10.5{\pm}1.6$ vs. $10.7{\pm}2.0$ years), total cholesterol levels ($183.0{\pm}29.1$ vs. $183.7{\pm}31.3$ mg/dL), HDL-cholesterol levels ($53.0{\pm}10.2$ vs. $55.7{\pm}13.0$ mg/dL), LDL-cholesterol levels ($113.4{\pm}30.2$ vs. $113.0{\pm}30.0$ mg/dL), triglyceride levels ($99.4{\pm}62.9$ vs. $114.2{\pm}47.3$ mg/dL), obesity indexes ($44.7{\pm}12.2$ vs. $47.9{\pm}15.1%$), and body fat percentages ($32.7{\pm}5.0$ vs. $34.0{\pm}4.8%$) of group 1 (ALT${\leq}$40 IU/L) were compared with those of group 2 (ALT${\geq}$41 IU/L), no significant differences were observed (p>0.05). However, hypertriglyceridemia (TG${\geq}$110 mg/dL) was more frequent in group 2 than in group 1 (p=0.023). Conclusion: TG may be an important risk factor in non-alcoholic steatohepatitis and further study regarding the risk factors in non-alcoholic steatohepatitis is required.

얼굴인식을 위한 입술영역에 효과적인 말스버그 가보 웨이브렛 커널의 최적화

윤은실 ( Eun-sil Yun ),이필규 ( Phill-kyu Rhee ) 한국정보처리학회 2007 한국정보처리학회 학술대회논문집 Vol.14 No.1

얼굴 인식은 생체인식 기술 중 비 강압식이라는 장점으로 인해 각광받고 있는 분야이다. 그러나 얼굴 인식은 조명, 표정에 의해 인식 성능이 저하되는 단점이 있다. 그 중 얼굴표정에 많은 영향을 받으며, 잡음이 많은 부분이 입술부분이다. 입술모양의 변화에 따라 가보벡터 추출에 잡음이 포함되기 때문에, 얼굴 인식 성능이 저하되는 현상이 발생됨을 실험을 통해 알 수 있었다. 따라서 본 논문에서는 입술모양의 변화에 따른 잡음을 줄이기 위해 입술영역에 최적화된 말스버그 가보 웨이브렛 커널(Malsburg Gabor Wavelet Kerne)을 제안한다. 각 입술 특징점에 말스 버그 가보 웨이브렛을 적용하여, 추출된 가보벡터를 통계적으로 분석함으로써 잡음을 확인 할 수 있었으며, 잡음을 최소화하기 위해 입술 영역에 적응적인 말스버그 가보 웨이브렛 커널을 제안하였다. 실험에 사용한 이미지는 1196 FERET Gellery 이미지를 사용하였으며, 얼굴 인식 성능이 향상됨을 알 수 있었다.

일과 삶의 균형(Work-Life Balance,WLB)이 조직몰입과 조직시민행동에 미치는 영향

최은실,서창적,윤주옥 한국고객만족경영학회 2019 고객만족경영연구 Vol.21 No.4

This research addresses the effect of work-life balance on organizational commitment and organizational citizenship behavior. To practically analyze the effectiveness of the work-life balance, such as the work-grow balance, the work-leisure balance, the work-family balance, and the hypothesis were established to demonstrate the relationship among work-life balance, organizational commitment and organizational citizenship behavior. A total of 514 pieces of data were analyzed using a structural equation. The results of this study show that the work-growth balance and work-family balance have a significant positive impact on organizational commitment and organizational citizenship behavior. It is appeared that the work-leisure balance does not have significant impact on organizational commitment but negatively impact organizational citizenship behavior. This study analyzed the relationship between work-life balance and organization commitment, organizational citizenship behavior by dividing it into quantitative studies, and specifically identified practical problems regarding work-life balance. Through this process, the study can present the following implications. It is meaningful that this study identified the relationship between work-life balance and organizational performance and how the WLB could affect the organization. Therefore, it is expected that organizational managers will be able to use the work-life balance system as a practical basis for introducing it. 본 연구는 일과 삶의 균형이 조직몰입과 조직시민행동에 미치는 영향을 규명한 것이다. 일과 삶의 균형과의 효과성을 실질적으로 분석하기 위하여 일-성장/ 일-여가/일-가족 간의 균형 요소로 구분하여 연구 모형을 수립하고 가설을 설정하여 일과 삶의 균형과 조직몰입, 조직시민행동과의 관계를 양적 연구를 진행하여 실증하였다. 양적 연구로 포괄적인 산업에서 근무하는 직장인 대상으로 설문조사를 실시, 총 514부의 자료를 대상으로 구조방정식을 이용하여 분석 하였다. 실증분석 결과, 일과 삶의 구성요소 중 일-성장 균형, 일-가정 균형 요소가 조직몰입, 조직시민행동에 유의한 정(+)의 영향을 미치는 것으로 나타났고, 일-여가 균형은 조직몰입에 유의한 영향을 미치지 않으며 조직시민행동에는 부(-)의 영향을 미치는 것으로 나타났다. 본 연구는 일과 삶의 균형의 세부요인과 조직몰입, 조직시민행동과의 관계를 분석 하였으며, 일과 삶의 균형에 대한 현실적인 문제에 대해 구체적으로 규명하였다. 본 연구는 일과 삶의 균형과 조직성과에 직접 영향을 미치는 조직몰입, 조직시민행동과의 영향관계를 규명하여, WLB이 어떠한 방식으로 조직에 영향을 미칠 수 있는지에 대하여 실질적으로 연구했다는데 의의가 있다. 따라서 조직 관리자가 일과 삶의 균형 제도 도입시 실무적 기초 자료로 사용할 수 있을 것으로 기대한다.

영아의 혀에 발생한 유아조직 1례

이희정,윤은실,최준혁,최광해 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Tongue tumors of pediatric patients are the most common soft tissue tumor of pediatric oral and maxillofacial tumors. There are many kind of pediatric tongue lesions such as hemangioma, lymphangioma, papilloma, and cyst. Most of these lesions are benign, but malignant tumors of tongue may be occurred. Therefore, malignancy should be ruled out Sometimes, tongue lesions are present with dyspnea, dysphagia, dyarthria, bleeding, or cosmetic problem. We experienced a case of chronic inflammatory mass on posterior 1/3 of symptom occurred because of tongue mass effect. The tongue mass was confirmed as granulation tissue by microscopic examination After excision of tongue mass, she had no problem with swallowing and breathing.

Characterization of a Methyl Jasmonate Specific Esterase in Arabidopsis

구연종,윤은실,서준성,김주곤,최양도 한국응용생명화학회 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.1

Methyl jasmonate (MeJA)-specific methyl esterase of Arabidopsis (AtMJE) was identified and characterized. AtMJE has high substrate specificity to MeJA compared to other related substrates, methyl indole-3-acetate (MeIAA) and methyl salicylate (MeSA). Through enzyme kinetics analysis, we found AtMJE has similar level of substrate affinity to JA carboxyl methyltransferase (AtJMT). However, AtMJE has 10 times lower catalytic efficiency than AtJMT at low substrate concentrations. AtMJE gene expression was suppressed for 2 h after MeJA treatment, even though its expression recovered and was induced to maximum level within 8 h after treatment. AtMJE overexpressing plants (AtMJEox)showed enhanced MeJA methyl esterase activity demonstrating esterase activity of AtMJE in vivo. AtMJEox plants responded differentially to JA and MeJA in root growth. MeJA in the media could be a source for more JA production in AtMJEox plants,which resulted in root growth inhibition. In contrast, AtMJEox plants grown on JA containing media showed similar root growth inhibition as wild-type. These results show that AtMJE functions in altering JA/MeJA ratios in Arabidopsis and increased JA,because the conversion of MeJA to JA enhances JA responsive gene expression.

신생아에 발생한 원인 불명의 일시적인 복부 팽만 3 예

최정연,윤은실,최광해 영남대학교 의과대학 2006 Yeungnam University Journal of Medicine Vol.23 No.1

Abdominal distension is not an uncommon symptom in the neonate; it is indistinguishable from Hirschsprung disease by symptoms and X-ray findings. In three patients, severe abdominal distension was found at early infancy and improved with conservative treatment without relapse. The findings were different from those of Hirschsprung disease. Immaturity or poor coordination of peristaltic movement is postulated as the cause. With maturation such problems can normalize. However the pathogenesis remains unclear and further investigation is needed to improve our understanding.

해삼추출액을 함유한 면의 특성 및 혼합물 설계법을 통한 혼합비의 최적화

유진실,홍은실,홍광원,윤원병 한국산업식품공학회 2016 학술대회 및 심포지엄 Vol.2016 No.10

Sea cucumber, Stichopus japonicas, is widely used in East Asia as a traditional medical component for the treatment of asthma, arthritis, and sinus congestion. The hydrolysate of sea cucumber after treating with a protease is also widely used as an ingredient for the processed food application such as noodles. Tensile force and deformation are important texture properties of noodle. The peptides prepared by hydrolyzing sea cucumber could affect the tensile properties of noodle as well as DPPH radical scavenging. The objectives of this study were to characterize the tensile properties, the texture properties, color, and DPPH radical scavenging of noodle with the hydrolysate of sea cucumber and to determine an optimum formulation of dough with the hydrolysate of sea cucumber for noodle. The hydrolysate of sea cucumber was prepared by hydrolyzing dried sea cucumber powder with distilled water and a protease, Protamex (Novozyme Nordisk, Bagsvaerd, Denmark). Tensile test was used for measuring the breaking strength and the breaking distance of noodle. The tensile properties and antioxidant activity (DPPH radical scavenging) were used as major constraint functions for the optimization. Central composite design was used to determine the experimental points for the optimization. Quadratic models were developed to represent the constraint functions. The optimum ratio was determined to flour: water: the hydrolysate of sea cucumber = 69.27: 22.48: 7.05% (w/w). Increasing the amount of hydrolysate of sea cucumber in the formulation increased the tensile force but no significant difference was observed in the deformation. The hydrolysate of sea cucumber was successfully applied to a noodle formulation without degrading the major quality indices of noodle with enhancing the antioxidant activities.

환자경험 평가와 의료 현장의 변화: 의료기관 환자경험 업무 담당자의 관점

송영채,윤은실,한세영,태지연,유수경,도영경 한국의료질향상학회 2022 한국의료질향상학회지 Vol.28 No.1

Purpose: To examine whether the Patient Experience Assessment (PEA) has led to perceptible changes at the ground level of health care, as a way of evaluating PEA as a policy intervention for quality improvement. Methods: Four focus group discussions (FGDs) were conducted, each comprising six to eight participants who were employees responsible for patient experience at their respective hospitals. The primary focus of the FGDs was on questions such as: 1) How do hospitals respond to PEA? 2) What significant changes were observed after the implementation of PEA? 3) What were the unintended consequences of implementing PEA, if any? 4) What areas of improvement have been identified for maximizing the potential of PEA? Results: Two broad themes emerged out of the FGDs: changes observed post implementation of PEA, and areas for improvement of PEA. Four significant changes were reported by participants: changes in perception and attitude regarding patient experience in hospital employees, increased active involvement by the hospital leadership, enhanced efforts to improve patient experience, and increased cooperation between such activities. Furthermore, eight areas of improvement were identified, which have been grouped in three categories: improving the process of data collection for PEA, introducing additional catalysts to facilitate further changes, and paying attention to structure- and patient-level constraints that must be addressed in parallel. Conclusion: The implementation of PEA led to perceptible changes within hospitals, which implies that it can serve as an effective catalyst for improving patient experience. A number of areas of improvement that would aid in maximizing the potential of PEA were also identified.

총간관에서 발생한 선암을 동반한 융모성 선종 1예

김준,신정현,윤영진,김은경,김종철,김명환,장우영,민영일,손정민,고관호,박경하,정선미,유은실 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.1

Villous adenoma of the extrahepatic duct is a rare disease, Even though it is benign, it has malignant potential and is considered a premalignant lesion. We here report one case of villous adenoma with foci of adenocarcinoma arising in the common hepatic duct. A 60-year-old male was admitted to our hospital because of epigastric pain. The cholangiogram revealed a large filling defect in the right intrahepatic and common hepatic duct with intrahepatic bile duct dilatation, The patient underwent right lobectomy. Grossly, stalked papillay tumor originated in the common hepatic duct was overriding the right intrahepatic duct. Microscopically, the tumor was composed of stratified tall columnar cells with various dysplasia and there were foci of invasive adenocarcinoma.