2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

흰쥐중심편도체핵에서 Neurotensin 면역양성세포의 다리옆핵으로의 투사

박인식,최정화,박봉수,백선용,김봉선,김재봉,김진정 대한해부학회 1996 Anatomy & Cell Biology Vol.29 No.2

후천성 면역 결핍증에서의 폐렴구균 감염 부검 1예 : An Autopsy Report

이미숙,우준희,진소영,김종원,최창현,김양수,김은옥,김백남,이동화,류지소 대한감염학회 1996 감염 Vol.28 No.3

28세 남자의 후천성 면역 결핍증 환자에서 S. pneumoniae 폐렴이 합병되어 사망한 1예를 경험하여 부검소견과 함께 보고하는 바이다. Pulmonary infections such as Pneumocystis carinii, cytomegalovirus, and tuberculosis are a major cause of morbidity and mortality in patients with human immunodeficiency virus(HIV) infection. Patients with HIV infection are at increased risk for bacterial pneumonia in addition to opportunistic infection. Although in a primary defect, HIV infection is associated with substantial dysfunction of humoral immunity, which predisposes patients to bacterial infections, particularly with encapsulated organisms, such as Streptococcus pneumoniae. We report a case of 28 year-old Korean male with HIV infection who died of respiratory failure due to pneumococcal pneumonia with autopsy findings.

Ligand - Binding Modulation of Adenosine A1 receptor by Frog - Skin phospholipase A2 and Gaegurin 4

Hwa Jin Baek,Hyen Wook Chang,Byeong Jae Lee 생화학분자생물학회 1996 생화학분자생물학회 춘계학술발표논문집 Vol.- No.-

Ligand binding inhibitors of A1 adenosine receptor from Rana rugosa are phospholipase A₂s

Baek, Hwa Jin,Kwon, So Yeon,Kim, Sunkyu,Kim, Sukwon S.,Oh, Utaek,Hwang, Seongbin,Chang, Hyeun Wook,Lee, Byeong Jae 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-

Inhibitors of the A1 adenosine receptor were isolated from the skin extract of Korean frog. Rana rugosa. The frog-skin extract was prepared by an electrical shock and fractionated with C_(4) followed by C_(?) reverse-phase HPLC. Two A1 receptor inhibitors were isolated using a filter binding assay and the molecular masses of the proteins were estimated by matrix-assisted laser desorption ionization time-of-flight mass spectrometry to be 15 347 and 15 404 Da, respectively. The inhibitory activity was also measured against other membrane receptors, such as the A2 adenosine receptor, muscarinic acetylcholine receptor and capsaicin receptor. Ligand binding to the A2 and muscarinic receptors was also severely inhibited by these proteins. However, they did not inhibit the functional activation of the capsaicin receptor by its ligand, capsaicin, suggesting that inhibition of ligand-receptor binding occurs specifically. Their N-terminal sequences were determined by Edman degradation. Surprisingly, they showed sequence similarity to the secretory protein, phospholipase A_(2) from various organisms. The phospholipase A_(2) activity of both proteins was ttested using Dole's assay technique. Both proteins showed phospholipase A_(2) activity, and therefore, they were designated as PLA_(2)-R1 and PLA_(2)-R2, respectively. In addition, their ligand-binding inhibitory activity depended on their phospholipase A_(2) activity. This is the first finding that the frog secretes a phospholipase A_(2) similar to that of snake venoms, which posess inhibitory activity against the adenosine A1, adenosine A2 and musearinic receptors.

Advantages and disadvantages of the ENVOY 6F distal access guiding catheter in endovascular coiling for anterior circulation aneurysms

JIN WOOK BAEK,Sung-Chul Jin,Sung Tae Kim,Young Jin Heo,Ji Yeon Han,Jung Hwa Seo,Sung Hwa Paeng,Jung Soo Kim,Hae Woong Jeong,Young-Gyun Jeong 대한뇌혈관외과학회 2019 Journal of Cerebrovascular and Endovascular Neuros Vol.21 No.1

Objective : Selecting an appropriate guiding catheter to provide both sufficient supportability for working devices and sufficient distal navigability is essential for ensuring the success of a procedure. This study aimed to evaluate the advantages and disadvantages of using the ENVOY 6F distal access (DA) guiding catheter in coil embolization of anterior circulation cerebral aneurysms. Methods : We included 98 patients (72 [73.5%] women, median age: 63 [range: 25-84] years) who underwent endovascular coiling with the ENVOY 6F DA guiding catheter from May to November 2016. We analyzed data on patient demographics and the number of co-axial techniques to position the guiding catheter, initial and final location of the catheter, and complications related to the catheter. Results : The co-axial technique was used to position the ENVOY 6F DA guiding catheter in the internal carotid artery (ICA) in 20 cases (20.41%). The initial position of the ENVOY 6F DA guiding catheter involved the cervical ICA (79.6%), horizontal petrous ICA (17.3%), and vertical petrous ICA (3.1%). Final control angiograms after endovascular coiling showed proximal change in the final, compared to the initial, position of the ENVOY 6F DA guiding catheter in 25 cases (25.51%). Procedure-related complications were observed in nine patients (9.18%), involving vasospasm in all cases; however, there was no symptomatic case. Conclusion : The ENVOY 6F DA guiding catheter had relatively sufficient distal navigability without symptomatic procedural complications. However, the change in the catheter position after endovascular coiling denoted insufficient supportability.

학교 메신저를 통한 교사PC의 정보 유출 위험 및 대응방안 연구

손백한(Baek-Han Son),백정헌(Jeong-Heon Baek),백승진(Seung-Jin Baek),오준석(Jun-Seok Oh),황동화(Dong-Hwa Hwang) 한국정보과학회 2016 한국정보과학회 학술발표논문집 Vol.2016 No.12

G-code 패킷 컨트롤을 통한 웹 기반 금형 가공 공정관리

최진화(Jin Hwa Choi),백세진(Se jin Baek),이정원(Jung Won Lee),전병철(Byung Cheol Jeon),조명우(Myeong Woo Cho) 한국생산제조학회 2006 한국공작기계학회 춘계학술대회논문집 Vol.2006 No.-

This paper is proposed web-based mold manufacturing process management system for the effective manufacturing processing management. Developed system is G-code analysis to include manufacturing information and organize according to cutting level, tool species, and tool path, etc. It is able to insert OMM(On Machine Measurement)-code in the organized G-code. And this system is developed to control remote-place manufacturing process management system by web-based Sever / Client system. So this is able to control remote-place system monitoring and mold manufacturing process management.

감마선 및 전자선 조사 처리 건조향신료에 대한 광자극발광, 열발광 및 전자스핀공명의 분광학적 분석 비교

정진화(Jin-Hwa Jeong),안재준(Jae-Jun Ahn),백지영(Ji-Yeong Baek),김효영(Hyo-Young Kim),권중호(Joong-Ho Kwon),진창현(Chang-Hyun Jin),정일윤(Il-Yun Jeong) 한국식품과학회 2014 한국식품과학회지 Vol.46 No.2

현재 사용되고 있는 물리적 확인시험법인 광자극발광법(PSL), 열발광분석법(TL), 전자스핀공명법(ESR)을 이용하여 4종의 시료에 대해 감마선과 전자선에 의한 확인시험법의 판별 특성을 확인하였다. PSL 측정 결과 고춧가루, 바질, 파슬리 시료는 선원 및 선량에 관계없이 조사된 시료는 photon count 값(PCs)이 5,000 이상인 7,004-70,519의 PCs로 측정되어 조사여부의 판정이 가능하였다. 하지만 조사된 후춧가루에서는 선원에 관계없이 threshold value가 5,000 이하인 442-1,572 PCs로 중간값 및 음성값을 나타냄에 따라 조사여부 확인이 어려웠다. TL 측정 결과에서는 고춧가루, 바질, 파슬리, 후춧가루 4종 모두 선원 및 선량에 관계없이 조사된 시료는 150-250℃ 사이에서 최대 glow curve peak가 나타났다. 또한 TL ratio값이 0.1 이상인 0.101-0.889을 나타내어 조사여부 판정이 가능하였다. ESR 측정 결과에서는 고춧가루만이 cellulose 유래의 signal을 보이면서 방사선 조사여부를 판정할 수 있었다. 다른 3종 시료에서는 single line signal을 나타내어 ESR 판정이 어렵다는 것이 확인되었다. 따라서 전자선조사 향신료에서도 현행 물리적 판별방법으로 조사 여부 확인이 가능하였으며, false 값에 대한 이유를 밝히는 연구가 추가적으로 수행되어야 할 것으로 사료된다. This study was conducted to determine the effect of gamma-ray and electron-beam irradiation on dried spices (black pepper, red pepper, parsley, and basil) using the photostimulated luminescence (PSL), thermoluminescence (TL) and electron spin resonance (ESR) methods. The spices were irradiated at 0, 1, 5, and 10 kGy. All non-irradiated spices had photon counts (PCs) less than 700 PCs. The PCs of three irradiated spices (red pepper, parsley, and basil) were clearly distinguishable from those of non-irradiated ones, exhibiting PSL signals higher than 5000 PCs. However, negative PSL counts (<700 PCs) were obtained for most irradiated black pepper, except those irradiated with 5 kGy gamma rays and 10 kGy electron-beams. TL glow curves of the irradiated spices showed a higher peak at 150-250oC. TL ratios were found to be less than 0.1 for non-irradiated spices and higher than 0.1 for irradiated ones. No ESR signal was observed for any irradiated spice except red pepper, which displayed cellulose-based ESR spectra. Therefore, the results suggest that the PSL, TL, and ESR methods are effective detection techniques for dried spices irradiated with electron beams as well as gamma rays.

Skull Base Dermoid Cyst in the Right Infratemporal Fossa Diagnosed Using the Dixon Technique: a Case Report and Review of Literature

Kim, Seung Jin,Baek, Hye Jin,Ryu, Kyeong Hwa,Choi, Bo Hwa,Moon, Jin Il,Cho, Soo Buem,Park, Sung Eun,Bae, Kyungsoo,Jeon, Kyung Nyeo,Cho, Eun Bin,An, Hyo Jung Korean Society of Magnetic Resonance in Medicine 2017 Investigative Magnetic Resonance Imaging Vol.21 No.2

Dermoid cysts are benign congenital tumors composed of keratinizing squamous epithelium and dermal derivatives. They account for less than 1% of all intracranial tumors and are rarely exhibited at the base of the skull. To the best of our knowledge, only one case report has presented computed tomography and conventional T1-weighted magnetic resonance (MR) findings that revealed an infratemporal dermoid cyst. In the present study, we report an unusual case of a dermoid cyst in the right infratemporal fossa, which was incidentally detected by MR imaging with the Dixon technique. This article also highlights the importance of meticulous radiological review and the usefulness of the Dixon technique in everyday clinical practice.