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<SUP>18</SUP>F-FDG PET-CT에서 진단된 갑상선 우연종의 악성종양 발견율 및 특징
이강영,고건<SUP>1<.SUP>,김선국<SUP>1<.SUP>,고진철<SUP>1<.SUP>,김행수,최상용,박신희,박용휘<SUP>2<.SUP>,Kang Young Rhee,Gun Koh,<SUP>1<.SUP>,Sun Kuk Kim,<SUP>1<.SUP>,Jin Chul Koh,<SUP>1<.SUP>,Haeng Soo Kim,Sang Yong Choi,Shin 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.1
<B>Purpose: </B>PET-CT is often used to differentiate benign or malignant thyroid incidentalomas. In this retrospective study, we evaluated whether the <SUP>18</SUP>F-FDG uptake pattern and PET-CT findings improved accuracy over the standardized uptake value (SUV). <B>Methods:</B> <SUP>18</SUP>F-FDG PET-CT was performed on 2,178 subjects from August, 2004, to October, 2007, in Sung-ae Hospital. PET-CT was performed on 806 patients (37%) with suspected or known nonthyroidal cancer and 1,372 healthy subjects (63%) without a previous history of cancer. We investigated the clinical characteristics of patients, history, standardized uptake value (SUV), ultrasonography, and hormone levels in blood. Thyroidal cancer was confirmed by ultrasonography-guided fine needle aspiration and pathology after thyroid operation. <B>Results:</B> The prevalence of focal thyroid lesions on PET-CT was 8.8% (191/2178). Thyroid cancer confirmation was 7.9% (15/191). The maximum SUV of malignant thyroid lesions were significantly higher than that of benign lesions (7.00±3.08 vs. 4.49±1.84, P<0.001). <B>Conclusion:</B> PET-CT image interpretation that includes 18F-FDG uptake and SUV is better than PET-CT alone for differentiating benign and malignant lesions. Thyroid cancer risk increases as SUVmax levels increase. <B>(Ko</B><B></B><B>rean J Endocrine Surg 2008;8:38-42)</B>
Inhibition of a Neutral Form of Sphingomyelinase by Alkylthioureido-1,3-propandiols, KY353X Series
( Sang Mi Jung ),( Eui Man Jeong ),( Dong Hwawn Jo ),( Mi Reyoung Chin ),( Hyung Jin Jun ),( Yong Hyun Kim ),( Hyung Jun Jeon ),( Dong Hun Lee ),( Mi Ja Park ),( Mi Jung Oh ),( Chul Bu Yim ),( Dae Kyo 한국응용약물학회 2003 Biomolecules & Therapeutics(구 응용약물학회지) Vol.11 No.3
( Sang Chul Park ),( Se Heang Oh ),( Jin Ho Lee ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.2
An asymmetrically porous nerve guide conduit (NGC) with selective permeability and hydrophilicity was prepared by rolling an asymmetrically porous poly(dioxanone-b-caprolactone) (PDOCL)/Pluronic F127 membrane fabricated by a novel immersion precipitation method. The asymmetrically porous PDOCL/Pluronic F127 membrane was fabricated by immersing the PDOCL/Pluronic F127 solution (in tetraglycol) in a mold into water. The PDOCL/Pluronic F127 mixture was precipitated in water by the diffusion of water into PDOCL/Pluronic F127 mixture solution. The prepared PDOCL/F127 NGC had an asymmetric column-shape pore structure. The inner surface of the tube had sub-micron pores (< 1 μm) that can prevent fibrous tissue infiltration but permeate nutrients/ oxygen, and the outer surface had micron pores (~ 200 μm) that can allow vascular ingrowth for the effective supply of nutrients and oxygen into the NGC to promote nerve regeneration. The PDOCL/F127 NGC with 3 wt% Pluronic F127 appeared to be optimal for its mechanical properties and hydrophilicity. To stimulate nerve regeneration, NGF was immobilized onto the pore surfaces of the NGC via heparin binding. The NGF immobilized on the heparinbound NGC was released in a sustained manner for up to 35 days. The NGF-immobilized asymmetrically porous PDOCL/F127 (3 wt%) NGC may be a good candidate as a NGC for enhanced nerve regeneration.
Occurrence of Veterinary Antibiotics in the Agro-Environment
Jin Wook Kim,Young Kyu Hong,Sung Chul Kim 한국토양비료학회 2020 한국토양비료학회지 Vol.53 No.2
Veterinary antibiotics (Vas) in agro-environment has been concerned because of antibiotic resistance genes (ARGs) production. The objective of this research was to monitor VAs in the agro-environment such as soil, sediment, and surface water near at the confined animal feeding operation (CAFOs). Total of 6 VAs including tetracycline (TC), chlortetracycline (CTC), oxytetracycline (OTC), sulfamethazine (SMT), sulfamethoxazole (SMX), and sulfathiazole (STZ) were monitored. Extraction of VAs was conducted with solid phase extraction (SPE) and quantified with high performance liquid chromatography mass spectrometry (HPLC/MS/MS). Result showed that only SMX was observed among 6 VAs and concentration range was following: soil (0.03-0.11 μg kg<SUP>-1</SUP>), sediment (0.04-0.07 μg kg<SUP>-1</SUP>), surface water (0.04-0.06 μg L<SUP>-1</SUP>). Correlation analysis showed that soil pH was negatively correlated with SMX concentration in soil (correlation coefficient: -0.66) indicating that less SMX was observed as soil pH was increased. The reason for negative correlation between soil pH and SMX concentration in soil was that SMX was negatively charged at higher soil pH and electric repulsion could be occurred between soil particles and SMX. However, more detailed research would be necessary to verify the occurrence, fate, and transport of VAs in agro-environment.
Sung, Hwa Jung,Kim, Seok Jin,Lee, Ji-Hye,Lee, Goeun,Lee, Kyung A,Choi, Chul Won,Kim, Byung Soo,Kim, Jun Suk KOREAN ACADEMY OF MEDICAL SCIENCE 2007 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.22//SUP No.-
<P>We report a case of pure red cell aplasia (PRCA), which was initially suspected as a result of bone marrow involvement of diffuse large B cell lymphoma. Persistent anemia without an obvious cause was observed in a 47-yr-old man diagnosed with relapsed diffuse large B cell lymphoma. The bone marrow study showed only erythroid hypoplasia without the evidence of bone marrow involvement with lymphoma cells, thus PRCA was suggested. However, parvovirus infection was excluded as a potential cause of PRCA because of negative IgM anti-parvovirus B19 antibody and negative parvovirus PCR in the serum. Latent Epstein-Barr virus (EBV) infection of bone marrow was suggested by in situ hybridization with EBV-encoded small RNA (EBER) that showed a strong positive expression in bone marrow cells. Thus, PRCA was thought to be associated with latent EBV infection in bone marrow cells. Although the finding of unexplained anemia is a possible predictor of bone marrow involvement with lymphoma cells, PRCA as a result of a viral infection including EBV should be considered in lymphoma patients. This is the first report of the occurrence of PRCA associated with latent EBV infection in a patient with non-Hodgkin's lymphoma.</P>
Polypyrrole Modified Electrode as a Nitrate Sensor
Sung Chul Kang,Keun-Sun Lee,Jin-Doo Kim,Kang-Jin Kim Korean Chemical Society 1990 Bulletin of the Korean Chemical Society Vol.11 No.2
The potentiometric response behavior of a polypyrrole(PPy) coated Pt electrode to nitrate ion has been studied. The electrode shows a nernstian behavior with a slope of 59 mV over 0.50 M to $1.0{\times}10^{-3}M\;NO_3\;^-$ and a detection limit of $1.0{\times}10^{-4}M\;NO_3\;^-$. The response of the electrode is fast and the selectivities for $I^-,\;ClO_4\;^-,\;and\;IO_4\;^-$ are found to be improved. The effect of pH on the potential response to $NO_3\;^-$ is compared with the existing nitrate ion selective electrodes.
Chrotective Effects of Wogonin in Experimental Models of Osteoarthritis in vitro and in vivo
( Jin Sung Park ),( Hyun Jae Lee ),( Dong Yeong Lee ),( Ho Seung Jo ),( Jin Hoon Jeong ),( Dong Hee Kim ),( Dae Cheol Nam ),( Choong Jae Lee ),( Sun-chul Hwang ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.5
We evaluated the chondroprotective effects of wogonin by investigating its effects on the gene expression and production of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as on production of MMP-3 in the rat knee. Rabbit articular chondrocytes were cultured in a monolayer, and RT-PCR was used to measure interleukin-1β (IL-1β)-induced expression of MMP-3, MMP-1, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), and type II collagen. In rabbit articular chondrocytes, the effects of wogonin on IL-1β-induced production and proteolytic activity of MMP-3 were investigated using western blot analysis and casein zymography, respectively. The effect of wogonin on MMP-3 protein production was also examined in vivo. In rabbit articular chondrocytes, wogonin inhibited the expression of MMP-3, MMP-1, MMP-13, and ADAMTS-4, but increased expression of type II collagen. Furthermore, wogonin inhibited the production and proteolytic activity of MMP-3 in vitro, and inhibited production of MMP-3 protein in vivo. These results suggest that wogonin can regulate the gene expression and production of MMP-3, by directly acting on articular chondrocytes.